Latest & greatest articles for copd

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Top results for copd

281. Effect of tiotropium on quality of life in COPD: a systematic review

Effect of tiotropium on quality of life in COPD: a systematic review Effect of tiotropium on quality of life in COPD: a systematic review Effect of tiotropium on quality of life in COPD: a systematic review Kaplan A CRD summary The author concluded that tiotropium improved the quality of life for patients with chronic obstructive pulmonary disease who required long-acting bronchodilator treatment. Given the unclear quality of included trials, the small number of trials and the absence (...) of clinically significant differences for many trials, the author's conclusions should be treated with caution. Authors' objectives To assess the impact of long-acting anticholinergic tiotropium on health related quality of life in patients with chronic obstructive pulmonary disease (COPD). Searching PubMed, EMBASE and BIOSIS Previews were searched for articles published in English from 1990 to 2009. Search terms were reported. Study selection Double-blind randomised controlled trials (RCTs) that compared

DARE.2010

282. Risk of myocardial infarction and cardiovascular death associated with inhaled corticosteroids in COPD

Risk of myocardial infarction and cardiovascular death associated with inhaled corticosteroids in COPD Risk of myocardial infarction and cardiovascular death associated with inhaled corticosteroids in COPD Risk of myocardial infarction and cardiovascular death associated with inhaled corticosteroids in COPD Loke YK, Kwok CS, Singh S CRD summary This review assessed the risk of myocardial infarction and mortality associated with long-term use of inhaled corticosteroids in patients (...) with chronic obstructive pulmonary disease. The authors concluded that observational studies suggested a cardiovascular or mortality benefit but randomised controlled trials did not. Further research was required to clarify these conflicting findings. The authors' conclusions are likely to be reliable. Authors' objectives To assess the risk of myocardial infarction, cardiovascular death and overall mortality associated with long-term use of inhaled corticosteroids in patients with chronic obstructive pulmonary disease (COPD). Searching

DARE.2010

283. Does tiotropium lower exacerbation and hospitalization frequency in COPD patients? Results of a meta-analysis

Does tiotropium lower exacerbation and hospitalization frequency in COPD patients? Results of a meta-analysis Does tiotropium lower exacerbation and hospitalization frequency in COPD patients? Results of a meta-analysis Does tiotropium lower exacerbation and hospitalization frequency in COPD patients? Results of a meta-analysis Van den Bruel A, Gailly J, Neyt M CRD summary The authors concluded that tiotropium reduced the number of exacerbations and hospitalisations (...) of chronic obstructive pulmonary disease (COPD) patients compared with placebo and ipratropium; compared with salmeterol, only the exacerbation frequency was reduced. Given the variability across trials, the possibility of inappropriate pooling and the poor quality of the evidence base, the authors’ conclusions should be interpreted with caution. Authors' objectives To estimate the effect of tiotropium (a long-acting anticholinergic inhalant) on exacerbation and chronic obstructive pulmonary disease (COPD)-related hospitalisation

DARE.2010

284. Inhaled corticosteroids vs placebo for preventing COPD exacerbations: a systematic review and metaregression of randomized controlled trials

Inhaled corticosteroids vs placebo for preventing COPD exacerbations: a systematic review and metaregression of randomized controlled trials Inhaled corticosteroids vs placebo for preventing COPD exacerbations: a systematic review and metaregression of randomized controlled trials Inhaled corticosteroids vs placebo for preventing COPD exacerbations: a systematic review and metaregression of randomized controlled trials Agarwal R, Aggarwal AN, Gupta D, Jindal SK CRD summary The review found (...) a modest reduction in risk of exacerbations in patients with severe to very severe chronic obstructive pulmonary disease with use of inhaled corticosteroids that was not related to the level of baseline lung function. The authors suggested that the role of inhaled corticosteroids needed to be further evaluated. Their cautious conclusions are appropriate and reliable. Authors' objectives To assess the efficacy of inhaled corticosteroids in reducing chronic obstructive pulmonary disease (COPD

DARE.2010

285. Economic analyses comparing tiotropium with ipratropium or salmeterol in UK patients with COPD

Economic analyses comparing tiotropium with ipratropium or salmeterol in UK patients with COPD Economic analyses comparing tiotropium with ipratropium or salmeterol in UK patients with COPD Economic analyses comparing tiotropium with ipratropium or salmeterol in UK patients with COPD Gani R, Griffin J, Kelly S, Rutten-van Molken M Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary (...) of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary This study compared the cost-effectiveness of tiotropium, ipratropium, and salmeterol, for the treatment of chronic obstructive pulmonary disease. The authors concluded that tiotropium was a cost-effective alternative to ipratropium and salmeterol, and switching patients from ipratropium and salmeterol to tiotropium led to considerable cost savings

NHS Economic Evaluation Database.2010

286. Steroids for COPD Exacerbation

Steroids for COPD Exacerbation Steroids for COPD Exacerbation – TheNNTTheNNT Systemic Steroids for Acute COPD Exacerbations 10 for prevented failed treatment In Summary, for those who took the steroids: Benefits in NNT 89.5% saw no benefit 10.5% were helped by not failing treatment 1 out of 10 were helped (preventing failed treatment) Harms in NNT 13.9% harmed by developing adverse drug effects 1 out of 7 were harmed (adverse drug effects) View As: NNT % Source: Efficacy Endpoints: Mortality (...) , Treatment Failure (Lack of resolution, worsening, or death) Harm Endpoints: Adverse Drug Effects Narrative: Chronic obstructive pulmonary disease (COPD), a term that encompasses both patients diagnosed with chronic bronchitis and emphysema, is an obstructive lung disease in many cases caused by years of tobacco smoking. It is thought that patients with COPD ‘exacerbation’ (increased shortness of breath or change in their chronic cough and sputum) may benefit from steroids, presumably by reducing

theNNT2010

287. Antibiotics for COPD Exacerbation

Antibiotics for COPD Exacerbation Antibiotics for COPD Exacerbation – TheNNTTheNNT Antibiotics for Acute COPD Exacerbations 8 for mortality In Summary, for those who took the antibiotics: Benefits in NNT 88.4% saw no benefit 11.6% were helped by being saved from death 1 in 8 were helped (life saved) 1 in 3 were helped (preventing failed treatment) Harms in NNT 5% were harmed by developing diarrhea 1 in 20 were harmed (diarrhea) View As: NNT % Source: Efficacy Endpoints: Mortality, Treatment (...) Failure (Lack of resolution, worsening, or death) Harm Endpoints: Diarrhea Narrative: Chronic obstructive pulmonary disease (COPD), a term that encompasses both patients diagnosed with chronic bronchitis and emphysema, is an obstructive lung disease, in many cases caused by tobacco smoking. It is thought that patients with COPD ‘exacerbation’ (increased shortness of breath or change in their chronic cough and sputum) may benefit from antibiotics, though the reasons for this are not well elucidated

theNNT2010

288. [Effectiveness of screening for COPD using spirometry]

[Effectiveness of screening for COPD using spirometry] Effektivitat eines COPD-screenings mittels spirolmetrie [Effectiveness of screening for COPD using spirometry] Effektivitat eines COPD-screenings mittels spirolmetrie [Effectiveness of screening for COPD using spirometry] Eisenmann A, Hiebinger C, Froschl B Record Status This is a bibliographic record of a published health technology assessment being undertaken by a member of INAHTA. No evaluation of the quality of this assessment has been (...) made for the HTA database. Citation Eisenmann A, Hiebinger C, Froschl B. Effektivitat eines COPD-screenings mittels spirolmetrie. [Effectiveness of screening for COPD using spirometry] Vienna: Gesundheit Osterreich GmbH (GOG). 2010 Authors' conclusions Screening for COPD using spirometry is not recommended for asymptomatic patients. Project page URL Indexing Status Subject indexing assigned by CRD MeSH Humans; Mass Screening; Pulmonary Disease, Chronic Obstructive; Spirometry Language Published

Health Technology Assessment (HTA) Database.2010

289. The impact of home-based physiotherapy interventions on breathlessness during activities of daily living in severe COPD: a systematic review

The impact of home-based physiotherapy interventions on breathlessness during activities of daily living in severe COPD: a systematic review The impact of home-based physiotherapy interventions on breathlessness during activities of daily living in severe COPD: a systematic review The impact of home-based physiotherapy interventions on breathlessness during activities of daily living in severe COPD: a systematic review Thomas MJ, Simpson J, Riley R, Grant E CRD summary This review assessed (...) the impact of home-based physiotherapy interventions on breathlessness during activities of daily living in severe chronic obstructive pulmonary disease and concluded that inspiratory muscle training and exercise seemed to be beneficial. Clinical variation and methodological weaknesses in the included studies mean that caution is required when judging the reliability of the authors’ conclusions. Authors' objectives To assess the impact of home-based physiotherapy interventions on breathlessness during

DARE.2010

290. Progressive resistance exercise improves muscle strength and may improve elements of performance of daily activities for people with COPD: a systematic review

Progressive resistance exercise improves muscle strength and may improve elements of performance of daily activities for people with COPD: a systematic review 19734323 2009 11 06 2010 01 06 2009 11 06 1931-3543 136 5 2009 Nov Chest Chest Progressive resistance exercise improves muscle strength and may improve elements of performance of daily activities for people with COPD: a systematic review. 1269-83 10.1378/chest.09-0029 Skeletal muscle weakness and its impact on exercise tolerance in many (...) people with COPD provide a rationale for the intervention of progressive resistance exercise during pulmonary rehabilitation. To optimize rehabilitation outcomes, clinicians prescribing resistance programs require up-to-date information on effectiveness, safety, and feasibility. Therefore, the review aimed to update the current evidence for progressive resistance exercise for people with COPD. Using the keywords of "COPD" and "strength/resistance/weight training," controlled trials relating

EvidenceUpdates2010

291. Community based integrated intervention for prevention and management of chronic obstructive pulmonary disease (COPD) in Guangdong, China: cluster randomised controlled trial.

Community based integrated intervention for prevention and management of chronic obstructive pulmonary disease (COPD) in Guangdong, China: cluster randomised controlled trial. 21123342 2010 12 02 2011 01 04 2015 11 19 1756-1833 341 2010 Dec 01 BMJ (Clinical research ed.) BMJ Community based integrated intervention for prevention and management of chronic obstructive pulmonary disease (COPD) in Guangdong, China: cluster randomised controlled trial. c6387 10.1136/bmj.c6387 bmj.c6387 To evaluate (...) the effects of a community based integrated intervention for early prevention and management of chronic obstructive pulmonary disease (COPD) in China. Cluster randomised controlled trial. Eight healthcare units in two communities. Of 1062 people aged 40-89, 872 (101 with COPD and 771 without COPD) who fulfilled the inclusion and exclusion criteria were allocated to the intervention or the usual care programmes. Participants randomly assigned to integrated intervention (systematic health education

BMJ2010 Full Text: Link to full Text with Trip Pro

293. MMP12, Lung Function, and COPD in High-Risk Populations.

MMP12, Lung Function, and COPD in High-Risk Populations. BACKGROUND: Genetic variants influencing lung function in children and adults may ultimately lead to the development of chronic obstructive pulmonary disease (COPD), particularly in high-risk groups. METHODS: We tested for an association between single-nucleotide polymorphisms (SNPs) in the gene encoding matrix metalloproteinase 12 (MMP12) and a measure of lung function (prebronchodilator forced expiratory volume in 1 second [FEV(1)]) in (...) more than 8300 subjects in seven cohorts that included children and adults. Within the Normative Aging Study (NAS), a cohort of initially healthy adult men, we tested for an association between SNPs that were associated with FEV(1) and the time to the onset of COPD. We then examined the relationship between MMP12 SNPs and COPD in two cohorts of adults with COPD or at risk for COPD. RESULTS: The minor allele (G) of a functional variant in the promoter region of MMP12 (rs2276109 [-82A-->G

NEJM2009 Full Text: Link to full Text with Trip Pro

294. Effects of unsupported upper extremity exercise training in patients with COPD: a randomized clinical trial

Effects of unsupported upper extremity exercise training in patients with COPD: a randomized clinical trial 19567487 2009 08 11 2009 09 02 2017 05 29 1931-3543 136 2 2009 Aug Chest Chest Effects of unsupported upper extremity exercise training in patients with COPD: a randomized clinical trial. 387-395 S0012-3692(09)60474-8 10.1378/chest.09-0165 Current guidelines on pulmonary rehabilitation (PR) recommend upper extremity exercise training (UEET) in patients with COPD. However, the literature (...) still questions the effectiveness of systematic UEET in this population. We studied the effects of 15 sessions of unsupported UEET on functional exercise capacity, the ability to perform activities of daily living (ADL), and symptoms perceived during activities involving arms in patients with COPD. We conducted a randomized trial that consisted of 3 weeks of inpatient PR, comparing the short-term effects of unsupported UEET plus PR (intervention group) to those of PR alone (control group). A change

EvidenceUpdates2009

295. The diagnostic value of history and physical examination for COPD in suspected or known cases: a systematic review

The diagnostic value of history and physical examination for COPD in suspected or known cases: a systematic review 19423699 2009 07 17 2009 11 04 2009 07 17 1460-2229 26 4 2009 Aug Family practice Fam Pract The diagnostic value of history and physical examination for COPD in suspected or known cases: a systematic review. 260-8 10.1093/fampra/cmp026 According to current guidelines, spirometry should be performed in patients suspected of chronic obstructive pulmonary disease (COPD) by the results (...) of history taking and physical examination. However, little is known about the diagnostic value of patient history and physical examination for COPD. To review the existing evidence on the diagnostic value of history taking and physical examination in recognizing COPD in patients suspected of COPD. A systematic literature search was performed in electronic medical databases. Studies were included after using defined inclusion and exclusion criteria and judged on their methodological quality by using

EvidenceUpdates2009

296. Nocturnal non-invasive nasal ventilation in stable hypercapnic COPD: a randomised controlled trial

Nocturnal non-invasive nasal ventilation in stable hypercapnic COPD: a randomised controlled trial 19213769 2009 06 29 2009 08 07 2013 11 21 1468-3296 64 7 2009 Jul Thorax Thorax Nocturnal non-invasive nasal ventilation in stable hypercapnic COPD: a randomised controlled trial. 561-6 10.1136/thx.2008.108274 Sleep hypoventilation has been proposed as a cause of progressive hypercapnic respiratory failure and death in patients with severe chronic obstructive pulmonary disease (COPD). A study was (...) undertaken to determine the effects of nocturnal non-invasive bi-level pressure support ventilation (NIV) on survival, lung function and quality of life in patients with severe hypercapnic COPD. A multicentre, open-label, randomised controlled trial of NIV plus long-term oxygen therapy (LTOT) versus LTOT alone was performed in four Australian University Hospital sleep/respiratory medicine departments in patients with severe stable smoking-related COPD (forced expiratory volume in 1 s (FEV1.0) <1.5 litres

EvidenceUpdates2009

297. Enhancement of daily physical activity increases physical fitness of outclinic COPD patients: Results of an exercise counseling program

Enhancement of daily physical activity increases physical fitness of outclinic COPD patients: Results of an exercise counseling program 19036552 2009 04 03 2009 07 24 2009 04 03 0738-3991 75 2 2009 May Patient education and counseling Patient Educ Couns Enhancement of daily physical activity increases physical fitness of outclinic COPD patients: results of an exercise counseling program. 274-8 10.1016/j.pec.2008.10.005 To investigate whether a 12-week pedometer-based exercise counseling (...) strategy is feasible and effectively enhances daily physical activity in outclinic Chronic Obstructive Pulmonary Disease (COPD) patients who do not participate in a rehabilitation program in a controlled way. 35 outclinic COPD patients (21 males, mean age 62 years, GOLD I-III, mean FEV(1)% predicted 64.7) were randomized for a 12-week individual pedometer-based exercise counseling program promoting daily physical activities or usual care. Daily physical activity (DigiWalker SW-200), physical fitness

EvidenceUpdates2009

298. Helium-Hyperoxia: A Novel Intervention To Improve the Benefits of Pulmonary Rehabilitation for Patients With COPD

Helium-Hyperoxia: A Novel Intervention To Improve the Benefits of Pulmonary Rehabilitation for Patients With COPD 19017883 2009 03 06 2009 04 09 2013 11 21 1931-3543 135 3 2009 Mar Chest Chest Helium-hyperoxia: a novel intervention to improve the benefits of pulmonary rehabilitation for patients with COPD. 609-18 10.1378/chest.08-1517 Helium-hyperoxia (HH) reduces dyspnea and increases exercise tolerance in patients with COPD. We investigated whether breathing HH would allow patients to perform (...) a greater intensity of exercise and improve the benefits of a pulmonary rehabilitation program. Thirty-eight nonhypoxemic patients with COPD (FEV(1)=47 +/- 17%(pred)) were randomized to rehabilitation breathing HH (60:40 He:O(2); n = 19) or air (n = 19). Patients cycled for 30 min, 3 days/week for 6 weeks breathing the assigned gas. Exercise intensity was prescribed from baseline, gas-specific, incremental exercise tests and was advanced as tolerated. The primary outcome was exercise tolerance assessed

EvidenceUpdates2009

299. Plasma markers of inflammation and incidence of hospitalisations for COPD: results from a population-based cohort study

Plasma markers of inflammation and incidence of hospitalisations for COPD: results from a population-based cohort study 18988660 2009 03 02 2009 03 26 2015 11 19 1468-3296 64 3 2009 Mar Thorax Thorax Plasma markers of inflammation and incidence of hospitalisations for COPD: results from a population-based cohort study. 211-5 10.1136/thx.2008.102079 The relationship between plasma markers of inflammation and the incidence of chronic obstructive pulmonary disease (COPD) is still unclear (...) . This population-based study explored whether raised levels of five inflammation-sensitive plasma proteins (ISPs) predicted hospital admissions for COPD during 25 years of follow-up. Spirometric tests and measurements of five ISPs (fibrinogen, ceruloplasmin, alpha(1)-antitrypsin, haptoglobin, orosomucoid) were performed in 5247 apparently healthy men from the city of Malmö (mean age 46 years). The incidence of hospitalisations for COPD was studied in relation to the number of ISPs in the fourth quartile

EvidenceUpdates2009

300. Cost-effectiveness of salmeterol, fluticasone, and combination therapy for COPD

Cost-effectiveness of salmeterol, fluticasone, and combination therapy for COPD Cost-effectiveness of salmeterol, fluticasone, and combination therapy for COPD Cost-effectiveness of salmeterol, fluticasone, and combination therapy for COPD Oba Y Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment (...) on the reliability of the study and the conclusions drawn. CRD summary The aim was to assess whether maintenance inhaled medication was cost-effective for patients with moderate-to-severe chronic obstructive pulmonary disease. The author concluded that, at willingness-to-pay thresholds over 52,800 US dollars per quality-adjusted life-year, combined fluticasone and salmeterol propionate therapy was most cost-effective, below this threshold no maintenance therapy, with bronchodilator use as needed, was most cost

NHS Economic Evaluation Database.2009