Latest & greatest articles for constipation

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Top results for constipation

141. Methylnaltrexone for opioid-induced constipation in advanced illness.

Methylnaltrexone for opioid-induced constipation in advanced illness. 18509120 2008 05 29 2008 06 03 2016 11 24 1533-4406 358 22 2008 May 29 The New England journal of medicine N. Engl. J. Med. Methylnaltrexone for opioid-induced constipation in advanced illness. 2332-43 10.1056/NEJMoa0707377 Constipation is a distressing side effect of opioid treatment. As a quaternary amine, methylnaltrexone, a mu-opioid-receptor antagonist, has restricted ability to cross the blood-brain barrier. We (...) investigated the safety and efficacy of subcutaneous methylnaltrexone for treating opioid-induced constipation in patients with advanced illness. A total of 133 patients who had received opioids for 2 or more weeks and who had received stable doses of opioids and laxatives for 3 or more days without relief of opioid-induced constipation were randomly assigned to receive subcutaneous methylnaltrexone (at a dose of 0.15 mg per kilogram of body weight) or placebo every other day for 2 weeks. Coprimary

NEJM2008

142. A placebo-controlled trial of prucalopride for severe chronic constipation.

A placebo-controlled trial of prucalopride for severe chronic constipation. 18509121 2008 05 29 2008 06 03 2016 07 19 1533-4406 358 22 2008 May 29 The New England journal of medicine N. Engl. J. Med. A placebo-controlled trial of prucalopride for severe chronic constipation. 2344-54 10.1056/NEJMoa0800670 In this 12-week trial, we aimed to determine the efficacy of prucalopride, a selective, high-affinity 5-hydroxytryptamine4 receptor agonist, in patients with severe chronic constipation. In our (...) multicenter, randomized, placebo-controlled, parallel-group, phase 3 trial, patients with severe chronic constipation (< or =2 spontaneous, complete bowel movements per week) received placebo or 2 or 4 mg of prucalopride, once daily, for 12 weeks. The primary efficacy end point was the proportion of patients having three or more spontaneous, complete bowel movements per week, averaged over 12 weeks. Secondary efficacy end points were derived from daily diaries and validated questionnaires completed

NEJM2008

143. Sacral nerve stimulation for faecal incontinence and constipation in adults.

Sacral nerve stimulation for faecal incontinence and constipation in adults. BACKGROUND: Faecal incontinence and constipation are disabling conditions that reduce quality of life. If conservative treatment fails, one option is sacral nerve stimulation (SNS), a minimally invasive technique allowing modulation of the nerves and muscles of the pelvic floor and hindgut. OBJECTIVES: To assess the effects of SNS for faecal incontinence and constipation in adults. SEARCH STRATEGY: We searched (...) the Cochrane Incontinence Group Specialised Trials Register (searched 24 April 2007) and the reference lists of relevant articles. SELECTION CRITERIA: All randomised or quasi-randomised trials assessing the effects of SNS for faecal incontinence or constipation in adults. DATA COLLECTION AND ANALYSIS: Two review authors independently screened the search results, assessed the methodological quality of the included studies, and undertook data extraction. MAIN RESULTS: Three crossover studies were included

Cochrane2007

144. Methylnatrexone for opioid induced constipation in advanced illness and palliative care: horizon scanning technology briefing

Methylnatrexone for opioid induced constipation in advanced illness and palliative care: horizon scanning technology briefing Methylnatrexone for opioid induced constipation in advanced illness and palliative care: horizon scanning technology briefing Methylnatrexone for opioid induced constipation in advanced illness and palliative care: horizon scanning technology briefing National Horizon Scanning Centre Record Status This is a bibliographic record of a published health technology assessment (...) from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation National Horizon Scanning Centre. Methylnatrexone for opioid induced constipation in advanced illness and palliative care: horizon scanning technology briefing. Birmingham: National Horizon Scanning Centre (NHSC). 2007 Authors' objectives This study examines the use of Methylnatrexone for opioid induced constipation in advanced illness and palliative care. Project page URL Indexing

Health Technology Assessment (HTA) Database.2007

145. Laxatives for the management of constipation in palliative care patients.

Laxatives for the management of constipation in palliative care patients. BACKGROUND: Constipation is a common problem for palliative care patients which can generate considerable suffering for patients due to both the unpleasant physical symptoms and psychological preoccupations that can arise. There is uncertainty about the 'best' management of constipation in palliative care patients and variation in practice between palliative care settings. OBJECTIVES: To determine the effectiveness (...) of laxative administration for the management of constipation in palliative care patients, and the differential efficacy of the laxatives used to manage constipation. SEARCH STRATEGY: We searched The Central Register of Controlled Trials (CENTRAL) (The Cochrane Library Issue four, 2005), MEDLINE (1966 to January 2005), EMBASE (1980 to January 2005), CANCERLIT, PUBMED, Science Citation Index, CINAHL, The Cochrane Library, SIGLE, NTIS, DHSS-DATA, Dissertation Abstracts, Index to Scientific and Technical

Cochrane2006

146. Review: good evidence supports use of polyethylene glycol and tegaserod for constipation

Review: good evidence supports use of polyethylene glycol and tegaserod for constipation Review: good evidence supports use of polyethylene glycol and tegaserod for constipation | Evidence-Based Nursing This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in via your Society Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword (...) Search for this keyword Main menu Log in via your Society Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Review: good evidence supports use of polyethylene glycol and tegaserod for constipation Article Text Treatment Review: good evidence supports use of polyethylene glycol and tegaserod for constipation Free Jane P Joy , RGN, MSc, PGDE Statistics from Altmetric.com No Altmetric data

Evidence-Based Nursing (Requires free registration)2006

147. Review: intravenous and oral opioids reduce chronic non-cancer pain but are associated with high rates of constipation, nausea, and sleepiness

Review: intravenous and oral opioids reduce chronic non-cancer pain but are associated with high rates of constipation, nausea, and sleepiness Review: intravenous and oral opioids reduce chronic non-cancer pain but are associated with high rates of constipation, nausea, and sleepiness | Evidence-Based Nursing This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in via your Society Log in using your username and password For personal accounts (...) OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in via your Society Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Review: intravenous and oral opioids reduce chronic non-cancer pain but are associated with high rates of constipation, nausea, and sleepiness Article Text Treatment Review

Evidence-Based Nursing (Requires free registration)2006

148. Systematic review: FDA-approved prescription medications for adults with constipation

Systematic review: FDA-approved prescription medications for adults with constipation Systematic review: FDA-approved prescription medications for adults with constipation Systematic review: FDA-approved prescription medications for adults with constipation Cash B D, Lacy B E CRD summary The authors concluded that there is a lack of high-quality evidence supporting the use of lactulose and polyethylene glycol-3350 in the treatment of chronic constipation, although the data does support use (...) in acute, episodic constipation. High-quality evidence supporting the use of tegaserod was found. Potential publication and language bias, limitations of the evidence, and differences between the studies mean that the authors' conclusions should be interpreted with caution. Authors' objectives To evaluate the effectiveness of U.S. Food and Drug Administration (FDA)-approved prescription treatments for adults with constipation. Searching MEDLINE (from 1966) and EMBASE (from 1980) were searched

DARE.2006

149. Review: soluble fibre improves overall symptoms and constipation but not abdominal pain in irritable bowel syndrome

Review: soluble fibre improves overall symptoms and constipation but not abdominal pain in irritable bowel syndrome Review: soluble fibre improves overall symptoms and constipation but not abdominal pain in irritable bowel syndrome | Evidence-Based Medicine This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name (...) or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Review: soluble fibre improves overall symptoms and constipation but not abdominal pain in irritable bowel syndrome Article Text Therapeutics Review: soluble fibre improves overall symptoms and constipation but not abdominal pain in irritable bowel syndrome Free G Richard

Evidence-Based Medicine (Requires free registration)2005

150. Is polyethylene glycol safe and effective for chronic constipation in children?

Is polyethylene glycol safe and effective for chronic constipation in children? BestBets: Is polyethylene glycol safe and effective for chronic constipation in children? Is polyethylene glycol safe and effective for chronic constipation in children? Report By: R Arora and R Srinivasan - Specialist Registrars Search checked by Bob Phillips - Section Editor Archimedes, Archives of Disease in Childhood Institution: Llandough Hospital, Cardiff, UK Date Submitted: 25th May 2005 Date Completed: 25th (...) May 2005 Last Modified: 25th May 2005 Status: Green (complete) Three Part Question In [children with chronic constipation] is [polyethylene glycol] better [in improving stool frequency and consistency while causing fewer side effects]? Clinical Scenario Chronic constipation is a frequently encountered problem in the paediatric wards and clinics. Your usual line of management has been to prescribe adequate doses of regular lactulose and use sodium picosulphate as a second line laxative or as add

BestBETS2005

151. Prevention of constipation in the older adult population.

Prevention of constipation in the older adult population. Prevention of constipation in the older adult population. | National Guideline Clearinghouse Search Sign In Username or Email * Password * Remember Me Don't have an account? Guideline Summary NGC:004213 This guideline summary has been replaced by an updated version. Please update your bookmarks. View the updated summary: NGC:010100 View all updated summaries in the . About NGC Guideline Summaries NGC's guidelines summaries contain

Registered Nurses' Association of Ontario2005

152. Diagnostic value of abdominal radiography in constipated children: a systematic review

Diagnostic value of abdominal radiography in constipated children: a systematic review Diagnostic value of abdominal radiography in constipated children: a systematic review Diagnostic value of abdominal radiography in constipated children: a systematic review Reuchlin-Vroklage L M, Bierma-Zeinstra S, Benninga M A, Berger M Y CRD summary This review examined the relationship between a clinical diagnosis of constipation and faecal loading on abdominal plain radiograph in children. The authors (...) concluded that the limited evidence was conflicting and that further research is required. Although the literature search was somewhat limited, the review was generally well conducted and the authors' conclusions were appropriate. Authors' objectives To assess the evidence, from observational controlled studies, on the association between abdominal radiography and symptoms and signs of constipation in children. Searching MEDLINE was searched from inception to April 2004; the search terms were reported

DARE.2005

153. Clinical utility of diagnostic tests for constipation in adults: a systematic review

Clinical utility of diagnostic tests for constipation in adults: a systematic review Clinical utility of diagnostic tests for constipation in adults: a systematic review Clinical utility of diagnostic tests for constipation in adults: a systematic review Rao S S, Ozturk R, Laine L CRD summary This review assessed the usefulness of diagnostic tests in the work-up of patients with constipation. The authors concluded that there is a lack of evidence supporting blood tests, radiography and (...) endoscopy, and that further research is required. The limited search strategy and poor reporting of review methodology mean that the completeness and accuracy of the data presented are uncertain. Authors' objectives To assess the utility of commonly used diagnostic tests in differentiating between patients with functional constipation, its subtypes, and organic disorders. Searching MEDLINE was searched from inception to 2004 for articles published in full in the English language; the search terms were

DARE.2005

154. Efficacy and safety of traditional medical therapies for chronic constipation: systematic review

Efficacy and safety of traditional medical therapies for chronic constipation: systematic review Efficacy and safety of traditional medical therapies for chronic constipation: systematic review Efficacy and safety of traditional medical therapies for chronic constipation: systematic review Ramkumar D, Rao S S CRD summary This review assessed the efficacy and safety of medical therapies in adults with chronic constipation. The authors concluded that there was good evidence for polyethylene (...) glycol, tegaserod, lactulose and psyllium, but few trials assessed other commonly used agents. The limited search and incomplete reporting of the review methods make it difficult to assess the strength of the authors' conclusions. Authors' objectives To assess the efficacy and safety of medical therapies in adults with chronic constipation. Searching MEDLINE and PubMed were searched from 1966 to 2004 for studies published in English as full manuscripts; the search terms were reported

DARE.2005

155. Does successful treatment of constipation or faecal impaction resolve lower urinary tract symptoms: a structured review of the literature. Systematic review

Does successful treatment of constipation or faecal impaction resolve lower urinary tract symptoms: a structured review of the literature. Systematic review Does successful treatment of constipation or faecal impaction resolve lower urinary tract symptoms: a structured review of the literature. Systematic review Does successful treatment of constipation or faecal impaction resolve lower urinary tract symptoms: a structured review of the literature. Systematic review Ostaszkiewicz J, Ski C (...) , Hornby L CRD summary The authors concluded that there was limited and conflicting evidence about the relationship between constipation or faecal impaction and urinary incontinence and other lower urinary tract symptoms, and that further research is required. There were limitations to this review but, overall, the authors' conclusions appear to reflect the limitations of the evidence presented. Authors' objectives To evaluate the relationship between constipation or faecal impaction and urinary

DARE.2005

156. Management of constipation in residents with dementia: sorbitol effectiveness and cost

Management of constipation in residents with dementia: sorbitol effectiveness and cost Management of constipation in residents with dementia: sorbitol effectiveness and cost Management of constipation in residents with dementia: sorbitol effectiveness and cost Volicer L, Lane P, Panke J A, Lyman P Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions (...) followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The study compared the therapeutic substitution of sorbitol for lactulose in the treatment of chronic constipation among nursing home residents with dementia. The doses ranged from 30 mL every other day to 6 mL twice daily. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population The study population comprised the residents of a dementia

NHS Economic Evaluation Database.2004

157. Dietary fiber for constipation in older adults: a systematic review

Dietary fiber for constipation in older adults: a systematic review Dietary fiber for constipation in older adults: a systematic review Dietary fiber for constipation in older adults: a systematic review Kenny K A, Skelly J M Authors' objectives To assess the effectiveness of dietary fibre for constipation in older adults. Searching MEDLINE (from 1966 to present) and CINAHL (from 1982 to present) were searched for publications in the English language, using the terms 'constipation' and 'dietary (...) of magnesia, enemas, and suppositories. Participants included in the review Older patients (aged 60 years or over) with constipation were eligible. The included participants were either in hospital or long-stay care settings. No definition of constipation was specified as an inclusion criteria for the review. Patients with irritable bowel syndrome or diverticular disease were excluded. Outcomes assessed in the review Trials that quantified outcomes for at least one measure of bowel function were eligible

DARE.2001

158. Interventions for treating constipation in pregnancy.

Interventions for treating constipation in pregnancy. BACKGROUND: Constipation is a common problem in late pregnancy. Circulating progesterone may be the cause of slower gastrointestinal movement in mid and late pregnancy. OBJECTIVES: The objective of this review was to assess the effects of different methods for treating constipation in pregnancy. SEARCH STRATEGY: We searched the Cochrane Pregnancy and Childbirth Group trials register, the Cochrane Controlled Trials Register and MEDLINE. Date (...) of last search: January 2001. SELECTION CRITERIA: Randomised trials of any treatment for constipation in pregnancy. DATA COLLECTION AND ANALYSIS: Trial quality assessments and data extraction were done independently by two reviewers. MAIN RESULTS: Two suitable trials were identified. Fibre supplements increased the frequency of defecation (odds ratio 0.18, 95% confidence interval 0.05 to 0.67), and lead to softer stools. Stimulant laxatives are more effective than bulk-forming laxatives (odds ratio

Cochrane2001

159. What is the role of stimulant laxatives in the management of childhood constipation and soiling?.

What is the role of stimulant laxatives in the management of childhood constipation and soiling?. BACKGROUND: Constipation is extremely common in childhood and may lead to overflow soiling/encopresis. Standard treatment of the more severe case is to empty the bowels of impacted faeces by the use of oral or rectal laxatives and then maintain regular bowel movements by the continuation of osmotic and stimulant laxatives. OBJECTIVES: The objective of the review was to determine the effect (...) of stimulant laxative treatment in children with chronic constipation who may also suffer from soiling / encopresis. SEARCH STRATEGY: The Cochrane database of randomised controlled trials was searched. Additional citations were sought by hand searching of paediatric journals and from contact with known professionals in the field. SELECTION CRITERIA: All identified randomised controlled trials (RCTs) which compare the administering of stimulant laxatives to children with either placebo or alternative

Cochrane2001

160. Management of faecal incontinence and constipation in adults with central neurological diseases.

Management of faecal incontinence and constipation in adults with central neurological diseases. BACKGROUND: People with neurological disease have a much higher risk of both faecal incontinence and constipation than the general population. There is often a fine dividing line between the two conditions, with any management intended to ameliorate, one risking precipitating the other. Bowel problems are observed to be the cause of much anxiety and may reduce quality of life in these people (...) . Current bowel management is largely empirical with a limited research base. OBJECTIVES: To determine the effects of management strategies for faecal incontinence and constipation in people with neurological diseases affecting the central nervous system. SEARCH STRATEGY: We searched the Cochrane Incontinence Group Trials Register, the Cochrane Controlled Trials Register, MEDLINE, EMBASE and all reference lists of relevant articles. Date of the most recent searches: May 2000. SELECTION CRITERIA: All

Cochrane2001