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Latest & greatest articles for clonidine
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Heavy smokers, smoking cessation, and clonidine. Results of a double-blind, randomized trial. 3367452 1988 06 10 1988 06 10 2016 10 17 0098-7484 259 19 1988 May 20 JAMA JAMA Heavy smokers, smoking cessation, and clonidine. Results of a double-blind, randomized trial. 2863-6 Seventy-one heavy smokers who had failed in previous attempts to stop smoking participated in a randomized clinical trial to test the efficacy of clonidine as an aid in smoking cessation. The success rate in clonidine (...) -treated subjects (verified by serum cotinine concentration) was more than twice that in the placebo-treated subjects. When the data were stratified by gender, a strong effect present in women was not apparent in men. After six months, cessation rates remained significantly higher among smokers treated with clonidine than those receiving placebo. The data also revealed an unexpectedly high prevalence (61%) of a history of major depression in this sample and a significant negative effect
Lack of benefit of clonidine treatment for short stature in a double-blind, placebo-controlled trial. 2902319 1988 11 10 1988 11 10 2015 06 16 0140-6736 2 8616 1988 Oct 15 Lancet (London, England) Lancet Lack of benefit of clonidine treatment for short stature in a double-blind, placebo-controlled trial. 874-7 Twelve short (more than two standard deviations below the mean height for age), prepubertal children (ten boys, two girls) who had a normal peak growth hormone (GH) response (...) to provocative stimulation with clonidine (more than 10 ng/ml) were enrolled in a double-blind, placebo-controlled, crossover study of the effects of a single, nightly dose of clonidine (0.1 mg/m2 by mouth). The children's mean age was 7.2 years (range 3.6-10.5 years). The results of 6 months of clonidine therapy were compared with those of 6 months of placebo. Clonidine therapy resulted in no significant difference in height standard deviation score, growth velocity, bone age, 24 h integrated GH
Clonidine blocks acute opiate-withdrawal symptoms. 80526 1978 11 18 1978 11 18 2015 06 16 0140-6736 2 8090 1978 Sep 16 Lancet (London, England) Lancet Clonidine blocks acute opiate-withdrawal symptoms. 599-602 In a double-blind, placebo-controlled, cross-over trial, clonidine eliminated objective signs and subjective symptoms of opiate withdrawal for 240--360 min in eleven addicts in a hospital setting. In an open pilot study of the effects of clonidine on longer-term opiate abstinence (...) and symptoms, the same patients did well while taking clonidine for one week. There was only one documented instance of heroin use, in a patient who did not take clonidine after hospital discharge. 6 weeks or more after the study, four patients were back on reduced doses of methadone, one was on tricyclic antidepressants, and seven were off of all opiates. All eleven patients were doing well. These data suggest that opiate withdrawal is due to increased neuronal activity in areas such as the locus