Latest & greatest articles for clonidine

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Top results for clonidine

21. Tricyclic antidepressants, clonidine, venlafaxine, and modafinil for the treatment of attention-deficit/hyperactivity disorder in adults: a review of the clinical evidence

Tricyclic antidepressants, clonidine, venlafaxine, and modafinil for the treatment of attention-deficit/hyperactivity disorder in adults: a review of the clinical evidence Tricyclic antidepressants, clonidine, venlafaxine, and modafinil for the treatment of attention-deficit/hyperactivity disorder in adults: a review of the clinical evidence Tricyclic antidepressants, clonidine, venlafaxine, and modafinil for the treatment of attention-deficit/hyperactivity disorder in adults: a review (...) of the clinical evidence CADTH Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation CADTH. Tricyclic antidepressants, clonidine, venlafaxine, and modafinil for the treatment of attention-deficit/hyperactivity disorder in adults: a review of the clinical evidence. Ottawa: Canadian Agency for Drugs and Technologies in Health (CADTH). Rapid Response - Summary

2014 Health Technology Assessment (HTA) Database.

22. Clonidine in Patients Undergoing Noncardiac Surgery. Full Text available with Trip Pro

Clonidine in Patients Undergoing Noncardiac Surgery. Marked activation of the sympathetic nervous system occurs during and after noncardiac surgery. Low-dose clonidine, which blunts central sympathetic outflow, may prevent perioperative myocardial infarction and death without inducing hemodynamic instability.We performed a blinded, randomized trial with a 2-by-2 factorial design to allow separate evaluation of low-dose clonidine versus placebo and low-dose aspirin versus placebo in patients (...) with, or at risk for, atherosclerotic disease who were undergoing noncardiac surgery. A total of 10,010 patients at 135 centers in 23 countries were enrolled. For the comparison of clonidine with placebo, patients were randomly assigned to receive clonidine (0.2 mg per day) or placebo just before surgery, with the study drug continued until 72 hours after surgery. The primary outcome was a composite of death or nonfatal myocardial infarction at 30 days.Clonidine, as compared with placebo, did not reduce

2014 NEJM Controlled trial quality: predicted high

23. Guided paravertebral blocks with versus without clonidine for women undergoing breast surgery: a prospective double-blinded randomized study (Abstract)

Guided paravertebral blocks with versus without clonidine for women undergoing breast surgery: a prospective double-blinded randomized study Paravertebral blocks (PVBs) have been introduced as an alternative to general anesthesia for breast cancer surgeries. The addition of clonidine as an adjuvant in PVBs may enhance quality and duration of analgesia and significantly reduce the consumption of analgesics after breast surgery. In this prospective randomized double-blind study, we assessed (...) the significance of adding clonidine to the anesthetic mixture for women undergoing mastectomy.Sixty patients were randomized equally into 2 groups, both of which received PVB block, either with or without clonidine. Analgesic consumption was noted up to 2 weeks after the operation. A visual analog scale was used to assess pain postoperatively during the hospital stay, and a numeric rating scale was used when patients were discharged.Analgesic consumption was significantly lower in the clonidine group 48 hours

2013 EvidenceUpdates Controlled trial quality: predicted high

24. Tricyclic Antidepressants, Clonidine, Venlafaxine, and Modafinil for the Treatment of Attention-Deficit/Hyperactivity Disorder in Adults: A Review of the Clinical Evidence

Tricyclic Antidepressants, Clonidine, Venlafaxine, and Modafinil for the Treatment of Attention-Deficit/Hyperactivity Disorder in Adults: A Review of the Clinical Evidence Disclaimer: The Rapid Response Service is an information service for those involved in planning and providing health care in Canada. Rapid responses are based on a limited literature search and are not comprehensive, systematic reviews. The intent is to provide a list of sources of the best evidence on the topic that CADTH (...) by the owners’ own terms and conditions. TITLE: Tricyclic Antidepressants, Clonidine, Venlafaxine, and Modafinil for the Treatment of Attention-Deficit/Hyperactivity Disorder in Adults: A Review of the Clinical Evidence DATE: 21 March 2013 CONTEXT AND POLICY ISSUES Attention-deficit/hyperactivity disorder (ADHD) is a common neurobehavioral disorder with inappropriate levels of inattention, hyperactivity, and impulsivity manifesting in childhood and continuing into adulthood, resulting in functional

2013 Canadian Agency for Drugs and Technologies in Health - Rapid Review

25. Attention deficit hyperactivity disorder in children and young people: clonidine

Attention deficit hyperactivity disorder in children and young people: clonidine Attention deficit h Attention deficit hyper yperactivity disorder in activity disorder in children and y children and young people: clonidine oung people: clonidine Evidence summary Published: 2 April 2013 nice.org.uk/guidance/esuom8 pathways K Ke ey points from the e y points from the evidence vidence The content of this evidence summary was up-to-date in April 2013. See summaries of product characteristics (SPCs (...) ), British national formulary (BNF) or the MHRA or NICE websites for up- to-date information. Clonidine is an alpha 2 -adrenergic agonist that is licensed in the UK for adults to prevent migraine, prevent hot flushing associated with menopause, and treat hypertension. It does not have a UK licence to treat attention deficit hyperactivity disorder (ADHD) in any age group. It is sometimes used off-label (generally as an add-on to a licensed psychostimulant medicine, such as methylphenidate) to treat ADHD

2013 National Institute for Health and Clinical Excellence - Advice

26. Efficacy of adding clonidine to intrathecal morphine in acute postoperative pain: meta-analysis

Efficacy of adding clonidine to intrathecal morphine in acute postoperative pain: meta-analysis Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2013 DARE.

27. A comparison study of dexmedetomidine vs clonidine for sympathoadrenal response, perioperative drug requirements and cost analysis

A comparison study of dexmedetomidine vs clonidine for sympathoadrenal response, perioperative drug requirements and cost analysis A comparison study of dexmedetomidine vs clonidine for sympathoadrenal response, perioperative drug requirements and cost analysis A comparison study of dexmedetomidine vs clonidine for sympathoadrenal response, perioperative drug requirements and cost analysis Panda BK, Singh P, Marne S, Pawar A, Keniya V, Ladi S, Swami S Record Status This is a critical abstract (...) , before anaesthesia and during surgery, significantly reduced blood pressure and heart rate fluctuation, and reduced opioid and anaesthetic use, compared with clonidine. There were limitations to the study design, which affected its validity and generalisability, and the conclusions should be considered with caution. Type of economic evaluation Cost-effectiveness analysis Study objective This study compared the requirements for various drugs and costs of alpha-2 agonists, given before anaesthesia

2012 NHS Economic Evaluation Database.

28. Efficacy and safety of clonidine as additive for caudal regional anesthesia: a quantitative systematic review of randomized controlled trials

Efficacy and safety of clonidine as additive for caudal regional anesthesia: a quantitative systematic review of randomized controlled trials Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2011 DARE.

29. Cochrane systematic review: Clonidine, SSRIs, SNRIs and gabapentin reduce hot flushes in women with a history of breast cancer; relaxation therapy may have a mild effect in the short term

Cochrane systematic review: Clonidine, SSRIs, SNRIs and gabapentin reduce hot flushes in women with a history of breast cancer; relaxation therapy may have a mild effect in the short term Clonidine, SSRIs, SNRIs and gabapentin reduce hot flushes in women with a history of breast cancer; relaxation therapy may have a mild effect in the short term | Evidence-Based Nursing We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings (...) via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Clonidine, SSRIs, SNRIs and gabapentin

2011 Evidence-Based Nursing

30. The efficacy of intrathecal morphine with or without clonidine for postoperative analgesia after radical prostatectomy (Abstract)

The efficacy of intrathecal morphine with or without clonidine for postoperative analgesia after radical prostatectomy In this randomized study, we compared intrathecal (i.t.) morphine with or without clonidine and i.v. postoperative patient-controlled analgesia (PCA) morphine for analgesia after radical retropubic prostatectomy.Fifty patients were randomly divided into three groups. They were allocated to receive i.t. morphine (4 microg/kg) (M group), i.t. morphine and clonidine (1 microg/kg (...) pain score at rest and on coughing were lower in the M group until the 18th postoperative hour and until the 24th postoperative hour in the MC group. The first requests for PCA were delayed in these two groups. The need for intraoperative sufentanil was significantly lower in the MC group.IT morphine provided a significant reduction in morphine requirement during the first 48 postoperative hours after a radical prostatectomy. The addition of clonidine to i.t. morphine reduced intraoperative

2009 EvidenceUpdates Controlled trial quality: uncertain

31. Clonidine as an adjunct therapy to opioids for neonatal abstinence syndrome: a randomized, controlled trial. Full Text available with Trip Pro

Clonidine as an adjunct therapy to opioids for neonatal abstinence syndrome: a randomized, controlled trial. To determine if oral clonidine would reduce the duration of opioid detoxification for neonatal abstinence syndrome.Infants with intrauterine exposure to methadone or heroin and neonatal abstinence syndrome (2 consecutive modified Finnegan scores of > or =9) were enrolled at 2 hospitals during 2002-2005 and followed until final hospital discharge. All enrolled infants (80) received oral (...) diluted tincture of opium according to a standardized algorithm and were randomly assigned to receive oral clonidine (1 microg/kg every 4 hours) (40 infants) or placebo (40 infants). Primary outcome was duration of opioid therapy. Secondary outcomes included the amount of opium required to control symptoms, number of treatment failures, and differences in blood pressure, heart rate, and oxygen saturation.The median length of therapy was 27% shorter in the clonidine group (11 [95% confidence interval

2009 EvidenceUpdates Controlled trial quality: predicted high

32. The analgesic effect of epidural clonidine after spinal surgery: a randomized placebo-controlled trial Full Text available with Trip Pro

The analgesic effect of epidural clonidine after spinal surgery: a randomized placebo-controlled trial Clonidine is an alpha(2) adrenoreceptor and imidazoline receptor agonist, which has analgesic, sedative, and minimum alveolar anesthetic concentration-sparing effects. It has been used orally, IV, and epidurally. In spinal surgery, there is a reluctance to use local anesthetic-based epidural analgesia postoperatively because of fears of masking important signs of nerve root or spinal cord (...) injury.We randomized 66 patients undergoing uncomplicated decompressive spinal surgery to receive an epidural infusion of either clonidine (Group C) or saline placebo (Group P) postoperatively. Morphine consumption by patient-controlled analgesia device was recorded for 36 h.Morphine consumption was significantly lower in Group C. The mean consumption at 36 h was 35 mg (95% confidence interval 21-50 mg) in Group C, compared with 61 mg (95% confidence interval 48-74 mg) in the control group. Nausea

2009 EvidenceUpdates Controlled trial quality: predicted high

33. Clonidine as an adjuvant to local anesthetics for peripheral nerve and plexus blocks: a meta-analysis of randomized trials

Clonidine as an adjuvant to local anesthetics for peripheral nerve and plexus blocks: a meta-analysis of randomized trials Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2009 DARE.

34. Clonidine and analgesic duration after popliteal fossa nerve blockade: randomized, double-blind, placebo-controlled study Full Text available with Trip Pro

Clonidine and analgesic duration after popliteal fossa nerve blockade: randomized, double-blind, placebo-controlled study We tested the hypothesis that 100 microg clonidine added to 0.375% bupivacaine would prolong the duration of analgesia from popliteal fossa nerve blockade.Ninety-nine patients scheduled for hospital admission after foot or ankle surgery entered this randomized, double-blind, placebo-controlled trial. Patients received a popliteal fossa block (nerve stimulator technique, via (...) the posterior approach) using 30 mL 0.375% bupivacaine, with epinephrine. Patients were randomized to receive no clonidine, 100 microg clonidine IM, or 100 microg clonidine with bupivacaine for the popliteal block. Patients also received a combined spinal-epidural anesthetic, a saphenous nerve block, and postoperative IV patient-controlled analgesia. The primary outcome was patient-reported duration of analgesia.Duration of analgesia was statistically longer in the block clonidine group (18 +/- 6 h

2008 EvidenceUpdates Controlled trial quality: predicted high

35. Clonidine as an adjuvant to intrathecal local anesthetics for surgery: systematic review of randomized trials

Clonidine as an adjuvant to intrathecal local anesthetics for surgery: systematic review of randomized trials Clonidine as an adjuvant to intrathecal local anesthetics for surgery: systematic review of randomized trials Clonidine as an adjuvant to intrathecal local anesthetics for surgery: systematic review of randomized trials Elia N, Culebras X, Mazza C, Schiffer E, Tramer M R CRD summary The authors concluded that adding clonidine to intrathecal local anaesthetic had beneficial effects (...) on some, but not all measures of motor and sensory block. Adding clonidine reduced intra-operative pain but increased the risk of arterial hypotension. Given the low quality of the included studies and the possibility of publication bias, the reliability of the results is questionable. Authors' objectives To assess the efficacy and harm associated with adding clonidine to intrathecal local anaesthetics for surgery. Searching MEDLINE, EMBASE, CINAHL, BIOSIS Previews, INDMED and Cochrane Central

2008 DARE.

36. Should we add clonidine to local anesthetic for peripheral nerve blockade: a qualitative systematic review of the literature

Should we add clonidine to local anesthetic for peripheral nerve blockade: a qualitative systematic review of the literature Should we add clonidine to local anesthetic for peripheral nerve blockade: a qualitative systematic review of the literature Should we add clonidine to local anesthetic for peripheral nerve blockade: a qualitative systematic review of the literature McCartney C J, Duggan E, Apatu E CRD summary Clonidine improved the duration of analgesia and anaesthesia when used (...) as an adjunct to intermediate-acting local anaesthetics for some peripheral nerve blocks. The authors' conclusions reflected the evidence presented, but in light of both a lack of reporting, and the presence of several methodological concerns with the review, the authors' conclusions may not be reliable. Authors' objectives To determine the effectiveness of adding clonidine to local anaesthetics for peripheral nerve block. Searching PubMed and EMBASE were searched from July 1991 to October 2006 for English

2007 DARE.

37. Review: clonidine is more effective than placebo for long term smoking cessation, but has side effects Full Text available with Trip Pro

Review: clonidine is more effective than placebo for long term smoking cessation, but has side effects Review: clonidine is more effective than placebo for long term smoking cessation, but has side effects | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal (...) accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Review: clonidine is more effective than placebo for long term smoking cessation, but has side effects Article Text Therapeutics Review: clonidine is more effective than placebo for long

2006 Evidence-Based Medicine

38. Anesthesia-assisted vs buprenorphine- or clonidine-assisted heroin detoxification and naltrexone induction: a randomized trial. Full Text available with Trip Pro

Anesthesia-assisted vs buprenorphine- or clonidine-assisted heroin detoxification and naltrexone induction: a randomized trial. Rapid opioid detoxification with opioid antagonist induction using general anesthesia has emerged as an expensive, potentially dangerous, unproven approach to treat opioid dependence.To determine how anesthesia-assisted detoxification with rapid antagonist induction for heroin dependence compared with 2 alternative detoxification and antagonist induction methods.A (...) included if they had an American Society of Anesthesiologists physical status of I or II, were without major comorbid psychiatric illness, and were not dependent on other drugs or alcohol.Anesthesia-assisted rapid opioid detoxification with naltrexone induction, buprenorphine-assisted rapid opioid detoxification with naltrexone induction, and clonidine-assisted opioid detoxification with delayed naltrexone induction.Withdrawal severity scores on objective and subjective scales; proportions of patients

2005 JAMA Controlled trial quality: uncertain

39. Buprenorphine may be more effective than clonidine and other symptomatic medications for short term ambulatory heroin withdrawal Full Text available with Trip Pro

Buprenorphine may be more effective than clonidine and other symptomatic medications for short term ambulatory heroin withdrawal Buprenorphine may be more effective than clonidine and other symptomatic medications for short term ambulatory heroin withdrawal | Evidence-Based Mental Health We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our (...) . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Buprenorphine may be more effective than clonidine and other symptomatic medications for short term ambulatory heroin withdrawal

2004 Evidence-Based Mental Health

40. Efficacy of clonidine for prevention of perioperative myocardial ischemia: a critical appraisal and meta-analysis of the literature

Efficacy of clonidine for prevention of perioperative myocardial ischemia: a critical appraisal and meta-analysis of the literature Efficacy of clonidine for prevention of perioperative myocardial ischemia: a critical appraisal and meta-analysis of the literature Efficacy of clonidine for prevention of perioperative myocardial ischemia: a critical appraisal and meta-analysis of the literature Nishina K, Mikawa K, Uesugi T, Obara H, Maekawa M, Kamae I, Nishi N Authors' objectives To determine (...) whether clonidine premedication can reduce the occurrence of peri-operative myocardial ischaemia. Searching MEDLINE was searched from 1980 to 1999 using the following MeSH terms: 'myocardial ischaemia', 'coronary disease', 'myocardial infarction', 'coronary arteriosclerosis', 'coronary thrombosis', 'angina pectoris', 'prospective studies', 'clinical trials', 'randomized controlled trials', 'controlled clinical trials', 'intervention studies'. Only English language articles were considered. Personal

2002 DARE.