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Latest & greatest articles for chronic kidney disease
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Do attributes of persons with chronickidneydisease differ in low-income and middle-income countries compared with high-income countries? Evidence from population-based data in six countries Kidney biopsies to elucidate the cause of chronickidneydisease (CKD) are performed in a minority of persons with CKD living in high-income countries, since associated conditions-that is, diabetes mellitus, vascular disease or obesity with pre-diabetes, prehypertension or dyslipidaemia-can inform (...) as reference. In the USA, urban India and Moldova, 79.0%-83.9%; in China and Nepal, 62.4%-66.7% and in Nigeria, 51.6% persons with CKD fit one of three established risk profiles. Diabetes was most common in urban India and vascular disease in Moldova (50.7% and 33.2% of persons with CKD in urban India and Moldova, respectively). In Nigeria, 17.8% of persons with CKD without established risk factors had albuminuria ≥300 mg/g, the highest proportion in any country. While the majority of persons with CKD
Afshinnia F, Rajendiran TM, Karnovsky A, etÂ al. Lipidomic Signature of Progression of ChronicKidneyDisease in the ChronicRenal Insufficiency Cohort. Kidney Int Rep. 2016;1:256â€“268 [This corrects the article DOI: 10.1016/j.ekir.2016.08.007.].
A policy model of cardiovascular disease in moderate-to-advanced chronickidneydisease To present a long-term policy model of cardiovascular disease (CVD) in moderate-to-advanced chronickidneydisease (CKD).A Markov model with transitions between CKD stages (3B, 4, 5, on dialysis, with kidney transplant) and cardiovascular events (major atherosclerotic events, haemorrhagic stroke, vascular death) was developed with individualised CKD and CVD risks estimated using the 5 years' follow-up data (...) of the 9270 patients with moderate-to-severe CKD in the Study of Heart and Renal Protection (SHARP) and multivariate parametric survival analysis. The model was assessed in three further CKD cohorts and compared with currently used risk scores.Higher age, previous cardiovascular events and advanced CKD were the main contributors to increased individual disease risks. CKD and CVD risks predicted by the state-transition model corresponded well to risks observed in SHARP and external cohorts. The model's
Altered Protein Composition of Subcutaneous Adipose Tissue in ChronicKidneyDisease Loss of renal function is associated with high mortality from cardiovascular disease (CVD). Patients with chronickidneydisease (CKD) have altered circulating adipokine and nonesterified fatty acid concentrations and insulin resistance, which are features of disturbed adipose tissue metabolism. Because dysfunctional adipose tissue contributes to the development of CVD, we hypothesize that adipose tissue
Estimating One-Year Risk of Incident ChronicKidneyDisease: Retrospective Development and Validation Study Using Electronic Medical Record Data From the State of Maine Chronickidneydisease (CKD) is a major public health concern in the United States with high prevalence, growing incidence, and serious adverse outcomes.We aimed to develop and validate a model to identify patients at risk of receiving a new diagnosis of CKD (incident CKD) during the next 1 year in a general population.The study
Management of Severe Hyponatremia With a Custom Continuous Renal Replacement Therapy in an Infant With Newly Diagnosed ChronicKidneyDisease 29270536 2019 02 26 2468-0249 2 6 2017 Nov Kidney international reports Kidney Int Rep Management of Severe Hyponatremia With a Custom Continuous Renal Replacement Therapy in an Infant With Newly Diagnosed ChronicKidneyDisease. 1254-1258 10.1016/j.ekir.2017.07.003 Gaudreault-Tremblay Marie-Michèle MM Division of Nephrology, The Hospital for Sick (...) of Toronto, Toronto, Ontario, Canada. Lemaire Mathieu M Division of Nephrology, The Hospital for Sick Children, Toronto, Ontario, Canada. Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada. eng Case Reports 2017 07 20 United States Kidney Int Rep 101684752 2468-0249 2017 12 23 6 0 2017 12 23 6 0 2017 12 23 6 1 epublish 29270536 10.1016/j.ekir.2017.07.003 S2468-0249(17)30301-7 PMC5733878 J Am Soc Nephrol. 2012 Jul;23(7):1140-8 22626822 Pediatr Nephrol. 2010 Jul;25(7):1225-38
Serum Potassium Levels and Risk of Sudden Cardiac Death Among Patients With ChronicKidneyDisease and Significant Coronary Artery DiseaseChronickidneydisease (CKD) patients have increased risks of sudden cardiac arrest and sudden cardiac death (SCA/SCD) that are not explained by traditional risk factors. We examined associations between serum potassium and SCA/SCD in a large cohort of patients with coronary artery disease (CAD) and moderate CKD.Among 22,009 patients who underwent cardiac (...) catheterization at our institution between 1999 and 2011, 6181 patients had an estimated glomerular filtration rate of ≤60 ml/min per 1.73 m2 and were not receiving renal replacement therapy. The risk of SCA/SCD and all-cause mortality associated with potassium concentration was evaluated at the time of cardiac catheterization (baseline) and most proximate to SCA/SCD events. Covariate-adjusted Cox models were used to examine relationships between baseline potassium measurements and outcomes. A propensity
Impact of chronickidneydisease on the diuretic response of tolvaptan in acute decompensated heart failure This study investigated the relationship between the initial diuretic response to tolvaptan and clinical predictors for tolvaptan responders in patients with acute decompensated heart failure (ADHF).Patients (153) with ADHF (clinical scenario 2 or 3 with signs of fluid retention) who were administered tolvaptan were enrolled. Tolvaptan (15 or 7.5 mg) was administered for at least 7 days (...) to those patients in whom fluid retention was observed even after standard treatment. The maximum urine volume immediately after tolvaptan administration showed good correlations with the ejection fraction and estimated glomerular filtration rate that were independent predictors of the urine volume (UV) responders (≥1500 mL increase in urine volume). The diuretic response (in terms of maximum diuresis) diminished with advancing chronickidneydisease (CKD) stage and concomitant deterioration
Chronickidneydisease and the global NCDs agenda 29225940 2019 01 31 2059-7908 2 2 2017 BMJ global health BMJ Glob Health Chronickidneydisease and the global NCDs agenda. e000380 10.1136/bmjgh-2017-000380 Neuen Brendon Lange BL Department of Renal Medicine, Royal Prince Alfred Hospital, Sydney, Australia. Renal and Metabolic Division, George Institute for Global Health, Sydney, Australia. Chadban Steven James SJ Department of Renal Medicine, Royal Prince Alfred Hospital, Sydney, Australia (...) . Charles Perkins Centre, University of Sydney, Sydney, Australia. Demaio Alessandro Rhyl AR World Health Organization, Geneva, Switzerland. Johnson David Wayne DW Centre for KidneyDisease Research, University of Queensland, Brisbane, Australia. Department of Nephrology, Princess Alexandra Hospital, Brisbane, Australia. Translational Research Institute, Brisbane, Australia. Perkovic Vlado V Renal and Metabolic Division, George Institute for Global Health, Sydney, Australia. Department of Renal Medicine
Interventions for chronickidneydisease in people with sickle cell disease. Sickle cell disease (SCD) is one of the commonest severe monogenic disorders in the world, due to the inheritance of two abnormal haemoglobin (beta-globin) genes. SCD can cause severe pain, significant end-organ damage, pulmonary complications, and premature death. Kidneydisease is a frequent and potentially severe complication in people with SCD.Chronic kidneydisease is defined as abnormalities of kidney structure (...) searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Trials Register: 13 April 2017.Randomised controlled trials comparing interventions to prevent or reduce kidney complications or chronickidneydisease in people with SCD. There were no restrictions by outcomes examined, language or publication status.Two authors independently assessed trial eligibility, extracted data and assessed the risk of bias.We included two trials with 215 participants. One trial was published in 2011 and included
[Intradialytic parenteral nutrition in patients with chronickidneyconditions] [Intradialytic parenteral nutrition in patients with chronickidneyconditions] [Intradialytic parenteral nutrition in patients with chronickidneyconditions] Molinari LM, Bardach A, Pichon-Riviere A, Augustovski F, García Martí S, Alcaraz A, Ciapponi A Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment (...) has been made for the HTA database. Citation Molinari LM, Bardach A, Pichon-Riviere A, Augustovski F, García Martí S, Alcaraz A, Ciapponi A. [Intradialytic parenteral nutrition in patients with chronickidneyconditions] Buenos Aires: Institute for Clinical Effectiveness and Health Policy (IECS). Documentos de Evaluación de Tecnologías Sanitarias, Informe de Respuesta Rapida No 528. 2017 Authors' conclusions Scarce evidence of moderate quality shows that in hemodialyzed patients, Intradialytic
Prediction of ChronicKidneyDisease Stage 3 by CKD273, a Urinary Proteomic Biomarker CKD273 is a urinary biomarker, which in advanced chronickidneydisease predicts further deterioration. We investigated whether CKD273 can also predict a decline of estimated glomerular filtration rate (eGFR) to <60 ml/min per 1.73 m2.In analyses of 2087 individuals from 6 cohorts (46.4% women; 73.5% with diabetes; mean age, 46.1 years; eGFR ≥ 60 ml/min per 1.73 m2, 100%; urinary albumin excretion rate [UAE (...) improved the net reclassification index (P ≤ 0.0003), except for UAE per threshold (P = 0.086).In conclusion, while accounting for baseline eGFR, albuminuria, and covariables, CKD273 adds to the prediction of stage 3 chronickidneydisease, at which point intervention remains an achievable therapeutic target.
ChronicKidneyDisease in Panama: Results From the PREFREC Study and National Mortality Trends The magnitude of chronickidneydisease (CKD) in Panama has yet to be described. We investigated the association between sociodemographic and cardiovascular exposures with CKD in 2 Panamanian provinces. Further, we analyzed national trends of CKD mortality from 2001 to 2014.Data were derived from Prevalencia de Factores de Riesgo de Enfermedad Cardiovascular (PREFREC [Survey on Risk Factors Associated (...) With Cardiovascular Disease]), a cross-sectional study designed to analyze the prevalence of risk factors associated with cardiovascular disease. Biomarkers of kidney function were measured in 3590 participants. CKD was defined as an estimated glomerular filtration rate (eGFR) of <60 ml/min/1.73 m2 and/or albuminuria ≥30 mg/g creatinine. Odds ratios (ORs) with 95% confidence intervals (CIs) for CKD were calculated using logistic regression. We calculated age-standardized CKD mortality rates in the country using
Chronickidneydisease in low-income to middle-income countries: the case for increased screening Chronickidneydisease (CKD) is fast becoming a major public health issue, disproportionately burdening low-income to middle-income countries, where detection rates remain low. We critically assessed the extant literature on CKD screening in low-income to middle-income countries. We performed a PubMed search, up to September 2016, for studies on CKD screening in low-income to middle-income (...) countries. Relevant studies were summarised through key questions derived from the Wilson and Jungner criteria. We found that low-income to middle-income countries are ill-equipped to deal with the devastating consequences of CKD, particularly the late stages of the disease. There are acceptable and relatively simple tools that can aid CKD screening in these countries. Screening should primarily include high-risk individuals (those with hypertension, type 2 diabetes, HIV infection or aged >60 years
Re: Timely Referral to Outpatient Nephrology Care Slows Progression and Reduces Treatment Costs of ChronicKidneyDiseases 29142994 2019 01 18 2468-0249 2 4 2017 Jul Kidney international reports Kidney Int Rep Re: Timely Referral to Outpatient Nephrology Care Slows Progression and Reduces Treatment Costs of ChronicKidneyDiseases. 779 10.1016/j.ekir.2017.05.005 Auguste Bourne L BL Division of Nephrology, University of Toronto, Toronto Ontario, Canada, on behalf of the University of Toronto (...) City-wide Nephrology Journal Club. Naimark David M J DMJ Division of Nephrology, University of Toronto, Toronto Ontario, Canada, on behalf of the University of Toronto City-wide Nephrology Journal Club. eng Journal Article 2017 05 12 United States Kidney Int Rep 101684752 2468-0249 2017 04 26 2017 05 05 2017 11 17 6 0 2017 11 17 6 0 2017 11 17 6 1 epublish 29142994 10.1016/j.ekir.2017.05.005 S2468-0249(17)30120-1 PMC5678618 J Am Soc Nephrol. 2003 Nov;14(11):2934-41 14569104 J Am Soc Nephrol. 2009
The Association of Daily Activity Levels and Estimated Kidney Function in Men and Women With Predialysis ChronicKidneyDiseaseChronickidneydisease (CKD) is often accompanied by complications including poor physical activity level. However, only a few studies have objectively characterized physical activity levels in predialysis CKD. Our study sought to measure daily activity levels by accelerometry in individuals with CKD (stages III-V) and to determine the association between daily (...) activity and kidney function.We determined kidney function by means of the estimated glomerular filtration rate (eGFR) using the Modification of Diet and RenalDisease (MDRD) equation. Participants wore an accelerometer for 7 consecutive days, and we measured multiple physical activity outcomes including total daily activity, sedentary, light, and moderate-vigorous activity. Average durations and intensity of activity were determined according to stage of CKD. The association between kidney function
Association of Sleep Duration, Symptoms, and Disorders With Mortality in Adults With ChronicKidneyDisease In general populations, short and long sleep duration, poor sleep quality and sleep disorders have been associated with increased risk of death. We evaluated these associations in individuals with chronickidneydisease (CKD).Prospective cohort study of 1,452 National Health and Nutrition Examination Survey (NHANES) 2005-2008 participants with CKD. CKD was defined by estimated glomerular (...) filtration rate <60 ml/min/1.73m2 or urine albumin-to-creatinine ratio ≥30 mg/g. Sleep duration, sleep symptoms (difficulty falling asleep, difficulty staying asleep, daytime sleepiness and non-restorative sleep), and sleep disorders (restless legs syndrome and sleep apnea) were self-reported. Vital status was determined using NHANES mortality linkage through December 2011.Mean age was 61 years, 58% were women, and 75% non-Hispanic white. During 4.4 years of median follow-up, we observed 234 deaths
Examining the Roles and Experiences of Fathers of Children With ChronicKidneyDisease This study examined roles and experiences of fathers of children with chronickidneydisease (CKD). Based on interpretive description, semistructured interviews were conducted with 22 fathers of children receiving a range of treatments (transplant, peritoneal dialysis, hemodialysis, and CKD not requiring renal replacement therapy). Fathers described various experiences and means of adjusting to shifts