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Latest & greatest articles for chronic kidney disease
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ChronickidneydiseaseChronickidneydisease - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search Chronickidneydisease Last reviewed: August 2018 Last updated: November 2017 Summary Proteinuria or haematuria, and/or a reduction in the GFR for more than 3 months' duration. The most common causes are diabetes mellitus (DM) and hypertension (HTN). The majority of people are asymptomatic, and the diagnosis is determined (...) only by laboratory studies. Glycaemic control for diabetic nephropathy and optimisation of BP are key in slowing the progression of disease. Increased risk for cardiovascular disease. Definition Chronickidneydisease, also known as chronic renal failure, is defined by either a pathological abnormality of the kidney, such as haematuria and/or proteinuria, or a reduction in the GFR to <60 mL/minute/1.73 m^2 for ≥3 months' duration. KDOQI Advisory Board Members. Clinical practice guidelines
Association of British Clinical Diabetologists - Renal Association (ABCD-RA) Clinical Practice Guidelines for Management of Lipids in Adults with Diabetes Mellitus and Nephropathy and/or ChronicKidneyDisease
Urinary Calcium Excretion and Risk ofÂ ChronicKidneyDisease in the GeneralÂ Population 29318214 2018 11 13 2468-0249 2 3 2017 May Kidney international reports Kidney Int Rep Urinary Calcium Excretion and Risk of ChronicKidneyDisease in the General Population. 366-379 10.1016/j.ekir.2016.12.007 High urinary calcium excretion (UCaE) has been shown to lead to accelerated renal function decline in individuals with renal tubular diseases. It is not known whether this association also exists (...) in the general population. Therefore, we investigated whether high UCaE is associated with risk of developing chronickidneydisease (CKD) in community-dwelling subjects. Urine samples of 5491 subjects who were free of CKD at baseline and participated in the Prevention of Renal and Vascular End-Stage Disease study (a prospective, observational, general population-based cohort of Dutch men and women aged 28-75 years) were examined for UCaE. UCa concentration was measured in two 24-hour urine samples
Oral Magnesium Supplementation in ChronicKidneyDisease Stages 3 and 4: Efficacy, Safety, and Effect on Serum Calcification Propensityâ€”AÂ Prospective Randomized Double-Blinded Placebo-Controlled Clinical Trial 29142966 2018 11 13 2468-0249 2 3 2017 May Kidney international reports Kidney Int Rep Oral Magnesium Supplementation in ChronicKidneyDisease Stages 3 and 4: Efficacy, Safety, and Effect on Serum Calcification Propensity-A Prospective Randomized Double-Blinded Placebo-Controlled (...) Clinical Trial. 380-389 10.1016/j.ekir.2016.12.008 Chronickidneydisease (CKD) is associated with high cardiovascular morbidity and mortality. Recent evidence suggests that increases in both serum and intracellular magnesium (Mg) can slow or even prevent the development of vascular calcification seen in CKD. Serum calcification propensity ( T 50 ) is a novel functional test, which is associated with all-cause mortality in CKD and measures the ability of serum to delay the formation of crystalline
ChronicKidneyDisease. The definition and classification of chronickidneydisease (CKD) have evolved over time, but current international guidelines define this condition as decreased kidney function shown by glomerular filtration rate (GFR) of less than 60 mL/min per 1·73 m 2 , or markers of kidney damage, or both, of at least 3 months duration, regardless of the underlying cause. Diabetes and hypertension are the main causes of CKD in all high-income and middle-income countries, and also (...) measured either via exogenous markers (eg, DTPA, iohexol), or estimated using equations. Presence of proteinuria is associated with increased risk of progression of CKD and death. Kidney biopsy samples can show definitive evidence of CKD, through common changes such as glomerular sclerosis, tubular atrophy, and interstitial fibrosis. Complications include anaemia due to reduced production of erythropoietin by the kidney; reduced red blood cell survival and iron deficiency; and mineral bone disease
Metabolically Healthy Obesity and Development of ChronicKidneyDisease 27842407 2017 12 07 2018 11 13 1539-3704 165 10 2016 11 15 Annals of internal medicine Ann. Intern. Med. Metabolically Healthy Obesity and Development of ChronicKidneyDisease. 743 10.7326/L16-0407 Kahn Henry S HS From Centers for Disease Control and Prevention, Atlanta, Georgia. Pavkov Meda E ME From Centers for Disease Control and Prevention, Atlanta, Georgia. eng CC999999 Intramural CDC HHS United States Journal Article (...) Comment United States Ann Intern Med 0372351 0003-4819 AIM IM Ann Intern Med. 2016 Mar 1;164(5):305-12 26857595 Int J Obes (Lond). 2016 May;40(5):883-6 26841729 PLoS One. 2016 Jan 05;11(1):e0146057 26731527 Ann Intern Med. 2016 Mar 1;164(5):305-12 26857595 JAMA. 2015 Feb 24;313(8):837-46 25710660 Prog Cardiovasc Dis. 2014 Jan-Feb;56(4):369-81 24438728 Ann Intern Med. 2016 Nov 15;165(10 ):744-745 27842405 Body Mass Index Humans Obesity Obesity, Metabolically Benign Renal Insufficiency, Chronic 2016 11
Sarcopenia, Obesity, and Mortality in US Adults With and Without ChronicKidneyDisease 28439567 2018 11 13 2468-0249 2 2 2017 Mar Kidney international reports Kidney Int Rep Sarcopenia, obesity, and mortality in US adults with and without chronickidneydisease. 201-211 10.1016/j.ekir.2016.10.008 In pre-dialysis chronickidneydisease (CKD), the association of muscle mass with mortality is poorly defined, and no study has examined outcomes related to the co-occurrence of low muscle mass (...) Endocrinol Metab. 2015 Apr 15;308(8):E670-9 25670829 Am J Clin Nutr. 2007 Sep;86(3):633-8 17823427 J Gerontol A Biol Sci Med Sci. 2009 Apr;64(4):455-61 19196644 BMC Nephrol. 2014 Jul 08;15:108 25005601 J Am Soc Nephrol. 2006 Jun;17(6):1695-702 16641153 Am J Clin Nutr. 2006 Sep;84(3):475-82 16960159 J Am Soc Nephrol. 2014 Sep;25(9):2088-96 24652789 Cell Metab. 2013 Sep 3;18(3):368-79 24011072 appendicular skeletal muscle mass index body composition chronickidneydisease lean body mass sarcopenic obesity
Downregulation of AdipoR1 is Associated with increased Circulating Adiponectin Levels in Serbian ChronicKidneyDisease Patients 28670196 2018 11 13 1452-8258 35 4 2016 Oct Journal of medical biochemistry J Med Biochem Downregulation of AdipoR1 is Associated with increased Circulating Adiponectin Levels in Serbian ChronicKidneyDisease Patients. 436-442 10.1515/jomb-2016-0007 Since the rise in plasma adiponectin levels in chronickidneydisease (CKD) patients has not yet been elucidated, we (...) sought to investigate if patients on hemodialysis (HD) have altered expression of adiponectin receptors in peripheral blood mononuclear cells (PBMCs) compared to healthy subjects. This study included 31 patients with chronickidneydisease on HD and 33 healthy subjects (CG). Circulating adiponectin levels were measured by ELISA while AdipoR1 and AdipoR2 mRNA levels in PBMCs were determined by real-time PCR. Plasma adiponectin levels were significantly higher in patients compared to control group (P
Hypertension Control, Apparent Treatment Resistance, and Outcomes in the Elderly Population With ChronicKidneyDisease 29142956 2018 11 13 2468-0249 2 2 2017 Mar Kidney international reports Kidney Int Rep Hypertension Control, Apparent Treatment Resistance, and Outcomes in the Elderly Population With ChronicKidneyDisease. 180-191 10.1016/j.ekir.2016.10.006 Chronickidneydisease (CKD) is often associated with poor hypertension control and treatment resistance, but whether CKD modifies (...) 22379110 Ann Intern Med. 2006 Aug 15;145(4):247-54 16908915 cardiovascular chronickidneydisease hypertension 2016 08 22 2016 10 15 2016 10 25 2017 11 17 6 0 2017 11 17 6 0 2017 11 17 6 1 epublish 29142956 10.1016/j.ekir.2016.10.006 S2468-0249(16)30162-0 PMC5678838