Latest & greatest articles for chlorhexidine

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on chlorhexidine or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on chlorhexidine and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for chlorhexidine

161. Comparison of 0.12 percent to 0.2 percent chlorhexidine on periodontal health: limited clinical difference in effect on plaque accumulation

Comparison of 0.12 percent to 0.2 percent chlorhexidine on periodontal health: limited clinical difference in effect on plaque accumulation Comparison of 0.12 percent to 0.2 percent chlorhexidine on periodontal health: limited clinical difference in effect on plaque accumulation ADA Websites Access news, member benefits and ADA policy Attend ADA's premier event Access cutting-edge continuing education courses Find evidence to support your clinical decisions Access member-only practice content (...) and certifying boards Evidence Education * Associated Topics Comparison of 0.12 percent to 0.2 percent chlorhexidine on periodontal health: limited clinical difference in effect on plaque accumulation Paul Hunter DMD, MLIS . Overview Systematic Review Conclusion A comparison of 0.12 percent to 0.2 percent chlorhexidine indicates that there is a small difference on plaque accumulation, no effect on gingivitis, and a lack of research for periodontal pocketing or attachment levels. Critical Summary Assessment

2012 ADA Center for Evidence-Based Dentistry

162. Comparison of 0.12 percent to 0.2 percent chlorhexidine on periodontal health: limited clinical difference in effect on plaque accumulation

Comparison of 0.12 percent to 0.2 percent chlorhexidine on periodontal health: limited clinical difference in effect on plaque accumulation Comparison of 0.12 percent to 0.2 percent chlorhexidine on periodontal health: limited clinical difference in effect on plaque accumulation ADA Websites Access news, member benefits and ADA policy Attend ADA's premier event Access cutting-edge continuing education courses Find evidence to support your clinical decisions Access member-only practice content (...) and certifying boards Evidence Education * Associated Topics Comparison of 0.12 percent to 0.2 percent chlorhexidine on periodontal health: limited clinical difference in effect on plaque accumulation Paul Hunter DMD, MLIS . Overview Systematic Review Conclusion A comparison of 0.12 percent to 0.2 percent chlorhexidine indicates that there is a small difference on plaque accumulation, no effect on gingivitis, and a lack of research for periodontal pocketing or attachment levels. Critical Summary Assessment

2012 ADA Center for Evidence-Based Dentistry

163. Chlorhexidine body washing to control antimicrobial-resistant bacteria in intensive care units: a systematic review. (Full text)

Chlorhexidine body washing to control antimicrobial-resistant bacteria in intensive care units: a systematic review. Infections caused by antimicrobial-resistant bacteria (AMRB) are increasing worldwide, especially in intensive care units (ICUs). Chlorhexidine body washing (CHG-BW) has been proposed as a measure to limit the spread of AMRB. We have systematically assessed the evidence on the effectiveness of CHG-BW in reducing colonization and infection with AMRB in adult ICU patients.PubMed (...) , Embase, CINAHL, and OpenSigle databases were searched using synonyms for "intensive care unit," "hospital," and "chlorhexidine." All potentially relevant articles were examined by two independent reviewers. Inclusion was limited to studies with ICU patients as domain, providing outcomes related to colonization or infection with AMRB. Data from 16 studies were extracted; 9 were excluded because of assessed high risk of bias or inadequate analyses. The remaining studies differed markedly in (co

2012 Intensive Care Medicine PubMed abstract

164. Chlorhexidine Gluconate versus Hydrogen Peroxide Oral Hygiene Rinse Preparations for the Prevention of Ventilator-Associated Pneumonia: Comparative Clinical Effectiveness and Safety

Chlorhexidine Gluconate versus Hydrogen Peroxide Oral Hygiene Rinse Preparations for the Prevention of Ventilator-Associated Pneumonia: Comparative Clinical Effectiveness and Safety Disclaimer: The Rapid Response Service is an information service for those involved in planning and providing health care in Canada. Rapid responses are based on a limited literature search and are not comprehensive, systematic reviews. The intent is to provide a list of sources of the best evidence on the topic (...) by the owners’ own terms and conditions. TITLE: Chlorhexidine Gluconate versus Hydrogen Peroxide Oral Hygiene Rinse Preparations for the Prevention of Ventilator-Associated Pneumonia: Comparative Clinical Effectiveness and Safety DATE: 25 April 2012 RESEARCH QUESTIONS 1. What is the comparative clinical effectiveness of 0.12% chlorhexidine gluconate oral rinse solutions versus hydrogen peroxide oral rinse solutions for the prevention of ventilator-associated pneumonia? 2. What is the clinical evidence

2012 Canadian Agency for Drugs and Technologies in Health - Rapid Review

165. Clinically Significant Data to Prove Chlorhexidine Ineffective in Caries Prevention

Clinically Significant Data to Prove Chlorhexidine Ineffective in Caries Prevention UTCAT2236, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Clinically Significant Data to Prove Chlorhexidine Ineffective in Caries Prevention Clinical Question In an adult patient presenting with high caries risk, does chlorhexidine varnish or chlorhexidine rinse prevent new caries development when compared to placebo? Clinical Bottom (...) Line Chlorhexidine varnish and chlorhexidine rinse do not prevent the development of coronal caries in adults compared to placebo. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Papas/2012 983 adults, 20 intact teeth, 2 or more lesions at screening, mean age: 42, age range: 18-80 Randomized Controlled Trial Key results This clinical trial found no significant difference in new caries development

2012 UTHSCSA Dental School CAT Library

166. Economic evaluation of chlorhexidine-impregnated sponges for preventing catheter-related infections in critically ill adults in the Dressing Study (Full text)

Economic evaluation of chlorhexidine-impregnated sponges for preventing catheter-related infections in critically ill adults in the Dressing Study The randomized two-way factorial Dressing Study (1,636 patients, 28,931 catheter days) showed that a chlorhexidine-impregnated sponge decreased the incidence of major catheter-related infections from 1.4‰ to 0.6‰ catheter days, and that scheduled dressing changes every 7 days was not inferior to scheduled changes every 3 days. Here, we assessed (...) the cost benefits of chlorhexidine-impregnated sponge use.Costs directly related to major catheter-related infections and the costs of chlorhexidine-impregnated sponge and contact dermatitis were calculated prospectively using microcosting methods during the original study. The added length of stay in the intensive care unit due to major catheter-related infection was estimated using the disability model and assuming a cost of $2,118/intensive care unit day. The cost of each strategy was estimated

2012 EvidenceUpdates Controlled trial quality: uncertain PubMed abstract

167. Chlorhexidine Rinse Treatment Improved Patients? Outcome When Combined With Scaling And Root Planning

Chlorhexidine Rinse Treatment Improved Patients? Outcome When Combined With Scaling And Root Planning UTCAT2266, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Chlorhexidine Rinse Treatment Improved Patients’ Outcome When Combined With Scaling And Root Planning Clinical Question In adult periodontitis patients, will the use of Chlorhexidine rinse in conjunction with scaling and root planning be more effective than (...) scaling and root planning alone in reducing the pocket depths? Clinical Bottom Line Combining chlorhexidine rinse with scaling and root planning improves pocket depth more effectively than scaling and root planning alone. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Feres/2009 Sixty subjects from 30 to 55 years of age have untreated periodontal disease selected from clinical referral Randomized

2012 UTHSCSA Dental School CAT Library

168. Economic impact of use of chlorhexidine-impregnated sponge dressing for prevention of central line-associated infections in the United States

Economic impact of use of chlorhexidine-impregnated sponge dressing for prevention of central line-associated infections in the United States Economic impact of use of chlorhexidine-impregnated sponge dressing for prevention of central line-associated infections in the United States Economic impact of use of chlorhexidine-impregnated sponge dressing for prevention of central line-associated infections in the United States Ye X, Rupnow M, Bastide P, Lafuma A, Ovington L, Jarvis WR Record Status (...) This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary The objective was to examine the clinical and economic impact, from a hospital perspective, of adding a chlorhexidine gluconate-impregnated sponge dressing to the standard care for the prevention of central-line

2012 NHS Economic Evaluation Database.

169. Chlorhexidine cord cleansing to reduce neonatal mortality (Full text)

Chlorhexidine cord cleansing to reduce neonatal mortality 22322125 2012 03 27 2018 12 01 1474-547X 379 9820 2012 Mar 17 Lancet (London, England) Lancet Chlorhexidine cord cleansing to reduce neonatal mortality. 984-6 10.1016/S0140-6736(12)60114-7 Osrin David D UCL Institute for Global Health, London, UK. d.osrin@ucl.ac.uk Hill Zelee Elizabeth ZE eng 091561 Wellcome Trust United Kingdom Journal Article Comment 2012 02 08 England Lancet 2985213R 0140-6736 0 Anti-Infective Agents, Local R4KO0DY52L (...) Chlorhexidine AIM IM Lancet. 2012 Mar 17;379(9820):1022-8 22322124 Lancet. 2012 Mar 17;379(9820):1029-36 22322126 Anti-Infective Agents, Local administration & dosage Bacterial Infections prevention & control Chlorhexidine administration & dosage Community Health Workers Female Humans Pregnancy Sepsis prevention & control Umbilical Cord microbiology UKMS47773 2012 2 11 6 0 2012 2 11 6 0 2012 3 28 6 0 ppublish 22322125 S0140-6736(12)60114-7 10.1016/S0140-6736(12)60114-7 PMC3428896 UKMS47773 J Health Popul

2012 Lancet PubMed abstract

170. Chlorhexidine: reminder of potential for hypersensitivity

Chlorhexidine: reminder of potential for hypersensitivity Chlorhexidine: reminder of potential for hypersensitivity - GOV.UK GOV.UK uses cookies to make the site simpler. or Search Chlorhexidine: reminder of potential for hypersensitivity Healthcare professionals are reminded that chlorhexidine is known to induce hypersensitivity, including generalised allergic reactions and anaphylactic shock. Published 11 December 2014 From: Therapeutic area: Article date: January 2012 Chlorhexidine (...) is an antibacterial present in a wide range of topical and oromucosal antiseptic products, including over-the-counter mouthwashes. It can also be used in some indwelling catheters to prevent contamination. Healthcare professionals are reminded that chlorhexidine is known to induce hypersensitivity, including generalised allergic reactions and anaphylactic shock. The prevalence of chlorhexidine hypersensitivity is unknown, but available literature suggests this is likely to be very rare. Products or medical

2012 MHRA Drug Safety Update

171. The effect of cord cleansing with chlorhexidine on neonatal mortality in rural Bangladesh: a community-based, cluster-randomised trial. (Abstract)

The effect of cord cleansing with chlorhexidine on neonatal mortality in rural Bangladesh: a community-based, cluster-randomised trial. Up to half of neonatal deaths in high mortality settings are due to infections, many of which can originate through the freshly cut umbilical cord stump. We aimed to assess the effectiveness of two cord-cleansing regimens with the promotion of dry cord care in the prevention of neonatal mortality.We did a community-based, parallel cluster-randomised trial (...) in Sylhet, Bangladesh. We divided the study area into 133 clusters, which were randomly assigned to one of the two chlorhexidine cleansing regimens (single cleansing as soon as possible after birth; daily cleansing for 7 days after birth) or promotion of dry cord care. Randomisation was done by use of a computer-generated sequence, stratified by cluster-specific participation in a previous trial. All livebirths were eligible; those visited within 7 days by a local female village health worker trained

2012 Lancet Controlled trial quality: predicted high

172. Topical application of chlorhexidine to neonatal umbilical cords for prevention of omphalitis and neonatal mortality in a rural district of Pakistan: a community-based, cluster-randomised trial. (Abstract)

Topical application of chlorhexidine to neonatal umbilical cords for prevention of omphalitis and neonatal mortality in a rural district of Pakistan: a community-based, cluster-randomised trial. Umbilical cord infection (omphalitis) is a risk factor for neonatal sepsis and mortality in low-resource settings where home deliveries are common. We aimed to assess the effect of umbilical-cord cleansing with 4% chlorhexidine (CHX) solution, with or without handwashing with antiseptic soap

2012 Lancet Controlled trial quality: predicted high

173. Reduced costs for Staphylococcus aureus carriers treated prophylactically with mupirocin and chlorhexidine in cardiothoracic and orthopaedic surgery. (Full text)

Reduced costs for Staphylococcus aureus carriers treated prophylactically with mupirocin and chlorhexidine in cardiothoracic and orthopaedic surgery. A multi centre double-blind randomised-controlled trial (M-RCT), carried out in the Netherlands in 2005-2007, showed that hospitalised patients with S. aureus nasal carriage who were treated prophylactically with mupirocin nasal ointment and chlorhexidine gluconate medicated soap (MUP-CHX), had a significantly lower risk of health-care associated

2012 PloS one Controlled trial quality: predicted high PubMed abstract

174. Chlorhexidine for the prevention of alveolar osteitis. (Abstract)

Chlorhexidine for the prevention of alveolar osteitis. This systematic review assessed the efficacy of chlorhexidine for the prevention of alveolar osteitis and occurrence of adverse reactions. Databases were searched until 20 April 2011. Trial inclusion criteria were: titles/abstracts relevant to topic; prospective 2-arm (or more) clinical study design. Trial exclusion criteria were: not all entered subjects accounted for; subjects of both groups not followed up the same way; lack (...) of computable data; chlorhexidine not the primary test agent; duplication of data; outcome of interest other than incidence of alveolar osteitis. Individual datasets were extracted from accepted articles. Bias risk in trials was assessed. 10 of 13 included trials were accepted. From these, 16 dichotomous datasets were extracted. Two of six application protocols favoured chlorhexidine over placebo: Single application of 0.2% chlorhexidine gel placed in the socket immediately after extraction versus placebo

2012 International Journal of Oral and Maxillofacial Surgery

175. Essential oil mouthwash (EOMW) may be equivalent to chlorhexidine (CHX) for long-term control of gingival inflammation but CHX appears to perform better than EOMW in plaque control. (Abstract)

Essential oil mouthwash (EOMW) may be equivalent to chlorhexidine (CHX) for long-term control of gingival inflammation but CHX appears to perform better than EOMW in plaque control. For inclusion in this systematic review, studies had to be randomized clinical trials (RCTs) or controlled trials in healthy human subjects comparing the effects of essential-oil mouthwash (EOMW) with chlorhexidine (CHX) on plaque and calculus accumulation, tooth staining, and gingival inflammation. Included studies (...) , or gingival index.The primary outcomes of this systematic review and meta-analysis were differences in mean plaque index, calculus index, and tooth staining index, gingival index, and gingival bleeding after daily use of either chlorhexidine gluconate or essential oil mouthwash for < 4 or > 4 weeks.Nineteen randomized or controlled clinical trials were included in this systematic review. In 5 of the 7 studies of plaque index, CHX was found to be significantly better than EOMW at reducing plaque

2012 Journal of Evidence Based Dental Practice

176. Does chlorhexidine prevent dry socket? (Full text)

Does chlorhexidine prevent dry socket? The BBO (Bibliografia Brasileira de Odontologia), Biomed Central, Cochrane Library, Directory of Open Access Journals, LILACS, Open-J-Gate, OpenSIGLE, PubMed, Sabinet and Science-Direct databases were searched.Articles were selected for review from the search results on the basis of their compliance with the broad inclusion criteria: relevant to the review question; and prospective two-arm (or more) clinical study. The primary outcome measure (...) Cochrane guidelines. Meta-analysis was conducted with homogeneous datasets. Publication bias was assessed by use of a funnel plot and Egger's regression.Ten randomised trials were included; almost all involved the removal of third molars. Only two of six identified application protocols (single application of chlorhexidine 0.2% gel or multiple application of 0.12% rinse versus placebo) were found to significantly decrease the incidence of AO.Within the limitations of this review, only two of six

2012 Evidence Based Dentistry PubMed abstract

177. Impact of non-rinse skin cleansing with chlorhexidine gluconate on prevention of healthcare-associated infections and colonization with multi-resistant organisms: a systematic review. (Abstract)

Impact of non-rinse skin cleansing with chlorhexidine gluconate on prevention of healthcare-associated infections and colonization with multi-resistant organisms: a systematic review. The topical use of chlorhexidine gluconate (CHG) is intended to reduce bacterial density on patients' skin.To assess the impact of body bath or skin cleansing with CHG-impregnated or CHG-saturated washcloths in preventing healthcare-associated infections and colonization.This systematic review included published

2012 The Journal of hospital infection

178. The efficacy of daily bathing with chlorhexidine for reducing healthcare-associated bloodstream infections: a meta-analysis. (Full text)

The efficacy of daily bathing with chlorhexidine for reducing healthcare-associated bloodstream infections: a meta-analysis. Systematic review and meta-analysis of randomized controlled trials and quasi-experimental studies to assess the efficacy of daily bathing with chlorhexidine (CHG) for prevention of healthcare-associated bloodstream infections (BSIs).Medical, surgical, trauma, and combined medical-surgical intensive care units (ICUs) and long-term acute care hospitals.Inpatients.Data

2012 Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America PubMed abstract

179. Effect of a chlorhexidine mouthrinse on plaque, gingival inflammation and staining in gingivitis patients: a systematic review. (Full text)

Effect of a chlorhexidine mouthrinse on plaque, gingival inflammation and staining in gingivitis patients: a systematic review. To systematically evaluate the efficacy of chlorhexidine (CHX) mouthrinses on plaque, gingival inflammation and staining in gingivitis patients.Medline, EMBASE and Cochrane Central Register of Controlled Trials were searched through April 2011. Randomized controlled clinical trials comparing CHX to placebo/control mouthrinses or oral hygiene (OH) ≥ 4 weeks were

2012 Journal of clinical periodontology PubMed abstract

180. Essential oil mouthwash (EOMW) may be equivalent to chlorhexidine (CHX) for long-term control of gingival inflammation but CHX appears to perform better than EOMW in plaque control. (Abstract)

Essential oil mouthwash (EOMW) may be equivalent to chlorhexidine (CHX) for long-term control of gingival inflammation but CHX appears to perform better than EOMW in plaque control. Essential oils compared to chlorhexidine with respect to plaque and parameters of gingival inflammation: a systematic review. Van Leeuwen MPC, Slot DE, Van der Weijden GA. J Periodontol 2011 Feb;82(2):174-94. Epub 2010 Nov 2.Anthony L. Neely, DDS, MDentSc, PhD.To determine whether essential oil mouthwash (...) is comparable to chlorhexidine gluconate with respect to reducing plaque and gingival inflammation and promoting calculus accumulation and extrinsic staining.Some support came from the Academic Center for Dentistry Amsterdam, University of Amsterdam and VU University Amsterdam. TYPE OF STUDY DESIGN: Systematic review with meta-analysis of data.Level 1: Good-quality, patient-oriented evidence.Grade B: Inconsistent or limited-quality patient-oriented evidence.Copyright © 2011. Published by Mosby, Inc.

2011 Journal of Evidence Based Dental Practice