Latest & greatest articles for children

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on children or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on children and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for children

101. Hydrocortisone (Alkindi) - replacement therapy of adrenal insufficiency in infants, children and adolescents (from birth to <18 years old)

Hydrocortisone (Alkindi) - replacement therapy of adrenal insufficiency in infants, children and adolescents (from birth to <18 years old)

Scottish Medicines Consortium2018

102. Dexrazoxane in children: European disagreements and arbitration

Dexrazoxane in children: European disagreements and arbitration Prescrire IN ENGLISH - Spotlight ''Dexrazoxane in children: European disagreements and arbitration'', 1 October 2018 {1} {1} {1} | | > > > Dexrazoxane in children: European disagreements and arbitration Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |   |   |   |   |   |   |   |  Spotlight In the October issue of Prescrire (...) International - Dexrazoxane in children: European disagreements and arbitration FREE DOWNLOAD In 2017, dexrazoxane was re-approved in the European Union for use in children treated with high doses of anthracyclines. However, uncertainties remain. Full text available for free download. Summary Since its introduction onto the European market in the 1990s, evaluation of dexrazoxane is insufficient to determine its harm-benefit balance. Nearly 20 years on , disagreement between agencies shows that substantial

Prescrire2018

103. The Relationship Between Fish Oil Supplementation During Pregnancy and Incidence of Asthma in Children

The Relationship Between Fish Oil Supplementation During Pregnancy and Incidence of Asthma in Children "The Relationship Between Fish Oil Supplementation During Pregnancy and" by JesAnne Tageson-Ramirez < > > > > > Title Author Date of Graduation Summer 8-11-2018 Degree Type Capstone Project Degree Name Master of Science in Physician Assistant Studies Rights . Abstract Background: The incidence of asthma is increasing in the United States. Some researchers believe this rise is due to higher (...) levels of n-6 fatty acids in relation to n-3 fatty acids that are found in cold-water fish. Several studies over the years have tried to discern if increasing fish oil in the diet or by supplementation can decrease the incidence of asthma in children. However, the results of these studies are not in agreement. Methods: A comprehensive search of available medical literature was performed using MEDLINE-Ovid, CINAHL, and Web of Science using the keywords: fatty acids, omega-3s, fish oil, LCPUFAs

Pacific University EBM Capstone Project2018

104. Restricted fluid bolus versus current practice in children with septic shock: the FiSh feasibility study and pilot RCT

Restricted fluid bolus versus current practice in children with septic shock: the FiSh feasibility study and pilot RCT Restricted fluid bolus versus current practice in children with septic shock: the FiSh feasibility study and pilot RCT Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from the navigation or try a website search above to find (...) Jones 4 , Mark D Lyttle 5 , Simon Nadel 1 , Mark J Peters 6 , David A Harrison 2 , Kathryn M Rowan 2 1 Paediatric Intensive Care Unit, St Mary’s Hospital, Imperial College Healthcare NHS Trust, London, UK 2 Clinical Trials Unit, Intensive Care National Audit and Research Centre, London, UK 3 Department of Psychological Sciences, North West Hub for Trials Methodology Research, University of Liverpool, Liverpool, UK 4 Parent representative, no affiliation, , 5 Faculty of Health and Applied Sciences

NIHR HTA programme2018

105. Standing frames for children with cerebral palsy: a mixed-methods feasibility study

Standing frames for children with cerebral palsy: a mixed-methods feasibility study Standing frames for children with cerebral palsy: a mixed-methods feasibility study Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from the navigation or try a website search above to find the information you need. >> >> >> >> Issue {{metadata .Issue }} Toolkit (...) 2, 7, * 1 Institute of Health & Society, Newcastle University, Newcastle upon Tyne, UK 2 Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK 3 Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK 4 Sussex Community NHS Foundation Trust, Chailey Clinical Services, Sussex, UK 5 Great North Children’s Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK 6 Robert Jones and Agnes Hunt Orthopaedic and District Hospital NHS

NIHR HTA programme2018

107. Addition of Vincristine and Irinotecan to Vincristine, Dactinomycin, and Cyclophosphamide Does Not Improve Outcome for Intermediate-Risk Rhabdomyosarcoma: A Report From the Children's Oncology Group

Addition of Vincristine and Irinotecan to Vincristine, Dactinomycin, and Cyclophosphamide Does Not Improve Outcome for Intermediate-Risk Rhabdomyosarcoma: A Report From the Children's Oncology Group 30091945 2018 09 28 1527-7755 36 27 2018 Sep 20 Journal of clinical oncology : official journal of the American Society of Clinical Oncology J. Clin. Oncol. Addition of Vincristine and Irinotecan to Vincristine, Dactinomycin, and Cyclophosphamide Does Not Improve Outcome for Intermediate-Risk (...) Rhabdomyosarcoma: A Report From the Children's Oncology Group. 2770-2777 10.1200/JCO.2018.77.9694 Purpose Intermediate-risk rhabdomyosarcoma (RMS) includes patients with either nonmetastatic, unresected embryonal RMS (ERMS) with an unfavorable primary site or nonmetastatic alveolar RMS (ARMS). The primary aim of this study was to improve the outcome of patients with intermediate-risk RMS by substituting vincristine and irinotecan (VI) for half of vincristine, dactinomycin, and cyclophosphamide (VAC) courses

EvidenceUpdates2018 Full Text: Link to full Text with Trip Pro

108. Improved Survival for Children and Young Adults With T-Lineage Acute Lymphoblastic Leukemia: Results From the Children`s Oncology Group AALL0434 Methotrexate Randomization

Improved Survival for Children and Young Adults With T-Lineage Acute Lymphoblastic Leukemia: Results From the Children`s Oncology Group AALL0434 Methotrexate Randomization 30138085 2018 10 05 1527-7755 36 29 2018 Oct 10 Journal of clinical oncology : official journal of the American Society of Clinical Oncology J. Clin. Oncol. Improved Survival for Children and Young Adults With T-Lineage Acute Lymphoblastic Leukemia: Results From the Children's Oncology Group AALL0434 Methotrexate (...) Randomization. 2926-2934 10.1200/JCO.2018.77.7250 Early intensification with methotrexate (MTX) is a key component of acute lymphoblastic leukemia (ALL) therapy. Two different approaches to MTX intensification exist but had not been compared in T-cell ALL (T-ALL): the Children's Oncology Group (COG) escalating dose intravenous MTX without leucovorin rescue plus pegaspargase escalating dose, Capizzi-style, intravenous MTX (C-MTX) regimen and the Berlin-Frankfurt-Muenster (BFM) high-dose intravenous MTX

EvidenceUpdates2018

109. Effects of backward gait training on balance, gross motor function, and gait in children with cerebral palsy: a systematic review

Effects of backward gait training on balance, gross motor function, and gait in children with cerebral palsy: a systematic review 30043634 2018 07 25 1477-0873 2018 Jul 25 Clinical rehabilitation Clin Rehabil Effects of backward gait training on balance, gross motor function, and gait in children with cerebral palsy: a systematic review. 269215518790053 10.1177/0269215518790053 To investigate the effects of backward gait training on balance, gross motor function, and gait parameters in children (...) with cerebral palsy. PubMed, Cochrane Library, Web of Science, Science Direct, Physiotherapy Evidence Database (PEDro), and Google Scholar were searched up to May 2018. Randomized controlled trials were included if they involved any form of backward gait training for children with cerebral palsy. Two authors independently screened articles, extracted data and assessed the methodological quality using PEDro scale, with any confliction resolved by the third author. Modified Sackett Scale was used to determine

EvidenceUpdates2018

110. Diagnosis and Management of Mild Traumatic Brain Injury in Children: A Systematic Review

Diagnosis and Management of Mild Traumatic Brain Injury in Children: A Systematic Review 30193325 2018 09 07 2168-6211 2018 Sep 04 JAMA pediatrics JAMA Pediatr Diagnosis and Management of Mild Traumatic Brain Injury in Children: A Systematic Review. e182847 10.1001/jamapediatrics.2018.2847 In recent years, there has been an exponential increase in the research guiding pediatric mild traumatic brain injury (mTBI) clinical management, in large part because of heightened concerns about (...) the consequences of mTBI, also known as concussion, in children. The CDC National Center for Injury Prevention and Control's (NCIPC) Board of Scientific Counselors (BSC), a federal advisory committee, established the Pediatric Mild TBI Guideline workgroup to complete this systematic review summarizing the first 25 years of literature in this field of study. To conduct a systematic review of the pediatric mTBI literature to serve as the foundation for an evidence-based guideline with clinical recommendations

EvidenceUpdates2018

111. Centers for Disease Control and Prevention Guideline on the Diagnosis and Management of Mild Traumatic Brain Injury Among Children

Centers for Disease Control and Prevention Guideline on the Diagnosis and Management of Mild Traumatic Brain Injury Among Children 30193284 2018 09 07 2168-6211 2018 Sep 04 JAMA pediatrics JAMA Pediatr Centers for Disease Control and Prevention Guideline on the Diagnosis and Management of Mild Traumatic Brain Injury Among Children. e182853 10.1001/jamapediatrics.2018.2853 Mild traumatic brain injury (mTBI), or concussion, in children is a rapidly growing public health concern because (...) epidemiologic data indicate a marked increase in the number of emergency department visits for mTBI over the past decade. However, no evidence-based clinical guidelines have been developed to date for diagnosing and managing pediatric mTBI in the United States. To provide a guideline based on a previous systematic review of the literature to obtain and assess evidence toward developing clinical recommendations for health care professionals related to the diagnosis, prognosis, and management/treatment

EvidenceUpdates2018

112. Long-Term Academic Functioning following Cogmed Working Memory Training for Children Born Extremely Preterm: A Randomized Controlled Trial

Long-Term Academic Functioning following Cogmed Working Memory Training for Children Born Extremely Preterm: A Randomized Controlled Trial 30177350 2018 09 04 1097-6833 2018 Aug 31 The Journal of pediatrics J. Pediatr. Long-Term Academic Functioning following Cogmed Working Memory Training for Children Born Extremely Preterm: A Randomized Controlled Trial. S0022-3476(18)30896-5 10.1016/j.jpeds.2018.07.003 To assess the effectiveness of Cogmed Working Memory Training compared with a placebo (...) program in improving academic functioning 24 months post-training in extremely preterm/extremely low birth weight 7-year-olds. A multicenter double-blind, placebo-controlled randomized controlled trial was conducted across all tertiary neonatal hospitals in the state of Victoria, Australia. Participants were 91 extremely preterm/extremely low birth weight 7-year-old children born in Victoria in 2005. Children were randomly assigned to either the Cogmed or placebo arm and completed the Cogmed

EvidenceUpdates2018

113. Diagnosis, Evaluation, and Management of High Blood Pressure in Children and Adolescents

Diagnosis, Evaluation, and Management of High Blood Pressure in Children and Adolescents Diagnosis, Evaluation, and Management of High Blood Pressure in Children and Adolescents | From the American Academy of Pediatrics | Pediatrics '); document.write(''); } function OAS_AD(pos) { if (OAS_version >= 11 && typeof(OAS_RICH)!='undefined') { OAS_RICH(pos); } else { OAS_NORMAL(pos); } } //--> Search for this keyword Source User menu Sections Sign up for highlighting editor-chosen studies (...) with the greatest impact on clinical care. Looking for a change of scenery? Attend the ! . We want to hear from you! Complete our and get $30 off a print & online 2019 AAP Grand Rounds subscription! Diagnosis, Evaluation, and Management of High Blood Pressure in Children and Adolescents Carissa M. Baker-Smith , Susan K. Flinn , Joseph T. Flynn , David C. Kaelber , Douglas Blowey , Aaron E. Carroll , Stephen R. Daniels , Sarah D. de Ferranti , Janis M. Dionne , Bonita Falkner , Samuel S. Gidding , Celeste

American Academy of Pediatrics2018

116. Vigabatrin (Kigabeq) - epilepsy in children between 1 month and 7 years of age

Vigabatrin (Kigabeq) - epilepsy in children between 1 month and 7 years of age Kigabeq | European Medicines Agency Search Search Menu Kigabeq vigabatrin Table of contents Authorised This medicine is authorised for use in the European Union. Overview Kigabeq is a medicine for treating epilepsy in children between 1 month and 7 years of age. It is used in the following ways: on its own to treat infantile spasms (West syndrome), a rare epilepsy disorder that starts at a very young age, usually (...) KB) (PDF/39.52 KB) (PDF/39.4 KB) (PDF/39.4 KB) (PDF/36.88 KB) (PDF/36.88 KB) (PDF/13.59 KB) (PDF/13.59 KB) (PDF/36 KB) (PDF/36 KB) (PDF/21.52 KB) (PDF/21.52 KB) (PDF/37.23 KB) (PDF/37.23 KB) (PDF/34.84 KB) (PDF/34.84 KB) (PDF/35.27 KB) (PDF/35.27 KB) (PDF/21.77 KB) (PDF/21.77 KB) (PDF/21.26 KB) (PDF/21.26 KB) Pharmacotherapeutic group ANTIEPILEPTICS Therapeutic indication Kigabeq is indicated in infants and children from 1 month to less than 7 years of age for: Treatment in monotherapy

European Medicines Agency - EPARs2018

117. Melatonin (Slenyto) - insomnia (difficulty sleeping) in children and adolescents (2 to 18 years old)

Melatonin (Slenyto) - insomnia (difficulty sleeping) in children and adolescents (2 to 18 years old) Slenyto | European Medicines Agency Search Search Menu Slenyto melatonin Table of contents Authorised This medicine is authorised for use in the European Union. Overview Slenyto is a medicine for treating insomnia (difficulty sleeping) in children and adolescents (2 to 18 years old) who have: autism spectrum disorder (ASD), a range of conditions that affects the patient’s social interactions (...) ? Slenyto has been shown to be effective at improving sleeping time in children and adolescents with neurological conditions, including autism spectrum disorder and Smith-Magenis syndrome. In a main study of 125 patients, those given Slenyto over 13 weeks slept on average for 51 extra minutes of sleep a night compared with and 19 extra minutes for those given placebo (a dummy treatment). In addition, children who took Slenyto fell asleep around 38 minutes earlier than normal while those taking placebo

European Medicines Agency - EPARs2018

119. APA Consensus Statement on updated fluid fasting guidelines for children prior to elective general anaesthesia

APA Consensus Statement on updated fluid fasting guidelines for children prior to elective general anaesthesia ‘We the undersigned representatives of our respective national societies agree that, based on the current convincing evidence base, unless there is a clear contra-indication, it is safe and recommended for all children able to take clear fluids*, to be allowed and encouraged to have them up to one hour before elective general anaesthesia’ Charles Stack, President, Association (...) of Paediatric Anaesthetists of Great Britain and Ireland Francis Veyckemans, President, European Society of Pediatric Anesthetists Anne Laffargue, Présidente, L’Association Des Anesthésistes-Réanimateurs Pédiatriques d’Expression Française

Association of Paediatric Anaesthetists of Great Britain and Ireland2018

120. Psychological therapies for the management of chronic and recurrent pain in children and adolescents.

Psychological therapies for the management of chronic and recurrent pain in children and adolescents. BACKGROUND: This is an update of the original Cochrane review first published in Issue 1, 2003, and previously updated in 2009, 2012 and 2014. Chronic pain, defined as pain that recurs or persists for more than three months, is common in childhood. Chronic pain can affect nearly every aspect of daily life and is associated with disability, anxiety, and depressive symptoms. OBJECTIVES: The aim (...) of this review was to update the published evidence on the efficacy of psychological treatments for chronic and recurrent pain in children and adolescents.The primary objective of this updated review was to determine any effect of psychological therapy on the clinical outcomes of pain intensity and disability for chronic and recurrent pain in children and adolescents compared with active treatment, waiting-list, or treatment-as-usual care.The secondary objective was to examine the impact of psychological

Cochrane2018