Latest & greatest articles for children

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Top results for children

61. Methylphenidate remains first-choice drug treatment for children and young people with ADHD

Methylphenidate remains first-choice drug treatment for children and young people with ADHD Methylphenidate remains first-choice drug treatment for children and young people with ADHD Dissemination Centre Discover Portal NIHR DC Discover Methylphenidate remains first-choice drug treatment for children and young people with ADHD Published on 6 November 2018 doi: The stimulant methylphenidate has the best balance of effectiveness against side effects in children and young people (...) with attention deficit hyperactivity disorder. Amphetamines are more effective, but also more likely to be stopped for a reason other than side effects. This large, NIHR-funded systematic review compared a range of drugs against each other through a network meta-analysis. Effectiveness and tolerability were assessed at about 12 weeks of treatment. Other second-line drug treatments were also effective and well-tolerated, including modafinil which is currently not licensed for children in the UK. There were some quality issues due to risk

2019 NIHR Dissemination Centre

62. Sodium thiosulfate reduces hearing loss in children treated with chemotherapy

Sodium thiosulfate reduces hearing loss in children treated with chemotherapy Sodium thiosulfate reduces hearing loss in children treated with chemotherapy Dissemination Centre Discover Portal NIHR DC Discover Sodium thiosulfate reduces hearing loss in children treated with chemotherapy Published on 6 November 2018 doi: Treatment with sodium thiosulfate alongside cisplatin chemotherapy can reduce hearing loss in children with a liver tumour called hepatoblastoma. The risk of hearing (...) loss was reduced by 48% in children who had the combination treatment compared with those who had cisplatin only. This phase 3 trial involved 109 children with standard-risk hepatoblastoma and tested the addition of sodium thiosulfate six hours after cisplatin treatment. The additional drug caused few major side effects, and there was no difference in event-free or overall survival between treatment groups after three years. Although small, the study adds to growing evidence that this well tolerated, cheap

2019 NIHR Dissemination Centre

63. Oral steroids do not help hearing for children with glue ear

Oral steroids do not help hearing for children with glue ear Glue ear hearing not helped by oral steroids Dissemination Centre Discover Portal NIHR DC Discover Oral steroids do not help hearing for children with glue ear Published on 13 November 2018 doi: Oral steroids do not improve hearing, symptoms, or quality of life in children with glue ear. This NIHR-funded trial compared oral steroids with placebo for 389 children with glue ear, also called otitis media with effusion, and found (...) no significant effect on those outcomes. Glue ear is when the middle ear fills with fluid, often following an ear or respiratory infection. The fluid makes hearing more difficult. It usually resolves within three months without treatment, but if it lasts longer, the hearing loss may cause delayed language development or difficulties with communicating, for instance at school. This study shows that many children will improve spontaneously, even after three months of glue ear and confirms that steroids

2019 NIHR Dissemination Centre

64. General hospital care for children with learning disabilities has scope for improvement

General hospital care for children with learning disabilities has scope for improvement General hospital care for children with learning disabilities has scope for improvement Dissemination Centre Discover Portal NIHR DC Discover General hospital care for children with learning disabilities has scope for improvement Published on 18 September 2018 doi: Less than half of NHS staff surveyed said they were routinely informed that a child has learning disabilities through a dedicated flagging system (...) on admission. Many general hospital staff lack confidence and organisational support in providing care for children and young people with learning disabilities. In an NIHR national hospital staff-awareness survey, staff were uncertain or unaware of local policy and practice. Only half of the children’s hospitals had a learning disability nurse, and where they did exist, there was disparity in the status and importance attributed to the role. This is likely to prevent the needs of these children being fully

2019 NIHR Dissemination Centre

65. Association of Matched Sibling Donor Hematopoietic Stem Cell Transplantation With Transcranial Doppler Velocities in Children With Sickle Cell Anemia. (PubMed)

Association of Matched Sibling Donor Hematopoietic Stem Cell Transplantation With Transcranial Doppler Velocities in Children With Sickle Cell Anemia. Importance: In children with sickle cell anemia (SCA), high transcranial Doppler (TCD) velocities are associated with stroke risk, which is reduced by chronic transfusion. Whether matched sibling donor hematopoietic stem cell transplantation (MSD-HSCT) can reduce velocities in patients with SCA is unknown. Objective: To determine the association (...) of MSD-HSCT with TCD velocities as a surrogate for the occurrence of ischemic stroke in children with SCA. Design, Setting, and Participants: Nonrandomized controlled intervention study conducted at 9 French centers. Patients with SCA were enrolled between December 2010 and June 2013, with 3-year follow-up ending in January 2017. Children with SCA were eligible if younger than 15 years, required chronic transfusions for persistently elevated TCD velocities, and had at least 1 sibling without SCA from

2019 JAMA

66. Postoperative epidural analgesia versus systemic analgesia for thoraco-lumbar spine surgery in children. (PubMed)

Postoperative epidural analgesia versus systemic analgesia for thoraco-lumbar spine surgery in children. BACKGROUND: Spine surgery may be associated with severe acute postoperative pain. Compared with systemic analgesia alone, epidural analgesia may offer better pain control. However, epidural analgesia has sometimes been associated with rare but serious complications. Therefore, it is critical to quantify the real benefits of epidural analgesia over other modes of pain treatment. OBJECTIVES (...) : To assess the effectiveness and safety of epidural analgesia compared with systemic analgesia for acute postoperative pain control after thoraco-lumbar spine surgery in children. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase and Cumulative Index to Nursing and Allied Health Literature on 14 November 2018, together with the references lists of related reviews and retained trials, and two trials registers. SELECTION CRITERIA: We included all

2019 Cochrane

67. Obesity in children

Obesity in children Obesity in children - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Obesity in children Last reviewed: December 2018 Last updated: January 2019 Summary Behavioural and environmental factors are primarily responsible for the dramatic increase in obesity in the past two decades, although genes play an important role in regulation of body weight. Calculating body mass index (BMI) is the most widely (...) accepted method of screening for obesity in children. Abnormal BMI cut-offs in children are determined by age- and sex-specific percentiles. The dramatic increase in childhood obesity has led to a marked increase in the diagnosis of impaired glucose tolerance and type 2 diabetes mellitus in children. Preventing excessive weight gain in children is of paramount importance in confronting the obesity epidemic, as obesity is difficult to treat at all ages, and obese children tend to become obese adults

2019 BMJ Best Practice

68. Chest physiotherapy for pneumonia in children. (PubMed)

Chest physiotherapy for pneumonia in children. BACKGROUND: Pneumonia is a lung infection that causes more deaths in children aged under five years than any other single cause. Chest physiotherapy is widely used as adjuvant treatment for pneumonia. Physiotherapy is thought to help remove inflammatory exudates, tracheobronchial secretions, and airway obstructions, and reduce airway resistance to improve breathing and enhance gas exchange. This is an update of a review published in 2013 (...) . OBJECTIVES: To assess the effectiveness of chest physiotherapy with regard to time until clinical resolution in children (from birth to 18 years) of either gender with any type of pneumonia. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL; 2018, Issue 1), which includes the Cochrane Acute Respiratory Infections Group Specialised Register, MEDLINE (22 February 2018), Embase (22 February 2018), CINAHL (22 February 2018), LILACS (22 February 2018), Web of Science (22

2019 Cochrane

69. Management Guidelines for Children With Thyroid Nodules and Differentiated Thyroid Cancer

Management Guidelines for Children With Thyroid Nodules and Differentiated Thyroid Cancer Management Guidelines for Children With Thyroid Nodules and Differentiated Thyroid Cancer | From the American Academy of Pediatrics | Pediatrics '); document.write(''); } function OAS_AD(pos) { if (OAS_version >= 11 && typeof(OAS_RICH)!='undefined') { OAS_RICH(pos); } else { OAS_NORMAL(pos); } } //--> Search for this keyword Source User menu Sections . Sign up for highlighting editor-chosen studies (...) with the greatest impact on clinical care. Watch the to learn more about Pediatrics . Management Guidelines for Children With Thyroid Nodules and Differentiated Thyroid Cancer In July 2015, the American Academy of Pediatrics endorsed the following publication: Francis GL, Waguespack SG, Bauer AJ, et al; The American Thyroid Association Guidelines Task Force on Pediatric Thyroid Cancer. Management guidelines for children with thyroid nodules and differentiated thyroid cancer. Thyroid . 2015;25(7):716–759. doi

2019 American Academy of Pediatrics

70. High Blood Pressure in Children and Adolescents

High Blood Pressure in Children and Adolescents High Blood Pressure in Children and Adolescents - Clinical Practice Guideline -- Clinical Recommendation Welcome Search Search Specify your search AAFP.org Patient Care Clinical Practice Guideline High Blood Pressure in Children and Adolescents High Blood Pressure in Children and Adolescents (Affirmation of Value, February 2018) The guideline, Screening and Management of High Blood Pressure in Children and Adolescents was developed by the American (...) Academy of Pediatrics and categorized as Affirmation of Value by the American Academy of Family Physicians. Key Recommendations: Children and adolescents three years of age or older should have their blood pressured measured annually. Blood pressure checks should be performed at every health care encounter for children and adolescents who are obese, take medications that raise blood pressure, have renal disease, diabetes or a history of aortic arch obstruction or coarctation. Hypertension should be

2019 American Academy of Family Physicians

71. Clinical Practice Guideline: Maintenance Intravenous Fluids in Children

Clinical Practice Guideline: Maintenance Intravenous Fluids in Children Clinical Practice Guideline: Maintenance Intravenous Fluids in Children | From the American Academy of Pediatrics | Pediatrics '); document.write(''); } function OAS_AD(pos) { if (OAS_version >= 11 && typeof(OAS_RICH)!='undefined') { OAS_RICH(pos); } else { OAS_NORMAL(pos); } } //--> Search for this keyword Source User menu Sections . Sign up for highlighting editor-chosen studies with the greatest impact on clinical care (...) . Watch the to learn more about Pediatrics . Clinical Practice Guideline: Maintenance Intravenous Fluids in Children Leonard G. Feld , Daniel R. Neuspiel , Byron A. Foster , Michael G. Leu , Matthew D. Garber , Kelly Austin , Rajit K. Basu , Edward E. Conway Jr , James J. Fehr , Clare Hawkins , Ron L. Kaplan , Echo V. Rowe , Muhammad Waseem , Michael L. Moritz , SUBCOMMITTEE ON FLUID AND ELECTROLYTE THERAPY Abstract Maintenance intravenous fluids (IVFs) are used to provide critical supportive care

2019 American Academy of Pediatrics

72. Approaches to detecting tuberculosis in children and youth

Approaches to detecting tuberculosis in children and youth This practice point provides a framework for initiating investigation in children suspected of having infection with  Mycobacterium tuberculosis  (Mtb). Some areas in Canada have a high burden of tubercular disease, with Indigenous populations being most at risk. Tuberculosis (TB) can present either as an acute or subacute illness and both primary or reactivation infection can cause pulmonary or multisystem disease

2019 Canadian Paediatric Society

73. Health Effects for Infants and Young Children Associated with Breastfeeding: A Rapid Review

Health Effects for Infants and Young Children Associated with Breastfeeding: A Rapid Review Health Effects for Infants and Young Children Associated with Breastfeeding A Rapid Review Elizabeth Walker, Analyst, Research and Policy Kate Kerrigan, Public Health Nurse Rita Caprara, Supervisor Judy Buchan, Manager July 30, 2018 i Table of Contents Key Messages 1 Executive Summary 2 1 Issue 5 2 Context 6 3 Conceptual Framework 7 4 Literature Review Question 7 5 Literature Search 8 6 Relevance (...) increases the protective effect. Ever having been breastfed offers a modest protective effect against becoming overweight or obese in childhood. Night-time breastfeeding beyond 12 months of age may increase the risk of dental caries. There is no evidence of an association between the amount of breastfeeding and development of food allergies. Evidence is inconclusive for an association between breastfeeding and the development of Types 1 and 2 diabetes, asthma, eczema and allergic rhinitis. 2 Executive

2019 Peel Health Library

74. Hydrocortisone muco-adhesive buccal tablets: should not be used off-label for adrenal insufficiency in children due to serious risks

Hydrocortisone muco-adhesive buccal tablets: should not be used off-label for adrenal insufficiency in children due to serious risks Hydrocortisone muco-adhesive buccal tablets: should not be used off-label for adrenal insufficiency in children due to serious risks - GOV.UK GOV.UK uses cookies to make the site simpler. Search Hydrocortisone muco-adhesive buccal tablets: should not be used off-label for adrenal insufficiency in children due to serious risks Risk of insufficient cortisol (...) in insufficient cortisol absorption and, in stress situations, life-threatening adrenal crisis prescribers and pharmacists should only consider use of licensed hydrocortisone products for adrenal replacement therapy report suspected adverse drug reactions, including medication errors resulting in harm, on a Reports of off-label use in the UK We have received Yellow Card reports of off-label use of hydrocortisone muco-adhesive buccal tablets for adrenal insufficiency in children in the UK. The reports raised

2019 MHRA Drug Safety Update

75. Regulation of advertising for unhealthy food and beverage products to children

Regulation of advertising for unhealthy food and beverage products to children Regulation of advertising for unhealthy food and beverage products to children We use cookies on this website. By using this site, you agree that we may store and access cookies on your device. Swedish Agency for Health Technology Assessment and Assessment of Social Services Regulation of advertising for unhealthy food and beverage products to children Share: Reading time approx. 1 minute Unhealthy living habits may (...) result in overweight, obesity and secondary diseases such as high blood pressure, cardiovascular disease and type 2 diabetes. Childhood overweight and obesity are prevalent. Children and young are extra susceptible to commercial messages. An important question is if today’s regulation of advertising is enough for young consumers or if there are reasons for further regulation to protect their health. Question Advertising of unhealthy food and beverage products to children – Does statutory regulation

2019 Swedish Council on Technology Assessement

76. Quick Guide, National clinical guideline for the assessment of ADHD in children and young people

Quick Guide, National clinical guideline for the assessment of ADHD in children and young people National clinical guideline for assessment and treatment of ADHD in children and young people published by the Danish Health Authority Authority, November 2018 It was not considered necessary to update the recommendation in 2018. Professional observers are independent persons who have in-depth knowledge of both children's normal behaviour and development and of ADHD, and who take a multidisciplinary (...) approach to ADHD in their daily work. The observation must be geared to the specific problem with the child in question. It was not considered necessary to update the recommendation in 2018. It is recommended that young people with ADHD follow the Danish Veterinary and Food A d m i n i s t r a t i o n ’ s dietary advice – likewise all other children and young people. The recommendation was updated without amendments in 2018. It is recommended that young people with ADHD follow the Danish Veterinary

2019 Danish National Clinical Guidelines

77. Clinical Practice Guideline: Maintenance Intravenous Fluids in Children

Clinical Practice Guideline: Maintenance Intravenous Fluids in Children 30478247 2018 12 04 1098-4275 142 6 2018 Dec Pediatrics Pediatrics Clinical Practice Guideline: Maintenance Intravenous Fluids in Children. e20183083 10.1542/peds.2018-3083 Maintenance intravenous fluids (IVFs) are used to provide critical supportive care for children who are acutely ill. IVFs are required if sufficient fluids cannot be provided by using enteral administration for reasons such as gastrointestinal illness (...) , respiratory compromise, neurologic impairment, a perioperative state, or being moribund from an acute or chronic illness. Despite the common use of maintenance IVFs, there is high variability in fluid prescribing practices and a lack of guidelines for fluid composition administration and electrolyte monitoring. The administration of hypotonic IVFs has been the standard in pediatrics. Concerns have been raised that this approach results in a high incidence of hyponatremia and that isotonic IVFs could

2019 EvidenceUpdates

78. Regional Analgesia Added to General Anesthesia Compared With General Anesthesia Plus Systemic Analgesia for Cardiac Surgery in Children: A Systematic Review and Meta-analysis of Randomized Clinical Trials

Regional Analgesia Added to General Anesthesia Compared With General Anesthesia Plus Systemic Analgesia for Cardiac Surgery in Children: A Systematic Review and Meta-analysis of Randomized Clinical Trials 30300178 2018 12 14 1526-7598 128 1 2019 Jan Anesthesia and analgesia Anesth. Analg. Regional Analgesia Added to General Anesthesia Compared With General Anesthesia Plus Systemic Analgesia for Cardiac Surgery in Children: A Systematic Review and Meta-analysis of Randomized Clinical Trials. 130 (...) -136 10.1213/ANE.0000000000003831 The aim of this systematic review was to compare the effects of regional analgesic (RA) techniques with systemic analgesia on postoperative pain, nausea and vomiting, resources utilization, reoperation, death, and complications of the analgesic techniques in children undergoing cardiac surgery. A search was done in May 2018 in PubMed, Embase, and the Cochrane Central Register of Controlled Trials for randomized controlled trials comparing RA techniques

2019 EvidenceUpdates

79. Does Home-Based Progressive Resistance or High-Intensity Circuit Training Improve Strength, Function, Activity or Participation in Children With Cerebral Palsy?

Does Home-Based Progressive Resistance or High-Intensity Circuit Training Improve Strength, Function, Activity or Participation in Children With Cerebral Palsy? 30473019 2018 11 26 1532-821X 99 12 2018 Dec Archives of physical medicine and rehabilitation Arch Phys Med Rehabil Does Home-Based Progressive Resistance or High-Intensity Circuit Training Improve Strength, Function, Activity or Participation in Children With Cerebral Palsy? 2457-2464.e4 S0003-9993(18)30436-2 10.1016/j.apmr.2018.06.010 (...) Does home-based progressive resistance or high-intensity circuit training improve strength, function, activity, or participation in children with cerebral palsy (CP)? This was the first study on high-intensity circuit training for children with CP. This study was conducted as a randomized prospective controlled pilot study. Evaluation took place at the gait laboratory of the university hospital, training sessions were performed at home. Children (N=22) with CP (average age: 12y, 10mo, 19 Gross

2019 EvidenceUpdates

80. Effects of fascia iliaca compartment block combined with general laryngeal mask airway anesthesia in children undergoing femoral fracture surgery: a randomized trial

Effects of fascia iliaca compartment block combined with general laryngeal mask airway anesthesia in children undergoing femoral fracture surgery: a randomized trial 30519084 2018 12 17 1178-7090 11 2018 Journal of pain research J Pain Res Effects of fascia iliaca compartment block combined with general laryngeal mask airway anesthesia in children undergoing femoral fracture surgery: a randomized trial. 2821-2826 10.2147/JPR.S177122 Postoperative agitation after general anesthesia is a common (...) complication in children; however, pain or uncomfortable feeling is the main reason of emergence agitation. Here, we have investigated the effects of fascia iliaca compartment block (FICB) combined with general laryngeal mask airway (LMA) anesthesia in children undergoing femoral surgery. Eighty children undergoing femoral surgery were randomly divided into two groups: FICB + LMA group and control group (n=40). The FICB + LMA group received FICB combined with general LMA anesthesia, and the control group

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2019 EvidenceUpdates