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Diagnosis and management of acute osteoarticular infections in children Acute hematogenous osteomyelitis and septic arthritis are not uncommon infections in children and should be considered as part of the differential diagnosis of limb pain and pseudoparalysis. Most bone infections in children arise secondary to hematogenous seeding of bacteria into bone. The most common pathogens are Staphylococcus aureus and Kingella kingae . Children with septic arthritis should be evaluated promptly
Best Practices on Periodicity of Examination, Preventive Dental Services, Anticipatory Guidance/Counseling, and Oral Treatment for Infants, Children, and Adolescents 194 RECOMMENDATIONS: BEST PRACTICES REFERENCE MANUAL V 40 / NO 6 18 / 19 Review Council Council on Clinical Affairs Latest Revision 2018 Periodicity of Examination, Preventive Dental Services, Anticipatory Guidance/Counseling, and Oral T reatment for Infants, Children, and Adolescents ABBREVIATIONS AAPD: American Academy Pediatric (...) Dentistry. ECC: Early child- hood caries. SHCN: Special health care needs. Purpose The American Academy of Pediatric Dentistry (AAPD) intends these recommendations to help practitioners make clinical decisions concerning preventive oral health inter- ventions, including anticipatory guidance and preventive counseling, for infants, children, and adolescents. Methods This document was developed by the Clinical Affairs Committee and adopted in 1991. This document is a revision of the previous version, last
Best Practices for Pain Management in Infants, Children, Adolescents, and Individuals with Special Health Care Needs AMERICAN ACADEMY OF PEDIATRIC DENTISTRY RECOMMENDATIONS: BEST PRACTICES 321 Purpose The American Academy of Pediatric Dentistry ( AAPD) recognizes that infants, children, adolescents, and individuals with special health care needs can and do experience pain due to dental/orofacial injury, infection, and dental procedures, and that inadequate pain management may have significant (...) physical and psychological consequences for the patient. Appreciation of pediatric pain can help practitioners develop clinical approaches to prevent or substantially relieve dental pain. When pharmacological intervention is necessary to man- age pain, the practitioner must understand the consequences, morbidities, and toxicities associated with the use of specific therapeutic agents. These recommendations are intended to provide dental professionals and other stakeholders with cur- rent best practices
Evaluation of the pulmonary embolism rule out criteria (PERC rule) in children evaluated for suspected pulmonary embolism 29864629 2018 07 31 1879-2472 168 2018 Aug Thrombosis research Thromb. Res. Evaluation of the pulmonary embolism rule out criteria (PERC rule) in children evaluated for suspected pulmonary embolism. 1-4 S0049-3848(18)30367-0 10.1016/j.thromres.2018.05.026 The pulmonary embolism rule out criteria (PERC) reliably predicts a low probability of PE in adults. We examine (...) the diagnostic accuracy of the objective components of the PERC rule in children previously tested for PE. Children aged 5-17 who had a D-dimer or pulmonary vascular imaging ordered from 2004 to 2014 in a large multicenter hospital network were identified by query of administrative databases. Using explicit, predefined methods, trained abstracters selected charts of children clearly tested for PE, collected the 8 objective variables for PERC, and determined PE criterion standard status (image or autopsy
Molecular Karyotyping in Children and Adolescents with Gender Dysphoria 30094339 2018 11 14 2380-193X 3 1 2018 Transgender health Transgend Health Molecular Karyotyping in Children and Adolescents with Gender Dysphoria. 147-153 10.1089/trgh.2017.0051 Purpose: The presence of a disorder of sexual development (DSD) acts as a diagnostic specifier for gender dysphoria (GD) under DSM-5, while the International Classification of Diseases (ICD)-10 specifically states that its equivalent diagnosis (...) , gender identity disorder (GID), must not be the result of a chromosomal abnormality. For these reasons, routine karyotyping has been previously advocated in the clinical work-up of children and adolescents with suspected GD or GID. However, the utility of such testing remains unclear. Methods: The results of routine molecular karyotyping were analyzed in 128 patients attending our Australian statewide pediatric gender service from 2013 to 2016. Karyotyping was performed using an Illumina BeadChip
Temporal and regional trends of choking injuries in children in Italy, 2001â€“2013 30066094 2018 11 14 2197-1714 5 1 2018 Aug 01 Injury epidemiology Inj Epidemiol Temporal and regional trends of choking injuries in children in Italy, 2001-2013. 30 10.1186/s40621-018-0160-0 Choking injuries in children are a significant public health problem. The present study was aimed at examining the epidemiologic patterns of choking injuries in children using Italian official data from hospital discharge (...) records. Hospital discharge records (from 2001 to 2013) reporting cases of choking injuries corresponding to the ICD-9 CM codes 933 ("Foreign body in pharynx and larynx"), 934 ("Foreign body in trachea, bronchus, and lung"), and fourth digit specifications (933.0 "pharynx", 933.1 "larynx", 934.0 "trachea", 934.1 "main bronchus", 934.8 "other specified parts", 934.9 "respiratory tree, unspecified") occurred in children aged 0-14 years were analyzed to assess the temporal and regional trends. Annual
Antibiotics for prolonged wet cough in children. BACKGROUND: Cough is a frequent symptom presenting to doctors. The most common cause of childhood chronic (greater than fours weeks' duration) wet cough is protracted bacterial bronchitis (PBB) in some settings, although other more serious causes can also present this way. Timely and effective management of chronic wet or productive cough improves quality of life and clinical outcomes. Current international guidelines suggest a course (...) of antibiotics is the first treatment of choice in the absence of signs or symptoms specific to an alternative diagnosis. This review sought to clarify the current evidence to support this recommendation. OBJECTIVES: To determine the efficacy of antibiotics in treating children with prolonged wet cough (excluding children with bronchiectasis or other known underlying respiratory illness) and to assess risk of harm due to adverse events. SEARCH METHODS: We undertook an updated search (from 2008 onwards) using
Retrospective analysis of rhabdomyosarcoma (RMS) in children in a single center 30062849 2018 11 14 1759-7714 9 9 2018 Sep Thoracic cancer Thorac Cancer Retrospective analysis of rhabdomyosarcoma (RMS) in children in a single center. 1180-1184 10.1111/1759-7714.12823 This study was conducted to explore the influence of clinical features of rhabdomyosarcoma (RMS) and a refined therapeutic protocol on the therapeutic efficacy and prognosis in children in the past five years. Forty children (...) diagnosed with RMS were retrospectively studied, using a version of the therapeutic protocol refined by Shanghai Children's Medical Center (version 2009.9.1). The patients' demographic characteristics, clinical manifestations, pathological features, therapeutic efficacy, and prognosis were analyzed. Of the 40 children, 17 abandoned treatment. Of the remaining 23 cases, two children were rated as low risk, 12 as medium risk, and nine as high risk, and all received treatment. Patients in the low
NPHS2 V260E Is a Frequent Cause of Steroid-Resistant Nephrotic Syndrome in Black South African Children 30450462 2018 12 07 2468-0249 3 6 2018 Nov Kidney international reports Kidney Int Rep NPHS2 V260E Is a Frequent Cause of Steroid-Resistant Nephrotic Syndrome in Black South African Children. 1354-1362 10.1016/j.ekir.2018.07.017 In South Africa (SA), steroid-resistant nephrotic syndrome (SRNS) is more frequent in black than in Indian children. Seeking a genetic basis for this disparity, we (...) enrolled 33 Indian and 31 black children with steroid-sensitive nephrotic syndrome (SSNS) and SRNS from KwaZulu-Natal, SA; SRNS children underwent kidney biopsy. We sequenced NPHS2 and genotyped APOL1 in 15 SSNS and 64 SRNS unrelated patients and 104 controls and replicated results in 18 black patients with steroid-resistant focal segmental glomerulosclerosis (SR-FSGS). Known FSGS genes (n = 21) were sequenced in a subset of patients. Homozygosity for NPHS2 V260E was found in 8 of 30 black children
Blowing up a balloon with the nose helps restore hearing in children with glue ear Signal - Blowing up a balloon with the nose helps restore hearing in children with glue ear Dissemination Centre Discover Portal NIHR DC Discover Blowing up a balloon with the nose helps restore hearing in children with glue ear Published on 7 September 2015 The use of a simple nasal balloon can help restore hearing in children aged 4 to 11 with glue ear. After 3 months, this non-surgical treatment restored (...) normal hearing to 49.6% of children with glue ear compared with 38.3% receiving usual care. Children inflate the balloon by blowing it up with their noses rather than their mouths. The activity which is done three times a day can be taught by nurses in a GP surgery. Few non-surgical treatments exist for children with glue ear. Some, such as antibiotics, are used despite evidence they don’t work. It is hoped using the nasal balloon may help reduce this unnecessary use of antibiotics and reduce
Parent-mediated communication interventions for improving the communication skills of preschool children with non-progressive motor disorders. BACKGROUND: Children with motor disorders can have difficulties in producing accurate and consistent movements for speech, gesture or facial expression (or a combination of these), making their communication difficult to understand. Parents may be offered training to help recognise and interpret their child's signals and to stimulate their children's (...) development of new communication skills. OBJECTIVES: To assess the effectiveness of parent-mediated communication interventions, compared to no intervention, treatment as usual or clinician-mediated interventions, for improving the communication skills of preschool children up to five years of age who have non-progressive motor disorders. SEARCH METHODS: We searched CENTRAL, MEDLINE, Embase, CINAHL, PsycINFO, 12 other databases and three trials registers in July 2017. We also searched the reference lists
Diagnostic tests for autism spectrum disorder (ASD) in preschool children. BACKGROUND: Autism spectrum disorder (ASD) is a behaviourally diagnosed condition. It is defined by impairments in social communication or the presence of restricted or repetitive behaviours, or both. Diagnosis is made according to existing classification systems. In recent years, especially following publication of the Diagnostic and Statistical Manual of Mental Disorders - Fifth Edition (DSM-5; APA 2013), children (...) are given the diagnosis of ASD, rather than subclassifications of the spectrum such as autistic disorder, Asperger syndrome, or pervasive developmental disorder - not otherwise specified. Tests to diagnose ASD have been developed using parent or carer interview, child observation, or a combination of both. OBJECTIVES: Primary objectives1. To identify which diagnostic tools, including updated versions, most accurately diagnose ASD in preschool children when compared with multi-disciplinary team clinical
Healthcare Preparation for Syrian Refugee Children in Canada Healthcare Preparation for Syrian Refugee Children in Canada - Blogbaru MENU / / / / / / / / / / / / Healthcare Preparation for Syrian Refugee Children in Canada Monday, April 11, 2016 Healthcare Preparation for Syrian Refugee Children in Canada Date - Healthcare Preparation for Syrian Refugee Children in Canada - Hi, friend , in this article entitled Healthcare Preparation for Syrian Refugee Children in Canada, we have prepared (...) at the Caring for Refugee Children Webinar from the Government of Canada Teleconferencing Service (April 4, 2016). Specifically, they talked about CKNC as an useful web resource for health practitioners and migrant workers as well as the importance of providing culturally-sensitive support. Produced by Alice Shen. To listen to the full show, please click . Thank You and Good article Healthcare Preparation for Syrian Refugee Children in Canada this time, hopefully can benefit for you all. see you in other
Causes and incidence of community-acquired serious infections among young children in south Asia (ANISA): an observational cohort study. BACKGROUND: More than 500 000 neonatal deaths per year result from possible serious bacterial infections (pSBIs), but the causes are largely unknown. We investigated the incidence of community-acquired infections caused by specific organisms among neonates in south Asia. METHODS: From 2011 to 2014, we identified babies through population-based pregnancy
Difficult airway management in children and young adults with arthrogryposis 30101221 2018 11 14 2589-1081 4 2 2018 Jun World journal of otorhinolaryngology - head and neck surgery World J Otorhinolaryngol Head Neck Surg Difficult airway management in children and young adults with arthrogryposis. 122-125 10.1016/j.wjorl.2018.04.003 To review current evidence and experience with anesthesia and airway management issues in children and young adults with arthrogryposis. Review of existing world (...) literature and description of personal experience at a center for children's orthopedic surgery and rehabilitation over 2 decades. Description of common problems and their solutions in this unusual and diverse group of patients. Arthrogryposis multiplex congenital includes more than 400 conditions that lead to congenital joint contractures affecting more than one body area. Among the many causes of arthrogryposis, 50%-65% fall into two large categories - amyoplasia and distal arthrogryposis
Meta-analysis of the diagnostic and clinical utility of genome and exome sequencing and chromosomal microarray in children with suspected genetic diseases 30002876 2018 11 14 2056-7944 3 2018 NPJ genomic medicine NPJ Genom Med Meta-analysis of the diagnostic and clinical utility of genome and exome sequencing and chromosomal microarray in children with suspected genetic diseases. 16 10.1038/s41525-018-0053-8 Genetic diseases are leading causes of childhood mortality. Whole-genome sequencing (...) (WGS) and whole-exome sequencing (WES) are relatively new methods for diagnosing genetic diseases, whereas chromosomal microarray (CMA) is well established. Here we compared the diagnostic utility (rate of causative, pathogenic, or likely pathogenic genotypes in known disease genes) and clinical utility (proportion in whom medical or surgical management was changed by diagnosis) of WGS, WES, and CMA in children with suspected genetic diseases by systematic review of the literature (January 2011
Ketorolac for postoperative pain in children. BACKGROUND: Children who undergo surgical procedures in ambulatory and inpatient settings are at risk of experiencing acute pain. Nonsteroidal anti-inflammatory drugs (NSAIDs) can reduce moderate to severe pain without many of the side effects associated with opioids. However, NSAIDs may cause bleeding, renal and gastrointestinal toxicity, and potentially delay wound and bone healing. Intravenous administration of ketorolac for postoperative pain (...) in children has not been approved in many countries, but is routinely administered in clinical practise. OBJECTIVES: To assess the efficacy and safety of ketorolac for postoperative pain in children. SEARCH METHODS: We searched the following databases, without language restrictions, to November 2017: CENTRAL (The Cochrane Library 2017, Issue 10); MEDLINE, Embase, and LILACS. We also checked clinical trials registers and reference lists of reviews, and retrieved articles for additional studies. SELECTION
Effects of total fat intake on bodyweight in children. BACKGROUND: As part of efforts to prevent childhood overweight and obesity, we need to understand the relationship between total fat intake and body fatness in generally healthy children. OBJECTIVES: To assess the effects and associations of total fat intake on measures of weight and body fatness in children and young people not aiming to lose weight. SEARCH METHODS: For this update we revised the previous search strategy and ran it over (...) all years in the Cochrane Library, MEDLINE (Ovid), MEDLINE (PubMed), and Embase (Ovid) (current to 23 May 2017). No language and publication status limits were applied. We searched the World Health Organization International Clinical Trials Registry Platform and ClinicalTrials.gov for ongoing and unpublished studies (5 June 2017). SELECTION CRITERIA: We included randomised controlled trials (RCTs) in children aged 24 months to 18 years, with or without risk factors for cardiovascular disease
Different infusion durations for preventing platinum-induced hearing loss in children with cancer. BACKGROUND: Platinum-based therapy, including cisplatin, carboplatin or oxaliplatin, or a combination of these, is used to treat a variety of paediatric malignancies. Unfortunately, one of the most important adverse effects is the occurrence of hearing loss or ototoxicity. In an effort to prevent this ototoxicity, different platinum infusion durations have been studied. This review is the second (...) update of a previously published Cochrane review. OBJECTIVES: To assess the effects of different durations of platinum infusion to prevent hearing loss or tinnitus, or both, in children with cancer. Secondary objectives were to assess possible effects of these infusion durations on: a) anti-tumour efficacy of platinum-based therapy, b) adverse effects other than hearing loss or tinnitus, and c) quality of life. SEARCH METHODS: We searched the electronic databases Cochrane Central Register
Serum IL-1 Receptor Antagonist Concentrations Associate With Unfavorable Metabolic Features in 12-Year-Old Children 30094409 2018 11 14 2472-1972 2 8 2018 Aug 01 Journal of the Endocrine Society J Endocr Soc Serum IL-1 Receptor Antagonist Concentrations Associate With Unfavorable Metabolic Features in 12-Year-Old Children. 870-881 10.1210/js.2018-00159 Elevated IL-1 receptor antagonist (IL-1Ra) concentrations are associated with obesity, insulin resistance, and cardiovascular disease (CVD) risk (...) in adults. To determine if serum IL-1Ra and high-sensitivity C-reactive protein (hs-CRP) levels are associated with markers of reduced insulin sensitivity (IS) and serum lipids in 12-year-old children. Of 191 children (n = 109 girls), 78 were categorized as having had birth weight and length appropriate for gestational age (AGA), 69 were small for gestational age, and 44 were AGA and from preeclamptic pregnancies. Serum markers of low-grade inflammation, IS, and lipids were measured. Quantitative