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The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on children or other clinical topics then use Trip today.
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failure in Japan: importance of mechanical circulatory support. Heart Vessels . 2016 ; 31 : 1162–1167 Australia (22% mortality with 7% delisted for clinical deterioration), x 4 Shi, WY, Rouse, M, Weintraub, RG et al. Predictors of outcomes in children awaiting heart transplantation: an experience from a National Paediatric Heart Transplantation Programme. Eur J Cardio Thorac Surg . 2016 ; 49 : 1711–1718 Eurotransplant (18%), x 5 Smits, JM, Thul, J, De Pauw, M et al. Pediatric heart allocation (...) Division of Pediatric Cardiology, University of Texas Southwestern Medical Center, Children's Medical Center, Dallas, Texas Correspondence Reprint requests: Richard Kirk, MD, MA, FRCP, FRCPCH, Division of Pediatric Cardiology, University of Texas Southwestern Medical Center, Children's Medical Center, 1935 Medical District Drive, B3.440, Dallas, TX 75235. Telephone: +1-469-866-6787. Fax: 214-456-6154. , MA, FRCP, FRCPCH a , , x Richard Kirk Affiliations Division of Pediatric Cardiology, University
discharge. Child outcomes Infant cognitive and motor development Authors' conclusion: “Interventions with a component that focused on the parent-infant relationship had a greater impact on cognitive outcomes at infancy and preschool age when compared with interventions that focused on infant development or parent support alone.” “The current review has demonstrated diminishing effects of early developmental interventions over time. These diminishing effects support the need for further intervention (...) risk of bias Included studies Population/Intervention Outcome O’Hara et al 2019  22 studies, 3 on preterm population Population: Children <5 years old at risk of poor outcomes. N total=1 889 parent-child dyads or family units (n=17 –237), of which n=294 parent-preterm infant dyads Intervention: Video feedback on parental interaction with child Primary Outcomes: Parental outcomes Parental sensitivity Parental reflective functioning Attachment security Parental stress Parental anxiety Secondary
, London, United Kingdom. 3 Department of Medicine, Division of Critical Care, and Department of Health Research Methods and Impact, McMaster University, Hamilton, ON, Canada. 4 Department of Pediatrics (to Dr. Agus), Department of Anesthesiology, Critical Care and Pain (to Drs. Mehta and Randolph), Boston Children’s Hospital and Harvard Medical School, Boston, MA. 5 C.S. Mott Children’s Hospital, Ann Arbor, MI. 6 St. Mary’s Hospital, London, United Kingdom. 7 Paediatric Critical Care Research Group (...) Pediatric Society, and the French Society of Intensive Care. The remaining authors have disclosed that they do not have any potential conflicts of interest. For information regarding this article, E-mail: Pediatric Critical Care Medicine: doi: 10.1097/PCC.0000000000002198 Free Metrics Abstract Objectives: To develop evidence-based recommendations for clinicians caring for children (including infants, school-aged children, and adolescents) with septic shock and other sepsis -associated organ dysfunction
exposure tasks, and reinforcement. The CBT intervention adapted for ASD was similar but also addressed social communication and self-regulation challenges with perspective-taking training and behavior-analytic techniques. Main outcomes and measures: The primary outcome measure per a priori hypotheses was the Pediatric Anxiety Rating Scale. Secondary outcomes included treatment response on the Clinical Global Impressions-Improvement scale and checklist measures. Results: Of 214 children initially (...) enrolled, 167 were randomized, 145 completed treatment, and 22 discontinued participation. Those who were not randomized failed to meet eligibility criteria (eg, confirmed ASD). There was no significant difference in discontinuation rates across conditions. Randomized children had a mean (SD) age of 9.9 (1.8) years; 34 were female (20.5%). The CBT program adapted for ASD outperformed standard-of-practice CBT (mean [SD] Pediatric Anxiety Rating Scale score, 2.13 [0.91] [95% CI, 1.91-2.36] vs 2.43 [0.70
(AFI), 3ie, MEDA, MasterCard Foundation, United Nations Capital Development Foundation‐YouthStart, World Health Organization, Microfinance Opportunities, Women's World Banking, International Labor Organization, Freedom from Hunger, Save the children—Youthsave, FHI 360, Population Council, Microsave, Child and Youth Finance International, International Gateway for Financial Education (OECD), Google Scholar, UNDP, World Bank, Sultan Qabus University of Oman, Jordanian Public University Library, King (...) evidence that savings account access and financial education complement one another. An intervention in Ghana compared financial education and savings with plural education (combined with personal awareness and child rights education) and savings (Berry et al., ). Both led to a positive effect on savings after 9 months mainly due to a change in location (from home to school) rather than an increase. Children were also more likely to work than have leisure with financial education but no negative effect
Trial , , , , Affiliations Expand Affiliations 1 Division of Children's Health Services Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis. 2 Regenstrief Institute Inc, Indianapolis, Indiana. 3 Axon Health Associates LLC, Indianapolis, Indiana. 4 Department of Biostatistics, Indiana University School of Medicine, Indianapolis. 5 Division of Pediatric and Adolescent Comparative Effectiveness Research, Department of Pediatrics, Indiana University School of Medicine (...) , Indianapolis. PMID: 31851348 PMCID: DOI: Item in Clipboard Effect of a Computer-Based Decision Support Intervention on Autism Spectrum Disorder Screening in Pediatric Primary Care Clinics: A Cluster Randomized Clinical Trial Stephen M Downs et al. JAMA Netw Open . 2019 Show details JAMA Netw Open Actions , 2 (12), e1917676 Authors , , , , Affiliations 1 Division of Children's Health Services Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis. 2 Regenstrief Institute Inc
are present (see Table 3B). • For pediatric patients meeting severe or fulminant clinical criteria (Table 3B), or having risk factors associated with severe CDI disease (Table 3B), testing should be performed as described above (Figure 2), and empiric therapy should be strongly considered while awaiting results. The majority of CDI in infants and children is of mild to moderate disease severity criteria. 21,22,63 Applying the same criteria for adult severe disease to pediatric populations tends (...) in Adults and Children 12/2019 Key Points for Patients =18 Years of Age: Diagnosis The decision to test children for CDI is complicated given a high rate of asymptomatic carriage, especially in infants 15,000 cells/mm 3 ]) ? Abdominal pain with radiographic evidence of bowel thickening ? Radiographic evidence of toxic megacolon OR 2. Colonoscopic or histopathologic evidence of pseudomembranous colitis. 6 UMHS C. difficile Infection in Adults and Children 12/2019 Table 3A. Classification and Treatment
the quality of all the studies, extracted all relevant data from them, and then combined and summarised the results. The relationship between childhood socioeconomic position and Adverse Childhood Experiences (ACEs) This research set out to better understand the relationship between the socioeconomic circumstances in which children are raised and their risk of experiencing Adverse Childhood Experiences (ACEs). The research was conducted with colleagues at NHS Health Scotland and NHS Greater Glasgow (...) was to better understand this by means of a detailed examination of the evidence. Although a vast amount of research has been published in recent years on the topic of ACEs, remarkably few of these studies have examined the relationship with childhood SEP. We found more evidence of this relationship in the (largely American) literature on the topic of ‘child maltreatment’. Although this is a more specific issue, the definition overlaps considerably with ‘standard’ definitions of ACEs used in different
Plerixafor (Mozobil) - children aged 1 year to <18 years with lymphoma or solid malignant tumours Published 10 February 2020 1 Product update SMC2249 plerixafor 20mg/mL solution for injection (Mozobil®) Sanofi Aventis 10 January 2020 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product and advises NHS Boards and Area Drug and Therapeutic Committees (ADTCs) on its use in NHSScotland. The advice is summarised as follows: ADVICE: following an abbreviated (...) submission plerixafor (Mozobil®) is accepted for use within NHSScotland. Indication under review: in combination with granulocyte-colony stimulating factor (G-CSF) to enhance mobilisation of haematopoietic stem cells to the peripheral blood for collection and subsequent autologous transplantation in children aged 1 year to <18 years with lymphoma or solid malignant tumours, either: - pre-emptively, when circulating stem cell count on the predicted day of collection after adequate mobilisation with G-CSF
Voretigene neparvovec (Luxturna) - For the treatment of adult and paediatric patients with vision loss due to inherited retinal dystrophy caused by confirmed biallelic RPE65 mutations www.scottishmedicines.org.uk Assessment explained Medicine: voretigene neparvovec (brand name: Luxturna®) for inherited retinal dystrophy due to biallelic RPE65 mutations Novartis Pharmaceuticals UK Ltd Voretigene neparvovec meets the SMC definition of an ultra-orphan medicine, which is a medicine to treat (...) an extremely rare condition. This document summarises the initial SMC assessment of voretigene neparvovec. What is voretigene neparvovec used for? Voretigene neparvovec is used to treat adults and children with loss of vision due to inherited retinal dystrophy, which is a rare genetic condition that affects the light sensing cells at the back of the eye (retina). Voretigene neparvovec is for use in patients who still have enough working cells left in the retina and when the disease is caused by mutations
Taskforce Charter: National Quality Improvement Taskforce for children and young people’s mental health inpatient services NHS England » Taskforce Charter: National Quality Improvement Taskforce for children and young people’s mental health inpatient services Search Search Menu Taskforce Charter: National Quality Improvement Taskforce for children and young people’s mental health inpatient services Document first published: 24 January 2020 Page updated: 24 January 2020 Topic: , Publication type (...) : This document provides details of our vision is for mental health, learning disability, and autism inpatient services to be delivered to the consistently high standard that children and young people deserve. Document PDF 169 KB 3 pages
Joint AAD-NPF guidelines of care for the management and treatment of psoriasis in pediatric patients Joint American Academy of Dermatology–National Psoriasis Foundation guidelines of care for the management and treatment of psoriasis in pediatric patients - Journal of the American Academy of Dermatology Email/Username: Password: Remember me Search JAAD & JAAD Case Reports Search Terms Search within Search Volume 82, Issue 1, Pages 161–201 To read this article in full, please review your options (...) for gaining access at the bottom of the page. Joint American Academy of Dermatology–National Psoriasis Foundation guidelines of care for the management and treatment of psoriasis in pediatric patients x Alan Menter Affiliations Baylor University Medical Center, Dallas, Texas , MD (Co-Chair) a , x Kelly M. Cordoro Affiliations University of California, San Francisco School of Medicine, Department of Dermatology, San Francisco, California , MD b , x Dawn M.R. Davis Affiliations Mayo Clinic, Rochester
. Division of Developmental Medicine, Boston Children’s Hospital, Boston, MA 24 2 7. Departments of Pediatrics and Psychiatry, The Ohio State University College of 1 Medicine, Columbus 2 8. Duke Center for Autism and Brain Development, Duke Institute for Brain Sciences, and 3 Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, 4 Durham, NC 5 9. Northern Michigan Neurology, Traverse City 6 10. Department of Child and Behavioral Sciences, Johns Hopkins University (...) Stephen Ashwal, MD 14 15 16 1. Pediatrics and Developmental Neuroscience Branch, National Institute of Mental Health, 17 NIH, Bethesda, MD 18 2. Department of Neurological Sciences, University of Vermont Medical Center, Burlington 19 3. Department of Pediatric Neurology, McGill University Health Centre, Montréal, Québec, 20 Canada 21 4. Department of Neurology, University of Florida College of Medicine, Gainesville 22 5. Developmental Pediatrics, Our Special KidsPediatric Care, Los Angeles, CA 23 6
Beta-lactam allergy in the paediatric population Beta-lactam allergy is commonly diagnosed in paediatric patients, but over 90% of individuals reporting this allergy are able to tolerate the medications prescribed after evaluation by an allergist. Beta-lactam allergy labels are associated with negative clinical and administrative outcomes, including use of less desirable alternative antibiotics, longer hospitalizations, increasing antibiotic-resistant infections, and greater medical costs. Also (...) , children with true IgE-mediated allergy to penicillin medications are often advised to avoid all beta-lactam antibiotics, including cephalosporins, which is likely unnecessary in greater than 97% of those reporting penicillin allergies. Most patients can be safely treated with penicillin or amoxicillin if they do not have a history compatible with IgE-mediated or systemic, delayed reactions such as Stevens-Johnson syndrome (SJS), serum sickness-like reactions, drug reaction with eosinophilia
Dietary intake of sodium by children: Why it matters Dietary sodium is required in very small amounts to support circulating blood volume and blood pressure (BP). Available nutritional surveillance data suggest that most Canadian children consume sodium in excess of their dietary requirements. Approximately 80% of the sodium Canadians consume comes from processed and packaged foods. High sodium intakes in children may be an indicator of poor diet quality. Results from systematic reviews (...) and meta-analyses have demonstrated that decreasing dietary sodium in children leads to small but clinically insignificant decreases in BP. However, population-level strategies to reduce sodium consumption, such as food product reformulation, modifying food procurement processes, and federal healthy eating policies, are important public health initiatives that can produce meaningful reductions in sodium consumption and help to prevent chronic disease in adulthood. Keywords: Blood pressure; Children
Expand Affiliations 1 Centre for International Child Health, University of Melbourne, MCRI, Royal Children's Hospital, Parkville, Australia. 2 Department of Paediatrics, University College Hospital, Ibadan, Nigeria. 3 Department of Paediatrics, University of Ibadan, Ibadan, Nigeria. 4 Nossal Institute for Global Health, University of Melbourne, Parkville, Australia. 5 Ashdown Consultants, Hartfield, England. 6 Biomedical Services, University College Hospital, Ibadan, Nigeria. 7 Asia-Pacific Health (...) , New Vaccines, MCRI, Royal Children's Hospital, Parkville, Australia. 8 Clinical Epidemiology and Biostatistics Unit, MCRI, Royal Children's Hospital, Parkville, Australia. 9 Department of Paediatrics, University of Melbourne, Royal Children's Hospital, Parkville, Australia. 10 Department of Maternal, Newborn, Child and Adolescent Health, World Health Organization, Geneva, Switzerland. 11 Bill and Melinda Gates Foundation, Seattle, Washington, United States of America. PMID: 31710601 PMCID: DOI
2019 American Heart Association Focused Update on Pediatric Advanced Life Support: An Update to the American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care This 2019 focused update to the American Heart Association pediatric advanced life support guidelines follows the 2018 and 2019 systematic reviews performed by the Pediatric Life Support Task Force of the International Liaison Committee on Resuscitation. It aligns with the continuous evidence (...) review process of the International Liaison Committee on Resuscitation, with updates published when the International Liaison Committee on Resuscitation completes a literature review based on new published evidence. This update provides the evidence review and treatment recommendations for advanced airway management in pediatric cardiac arrest, extracorporeal cardiopulmonary resuscitation in pediatric cardiac arrest, and pediatric targeted temperature management during post-cardiac arrest care