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Latest & greatest articles for cardiac arrest
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Association Between Tracheal Intubation During Pediatric In-Hospital Cardiac Arrest and Survival. Importance: Tracheal intubation is common during pediatric in-hospital cardiac arrest, although the relationship between intubation during cardiac arrest and outcomes is unknown. Objective: To determine if intubation during pediatric in-hospital cardiac arrest is associated with improved outcomes. Design, Setting, and Participants: Observational study of data from United States hospitals in the Get (...) With The Guidelines-Resuscitation registry. Pediatric patients (<18 years) with index in-hospital cardiac arrest between January 2000 and December 2014 were included. Patients who were receiving assisted ventilation, had an invasive airway in place, or both at the time chest compressions were initiated were excluded. Exposures: Tracheal intubation during cardiac arrest . Main Outcomes and Measures: The primary outcome was survival to hospital discharge. Secondary outcomes included return of spontaneous
Early Bispectral Index and Sedation Requirements During Therapeutic Hypothermia Predict Neurologic Recovery Following Cardiac Arrest PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?
Hyperoxia is associated with increased mortality in patients treated with mild therapeutic hypothermia after sudden cardiac arrest PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?
Induction of Therapeutic Hypothermia During Out-of-Hospital Cardiac Arrest Using a Rapid Infusion of Cold Saline: The RINSE Trial (Rapid Infusion of Cold Normal Saline) 27562972 2016 09 13 2016 12 13 2016 12 30 1524-4539 134 11 2016 Sep 13 Circulation Circulation Induction of Therapeutic Hypothermia During Out-of-Hospital Cardiac Arrest Using a Rapid Infusion of Cold Saline: The RINSE Trial (Rapid Infusion of Cold Normal Saline). 797-805 10.1161/CIRCULATIONAHA.116.021989 Patients successfully (...) resuscitated by paramedics from out-of-hospital cardiac arrest often have severe neurologic injury. Laboratory and observational clinical reports have suggested that induction of therapeutic hypothermia during cardiopulmonary resuscitation (CPR) may improve neurologic outcomes. One technique for induction of mild therapeutic hypothermia during CPR is a rapid infusion of large-volume cold crystalloid fluid. In this multicenter, randomized, controlled trial we assigned adults with out-of-hospital
Early Identification of Patients With Out-of-Hospital Cardiac Arrest With No Chance of Survival and Consideration for Organ Donation. Background: In patients with out-of-hospital cardiac arrest (OHCA), care requirements can conflict with the need to promptly focus efforts on organ donation in patients who are pronounced dead. Objective: To evaluate objective criteria for identifying patients with OHCA with no chance of survival during the first minutes of cardiopulmonary resuscitation to enable (...) cohorts. Measurements: Evaluation of 3 objective criteria (OHCA not witnessed by emergency medical services personnel, nonshockable initial cardiac rhythm, and no return of spontaneous circulation before receipt of a third 1-mg dose of epinephrine), survival rate at hospital discharge among patients meeting these criteria, performance of the criteria, and number of patients eligible for organ donation. Results: In the Paris SDEC 1-year cohort, the survival rate among the 772 patients with OHCA who met
Outcomes Following Single and Recurrent In-Hospital CardiacArrests in Children With Heart Disease: A Report From American Heart Association's Get With the Guidelines Registry-Resuscitation PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?
The Extent of Myocardial Injury during Prolonged Targeted Temperature Management after Out-of-Hospital Cardiac Arrest 27477668 2016 08 29 2017 05 08 2017 05 08 1555-7162 130 1 2017 Jan The American journal of medicine Am. J. Med. The Extent of Myocardial Injury During Prolonged Targeted Temperature Management After Out-of-Hospital Cardiac Arrest. 37-46 S0002-9343(16)30735-5 10.1016/j.amjmed.2016.06.047 The aim of this study is to evaluate the extent of myocardial injury by cardiac biomarkers (...) during prolonged targeted temperature management of 24 hours vs 48 hours after out-of-hospital cardiac arrest. This randomized Scandinavian multicenter study compares the extent of myocardial injury quantified by area under the curve (AUC) of cardiac biomarkers during prolonged targeted temperature management at 33°C ± 1°C of 24 hours and 48 hours, respectively. Through a period of 2.5 years, 161 comatose out-of-hospital cardiac arrest patients were randomized to targeted temperature management
Effect of Cyclosporine in Nonshockable Out-of-Hospital Cardiac Arrest: The CYRUS Randomized Clinical Trial. 27433815 2016 08 19 2017 02 03 2380-6591 1 5 2016 Aug 01 JAMA cardiology JAMA Cardiol Effect of Cyclosporine in Nonshockable Out-of-Hospital Cardiac Arrest: The CYRUS Randomized Clinical Trial. 557-65 10.1001/jamacardio.2016.1701 Experimental evidence suggests that cyclosporine prevents postcardiac arrest syndrome by attenuating the systemic ischemia reperfusion response. To determine (...) whether early administration of cyclosporine at the time of resuscitation in patients with out-of-hospital cardiac arrest (OHCA) would prevent multiple organ failure. A multicenter, single-blind, randomized clinical trial was conducted from June 22, 2010, to March 13, 2013 (Cyclosporine A in Out-of-Hospital Cardiac Arrest Resuscitation [CYRUS]). Sixteen intensive care units in 7 university-affiliated hospitals and 9 general hospitals in France participated. A total of 6758 patients who experienced
Association of Circulating MicroRNA-124-3p Levels With Outcomes After Out-of-Hospital Cardiac Arrest: A Substudy of a Randomized Clinical Trial. 27438111 2016 07 21 2017 02 03 2380-6591 1 3 2016 Jun 01 JAMA cardiology JAMA Cardiol Association of Circulating MicroRNA-124-3p Levels With Outcomes After Out-of-Hospital Cardiac Arrest: A Substudy of a Randomized Clinical Trial. 305-13 10.1001/jamacardio.2016.0480 The value of microRNAs (miRNAs) as biomarkers has been investigated in various clinical (...) contexts. Initial small-scale studies suggested that miRNAs might be useful indicators of outcome after cardiac arrest. To address the prognostic value of circulating miRNAs in a large cohort of comatose patients with out-of-hospital cardiac arrest. This substudy of the Target Temperature Management After Cardiac Arrest (TTM) trial, a multicenter randomized, parallel-group, assessor-blinded clinical trial, compared the 6-month neurologic outcomes and survival of patients with cardiac arrest after
Early High-Dose Erythropoietin Therapy After Out-of-Hospital Cardiac Arrest: A Multicenter, Randomized Controlled Trial 27364049 2016 07 01 2017 02 03 1558-3597 68 1 2016 Jul 05 Journal of the American College of Cardiology J. Am. Coll. Cardiol. Early High-Dose Erythropoietin Therapy After Out-of-Hospital Cardiac Arrest: A Multicenter, Randomized Controlled Trial. 40-9 10.1016/j.jacc.2016.04.040 S0735-1097(16)33016-9 Preliminary data suggested a clinical benefit in treating out-of-hospital (...) cardiac arrest (OHCA) patients with a high dose of erythropoietin (Epo) analogs. The authors aimed to evaluate the efficacy of epoetin alfa treatment on the outcome of OHCA patients in a phase 3 trial. The authors performed a multicenter, single-blind, randomized controlled trial. Patients still comatose after a witnessed OHCA of presumed cardiac origin were eligible. In the intervention group, patients received 5 intravenous injections spaced 12 h apart during the first 48 h (40,000 units each, resulting
Usefulness of the Myocardial Infarction and Cardiac Arrest Calculator as a Discriminator of Adverse Cardiac Events After Elective Hip and Knee Surgery 27131613 2016 05 30 2017 05 02 2017 05 02 1879-1913 117 12 2016 Jun 15 The American journal of cardiology Am. J. Cardiol. Usefulness of the Myocardial Infarction and Cardiac Arrest Calculator as a Discriminator of Adverse Cardiac Events After Elective Hip and Knee Surgery. 1992-5 10.1016/j.amjcard.2016.03.050 S0002-9149(16)30437-4 The 2014 (...) American College of Cardiology and American Heart Association guidelines on perioperative evaluation recommend differentiating patients at low risk (<1%) versus elevated risk (≥1%) for cardiac complications to guide appropriate preoperative testing. Among the tools recommended for estimating perioperative risk is the National Surgical Quality Improvement Program (NSQIP) Myocardial Infarction and Cardiac Arrest (MICA) risk calculator. We investigated whether the NSQIP MICA risk calculator would
Defibrillation time intervals and outcomes of cardiac arrest in hospital: retrospective cohort study from Get With The Guidelines-Resuscitation registry. OBJECTIVE: To describe temporal trends in the time interval between first and second attempts at defibrillation and the association between this time interval and outcomes in patients with persistent ventricular tachycardia or ventricular fibrillation (VT/VF) arrest in hospital. DESIGN: Retrospective cohort study SETTING: 172 hospitals (...) in the United States participating in the Get With The Guidelines-Resuscitation registry, 2004-12. PARTICIPANTS: Adults who received a second defibrillation attempt for persistent VT/VF arrest within three minutes of a first attempt. INTERVENTIONS: Second defibrillation attempts categorized as early (time interval of up to and including one minute between first and second defibrillation attempts) or deferred (time interval of more than one minute between first and second defibrillation attempts). MAIN
Early administration of epinephrine (adrenaline) in patients with cardiac arrest with initial shockable rhythm in hospital: propensity score matched analysis. OBJECTIVES: To evaluate whether patients who experience cardiac arrest in hospital receive epinephrine (adrenaline) within the two minutes after the first defibrillation (contrary to American Heart Association guidelines) and to evaluate the association between early administration of epinephrine and outcomes in this population. DESIGN (...) : Prospective observational cohort study. SETTING: Analysis of data from the Get With The Guidelines-Resuscitation registry, which includes data from more than 300 hospitals in the United States. PARTICIPANTS: Adults in hospital who experienced cardiac arrest with an initial shockable rhythm, including patients who had a first defibrillation within two minutes of the cardiac arrest and who remained in a shockable rhythm after defibrillation. INTERVENTION: Epinephrine given within two minutes after the first
Effect of Inhaled Xenon on Cerebral White Matter Damage in Comatose Survivors of Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial. 26978207 2016 03 16 2016 03 22 2016 10 17 1538-3598 315 11 2016 Mar 15 JAMA JAMA Effect of Inhaled Xenon on Cerebral White Matter Damage in Comatose Survivors of Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial. 1120-8 10.1001/jama.2016.1933 Evidence from preclinical models indicates that xenon gas can prevent the development of cerebral damage (...) -of-hospital cardiac arrest were randomized. Patients were randomly assigned to receive either inhaled xenon combined with hypothermia (33°C) for 24 hours (n = 55 in the xenon group) or hypothermia treatment alone (n = 55 in the control group). The primary end point was cerebral white matter damage as evaluated by fractional anisotropy from diffusion tensor MRI scheduled to be performed between 36 and 52 hours after cardiac arrest. Secondary end points included neurological outcome assessed using
Pre-hospital versus in-hospital initiation of cooling for survival and neuroprotection after out-of-hospital cardiac arrest. BACKGROUND: Targeted temperature management (also known under 'therapeutic hypothermia', 'induced hypothermia'", or 'cooling') has been shown to be beneficial for neurological outcome in patients who have had successful resuscitation from sudden cardiac arrest, but it remains unclear when this intervention should be initiated. OBJECTIVES: To assess the effects of pre (...) -hospital initiation of cooling on survival and neurological outcome in comparison to in-hospital initiation of cooling for adults with pre-hospital cardiac arrest. SEARCH METHODS: We searched CENTRAL, MEDLINE, EMBASE, CINAHL, BIOSIS, and three trials registers from inception to 5 March 2015, and carried out reference checking, citation searching, and contact with study authors to identify additional studies. SELECTION CRITERIA: We searched for randomized controlled trials (RCTs) in adults with out
Association of Left Ventricular Systolic Function and Vasopressor Support With Survival Following Pediatric Out-of-Hospital Cardiac Arrest PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?
The association between hyperoxia and patient outcomes after cardiac arrest: analysis of a high-resolution database PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?