Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4)
Latest & greatest articles for cardiac arrest
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on cardiac arrest or other clinical topics then use Trip today.
This page lists the very latest high quality evidence on cardiac arrest and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.
What is Trip?
Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.
Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.
As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.
For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via email@example.com
Induced hypothermia is associated with reduced circulating subunits of mitochondrial DNA in cardiacarrest patients. Induced hypothermia may protect from ischemia reperfusion injury. The mechanism of protection is not fully understood and may include an effect on mitochondria. Here we describe the effect of hypothermia on circulating mitochondrial (mt) DNA in a substudy of a multicenter randomized trial (the Target Temperature Management trial). Circulating levels of mtDNA were elevated (...) in patients with cardiacarrest at all-time points compared to healthy controls. After 24 h of temperature management, patients kept at 33 °C had significantly lower levels of COX3, NADH1 and NADH2 compared to baseline, in contrast to those kept at 36 °C. After regain of temperature, cytochrome - B was significantly reduced in patients kept at 33 °C with cardiacarrest. Cardiacarrest results in circulating mtDNA levels, which reduced during a temperature management protocol in patients with a target
2018 American Heart Association Focused Update on Advanced Cardiovascular Life Support Use of Antiarrhythmic Drugs During and Immediately After CardiacArrest: An Update to the American Heart Association Guidelines for Cardiopulmonary Resuscitation and Em Antiarrhythmic medications are commonly administered during and immediately after a ventricular fibrillation/pulseless ventricular tachycardia cardiacarrest. However, it is unclear whether these medications improve patient outcomes. This 2018 (...) American Heart Association focused update on advanced cardiovascular life support guidelines summarizes the most recent published evidence for and recommendations on the use of antiarrhythmic drugs during and immediately after shock-refractory ventricular fibrillation/pulseless ventricular tachycardia cardiacarrest. This article includes the revised recommendation that providers may consider either amiodarone or lidocaine to treat shock-refractory ventricular fibrillation/pulseless ventricular
Incidence, outcomes and guideline compliance of out-of-hospital maternal cardiacarrest resuscitations: A population-based cohort study Incidence and survival rates after cardiacarrest among pregnant women are reported for in-hospital cardiacarrests; the incidence and outcomes of maternal out-of-hospital cardiacarrest (OHCA) are unknown. Current cardiopulmonary resuscitation guidelines contain recommendations specific to this population; compliance with these has not been investigated.To (...) report maternal OHCA incidence, outcomes, and compliance with recommended treatment guidelines.A population-based cohort study of consecutive maternal OHCAs from 2010 to 2014. Census data of all women of childbearing age provided the comparison. Resuscitation performance was measured against the 2010 American Heart Association (AHA) Guidelines.Six maternal OHCAs were identified among 1085 OHCAs occurring in females of child bearing age (15-49) years; Incidence 1.71 per 100,000 pregnant women (95% CI
?brillation out-of- hospital cardiacarrest. Circulation. 2015;132:1030-1037. 3. Kleinman ME, Brennan EE, Goldberger ZD, et al. Part 5: adult basic life support and cardiopulmonary resuscitation quality: 2015 American Heart Association guidelines update for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation. 2015;132:S414-S435. 4. Aufderheide TP, Sigurdsson G, Pirrallo RG, et al. Hyperventilation-induced hypotension during cardiopulmonary resuscitation. Circulation. 2004;109:1960 (...) Which Compression-to-Ventilation Ratio Yields Better CardiacArrest Outcomes? (SRS therapy) TAKE-HOME MESSAGE Continuous compressions with asynchronous ventilations and a compression-to- ventilation ratio of 30:2 resulted in improved outcomes in adults in cardiopulmonary arrest, whereas either 30:2 or 15:2 improved outcomes in children. Which Compression-to-Ventilation Ratio Yields Better CardiacArrest Outcomes? EBEM Commentators Dhimitri A. Nikolla, DO Jestin N. Carlson, MD, MS Department
Does Spontaneous Cardiac Motion, Identified With Point-of-Care Echocardiography During CardiacArrest, Predict Survival? (SRS prognosis) TAKE-HOME MESSAGE Point-of-care echocardiography demonstrating no spontaneous cardiac motion is associated with lower likelihood of return of spontaneous circulation and survival to hospital admission. This may be used to assist with decisionmaking about resuscitation termination. Does Spontaneous Cardiac Motion, Identi?ed With Point-of-Care Echocardiography (...) During CardiacArrest, Predict Survival? EBEM Commentators Michael D. April, MD, DPhil Brit Long, MD Department of Emergency Medicine SAUSHEC Fort Sam Houston, TX Results Summary of meta-analysis outcomes for 1,695 patients and 15 studies. Outcome No. Studies No. Patients* Sensitivity (95% CI) Speci?city (95% CI) LRD (95% CI) LR– (95% CI) AUROC (95% CI) I 2 (95% CI) ROSC 8 543 95 (72–99) 80 (63–91) 4.8 (2.5–9.4) 0.06 (0.01–0.39) 0.93 (0.91–0.95) 98 (97–99) Survival to hospital admission 10 1,018 90
Effectiveness of antiarrhythmic drugs for shockable cardiacarrest: A systematic review The purpose of this systematic review is to provide up-to-date evidence on effectiveness of antiarrhythmic drugs for shockable cardiacarrest to help inform the 2018 International Liaison Committee on Resuscitation Consensus on Science with Treatment Recommendations.A search was conducted in electronic databases Medline, Embase, and Cochrane Library from inception to August 15, 2017.Of the 9371 citations (...) , the results showed a significant increase for lidocaine compared with placebo (RR = 1.16; 95% CI, 1.03-1.29, p = 0.01).The high level evidence supporting the use of antiarrhythmic drugs during CPR for shockable cardiacarrest is limited and showed no benefit for critical outcomes of survival at hospital discharge, survival with favorable neurological function and long-term survival. Future high quality research is needed to confirm these findings and also to evaluate the role of administering
The CPR Coach – A Paradigm Shift in Resuscitation Teams for CardiacArrest Management The CPR Coach – A Paradigm Shift in Resuscitation Teams for CardiacArrest Management - CanadiEM The CPR Coach – A Paradigm Shift in Resuscitation Teams for CardiacArrest Management In , by Adam Cheng September 10, 2018 Survival outcomes from cardiacarrest remain poor despite recent advancements in resuscitation science and education. The delivery of high quality cardiopulmonary resuscitation (CPR) during (...) cardiacarrest is a key component of clinical care. The delivery of high quality CPR is associated with improved survival outcomes. Unfortunately, many studies have demonstrated that providers consistent struggle to provide guideline compliant CPR during cardiacarrest care 1 , 2 . The formula for survival in cardiacarrest outlines three key components that contribute to survival outcomes: medical science, educational efficiency, and local implementation 3 . Various research groups have explored
Survival and Long-Term Functional Outcomes for Children With CardiacArrest Treated With Extracorporeal Cardiopulmonary Resuscitation PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?
Efficacy and Safety of Combination Therapy of Shenfu Injection and Postresuscitation Bundle in Patients With Return of Spontaneous Circulation After In-Hospital CardiacArrest PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?
Efficacy and safety of mechanical versus manual compression in cardiacarrest - A Bayesian network meta-analysis To compare relative efficacy and safety of mechanical compression devices (AutoPulse and LUCAS) with manual compression in patients with cardiacarrest undergoing cardiopulmonary resuscitation (CPR).For this Bayesian network meta-analysis, seven randomized controlled trials (RCTs) were selected using PubMed/Medline, EMBASE, and CENTRAL (Inception- 31 October 2017). For all (...) the outcomes, median estimate of odds ratio (OR) from the posterior distribution with corresponding 95% credible interval (Cr I) was calculated. Markov chain Monte Carlo (MCMC) modeling was used to estimate the relative ranking probability of each intervention based on surface under the cumulative ranking curve (SUCRA).In analysis of 12, 908 patients with cardiacarrest [AutoPulse (2, 608 patients); LUCAS (3, 308 patients) and manual compression (6, 992 patients)], manual compression improved survival
Effect of a Strategy of Initial Laryngeal Tube Insertion vs Endotracheal Intubation on 72-Hour Survival in Adults With Out-of-Hospital CardiacArrest: A Randomized Clinical Trial. Emergency medical services (EMS) commonly perform endotracheal intubation (ETI) or insertion of supraglottic airways, such as the laryngeal tube (LT), on patients with out-of-hospital cardiacarrest (OHCA). The optimal method for OHCA advanced airway management is unknown.To compare the effectiveness of a strategy
Effect of a Strategy of a Supraglottic Airway Device vs Tracheal Intubation During Out-of-Hospital CardiacArrest on Functional Outcome: The AIRWAYS-2 Randomized Clinical Trial. The optimal approach to airway management during out-of-hospital cardiacarrest is unknown.To determine whether a supraglottic airway device (SGA) is superior to tracheal intubation (TI) as the initial advanced airway management strategy in adults with nontraumatic out-of-hospital cardiac arrest.Multicenter, cluster (...) randomized clinical trial of paramedics from 4 ambulance services in England responding to emergencies for approximately 21 million people. Patients aged 18 years or older who had a nontraumatic out-of-hospital cardiacarrest and were treated by a participating paramedic were enrolled automatically under a waiver of consent between June 2015 and August 2017; follow-up ended in February 2018.Paramedics were randomized 1:1 to use TI (764 paramedics) or SGA (759 paramedics) as their initial advanced airway
Mechanical versus manual chest compressions for cardiacarrest. Mechanical chest compression devices have been proposed to improve the effectiveness of cardiopulmonary resuscitation (CPR).To assess the effectiveness of resuscitation strategies using mechanical chest compressions versus resuscitation strategies using standard manual chest compressions with respect to neurologically intact survival in patients who suffer cardiac arrest.On 19 August 2017 we searched the Cochrane Central Register (...) in this update. In total, we included 11 trials in the review, including data from 12,944 adult participants, who suffered either out-of-hospital cardiacarrest (OHCA) or in-hospital cardiacarrest (IHCA). We excluded studies explicitly including patients with cardiacarrest caused by trauma, drowning, hypothermia and toxic substances. These conditions are routinely excluded from cardiacarrest intervention studies because they have a different underlying pathophysiology, require a variety of interventions
technique for induction of mild therapeutic hypothermia during CPR is a rapid infusion of large-volume cold crystalloid fluid. In this multicenter, randomized, controlled trial we assigned adults with out-of-hospital 2016 6. American Heart Association Response to the 2015 Institute of Medicine Report on Strategies to Improve CardiacArrest Survival American Heart Association Response to the 2015 Institute of Medicine Report on Strategies to Improve CardiacArrest Survival | Circulation Search (...) for this keyword Search Search for this keyword Search Header Publisher Menu AHA Special Report American Heart Association Response to the 2015 Institute of Medicine Report on Strategies to Improve CardiacArrest Survival (...) Jump to Abstract The American Heart Association (AHA) commends the recently released Institute of Medicine (IOM) report, Strategies to Improve CardiacArrest Survival: A Time to Act (2015). The AHA recognizes the unique opportunity created by the report to meaningfully advance
Mechanisms Underlying the Actions of Antidepressant and Antipsychotic Drugs That Cause Sudden CardiacArrest A number of antipsychotic and antidepressant drugs are known to increase the risk of ventricular arrhythmias and sudden cardiac death. Based largely on a concern over the development of life-threatening arrhythmias, a number of antipsychotic drugs have been temporarily or permanently withdrawn from the market or their use restricted. While many antidepressants and antipsychotics have (...) and environmental factors that predispose to, the development of cardiac arrhythmias and sudden cardiac death among patients taking antidepressant and antipsychotic drugs that are in clinical use.
Characteristics and Prognosis of Exercise-Related Sudden CardiacArrest Introduction: The previous studies about exercise-related sudden cardiacarrest (SCA) have mainly focused on sports activity, but information related to SCA in other forms of physical exercise is lacking. Our aim was to identify characteristics and prognosis of SCA victims in the general population who suffered SCA during physical activity. Methods and results: We collected retrospectively all cases of attempted (...) resuscitation in Oulu University Hospital Area between 2007 and 2012. A total of 300 cases were of cardiac origin. We only included witnessed cases with Emergency Medical System arrival time ≤15 min. Cases of low-intensity physical activity were excluded. A total of 47 SCAs occurred during moderate-to-vigorous physical activity (exercise-group) and 43 cases took place at rest (rest-group). The subjects in exercise-group were younger compared to the rest-group (60 ± 14 years vs. 67 ± 14 years, p = 0.016
A Randomized Trial of Epinephrine in Out-of-Hospital CardiacArrest. Concern about the use of epinephrine as a treatment for out-of-hospital cardiacarrest led the International Liaison Committee on Resuscitation to call for a placebo-controlled trial to determine whether the use of epinephrine is safe and effective in such patients.In a randomized, double-blind trial involving 8014 patients with out-of-hospital cardiacarrest in the United Kingdom, paramedics at five National Health Service (...) in more of the survivors in the epinephrine group than in the placebo group (39 of 126 patients [31.0%] vs. 16 of 90 patients [17.8%]).In adults with out-of-hospital cardiacarrest, the use of epinephrine resulted in a significantly higher rate of 30-day survival than the use of placebo, but there was no significant between-group difference in the rate of a favorable neurologic outcome because more survivors had severe neurologic impairment in the epinephrine group. (Funded by the U.K. National