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Guidance for Kyphoplasty and Vertebroplasty for Cancer Patients in Ontario GUIDANCE FOR KYPHOPLASTY AND VERTEBROPLASTY FOR CANCER PATIENTS IN ONTARIO: Recommendations Report 2017 Kyphoplasty and Vertebroplasty Working Group Interventional Oncology Steering Committee Page 1 of 16 Document Date: October 5, 2018 Contents Background 2 Value for Money 2 Recommendations for Vertebral Augmentation involving Kyphoplasty or Vertebroplasty for Cancer-Related Vertebral Compression Fractures 3 Clinical (...) Criteria 3 Rationale 4 Role of Radiation Treatment 4 Absolute Contraindications 4 Service Provider Requirements 4 Multidisciplinary Care 4 Volume Recommendations 7 Training Recommendations 8 Quality Assurance 8 Conclusions 8 References 9 Appendices 10 Appendix A: Kyphoplasty and Vertebroplasty Working Group Members 10 Appendix B: Malignant Potential Diagnosis Codes 10 Appendix C: Kyphoplasty and Vertebroplasty for Cancer Patients Referral Checklist 13 Document Revision History Document Date Revision
Bevacizumab (Mvasi) - Metastatic Colorectal Cancer (mCRC) or Locally Advanced, Metastatic or Recurrent Non-small Cell Lung Cancer (NSCLC) Search Page - Drug and Health Product Register Language selection Search and menus Search Search website Search Topics menu You are here: Summary Basis of Decision - - Health Canada Summary Basis of Decision (SBD) for Contact: Summary basis of decision (SBD) documents provide information related to the original authorization of a product. The for is located
Talazoparib (Talzenna) - For the treatment of locally advanced or metastatic breast cancer patients with a germline BRCA mutation Drug Approval Package: Talzenna (talazoparib) U.S. Department of Health and Human Services Search FDA Submit search Drug Approval Package: Talzenna (talazoparib) Company: Pfizer, Inc Application Number: 211651 Approval Date: 10/16/2018 Persons with disabilities having problems accessing the PDF files below may call (301) 796-3634 for assistance. FDA Approval Letter
Diagnosis, Assessment and Management of Constipation in Advanced Cancer: ESMO Clinical Practice Guidelines CLINICAL PRACTICE GUIDELINES Diagnosis, assessment and management of constipation in advanced cancer: ESMO Clinical Practice Guidelines † P. J. Larkin 1,2 , N. I. Cherny 3 , D. La Carpia 4 , M. Guglielmo 5 , C. Ostgathe 6 , F. Scotte ´ 7 & C. I. Ripamonti 5 ,on behalf of the ESMO Guidelines Committee * 1 School of Nursing, Midwifery and Health Systems, University College Dublin, Dublin; 2 (...) Our Lady’s Hospice and Care Services, Dublin, Ireland; 3 Cancer Pain and Palliative Medicine Service, Department of Oncology, Shaare Zedek Medical Center, Jerusalem, Israel; 4 Centro Medicina Dell’Invecchiamento (Ce.M.I.), Fondazione Policlinico Agostino, Gemelli, Roma; 5 Oncology-Supportive Care Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Italy; 6 Palliative Care Department, University Hospital Erlangen, Friedrich-Alexander-Universita ¨t Erlangen-Nu ¨rnberg, Erlangen, Germany; 7
Lung Cancer Screening New 2018 ACR Appropriateness Criteria ® 1 Lung Cancer Screening American College of Radiology ACR Appropriateness Criteria ® Lung Cancer Screening Variant 1: Lung cancer screening. Patient 55 to 80 years of age and 30 or more packs per year smoking history and currently smoke or have quit within the past 15 years. Procedure Appropriateness Category Relative Radiation Level CT chest without IV contrast screening Usually Appropriate ??? CT chest with IV contrast Usually (...) Not Appropriate ??? CT chest without and with IV contrast Usually Not Appropriate ??? FDG-PET/CT skull base to mid-thigh Usually Not Appropriate ???? MRI chest without and with IV contrast Usually Not Appropriate O MRI chest without IV contrast Usually Not Appropriate O Radiography chest Usually Not Appropriate ? Variant 2: Lung cancer screening. Patient 50 years of age or older and 20 or more packs per year history of smoking and one additional risk factor (ie, radon exposure or occupational exposure
Fosaprepitant (Ivemend) - prevention of nausea and vomiting associated with highly and moderately emetogenic cancer chemotherapy Published 12 November 2018 1 www.scottishmedicines.org.uk Product update SMC2108 fosaprepitant 150mg powder for solution for infusion (Ivemend) MSD UK Ltd 05 October 2018 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product and advises NHS Boards and Area Drug and Therapeutic Committees (ADTCs) on its use in NHS Scotland (...) . The advice is summarised as follows: ADVICE: following an abbreviated submission fosaprepitant (Ivemend 150mg ® ) is accepted for use within NHSScotland. Indication under review: prevention of nausea and vomiting associated with highly and moderately emetogenic cancer chemotherapy in paediatric patients aged 6 months to 17 years. Fosaprepitant is given as part of a combination therapy. SMC has previously accepted fosaprepitant as part of combination therapy for the prevention of acute and delayed nausea
Dental radiograph as an opportunistic screening tool for a colorectal cancer syndrome (CAT#3342) UTCAT3342, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Dental radiograph as an opportunistic screening tool for a colorectal cancer syndrome Clinical Question Does dental radiograph serve as an opportunistic screening tool for early detection of extraintestinal manifestations of Familial Adenomatous Polyposis (FAP (...) ) in children and adults? Clinical Bottom Line Incidental findings on dental radiographs could serve as screening tools for systemic diseases and syndromes. The attention should be raised when gene mutation, congenitally diseases or familial colorectal cancer are reported by patients during the medical history questionnaire. For patients with risk of FAP, the Dental panoramic radiographic score (DPRS) is inexpensive, and reinforce the referral for the further clinical investigation, gene mapping
Implant Based Breast Reconstruction With Acellular Dermal Matrix: Safety Data From an Open-label, Multicenter, Randomized, Controlled Trial in the Setting of Breast Cancer Treatment 30308615 2018 10 19 1528-1140 2018 Oct 17 Annals of surgery Ann. Surg. Implant Based Breast Reconstruction With Acellular Dermal Matrix: Safety Data From an Open-label, Multicenter, Randomized, Controlled Trial in the Setting of Breast Cancer Treatment. 10.1097/SLA.0000000000003054 To evaluate clinical outcomes (...) of using acellular dermal matrix (ADM) with implant based breast reconstructions (IBBRs) in a randomized controlled trial. The use of ADMs in IBBRs is widespread, but link between ADM and complications remain a controversial topic. In view of reports concerning harm, we present 6-months safety data of ADM-assisted IBBR in the setting of breast cancer treatment. An open-label, randomized, controlled trial recruiting patients from 4 centers in Sweden and 1 in UK. Eligible were women with breast cancer
A Prospective Adaptive Utility Trial to Validate Performance of a Novel Urine Exosome Gene Expression Assay to Predict High-grade Prostate Cancer in Patients with Prostate-specific Antigen 2-10ng/ml at Initial Biopsy 30237023 2018 11 17 1873-7560 74 6 2018 Dec European urology Eur. Urol. A Prospective Adaptive Utility Trial to Validate Performance of a Novel Urine Exosome Gene Expression Assay to Predict High-grade Prostate Cancer in Patients with Prostate-specific Antigen 2-10ng/ml at Initial (...) Biopsy. 731-738 S0302-2838(18)30604-3 10.1016/j.eururo.2018.08.019 Discriminating indolent from clinically significant prostate cancer (PCa) in the initial biopsy setting remains an important issue. Prospectively evaluated diagnostic assays are necessary to ensure efficacy and clinical adoption. Performance and utility assessment of ExoDx Prostate (IntelliScore) (EPI) urine exosome gene expression assay versus standard clinical parameters for discriminating Grade Group (GG) ≥2 PCa from GG1 PCa
OLGA Gastritis Staging for the Prediction of Gastric Cancer Risk: A Long-term Follow-up Study of 7436 Patients 30333540 2018 10 18 1572-0241 2018 Oct 17 The American journal of gastroenterology Am. J. Gastroenterol. OLGA Gastritis Staging for the Prediction of Gastric Cancer Risk: A Long-term Follow-up Study of 7436 Patients. 10.1038/s41395-018-0353-8 Gastritis OLGA-staging ranks the risk for gastric cancer (GC) in progressive stages (0-IV). This long-term follow-up study quantifies the GC risk (...) associated with each OLGA stage. Consecutive patients (7436) underwent esophagogastroscopy (T-0), with mapped gastric biopsies, OLGA staging, and H. pylori status assessment. Patients with neoplastic lesion (invasive or non-invasive) at the index endoscopy (and/or within 12 months) were excluded. All patients were followed-up (T-1) by combining different sources of clinical/pathological information (Regional Registries of: (i) esophagogastroduodenoscopies; (ii) pathology reports; (iii) cancer, (iv
Systematic Review of Systemic Therapies and Therapeutic Combinations with Local Treatments for High-risk Localized Prostate Cancer 30286948 2018 10 05 1873-7560 2018 Oct 01 European urology Eur. Urol. Systematic Review of Systemic Therapies and Therapeutic Combinations with Local Treatments for High-risk Localized Prostate Cancer. S0302-2838(18)30549-9 10.1016/j.eururo.2018.07.027 Systemic therapies, combined with local treatment for high-risk prostate cancer, are recommended (...) by the international guidelines for specific subgroups of patients; however, for many of the clinical scenarios, it remains a research field. To perform a systematic review, and describe current evidence and perspectives about the multimodal treatment of high-risk prostate cancer. We performed a systematic review of PubMED, Embase, Cochrane Library, European Society of Medical Oncology/American Society of Clinical Oncology Annual proceedings, and clinicalTrial.gov between January 2010 and February 2018 following
Avelumab versus docetaxel in patients with platinum-treated advanced non-small-cell lung cancer (JAVELIN Lung 200): an open-label, randomised, phase 3 study 30262187 2018 09 28 1474-5488 2018 Sep 21 The Lancet. Oncology Lancet Oncol. Avelumab versus docetaxel in patients with platinum-treated advanced non-small-cell lung cancer (JAVELIN Lung 200): an open-label, randomised, phase 3 study. S1470-2045(18)30673-9 10.1016/S1470-2045(18)30673-9 Antibodies targeting the immune checkpoint molecules PD (...) -1 or PD-L1 have demonstrated clinical efficacy in patients with metastatic non-small-cell lung cancer (NSCLC). In this trial we investigated the efficacy and safety of avelumab, an anti-PD-L1 antibody, in patients with NSCLC who had already received platinum-based therapy. JAVELIN Lung 200 was a multicentre, open-label, randomised, phase 3 trial at 173 hospitals and cancer treatment centres in 31 countries. Eligible patients were aged 18 years or older and had stage IIIB or IV or recurrent NSCLC