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Latest & greatest articles for calcium
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Effect of Vitamin D and Calcium Supplementation on Cancer Incidence in Older Women: A Randomized Clinical Trial. Evidence suggests that low vitamin D status may increase the risk of cancer.To determine if dietary supplementation with vitamin D3 and calcium reduces the risk of cancer among older women.A 4-year, double-blind, placebo-controlled, population-based randomized clinical trial in 31 rural counties (June 24, 2009, to August 26, 2015-the final date of follow-up). A total of 2303 healthy (...) postmenopausal women 55 years or older were randomized, 1156 to the treatment group and 1147 to the placebo group. Duration of treatment was 4 years.The treatment group (vitamin D3 + calcium group) received 2000 IU/d of vitamin D3 and 1500 mg/d of calcium; the placebo group received identical placebos.The primary outcome was the incidence of all-type cancer (excluding nonmelanoma skin cancers), which was evaluated using Kaplan-Meier survival analysis and proportional hazards modeling.Among 2303 randomized
Lack of Influence of Calcium/Phosphorus Ratio on Hip and Lumbar Bone Mineral Density in Older Americans: NHANES 2005-2006 Cross-Sectional Data We sought to ascertain the effect of a low dietary calcium/phosphorus (Ca:P) ratio on the bone health of older adults in the United States. The present analysis assessed whether a high dietary consumption of P, which generally leads to a low dietary Ca:P ratio, has an unfavorable effect on the bone mineral density (BMD) of the hip and lumbar vertebrae
The influence of phosphate, calcium and magnesium on matrix Gla-protein and vascular calcification: a systematic review. Vitamin K-dependent matrix Gla protein (MGP) is a key inhibitor of vascular calcification (VC). MGP is synthesized by chondrocytes and vascular smooth muscle cells (VSMC) and the absence or inactivity of MGP results in excessive calcification of both growth plate and vasculature. Apart from its vitamin K dependency little is known about other factors that influence MGP (...) metabolism. Phosphate, calcium and magnesium are involved in bone mineralization and play an important role in VC. In this review we provide a summary of the effect of phosphate, calcium, and magnesium on MGP metabolism. Elevated phosphate and calcium levels promote VC, in part by increasing the release of matrix vesicles (MV) that under the influence of calcium and phosphate become calcification competent. Phosphate and calcium simultaneously induce an upregulation of MGP protein and gene expression
Cardiac Society of Australia and New Zealand position statement executive summary: coronary artery calcium scoring Cardiac Society of Australia and New Zealand position statement executive summary: coronary artery calcium scoring | The Medical Journal of Australia mja-search search Use the for more specific terms. Title contains Body contains Date range from Date range to Article type Author's surname Volume First page doi: 10.5694/mja__.______ Search Reset close Individual Login Purchase (...) options Connect person_outline Login keyboard_arrow_down Individual Login Purchase options menu search Advertisement close Cardiac Society of Australia and New Zealand position statement executive summary: coronary artery calcium scoring Christian R Hamilton-Craig, Clara K Chow, John F Younger, V M Jelinek, Jonathan Chan and Gary YH Liew Med J Aust 2017; 207 (8): . || doi: 10.5694/mja16.01134 Published online: 16 October 2017 Topics Summary Introduction This article summarises the Cardiac Society
Urinary Calcium Excretion and Risk ofÂ Chronic Kidney Disease in the GeneralÂ Population High urinary calcium excretion (UCaE) has been shown to lead to accelerated renal function decline in individuals with renal tubular diseases. It is not known whether this association also exists in the general population. Therefore, we investigated whether high UCaE is associated with risk of developing chronic kidney disease (CKD) in community-dwelling subjects.Urine samples of 5491 subjects who were free
Calcium dobesilate for the treatment of chronic venous insufficiency Calcium dobesilate for the treatment of chronic venous insufficiency Calcium dobesilate for the treatment of chronic venous insufficiency Brito V, Rey-Ares L, Pichon-Riviere A, Augustovski F, García Martí S, Alcaraz A, Bardach A, Ciapponi A, López A Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made (...) for the HTA database. Citation Brito V, Rey-Ares L, Pichon-Riviere A, Augustovski F, García Martí S, Alcaraz A, Bardach A, Ciapponi A, López A. Calcium dobesilate for the treatment of chronic venous insufficiency. Buenos Aires: Institute for Clinical Effectiveness and Health Policy (IECS). Informe de Respuesta Rapida No. 487. 2016 Authors' conclusions Evidence of moderate quality shows that calcium dobesilate does not have a significant clinical impact on the progress of edema and ulcer healing, when
Experts Consensus Recommendations for the Management of Calcium Channel Blocker Poisoning in Adults To provide a management approach for adults with calcium channel blocker poisoning.Following the Appraisal of Guidelines for Research & Evaluation II instrument, initial voting statements were constructed based on summaries outlining the evidence, risks, and benefits.We recommend 1) for asymptomatic patients, observation and consideration of decontamination following a potentially toxic calcium (...) channel blocker ingestion (1D); 2) as first-line therapies (prioritized based on desired effect), IV calcium (1D), high-dose insulin therapy (1D-2D), and norepinephrine and/or epinephrine (1D). We also suggest dobutamine or epinephrine in the presence of cardiogenic shock (2D) and atropine in the presence of symptomatic bradycardia or conduction disturbance (2D); 3) in patients refractory to the first-line treatments, we suggest incremental doses of high-dose insulin therapy if myocardial dysfunction
Lack of Evidence Linking Calcium With or Without Vitamin D Supplementation to Cardiovascular Disease in Generally Healthy Adults: A Clinical Guideline From the National Osteoporosis Foundation and the American Society for Preventive Cardiology. Calcium is the dominant mineral present in bone and a shortfall nutrient in the American diet. Supplements have been recommended for persons who do not consume adequate calcium from their diet as a standard strategy for the prevention of osteoporosis (...) and related fractures. Whether calcium with or without vitamin D supplementation is beneficial or detrimental to vascular health is not known.The National Osteoporosis Foundation and American Society for Preventive Cardiology convened an expert panel to evaluate the effects of dietary and supplemental calcium on cardiovascular disease based on the existing peer-reviewed scientific literature. The panel considered the findings of the accompanying updated evidence report provided by an independent evidence
Calcium Intake and Cardiovascular Disease Risk: An Updated Systematic Review and Meta-analysis. Conflicting evidence exists regarding potential cardiovascular risks associated with high levels of calcium intake.To update and reanalyze 2 systematic reviews to examine the effects of calcium intake on cardiovascular disease (CVD) among generally healthy adults.MEDLINE; Cochrane Central Register of Controlled Trials; Scopus, including EMBASE; and previous evidence reports from English-language (...) publications from 1966 to July 2016.Randomized trials and prospective cohort and nested case-control studies with data on dietary or supplemental intake of calcium, with or without vitamin D, and cardiovascular outcomes.Study characteristics and results extracted by 1 reviewer were confirmed by a second reviewer. Two raters independently assessed risk of bias.Overall risk of bias was low for the 4 randomized trials (in 10 publications) and moderate for the 27 observational studies included. The trials did
Mitochondrial ROS versus ER ROS: Which Comes First in Myocardial Calcium Dysregulation? 27777931 2018 11 13 2297-055X 3 2016 Frontiers in cardiovascular medicine Front Cardiovasc Med Mitochondrial ROS versus ER ROS: Which Comes First in Myocardial Calcium Dysregulation? 36 Chaube Ruchi R Thrombosis and Atherosclerosis Research Institute, McMaster University , Hamilton, ON , Canada. Werstuck Geoff H GH Thrombosis and Atherosclerosis Research Institute, McMaster University , Hamilton, ON , Canada (...) . eng Journal Article 2016 10 10 Switzerland Front Cardiovasc Med 101653388 2297-055X calcium dysregulation endoplasmic reticulum stress heart failure mitochondrial ROS unfolded protein response 2016 05 22 2016 09 27 2016 10 26 6 0 2016 10 26 6 1 2016 10 26 6 0 epublish 27777931 10.3389/fcvm.2016.00036 PMC5056180 Int J Inflam. 2011;2011:514623 21860805 J Mol Cell Cardiol. 2010 Jun;48(6):1105-10 19913545 J Biol Chem. 2013 Aug 9;288(32):22961-71 23798702 Circ Res. 2003 Sep 19;93(6):487-90 14500331
Calcium supplementation and risk of dementia in women with cerebrovascular disease To determine whether calcium supplementation is associated with the development of dementia in women after a 5-year follow-up.This was a longitudinal population-based study. The sample was derived from the Prospective Population Study of Women and H70 Birth Cohort Study in Gothenburg, Sweden, and included 700 dementia-free women aged 70-92 years. At baseline in 2000-2001, and at follow-up in 2005-2006, the women (...) underwent comprehensive neuropsychiatric and somatic examinations. A CT scan was performed in 447 participants at baseline. Information on the use and dosage of calcium supplements was collected. Dementia was diagnosed according to DSM-III-R criteria.Women treated with calcium supplements (n = 98) were at a higher risk of developing dementia (odds ratio [OR] 2.10, 95% confidence interval [CI] 1.01-4.37, p = 0.046) and the subtype stroke-related dementia (vascular dementia and mixed dementia) (OR 4.40
Effect of Vitamin D and calcium supplementation on ischaemic stroke outcome: a randomised controlled open-label trial Vitamin D deficiency is a common problem in stroke survivors. Observational studies have reported an association of low vitamin D levels with greater stroke severity, poststroke mortality and functional disability. Randomised clinical trials are lacking. We sought to assess the effect of calcium and vitamin D supplementation in ischaemic stroke survivors with vitamin D (...) deficiency/insufficiency on disability/mortality outcomes.In this randomised controlled open-label trial, 73 patients of acute ischaemic stroke were screened for serum 25 hydroxy Vitamin D (25(OH)D) levels. A total of 53 patients with baseline 25(OH)D <75 nmol/L were randomised into two arms. One received vitamin D and calcium supplementation along with usual care (n=25) and the other received usual care alone (n=28). Primary outcome was the proportion of patients achieving a good outcome [modified
Structural insights into mitochondrial calcium uniporter regulation by divalent cations Calcium (Ca(2+)) flux into the matrix is tightly controlled by the mitochondrial Ca(2+) uniporter (MCU) due to vital roles in cell death and bioenergetics. However, the precise atomic mechanisms of MCU regulation remain unclear. Here, we solved the crystal structure of the N-terminal matrix domain of human MCU, revealing a β-grasp-like fold with a cluster of negatively charged residues that interacts
Alanine to Serine Variant at Position 986 of Calcium Sensing Receptor and Colorectal Cancer Risk With regard to the effect of calcium against colorectal cancer (CRC) and considering the key role of calcium sensing receptor (CaSR) in calcium homeostasis, this study investigated whether CaSR gene rs1801725 or A986S variant was associated with susceptibility to CRC risk.This study was conducted as a case-control study and 303 cases with CRC and 354 controls were enrolled. All 657 subjects were
Calcium Pyrophosphate Deposition Disease. 27355536 2016 07 07 2018 12 07 1533-4406 374 26 2016 Jun 30 The New England journal of medicine N. Engl. J. Med. Calcium Pyrophosphate Deposition Disease. 2575-84 10.1056/NEJMra1511117 Rosenthal Ann K AK From the Division of Rheumatology, Department of Medicine, Medical College of Wisconsin (A.K.R., L.M.R.), and the Department of Medicine, Zablocki Veterans Affairs Medical Center (A.K.R.) - both in Milwaukee. Ryan Lawrence M LM From the Division (...) of Rheumatology, Department of Medicine, Medical College of Wisconsin (A.K.R., L.M.R.), and the Department of Medicine, Zablocki Veterans Affairs Medical Center (A.K.R.) - both in Milwaukee. eng I01 CX001143 CX CSRD VA United States Journal Article Review United States N Engl J Med 0255562 0028-4793 0 Anti-Inflammatory Agents 0 Anti-Inflammatory Agents, Non-Steroidal 0 Glucocorticoids X69NU20D19 Calcium Pyrophosphate YL5FZ2Y5U1 Methotrexate AIM IM Anti-Inflammatory Agents therapeutic use Anti-Inflammatory