Latest & greatest articles for calcium

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Top results for calcium

281. Cost-effectiveness of sevelamer versus calcium carbonate plus atorvastatin to reduce LDL in patients with chronic renal insufficiency with dyslipidemia and hyperphosphatemia

Cost-effectiveness of sevelamer versus calcium carbonate plus atorvastatin to reduce LDL in patients with chronic renal insufficiency with dyslipidemia and hyperphosphatemia Cost-effectiveness of sevelamer versus calcium carbonate plus atorvastatin to reduce LDL in patients with chronic renal insufficiency with dyslipidemia and hyperphosphatemia Cost-effectiveness of sevelamer versus calcium carbonate plus atorvastatin to reduce LDL in patients with chronic renal insufficiency with dyslipidemia (...) and hyperphosphatemia Brophy D F, Wallace J F, Kennedy D T, Gehr T W, Holdford D A Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Sevelamer (403mg, two capsules three times per day with meals) was compared with calcium carbonate (1g (400mg

NHS Economic Evaluation Database.2000

282. Retrospective evaluation of the conversion of amlodipine to alternative calcium channel blockers

Retrospective evaluation of the conversion of amlodipine to alternative calcium channel blockers Retrospective evaluation of the conversion of amlodipine to alternative calcium channel blockers Retrospective evaluation of the conversion of amlodipine to alternative calcium channel blockers Parra D, Beckey N P, Korman L Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods (...) , the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The use of a variety of calcium channel blockers in the treatment of patients with hypertension. Type of intervention Treatment; Secondary prevention. Economic study type Cost-effectiveness analysis. Study population Individuals with a diagnosis of hypertension, for whom two blood pressure measurements prior to and post formulary conversion were available

NHS Economic Evaluation Database.2000

283. Randomised trial of effects of calcium antagonists compared with diuretics and beta-blockers on cardiovascular morbidity and mortality in hypertension: the Nordic Diltiazem (NORDIL) study.

Randomised trial of effects of calcium antagonists compared with diuretics and beta-blockers on cardiovascular morbidity and mortality in hypertension: the Nordic Diltiazem (NORDIL) study. 10972367 2000 09 14 2000 09 14 2015 06 16 0140-6736 356 9227 2000 Jul 29 Lancet (London, England) Lancet Randomised trial of effects of calcium antagonists compared with diuretics and beta-blockers on cardiovascular morbidity and mortality in hypertension: the Nordic Diltiazem (NORDIL) study. 359-65 (...) Calcium antagonists are a first-line treatment for hypertension. The effectiveness of diltiazem, a non-dihydropyridine calcium antagonist, in reducing cardiovascular morbidity or mortality is unclear. We compared the effects of diltiazem with that of diuretics, beta-blockers, or both on cardiovascular morbidity and mortality in hypertensive patients. In a prospective, randomised, open, blinded endpoint study, we enrolled 10,881 patients, aged 50-74 years, at health centres in Norway and Sweden, who had diastolic

Lancet2000

284. Morbidity and mortality in patients randomised to double-blind treatment with a long-acting calcium-channel blocker or diuretic in the International Nifedipine GITS study: Intervention as a Goal in Hypertension Treatment (INSIGHT).

Morbidity and mortality in patients randomised to double-blind treatment with a long-acting calcium-channel blocker or diuretic in the International Nifedipine GITS study: Intervention as a Goal in Hypertension Treatment (INSIGHT). 10972368 2000 09 14 2000 09 14 2015 06 16 0140-6736 356 9227 2000 Jul 29 Lancet (London, England) Lancet Morbidity and mortality in patients randomised to double-blind treatment with a long-acting calcium-channel blocker or diuretic in the International Nifedipine (...) GITS study: Intervention as a Goal in Hypertension Treatment (INSIGHT). 366-72 The efficacy of antihypertensive drugs newer than diuretics and beta-blockers has not been established. We compared the effects of the calcium-channel blocker nifedipine once daily with the diuretic combination co-amilozide on cardiovascular mortality and morbidity in high-risk patients with hypertension. We did a prospective, randomised, double-blind trial in Europe and Israel in 6321 patients aged 55-80 years

Lancet2000

285. Calcium and fibre supplementation in prevention of colorectal adenoma recurrence: a randomised intervention trial. European Cancer Prevention Organisation Study Group.

Calcium and fibre supplementation in prevention of colorectal adenoma recurrence: a randomised intervention trial. European Cancer Prevention Organisation Study Group. 11073017 2000 11 29 2000 11 29 2015 06 16 0140-6736 356 9238 2000 Oct 14 Lancet (London, England) Lancet Calcium and fibre supplementation in prevention of colorectal adenoma recurrence: a randomised intervention trial. European Cancer Prevention Organisation Study Group. 1300-6 Some epidemiological studies have suggested (...) that high dietary intake of calcium and fibre reduces colorectal carcinogenesis. Available data are not sufficient to serve as a basis for firm dietary advice. We undertook a multicentre randomised trial to test the effect of diet supplementation with calcium and fibre on adenoma recurrence. We randomly assigned 665 patients with a history of colorectal adenomas to three treatment groups, in a parallel design: calcium gluconolactate and carbonate (2 g elemental calcium daily), fibre (3.5 g ispaghula

Lancet2000

286. Calcium channel blockers for potential impaired fetal growth.

Calcium channel blockers for potential impaired fetal growth. BACKGROUND: Calcium channel blockers may increase the blood flow to the fetus or may improve fetal-placental cellular energy generation. This could enhance fetal growth. OBJECTIVES: The objectives of this review were to assess the effects of calcium channel blockers on fetal growth and neonatal morbidity and mortality in pregnancies where impaired fetal growth is suspected. SEARCH STRATEGY: We searched the Cochrane Pregnancy (...) and Childbirth Group trials register and the Cochrane Controlled Trials Register. Date of the last search: December 1999. SELECTION CRITERIA: Acceptably controlled trials of calcium channel blockers in women with potential impaired fetal growth. DATA COLLECTION AND ANALYSIS: Eligibility and trial quality were assessed. MAIN RESULTS: One study of 100 women (all smokers) was included. Mean birth weight was significantly higher in women receiving flunarizine compared to the control group. No other significant

Cochrane2000

287. Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems.

Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. BACKGROUND: Calcium supplementation may prevent high blood pressure through a number of mechanisms and may help to prevent preterm labour. OBJECTIVES: The objective of this review was to assess the effects of calcium supplementation during pregnancy on hypertensive disorders of pregnancy and related maternal and child adverse outcomes. SEARCH STRATEGY: We searched the Cochrane Pregnancy (...) and Childbirth Group trials register and the Cochrane Controlled Trials Register and we contacted study authors. SELECTION CRITERIA: Randomised trials comparing at least one gram daily of calcium during pregnancy compared to placebo. DATA COLLECTION AND ANALYSIS: Eligibility and trial quality were assessed. Data extraction was carried out independently by two reviewers. MAIN RESULTS: Nine studies were included, all of good quality. There was a modest reduction in high blood pressure with calcium

Cochrane2000

288. Calcium antagonists for aneurysmal subarachnoid haemorrhage.

Calcium antagonists for aneurysmal subarachnoid haemorrhage. BACKGROUND: Rupture of an intracranial aneurysm causes bleeding into the subarachnoid space, which may lead to spasm of the cerebral arteries and ischaemic damage to the brain. Prophylactic use of calcium antagonists in patients with ruptured intracranial aneurysms might reduce the risk of ischaemic damage. OBJECTIVES: This review aimed to determine whether calcium antagonists improve outcome in patients with aneurysmal (...) subarachnoid haemorrhage (SAH). SEARCH STRATEGY: The Cochrane Stroke Group trials register (last searched: March 1999) plus hand searching and personal contacts with trialists and pharmaceutical companies marketing calcium antagonists. SELECTION CRITERIA: All completed, unconfounded, truly randomised controlled trials comparing any calcium antagonist with control, within ten days of SAH onset. Eleven trials that met the inclusion criteria were included in the overview. DATA COLLECTION AND ANALYSIS: Two reviewers

Cochrane2000

289. Calcium and vitamin D for corticosteroid-induced osteoporosis.

Calcium and vitamin D for corticosteroid-induced osteoporosis. OBJECTIVES: To assess the effects of calcium and vitamin D compared to calcium alone or placebo in the prevention of bone loss in patients taking systemic corticosteroids. SEARCH STRATEGY: We searched the Cochrane Musculoskeletal trials register, Cochrane Controlled Trials Register, EMBASE and Medline up to 1996. We also conducted a hand search of abstracts from various scientific meetings and reference lists of selected trials (...) . SELECTION CRITERIA: All randomized trials comparing calcium and vitamin D to calcium alone or placebo in patients taking systemic corticosteroids. DATA COLLECTION AND ANALYSIS: Data was abstracted from trials by two investigators. Methodological quality was assessed in a similar manner. Analysis was performed using fixed effects models. MAIN RESULTS: Five trials were included, with 274 patients. The analysis was performed at two years after starting calcium and vitamin D. There was a significant

Cochrane2000

290. Calcium antagonists for acute ischemic stroke.

Calcium antagonists for acute ischemic stroke. BACKGROUND: The sudden loss of blood supply in ischemic stroke is associated with increased levels of calcium ions within neurones. Inhibiting this increase could protect neurones and is thought to reduce neurological impairment, disability and handicap after stroke. OBJECTIVES: The aim of this review is to determine whether calcium antagonists reduce the risk of death or dependency after acute ischemic stroke. The influence of different drugs (...) , dosages, routes of administration, time intervals after stroke and trial design on the risk of poor outcome was investigated. SEARCH STRATEGY: Relevant trials were identified in the Specialised Register of Controlled Trials (last searched: March 1999). SELECTION CRITERIA: All truly randomised trials comparing a calcium antagonist with control in patients with acute ischaemic stroke were included. DATA COLLECTION AND ANALYSIS: Two authors assessed all trials and extracted the data. Poor outcome

Cochrane2000

291. Calcium channel blockers for acute traumatic brain injury.

Calcium channel blockers for acute traumatic brain injury. BACKGROUND: Acute traumatic brain injury is a major cause of death and disability. Calcium channel blockers have been used in an attempt to prevent cerebral vasospasm after injury, maintain blood flow to the brain and so prevent further damage. OBJECTIVES: To estimate the effects of calcium channel blockers in patients with acute traumatic brain injury and in a subgroup of brain injury patients with traumatic subarachnoid haemorrhage (...) RCTs were identified as eligible for inclusion in the systematic review. The effect of calcium channel blockers on the risk of death was reported in all RCTs. The pooled odds ratio for the four studies was 0.91 (95% confidence interval 0. 70 to 1.17). For the three RCTs that reported death and severe disability the pooled odds ratio was 0.85 (95% CI 0.68 to 1.07). In the two RCTs which reported the risk of death in a sub group of traumatic subarachnoid haemorrhage patients, the pooled odds ratio

Cochrane2000

292. Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems.

Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. BACKGROUND: Calcium supplementation may prevent high blood pressure through a number of mechanisms and may help to prevent preterm labour. OBJECTIVES: The objective of this review was to assess the effects of calcium supplementation during pregnancy on hypertensive disorders of pregnancy and related maternal and child adverse outcomes. SEARCH STRATEGY: We searched the Cochrane Pregnancy (...) and Childbirth Group trials register and the Cochrane Controlled Trials Register and we contacted study authors. Date of last search: February 2000. SELECTION CRITERIA: Randomised trials comparing at least one gram daily of calcium during pregnancy with placebo. DATA COLLECTION AND ANALYSIS: Eligibility and trial quality were assessed. Data extraction was carried out and double entered. MAIN RESULTS: Ten studies were included, all of good quality. There was a modest reduction in high blood pressure

Cochrane2000

293. Meta-analysis of randomized trials for medical prevention of calcium oxalate nephrolithiasis

Meta-analysis of randomized trials for medical prevention of calcium oxalate nephrolithiasis Meta-analysis of randomized trials for medical prevention of calcium oxalate nephrolithiasis Meta-analysis of randomized trials for medical prevention of calcium oxalate nephrolithiasis Pearle M S, Roehrborn C G, Pak C Y Authors' objectives The authors aimed to compare the rates of recurrent calcium renal stone formation for medical treatment versus placebo or no treatment. Searching MEDLINE (...) assessed in the review Studies that assessed calcium renal stone formation were eligible for inclusion. The included studies measured stone formation as stones/patient per year or as remission rates. How were decisions on the relevance of primary studies made? The authors did not state how the papers were selected for the review, or how many reviewers performed the selection. Assessment of study quality The authors did not state that they assessed validity. Data extraction The authors did not state how

DARE.1999

294. Meta-analysis of trials comparing beta-blockers, calcium antagonists, and nitrates for stable angina

Meta-analysis of trials comparing beta-blockers, calcium antagonists, and nitrates for stable angina Meta-analysis of trials comparing beta-blockers, calcium antagonists, and nitrates for stable angina Meta-analysis of trials comparing beta-blockers, calcium antagonists, and nitrates for stable angina Heidenreich P A, McDonald K M, Hastie T, Fadel B, Hagan V, Lee B K, Hlatky M A Authors' objectives To compare the relative efficacy and tolerability of treatment with beta (...) -blockers, calcium antagonists, and long-acting nitrates for patients who have stable angina. Searching The authors searched for English language publications using the MEDLINE (1966-1997) and EMBASE (1974 to 1997) electronic databases using the search criteria of 'angina pectoris' or the textword 'angina' and the publication type 'randomized controlled trial' or text word containing a form of the word 'random'. The authors also performed searches using the criterion of 'controlled clinical trial' or text word 'double-blind

DARE.1999

295. The influence of dietary and nondietary calcium supplementation on blood pressure: an updated metaanalysis of randomized controlled trials

The influence of dietary and nondietary calcium supplementation on blood pressure: an updated metaanalysis of randomized controlled trials The influence of dietary and nondietary calcium supplementation on blood pressure: an updated metaanalysis of randomized controlled trials The influence of dietary and nondietary calcium supplementation on blood pressure: an updated metaanalysis of randomized controlled trials Griffith L E, Guyatt G H, Cook R J, Bucher H C, Cook D J Authors' objectives (...) To update the authors' previous systematic review investigating the effect of calcium supplementation on blood pressure. Searching The Cochrane Collaboration strategy (Dickersin 1994, see Other Publications of Related Interest) was used to search for relevant articles. MEDLINE was searched from January 1993 to May 1997. MESH search terms were 'calcium', 'calcium compounds' and 'blood pressure' or 'hypertension', combined with keyword searches of 'randomised controlled trials' and 'meta-analysis

DARE.1999

296. An evaluation of beta-blockers, calcium antagonists, nitrates, and alternative therapies for stable angina

An evaluation of beta-blockers, calcium antagonists, nitrates, and alternative therapies for stable angina An evaluation of beta-blockers, calcium antagonists, nitrates, and alternative therapies for stable angina An evaluation of beta-blockers, calcium antagonists, nitrates, and alternative therapies for stable angina Heidenreich P A, McDonald K M, Hastie T, Fadel B, Hagan V, Lee B K , Hlatky M A Authors' objectives To compare: (1) the relative efficacy and tolerability of treatment with beta (...) -blockers, calcium antagonists, and long-acting nitrates for patients who have stable angina; and (2) the efficacy of alternative therapies in patients who have stable angina. Searching MEDLINE (from 1966 to 1997) and EMBASE (from 1974 to 1997) were searched for publications in the English language using the following search criteria: MeSH term 'angina pectoris' or the textword 'angina', and publication type 'randomized controlled trial' or textword containing a form of the word 'random'. The authors also performed searches

DARE.1999

297. Supplemental calcium for the prevention of hip fracture: potential health-economic benefits

Supplemental calcium for the prevention of hip fracture: potential health-economic benefits Supplemental calcium for the prevention of hip fracture: potential health-economic benefits Supplemental calcium for the prevention of hip fracture: potential health-economic benefits Bendich A, Leader S, Muhuri P Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results (...) and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Supplemental calcium for the prevention of hip fracture. Type of intervention Primary prevention. Economic study type Cost-effectiveness analysis. Study population Male and female American adults of differing ages and ethnic backgrounds. Setting Community. The study was carried out in New Jersey, USA. Dates to which data relate Effectiveness and resource use data were

NHS Economic Evaluation Database.1999

298. An evaluation of beta-blockers, calcium antagonists, nitrates, and alternative therapies for stable angina

An evaluation of beta-blockers, calcium antagonists, nitrates, and alternative therapies for stable angina An evaluation of beta-blockers, calcium antagonists, nitrates, and alternative therapies for stable angina An evaluation of beta-blockers, calcium antagonists, nitrates, and alternative therapies for stable angina Agency for Healthcare Research and Quality Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation (...) of the quality of this assessment has been made for the HTA database. Citation Agency for Healthcare Research and Quality. An evaluation of beta-blockers, calcium antagonists, nitrates, and alternative therapies for stable angina. Rockville: Agency for Healthcare Research and Quality (AHRQ). Evidence Report/Technology Assessment No. 10. 1999 Authors' objectives The aim of this report is to assess the use of beta-blockers, calcium antagonists, nitrates, and alternative therapies for stable angina. Authors

Health Technology Assessment (HTA) Database.1999

299. Calcium supplements for the prevention of colorectal adenomas. Calcium Polyp Prevention Study Group.

Calcium supplements for the prevention of colorectal adenomas. Calcium Polyp Prevention Study Group. 9887161 1999 01 19 1999 01 19 2013 11 21 0028-4793 340 2 1999 Jan 14 The New England journal of medicine N. Engl. J. Med. Calcium supplements for the prevention of colorectal adenomas. Calcium Polyp Prevention Study Group. 101-7 Laboratory, clinical, and epidemiologic evidence suggests that calcium may help prevent colorectal adenomas. We conducted a randomized, double-blind trial of the effect (...) of supplementation with calcium carbonate on the recurrence of colorectal adenomas. We randomly assigned 930 subjects (mean age, 61 years; 72 percent men) with a recent history of colorectal adenomas to receive either calcium carbonate (3 g [1200 mg of elemental calcium] daily) or placebo, with follow-up colonoscopies one and four years after the qualifying examination. The primary end point was the proportion of subjects in whom at least one adenoma was detected after the first follow-up endoscopy but up

NEJM1999

300. Effects of calcium-channel blockade in older patients with diabetes and systolic hypertension. Systolic Hypertension in Europe Trial Investigators.

Effects of calcium-channel blockade in older patients with diabetes and systolic hypertension. Systolic Hypertension in Europe Trial Investigators. 10053176 1999 03 04 1999 03 04 2013 11 21 0028-4793 340 9 1999 Mar 04 The New England journal of medicine N. Engl. J. Med. Effects of calcium-channel blockade in older patients with diabetes and systolic hypertension. Systolic Hypertension in Europe Trial Investigators. 677-84 Recent reports suggest that calcium-channel blockers may be harmful (...) in patients with diabetes and hypertension. We previously reported that antihypertensive treatment with the calcium-channel blocker nitrendipine reduced the risk of cardiovascular events. In this post hoc analysis, we compared the outcome of treatment with nitrendipine in diabetic and nondiabetic patients. After stratification according to center, sex, and presence or absence of previous cardiovascular complications, 4695 patients (age, > or =60 years) with systolic blood pressure of 160 to 219 mm Hg

NEJM1999