Latest & greatest articles for bronchiolitis

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Bronchiolitis

Bronchiolitis is mainly caused by the respiratory syncytial virus (RSV). The virus travels down to the bronchioles in the lungs causing them to become inflamed making it difficult to breath.

Almost every child will be infected with RSV by the time they reach two years. Adults can also contract the virus, typically during winter months.

In mild cases bronchiolitis will clear up without treatment. The virus that causes bronchiolitis travels through tiny droplets of liquid and can be passed through the air or contracted by touching infected surfaces.

Symptoms include: Sore throat, dry cough, blocked nose and aches and pains throughout the body.

Although there is no cure for chronic bronchiolitis research and clinical studies on bronchiolitis suggest that some lifestyle changes can ease symptoms: avoid smoking, eat a healthy diet and maintain regular exercise. In extreme cases steroids can be prescribed to help minimise inflammation.

Read more on medications used to treat bronchiolitis and the causes of the virus.

Top results for bronchiolitis

101. Non-invasive ventilation as primary ventilatory support for infants with severe bronchiolitis

Non-invasive ventilation as primary ventilatory support for infants with severe bronchiolitis PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2011 PedsCCM Evidence-Based Journal Club

102. Constrictive bronchiolitis in soldiers returning from Iraq and Afghanistan. Full Text available with Trip Pro

Constrictive bronchiolitis in soldiers returning from Iraq and Afghanistan. In this descriptive case series, 80 soldiers from Fort Campbell, Kentucky, with inhalational exposures during service in Iraq and Afghanistan were evaluated for dyspnea on exertion that prevented them from meeting the U.S. Army's standards for physical fitness.The soldiers underwent extensive evaluation of their medical and exposure history, physical examination, pulmonary-function testing, and high-resolution computed (...) samples were abnormal, with 38 soldiers having changes that were diagnostic of constrictive bronchiolitis. In the remaining 11 soldiers, diagnoses other than constrictive bronchiolitis that could explain the presenting dyspnea were established. All soldiers with constrictive bronchiolitis had normal results on chest radiography, but about one quarter were found to have mosaic air trapping or centrilobular nodules on chest CT. The results of pulmonary-function and cardiopulmonary-exercise testing were

2011 NEJM

103. Inhaled Epinephrine, Steroids for Bronchiolitis

Inhaled Epinephrine, Steroids for Bronchiolitis Inhaled Epinephrine, Steroids for Bronchiolitis – TheNNTTheNNT Inhaled Epinephrine with or without Steroids for Bronchiolitis 15 for admission In Summary, for those who received the epinephrine with/without the steroids: Benefits in NNT 94.1% saw no benefit 5.9% were helped (epinephrine alone) by preventing hospital admission (day 1) 1 in 17 were helped (epinephrine alone) (hospitalization prevented, day 1) Harms in NNT None were harmed (...) by medication side effects None were harmed (medication side effects) View As: NNT % Source: Efficacy Endpoints: Admission Rate (Day 1) Harm Endpoints: None Narrative: Bronchiolitis, a viral respiratory infection in the first 2 years of life (most commonly caused by respiratory syncytial virus) often leads to significant use of healthcare resources. Optimal management strategies remain unclear, including pharmacotherapy for wheezing and shortness of breath. This Cochrane review identified and assessed six

2011 theNNT

104. Steroids and bronchodilators for acute bronchiolitis in the first two years of life: systematic review and meta-analysis

Steroids and bronchodilators for acute bronchiolitis in the first two years of life: systematic review and meta-analysis Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2011 DARE.

105. Nebulized Hypertonic Saline for Bronchiolitis

Nebulized Hypertonic Saline for Bronchiolitis Nebulized Hypertonic Saline for Bronchiolitis – TheNNTTheNNT Nebulized Hypertonic Saline for Bronchiolitis in Infants 1 less hospital day IMPORTANT! In Summary, for those who received the nebulized hypertonic saline: Benefits in NNT Hospitalized infants were helped by a 1-day decrease in their hospital stay Harms in NNT None were harmed View As: NNT % Source: Efficacy Endpoints: Duration of Hospital Stay, Decrease in Clinical Severity Scores (...) , Decrease in Admission Rates Harm Endpoints: Tachycardia, Hypertension, Pallor, Tremor, Nausea, and Vomiting Narrative: Acute bronchiolitis is the one of the most common respiratory infections in infants. It affects the lower respiratory tract and is usually caused by a virus, with respiratory syncytial virus (RSV) being the most common pathogen. It is estimated that nearly all infants are infected with RSV and that between 1 and 2% of these develop symptoms severe enough to warrant admission. While

2011 theNNT

106. WITHDRAWN: Inhaled corticosteroids during acute bronchiolitis in the prevention of post-bronchiolitic wheezing. (Abstract)

WITHDRAWN: Inhaled corticosteroids during acute bronchiolitis in the prevention of post-bronchiolitic wheezing. Acute bronchiolitis in infants and young children is associated with long-term airway disease also known as post-bronchiolitic wheezing. Two major hypotheses have been proposed to explain the association between bronchiolitis and PBW. The first hypothesis considers bronchiolitis to be the first manifestation of recurrent wheezing in infants and children who are susceptible (...) to obstructive airway disease. The second hypothesis suggests that the infection and concomitant inflammatory reaction in the acute phase leads to airway epithelium injury resulting in long-term obstructive airway disease. In line with the latter hypothesis, corticosteroids may have a beneficial effect on the prevention of post-bronchiolitic wheezing.The objective of this review was to evaluate the effect of inhaled corticosteroids, started during the acute phase of bronchiolitis, on the prevention of post

2011 Cochrane

107. Steam inhalation or humidified oxygen for acute bronchiolitis in children up to three years of age. (Abstract)

Steam inhalation or humidified oxygen for acute bronchiolitis in children up to three years of age. Acute bronchiolitis is a common respiratory infection and a major cause of morbidity in young children. It is treated with bronchodilators (for example, salbutamol), corticosteroids or humidified air (steam inhalation or cool mist). Steam inhalation is preferred in low-income countries as it is inexpensive and easily available. It is thought to act as a secretolytic agent to lighten secretions (...) (1981 to March 2010), AMED (1985 to March 2010), Web of Science (2000 to March 2010) and LILACS (1982 to March 2010).Randomised controlled trials involving children up to three years old with bronchiolitis comparing steam inhalation (or cool mist) or humidified oxygen against bronchodilators, corticosteroids or placebo; alone or in combination.Two review authors independently assessed trial quality and extracted data.Only one study (156 children aged between seven weeks and 24 months with signs

2011 Cochrane

108. Palivizumab for immunoprophylaxis of respiratory syncitial virus (RSV) bronchiolitis in high-risk infants and young children: a systematic review and additional economic modelling of subgroup analyses

Palivizumab for immunoprophylaxis of respiratory syncitial virus (RSV) bronchiolitis in high-risk infants and young children: a systematic review and additional economic modelling of subgroup analyses Palivizumab for immunoprophylaxis of respiratory syncytial virus (RSV) bronchiolitis in high-risk infants and young children: a systematic review and additional economic modelling of subgroup analyses Palivizumab for immunoprophylaxis of respiratory syncytial virus (RSV) bronchiolitis in high-risk (...) infants and young children: a systematic review and additional economic modelling of subgroup analyses Wang D, Bayliss S, Meads C Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Wang D, Bayliss S, Meads C. Palivizumab for immunoprophylaxis of respiratory syncytial virus (RSV) bronchiolitis in high-risk infants and young children: a systematic

2011 Health Technology Assessment (HTA) Database.

109. Randomised controlled trial: Repeated dosing of nebulised 5% saline improves respiratory scores in inpatients with mild to moderate bronchiolitis at 48 h

Randomised controlled trial: Repeated dosing of nebulised 5% saline improves respiratory scores in inpatients with mild to moderate bronchiolitis at 48 h Repeated dosing of nebulised 5% saline improves respiratory scores in inpatients with mild to moderate bronchiolitis at 48 h | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use (...) bronchiolitis at 48 h Article Text Therapeutics Randomised controlled trial Repeated dosing of nebulised 5% saline improves respiratory scores in inpatients with mild to moderate bronchiolitis at 48 h Shawn Ralston Statistics from Altmetric.com Commentary on: Al-Ansari K , Sakran M , Davidson BL , et al . Nebulized 5% or 3% hypertonic or 0.9% saline for treating acute bronchiolitis in infants. . Context Nebulised hypertonic saline for acute viral bronchiolitis was first brought to public scrutiny in 2002

2011 Evidence-Based Medicine

110. Steroids and bronchodilators for acute bronchiolitis in the first two years of life: systematic review and meta-analysis. Full Text available with Trip Pro

Steroids and bronchodilators for acute bronchiolitis in the first two years of life: systematic review and meta-analysis. To evaluate and compare the efficacy and safety of bronchodilators and steroids, alone or combined, for the acute management of bronchiolitis in children aged less than 2 years.Systematic review and meta-analysis.Medline, Embase, Central, Scopus, PubMed, LILACS, IranMedEx, conference proceedings, and trial registers. Inclusion criteria Randomised controlled trials (...) of children aged 24 months or less with a first episode of bronchiolitis with wheezing comparing any bronchodilator or steroid, alone or combined, with placebo or another intervention (other bronchodilator, other steroid, standard care).Two reviewers assessed studies for inclusion and risk of bias and extracted data. Primary outcomes were selected by clinicians a priori based on clinical relevance: rate of admission for outpatients (day 1 and up to day 7) and length of stay for inpatients. Direct meta

2011 BMJ

111. Nebulized 5% or 3% hypertonic or 0.9% saline for treating acute bronchiolitis in infants (Abstract)

Nebulized 5% or 3% hypertonic or 0.9% saline for treating acute bronchiolitis in infants To compare the efficacy and safety of 5%, 3%, and 0.9% saline solution for treating acute bronchiolitis in the prehospital setting.This was a double-blind trial including consecutive infants aged <18 months treated in an urban urgent care setting. A total of 165 patients were randomized to receive nebulized 5%, 3%, or 0.9% (normal) saline with epinephrine every 4 hours. The primary efficacy outcome (...) was bronchiolitis severity score improvement at 48 hours (chi2 analysis). Scores and oxygen saturation immediately before and after each treatment were recorded to assess safety.A total of 187 previously healthy infants (median age, 3.1 months) diagnosed with bronchiolitis were enrolled. Positivity for respiratory syncytial virus was similar in the 3 treatment groups (mean, 56%). At 48 hours, the mean severity score for the 5% saline group was 3.69+/-1.09, and that for the 0.9% saline group was 4.12+/-1.11 (P

2010 EvidenceUpdates Controlled trial quality: predicted high

112. Survival after bronchiolitis obliterans syndrome among bilateral lung transplant recipients Full Text available with Trip Pro

Survival after bronchiolitis obliterans syndrome among bilateral lung transplant recipients Despite the importance of bronchiolitis obliterans syndrome (BOS) in lung transplantation, little is known regarding the factors that influence survival after the onset of this condition, particularly among bilateral transplant recipients.To identify factors that influence survival after the onset of BOS among bilateral lung transplant recipients.The effect of demographic or clinical factors, occurring

2010 EvidenceUpdates

113. High Flow Nasal Cannulae Therapy in Infants with Bronchiolitis

High Flow Nasal Cannulae Therapy in Infants with Bronchiolitis PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2010 PedsCCM Evidence-Based Journal Club

114. Epinephrine and dexamethasone in children with bronchiolitis

Epinephrine and dexamethasone in children with bronchiolitis PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2010 PedsCCM Evidence-Based Journal Club

115. A randomized trial of nebulized 3% hypertonic saline with epinephrine in the treatment of acute bronchiolitis in the emergency department Full Text available with Trip Pro

A randomized trial of nebulized 3% hypertonic saline with epinephrine in the treatment of acute bronchiolitis in the emergency department To determine whether nebulized 3% hypertonic saline with epinephrine is more effective than nebulized 0.9% saline with epinephrine in the treatment of bronchiolitis in the emergency department.Randomized, double-blind, controlled trial.Single-center urban pediatric emergency department.Infants younger than 12 months with mild to moderate (...) baseline characteristics. The RACS from baseline to 120 minutes demonstrated no improvement in respiratory distress in the hypertonic saline group compared with the normal saline control group. The change in oxygen saturation in the hypertonic saline group was not significant when compared with the control group. Rates of admission and return to the emergency department were not different between the 2 groups.In the treatment of acute bronchiolitis, hypertonic saline and epinephrine did not improve

2010 EvidenceUpdates Controlled trial quality: predicted high

116. Pharmacologic Treatment of Bronchiolitis in Infants and Children: A Systematic Review

Pharmacologic Treatment of Bronchiolitis in Infants and Children: A Systematic Review PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2010 PedsCCM Evidence-Based Journal Club

117. WITHDRAWN. Surfactant therapy for bronchiolitis in critically ill infants. (Abstract)

WITHDRAWN. Surfactant therapy for bronchiolitis in critically ill infants. Viral bronchiolitis is a common cause of respiratory failure in infants and children, and accounts for a significant portion of intensive care unit (ICU) admissions during seasonal epidemics. Currently there is no evidence to support the use of anything but supportive care for this disease. Surfactant is a potentially promising therapy; alterations in its composition have been described in bronchiolitis, and it may play (...) a role in the host immunity for this disease.To assess the efficacy of exogenous surfactant for the treatment of bronchiolitis in mechanically ventilated infants and children.We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library, 2006, issue 1) which contains the Acute Respiratory Infections Group's Specialized Register; MEDLINE (1966 to Week 1, February 2006); and EMBASE (1990 to September 2005).Randomised controlled trials (RCTs) comparing surfactant

2010 Cochrane

118. The Effectiveness of Dexamethasone as Adjunctive Therapy to Racemic Epinephrine for a Pediatric Patient With Bronchiolitis

The Effectiveness of Dexamethasone as Adjunctive Therapy to Racemic Epinephrine for a Pediatric Patient With Bronchiolitis "The Effectiveness of Dexamethasone as Adjunctive Therapy to Racemic Ep" by Michelle M. Harsono < > > > > > Title Author Date of Graduation 8-14-2010 Degree Type Capstone Project Degree Name Master of Science in Physician Assistant Studies First Advisor Rob Rosenow, PharmD, OD Second Advisor Annjanette Sommers MS, PAC Rights . Abstract Background: Bronchiolitis is a lower (...) respiratory tract infection that is most common in the pediatric population, and is the major cause of hospitalizations for patients in their first year of life. Despite the prevalence of this disease, a consensus for optimal treatment is elusive. Although numerous studies have addressed dexamethasone or epinephrine alone, the combination is not well established. The optimal therapeutic management of bronchiolitis is still controversial. The objective of this literature review is to determine

2010 Pacific University EBM Capstone Project

119. CPG on Acute Bronchiolitis

CPG on Acute Bronchiolitis Clinical Practice Guideline on Acute Bronchiolitis CLINICAL PRACTICE GUIDELINES IN THE SPANISH NATIONAL HEALTHCARE SYSTEM MINISTRY FOR HEALTH AND SOCIAL POLICYIt has been 5 years since the publication of this Clinical Practice Guideline and it is subject to updating. Clinical Practice Guideline on Acute Bronchiolitis CLINICAL PRACTICE GUIDELINES IN THE SPANISH NATIONAL HEALTHCARE SYSTEM MINISTRY FOR HEALTH AND SOCIAL POLICY It has been 5 years since the publication (...) been funded via an agreement entered into by the Carlos III Health Institute, an autonomous body within the Spanish Ministry for Science and Innovation, and the Catalan Agency for Health Technology Assessment, within the framework for cooperation established in the Quality Plan for the Spanish National Healthcare System of the Spanish Ministry for Health and Social Policy. This guideline must be cited: Working Group of the Clinical Practice Guideline on Acute Bronchiolitis; Sant Joan de Déu

2010 GuiaSalud

120. Bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation. (Abstract)

Bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation. With improvements in supportive care, both long-term survival following allogeneic hematopoietic stem cell transplantations (HSCTs) and the indications for this procedure have increased. As a result, the number of patients living with long-term toxic effects due to HSCT has increased. A once rare condition of the donor immune cells attacking healthy host tissues, termed chronic graft-vs-host disease, has become (...) a more common phenomenon. When chronic graft-vs-host disease affects the lung tissue, bronchiolitis obliterans syndrome ensues. Recent data suggest that bronchiolitis obliterans syndrome may affect up to 6% of HSCT recipients and dramatically alters survival, with overall survival of only 13% at 5 years. These statistics have not improved since the first presentation of this disease over 20 years ago. Challenges to the progress of medical management of bronchiolitis obliterans syndrome include

2009 JAMA