Latest & greatest articles for bronchiolitis

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Bronchiolitis

Bronchiolitis is mainly caused by the respiratory syncytial virus (RSV). The virus travels down to the bronchioles in the lungs causing them to become inflamed making it difficult to breath.

Almost every child will be infected with RSV by the time they reach two years. Adults can also contract the virus, typically during winter months.

In mild cases bronchiolitis will clear up without treatment. The virus that causes bronchiolitis travels through tiny droplets of liquid and can be passed through the air or contracted by touching infected surfaces.

Symptoms include: Sore throat, dry cough, blocked nose and aches and pains throughout the body.

Although there is no cure for chronic bronchiolitis research and clinical studies on bronchiolitis suggest that some lifestyle changes can ease symptoms: avoid smoking, eat a healthy diet and maintain regular exercise. In extreme cases steroids can be prescribed to help minimise inflammation.

Read more on medications used to treat bronchiolitis and the causes of the virus.

Top results for bronchiolitis

41. Are leukotriene inhibitors useful for bronchiolitis? Full Text available with Trip Pro

Are leukotriene inhibitors useful for bronchiolitis? Bronchiolitis is a prevalent disease in children under two years of age, which carries significant morbidity and mortality. However, there is controversy regarding the optimal therapeutic management. Leukotriene inhibitors have been proposed as an alternative, although its efficacy is not clear yet. Searching in Epistemonikos database, which is maintained by screening multiple databases, we identified two systematic reviews comprising six (...) trials addressing the question of this article. We extracted data, combined the evidence using meta-analysis and generated a summary of findings following the GRADE approach. We concluded leukotriene inhibitors might not decrease mortality levels on bronchiolitis patients and it is not clear whether they decrease length of hospital stay. They might reduce recurrent wheezing, but the certainty of the evidence is low, and they increase adverse effects.

2017 Medwave

42. High flow nasal cannula (HFNC) versus nasal continuous positive airway pressure (nCPAP) for the initial respiratory management of acute viral bronchiolitis in young infants: a multicenter randomized controlled trial (TRAMONTANE study)

High flow nasal cannula (HFNC) versus nasal continuous positive airway pressure (nCPAP) for the initial respiratory management of acute viral bronchiolitis in young infants: a multicenter randomized controlled trial (TRAMONTANE study) PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2017 PedsCCM Evidence-Based Journal Club

43. High-flow warm humidified oxygen versus standard low-flow nasal cannula oxygen for moderate bronchiolitis (HFWHO RCT): an open, phase 4, randomised controlled trial

High-flow warm humidified oxygen versus standard low-flow nasal cannula oxygen for moderate bronchiolitis (HFWHO RCT): an open, phase 4, randomised controlled trial PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2017 PedsCCM Evidence-Based Journal Club

44. IV Magnesium Sulfate for Bronchiolitis: A Randomized Trial (Abstract)

IV Magnesium Sulfate for Bronchiolitis: A Randomized Trial The goal of this study was to determine if IV magnesium, useful for severe pediatric asthma, reduces time to medical readiness for discharge in patients with bronchiolitis when added to supportive care.We compared a single dose of 100 mg/kg of IV magnesium sulfate vs placebo for acute bronchiolitis. Patients received bronchodilator therapy, nebulized hypertonic saline, and 5 days of dexamethasone if there was eczema and/or a family (...) history of asthma. Time to medical readiness for discharge was the primary efficacy outcome. Bronchiolitis severity scores and need for infirmary or hospital admission and for clinic revisits within 2 weeks were secondary outcomes. Cardiorespiratory instability onset was the safety outcome.A total of 162 previously healthy infants diagnosed with bronchiolitis aged 22 days to 17.6 months (median, 3.7 months) were enrolled. Approximately one-half of patients had eczema and/or a family history of asthma

2017 EvidenceUpdates

45. Effect of Nebulized Hypertonic Saline Treatment in Emergency Departments on the Hospitalization Rate for Acute Bronchiolitis: A Randomized Clinical Trial Full Text available with Trip Pro

Effect of Nebulized Hypertonic Saline Treatment in Emergency Departments on the Hospitalization Rate for Acute Bronchiolitis: A Randomized Clinical Trial Acute bronchiolitis is the leading cause of hospitalization among infants. Previous studies, underpowered to examine hospital admission, have found a limited benefit of nebulized hypertonic saline (HS) treatment in the pediatric emergency department (ED).To examine whether HS nebulization treatment would decrease the hospital admission rate (...) among infants with a first episode of acute bronchiolitis.The Efficacy of 3% Hypertonic Saline in Acute Viral Bronchiolitis (GUERANDE) study was a multicenter, double-blind randomized clinical trial on 2 parallel groups conducted during 2 bronchiolitis seasons (October through March) from October 15, 2012, through April 15, 2014, at 24 French pediatric EDs. Among the 2445 infants (6 weeks to 12 months of age) assessed for inclusion, 777 with a first episode of acute bronchiolitis with respiratory

2017 EvidenceUpdates

46. Is Nebulized Hypertonic Saline Solution Effective for Acute Bronchiolitis?

Is Nebulized Hypertonic Saline Solution Effective for Acute Bronchiolitis? TAKE-HOME MESSAGE Hypertonic saline solution is possibly effective in decreasing hospital admission and length of stay for infants with bronchiolitis. Is Nebulized Hypertonic Saline Solution Effective for Acute Bronchiolitis? EBEM Commentators Jennifer H. Chao, MD Division of Pediatric Emergency Medicine Department of Emergency Medicine SUNY Downstate Medical Center Brooklyn, NY Richard Sinert, DO Division of Research (...) of stay and hospital admission with hypertonic saline solution, although theseresultsneedtobetempered by the presence of substantial heterogeneity across studies because of inconsistency in de?ningbronchiolitis.Bronchiolitisis a clinical syndrome as opposed to a speci?c pathologic process. In everyday practice, the clinical pre- sentation of bronchiolitis overlaps that of a simple upper respiratory infection with an asthma exacerba- tion. Zheng et al 1 concluded that nebulized hypertonic saline

2017 Annals of Emergency Medicine Systematic Review Snapshots

47. High-flow warm humidified oxygen versus standard low-flow nasal cannula oxygen for moderate bronchiolitis (HFWHO RCT): an open, phase 4, randomised controlled trial. (Abstract)

High-flow warm humidified oxygen versus standard low-flow nasal cannula oxygen for moderate bronchiolitis (HFWHO RCT): an open, phase 4, randomised controlled trial. Bronchiolitis is the most common lung infection in infants and treatment focuses on management of respiratory distress and hypoxia. High-flow warm humidified oxygen (HFWHO) is increasingly used, but has not been rigorously studied in randomised trials. We aimed to examine whether HFWHO provided enhanced respiratory support, thereby (...) shortening time to weaning off oxygen.In this open, phase 4, randomised controlled trial, we recruited children aged less than 24 months with moderate bronchiolitis attending the emergency department of the John Hunter Hospital or the medical unit of the John Hunter Children's Hospital in New South Wales, Australia. Patients were randomly allocated (1:1) via opaque sealed envelopes to HFWHO (maximum flow of 1 L/kg per min to a limit of 20 L/min using 1:1 air-oxygen ratio, resulting in a maximum FiO2 of 0

2017 Lancet Controlled trial quality: predicted high

48. High-Flow Nasal Cannulaÿ (HFNC) versus Nasal Continuous Positive Airway Pressure (nCPAP)ÿversus Conventional Oxygen Therapy (COT) in acute moderate and severe bronchiolitis in children: a systematic review and network meta-analysis

High-Flow Nasal Cannulaÿ (HFNC) versus Nasal Continuous Positive Airway Pressure (nCPAP)ÿversus Conventional Oxygen Therapy (COT) in acute moderate and severe bronchiolitis in children: a systematic review and network meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record

2017 PROSPERO

49. Parent self-reports of experiences and information needs related to bronchiolitis: protocol for a mixed studies systematic review

Parent self-reports of experiences and information needs related to bronchiolitis: protocol for a mixed studies systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne

2017 PROSPERO

51. Respiratory bronchiolitis-associated interstitial lung disease (RB-ILD)

Respiratory bronchiolitis-associated interstitial lung disease (RB-ILD)

2017 DynaMed Plus

52. A systematic review of the effect of outdoor air pollution on the risk of hospitalisation for bronchiolitis in infants

A systematic review of the effect of outdoor air pollution on the risk of hospitalisation for bronchiolitis in infants Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence

2017 PROSPERO

53. Azithromycin for treatment of bronchiolitis obliterans syndrome in adult lung transplant recipients [Cochrane protocol]

Azithromycin for treatment of bronchiolitis obliterans syndrome in adult lung transplant recipients [Cochrane protocol] Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence

2017 PROSPERO

54. Risk factors for childhood asthma after infant hospitalization for bronchiolitis: a systematic review and meta-analysis

Risk factors for childhood asthma after infant hospitalization for bronchiolitis: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence

2017 PROSPERO

55. Viral bronchiolitis. Full Text available with Trip Pro

Viral bronchiolitis. Viral bronchiolitis is a common clinical syndrome affecting infants and young children. Concern about its associated morbidity and cost has led to a large body of research that has been summarised in systematic reviews and integrated into clinical practice guidelines in several countries. The evidence and guideline recommendations consistently support a clinical diagnosis with the limited role for diagnostic testing for children presenting with the typical clinical syndrome (...) of viral upper respiratory infection progressing to the lower respiratory tract. Management is largely supportive, focusing on maintaining oxygenation and hydration of the patient. Evidence suggests no benefit from bronchodilator or corticosteroid use in infants with a first episode of bronchiolitis. Evidence for other treatments such as hypertonic saline is evolving but not clearly defined yet. For infants with severe disease, the insufficient available data suggest a role for high-flow nasal cannula

2016 Lancet

56. Viral Bronchiolitis in Children. Full Text available with Trip Pro

Viral Bronchiolitis in Children. 27144865 2016 05 05 2018 12 02 1533-4406 374 18 2016 05 05 The New England journal of medicine N. Engl. J. Med. Viral Bronchiolitis in Children. 1791 10.1056/NEJMc1601509 DeVincenzo John P JP University of Tennessee College of Medicine, Memphis, TN jdevincenzo@uthsc.edu. Krilov Leonard R LR State University of New York at Stony Brook School of Medicine, Stony Brook, NY. Yogev Ram R Northwestern University Feinberg School of Medicine, Chicago, IL. eng Letter (...) Comment United States N Engl J Med 0255562 0028-4793 AIM IM N Engl J Med. 2016 Jan 7;374(1):62-72 26735994 N Engl J Med. 2016 May 5;374(18):1793-4 27144864 Bronchiolitis, Viral Humans Respiratory Syncytial Virus Infections 2016 5 5 6 0 2016 5 6 6 0 2016 5 6 6 1 ppublish 27144865 10.1056/NEJMc1601509 10.1056/NEJMc1601509#SA1

2016 NEJM

57. Viral Bronchiolitis in Children. Full Text available with Trip Pro

Viral Bronchiolitis in Children. 27144866 2016 05 05 2018 12 02 1533-4406 374 18 2016 05 05 The New England journal of medicine N. Engl. J. Med. Viral Bronchiolitis in Children. 1791-2 10.1056/NEJMc1601509 Connors Thomas T Columbia University Medical Center, New York, NY tc2625@cumc.columbia.edu. Baird John J Columbia University Medical Center, New York, NY tc2625@cumc.columbia.edu. Farber Donna L DL Columbia University Medical Center, New York, NY tc2625@cumc.columbia.edu. eng Letter Comment (...) United States N Engl J Med 0255562 0028-4793 AIM IM N Engl J Med. 2016 Jan 7;374(1):62-72 26735994 N Engl J Med. 2016 May 5;374(18):1793-4 27144864 Bronchiolitis, Viral Humans Respiratory Syncytial Virus Infections 2016 5 5 6 0 2016 5 6 6 0 2016 5 6 6 1 ppublish 27144866 10.1056/NEJMc1601509 10.1056/NEJMc1601509#SA2

2016 NEJM

58. Viral Bronchiolitis in Children. (Abstract)

Viral Bronchiolitis in Children. 27144864 2016 05 05 2018 12 02 1533-4406 374 18 2016 05 05 The New England journal of medicine N. Engl. J. Med. Viral Bronchiolitis in Children. 1793-4 10.1056/NEJMc1601509 Meissner H Cody HC eng Letter Comment United States N Engl J Med 0255562 0028-4793 AIM IM N Engl J Med. 2016 Jan 7;374(1):62-72 26735994 N Engl J Med. 2016 May 5;374(18):1791 27144865 N Engl J Med. 2016 May 5;374(18):1792-3 27144868 N Engl J Med. 2016 May 5;374(18):1792 27144867 N Engl J Med (...) . 2016 May 5;374(18):1791-2 27144866 N Engl J Med. 2016 Sep 22;375(12):1199-200 27653587 N Engl J Med. 2016 Sep 22;375(12):1199-200 27653586 Bronchiolitis, Viral Humans Respiratory Syncytial Virus Infections 2016 5 5 6 0 2016 5 6 6 0 2016 5 6 6 1 ppublish 27144864 10.1056/NEJMc1601509 10.1056/NEJMc1601509#SA5

2016 NEJM

59. Viral Bronchiolitis in Children. Full Text available with Trip Pro

Viral Bronchiolitis in Children. 27144867 2016 05 05 2018 12 02 1533-4406 374 18 2016 05 05 The New England journal of medicine N. Engl. J. Med. Viral Bronchiolitis in Children. 1792 10.1056/NEJMc1601509 Wall Michael M Oregon Health and Science University, Portland, OR wallm@ohsu.edu. eng Letter Comment United States N Engl J Med 0255562 0028-4793 AIM IM N Engl J Med. 2016 Jan 7;374(1):62-72 26735994 N Engl J Med. 2016 May 5;374(18):1793-4 27144864 Bronchiolitis, Viral Humans Respiratory

2016 NEJM

60. Viral Bronchiolitis in Children. Full Text available with Trip Pro

Viral Bronchiolitis in Children. 27144868 2016 05 05 2018 12 02 1533-4406 374 18 2016 05 05 The New England journal of medicine N. Engl. J. Med. Viral Bronchiolitis in Children. 1792-3 10.1056/NEJMc1601509 Rossi Giovanni A GA Istituto Giannina Gaslini, Genoa, Italy giovannirossi@gaslini.org. Silvestri Michela M Istituto Giannina Gaslini, Genoa, Italy giovannirossi@gaslini.org. Colin Andrew A AA University of Miami, Miami, FL. eng Letter Comment United States N Engl J Med 0255562 0028-4793 AIM (...) IM N Engl J Med. 2016 Jan 7;374(1):62-72 26735994 N Engl J Med. 2016 Sep 22;375(12):1204 27653590 N Engl J Med. 2016 May 5;374(18):1793-4 27144864 Bronchiolitis, Viral Humans Respiratory Syncytial Virus Infections 2016 5 5 6 0 2016 5 6 6 0 2016 5 6 6 1 ppublish 27144868 10.1056/NEJMc1601509 10.1056/NEJMc1601509#SA4

2016 NEJM