Latest & greatest articles for bronchiolitis

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Bronchiolitis

Bronchiolitis is mainly caused by the respiratory syncytial virus (RSV). The virus travels down to the bronchioles in the lungs causing them to become inflamed making it difficult to breath.

Almost every child will be infected with RSV by the time they reach two years. Adults can also contract the virus, typically during winter months.

In mild cases bronchiolitis will clear up without treatment. The virus that causes bronchiolitis travels through tiny droplets of liquid and can be passed through the air or contracted by touching infected surfaces.

Symptoms include: Sore throat, dry cough, blocked nose and aches and pains throughout the body.

Although there is no cure for chronic bronchiolitis research and clinical studies on bronchiolitis suggest that some lifestyle changes can ease symptoms: avoid smoking, eat a healthy diet and maintain regular exercise. In extreme cases steroids can be prescribed to help minimise inflammation.

Read more on medications used to treat bronchiolitis and the causes of the virus.

Top results for bronchiolitis

1. Acute Cough Due to Acute Bronchitis in Immunocompetent Adult Outpatients: CHEST Expert Panel Report

Acute Cough Due to Acute Bronchitis in Immunocompetent Adult Outpatients: CHEST Expert Panel Report Acute Cough Due to Acute Bronchitis in Immunocompetent Adult Outpatients CHEST Expert Panel Report Maeve P. Smith, MD; Mark Lown, PhD; Sonal Singh, MD; Belinda Ireland, MD; Adam T. Hill, MD; Jeffrey A. Linder, MD, MPH; and Richard S. Irwin, MD; on behalf of the CHEST Expert Cough Panel * BACKGROUND: Evidence for the diagnosis and management of cough due to acute bronchitis in immunocompetent (...) adult outpatients was reviewed as an update to the 2006 “Chronic Cough Due to Acute Bronchitis: American College of Chest Physicians (ACCP) Evidence- Based Clinical Practice Guidelines.” METHODS: Acute bronchitis was de?ned as an acute lower respiratory tract infection man- ifested predominantly by cough with or without sputum production, lasting no more than 3 weeks with no clinical or any recent radiographic evidence to suggest an alternative explanation. Two clinical population, intervention

2020 American College of Chest Physicians

2. Respiratory Virus Epidemiology Among US Infants With Severe Bronchiolitis: Analysis of 2 Multicenter, Multiyear Cohort Studies. (Full text)

Respiratory Virus Epidemiology Among US Infants With Severe Bronchiolitis: Analysis of 2 Multicenter, Multiyear Cohort Studies. In 2 multicenter cohort studies of 2912 infants hospitalized for bronchiolitis during 2007-2014, the 5 most common pathogens were RSV (76.5%), rhinovirus (23.8%), coronavirus (6.9%), adenovirus (6.4%) and human metapneumovirus (6.0%). Hospitalization months significantly differed for these common pathogens (P ≤ 0.01), except for coronavirus (P = 0.30

2020 The Pediatric infectious disease journal PubMed abstract

3. The characteristics of the frequent exacerbator with chronic bronchitis phenotype and non-exacerbator phenotype in patients with chronic obstructive pulmonary disease: a meta-analysis and system review. (Full text)

The characteristics of the frequent exacerbator with chronic bronchitis phenotype and non-exacerbator phenotype in patients with chronic obstructive pulmonary disease: a meta-analysis and system review. Chronic obstructive pulmonary disease (COPD) patients with different phenotypes show different clinical characteristics. Therefore, we conducted a meta-analysis to explore the clinical characteristics between the non-exacerbator (NE) phenotype and the frequent exacerbator with chronic bronchitis

2020 BMC pulmonary medicine PubMed abstract

4. Prevalence of Continuous Pulse Oximetry Monitoring in Hospitalized Children With Bronchiolitis Not Requiring Supplemental Oxygen. (Abstract)

Prevalence of Continuous Pulse Oximetry Monitoring in Hospitalized Children With Bronchiolitis Not Requiring Supplemental Oxygen. US national guidelines discourage the use of continuous pulse oximetry monitoring in hospitalized children with bronchiolitis who do not require supplemental oxygen.Measure continuous pulse oximetry use in children with bronchiolitis.A multicenter cross-sectional study was performed in pediatric wards in 56 US and Canadian hospitals in the Pediatric Research (...) in Inpatient Settings Network from December 1, 2018, through March 31, 2019. Participants included a convenience sample of patients aged 8 weeks through 23 months with bronchiolitis who were not receiving active supplemental oxygen administration. Patients with extreme prematurity, cyanotic congenital heart disease, pulmonary hypertension, home respiratory support, neuromuscular disease, immunodeficiency, or cancer were excluded.Hospitalization with bronchiolitis without active supplemental oxygen

2020 JAMA

5. High flow nasal cannula as respiratory support in treating infant bronchiolitis: a systematic review. (Abstract)

High flow nasal cannula as respiratory support in treating infant bronchiolitis: a systematic review. Bronchiolitis is a common respiratory illness in early childhood, often leading to hospitalization and associated healthcare costs. Low flow 100% oxygen through nasal prongs is the standard therapy for infants with bronchiolitis and hypoxemia. Nasal continuous positive airway pressure (nCPAP) or invasive ventilation is used in case of progressive respiratory failure. High flow heated (...) with the aim to provide advice on how to position HFNC in clinical practice.Conclusion: HFNC is a safe mode of respiratory support that can be positioned between SOT and nCPAP as rescue therapy for children not adequately supported by SOT. It does not seem to shorten the duration of oxygen need nor the duration of hospital admission.What is Known:• HFNC is being used increasingly in the context of infant bronchiolitis. However, evidence on efficacy and safety are limited. Different published studies

2020 European journal of pediatrics

6. [Systematic review and Meta-analysis of effect of Reduning Injection in treating acute tracheal-bronchitis]. (Abstract)

[Systematic review and Meta-analysis of effect of Reduning Injection in treating acute tracheal-bronchitis]. To systematically review the effectiveness and safety of Reduning Injection in the treatment of acute tracheal-bronchitis.Four Chinese databases( CNKI,VIP,Wan Fang,Sino Med) and three English databases( Cochrane Library,Medline,Web of Science) were systematically and comprehensively retrieved. The retrieval time was from the establishment of each database to April 2019.Randomized (...) controlled trials( RCTs) for the treatment of acute tracheal-bronchitis with Reduning Injection were collected. Two researchers independently conducted literature screening,data extraction and risk assessment for bias. Rev Man 5.3 software was used for data analysis. Fourteen studies were included,and the total sample size was 1 652 at last. Meta-analysis results show that in the aspect of total clinical effective rate,Reduning Injection was superior to ribavirin( RR = 1. 37,95%CI[1. 28,1. 47],P<0

2020 Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

7. [Meta-analysis of randomized controlled trials on effect of Tanreqing Injection combined with Western medicine on acute exacerbation of chronic bronchitis]. (Abstract)

[Meta-analysis of randomized controlled trials on effect of Tanreqing Injection combined with Western medicine on acute exacerbation of chronic bronchitis]. To systematically review the effectiveness and safety of Tanreqing Injection in treating acute exacerbation of chronic bronchitis( AECB). CNKI,Wan Fang,VIP,CBM,Medline,Cochrane Library,EMbase and Web of Science were retrieved,and randomized controlled trials for the effect of Tanreqing Injection in the treatment of acute exacerbation (...) of chronic bronchitis were screened. The quality of the included studies was evaluated according to the Cochrane Handbook's evaluation criteria. The data was analyzed by RevMan 5.3. Totally 23 RCTs involving 1 901 patients were included,including 952 in the experimental group and 949 in the control group. The Meta-analysis demonstrated that in terms of the disappearance time of fever,the group of Tanreqing Injection combined with the conventional therapy was superior to conventional therapy group

2020 Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

8. Chronic Cough Due to Stable Chronic Bronchitis: CHEST Expert Panel Report

Chronic Cough Due to Stable Chronic Bronchitis: CHEST Expert Panel Report Chronic Cough Due to Stable Chronic Bronchitis CHEST Expert Panel Report Q43 Mark A. Malesker, PharmD, FCCP Q1 ; Priscilla Callahan-Lyon, MD; J. Mark Madison, MD, FCCP; Belinda Ireland, MD Q2 ; and Richard S. Irwin, MD, Master FCCP; on behalf of the CHEST Expert Cough Panel * BACKGROUND: Q7 Chronic cough due to chronic bronchitis (CB) causes signi?cant Q8 impairment in quality of life, and effective treatment strategies (...) and of low quality. This article provides guidance on treatment by presenting suggestions based on the best currently available evidence and identi?es gaps in our knowledge and areas for future research. CHEST 2020;-(-):--- KEY WORDS: chronic bronchitis; chronic cough; nonpharmacological treatment; pharmacological treatment Q9 ABBREVIATIONS: CB = chronic bronchitis; CHEST = American Col- lege of Chest Physicians; GOC = Guidelines Oversight Committee; GRADE = Grading of Recommendations Assessment

2020 American College of Chest Physicians

9. Effect of Orally Administered N-Acetylcysteine on Chronic Bronchitis: A Meta-analysis. (Abstract)

Effect of Orally Administered N-Acetylcysteine on Chronic Bronchitis: A Meta-analysis. The effect of N-acetylcysteine (NAC) treatment for patients with chronic bronchitis (CB) is controversial. To better understand the role of NAC in CB treatment, we performed a meta-analysis to provide a more accurate estimation of the importance of NAC treatment.PubMed, Embase, and CNKI were systematically searched. The pooled relative risk (RR) and 95% confidence intervals (CI) were calculated using either

2020 Advances in therapy

10. Hypertonic saline in bronchiolitis: an updated meta-analysis. (Abstract)

Hypertonic saline in bronchiolitis: an updated meta-analysis. 32213483 2020 03 27 1468-2044 2020 Mar 25 Archives of disease in childhood Arch. Dis. Child. Hypertonic saline in bronchiolitis: an updated meta-analysis. archdischild-2020-319048 10.1136/archdischild-2020-319048 Heikkilä Paula P Tampre Center for Child Health Research, Tampere University, Tampere, Pirkanmaa, Finland. Korppi Matti M Tampre Center for Child Health Research, Tampere University, Tampere, Pirkanmaa, Finland matti.korppi

2020 Archives of Disease in Childhood

11. Corrigendum to: A Systematic Review of Clinical Practice Guidelines for the Diagnosis and Management of Bronchiolitis. (Full text)

Corrigendum to: A Systematic Review of Clinical Practice Guidelines for the Diagnosis and Management of Bronchiolitis. 31917442 2020 03 17 1537-6613 221 7 2020 Mar 16 The Journal of infectious diseases J. Infect. Dis. Corrigendum to: A Systematic Review of Clinical Practice Guidelines for the Diagnosis and Management of Bronchiolitis. 1204 10.1093/infdis/jiz600 Kirolos Amir A Usher Institute of Population Health Sciences and Informatics. Manti Sara S Department of Pediatrics, University

2020 The Journal of infectious diseases PubMed abstract

12. Complementary and alternative medicine in the treatment of acute bronchitis in children: A systematic review. (Abstract)

Complementary and alternative medicine in the treatment of acute bronchitis in children: A systematic review. Our review summarizes published literature of complementary and alternative medicine (CAM) used for the treatment of acute bronchitis in children.Acute bronchitis is one of the most frequent pediatric diseases and has high prevalence for in- and outpatient care. Acute bronchitis is mainly a viral-caused infection, but a high and inappropriate use of antibiotics has been demonstrated

2020 Complementary Therapies In Medicine

13. Evaluating the Placebo Status of Nebulized Normal Saline in Patients With Acute Viral Bronchiolitis: A Systematic Review and Meta-analysis. (Abstract)

Evaluating the Placebo Status of Nebulized Normal Saline in Patients With Acute Viral Bronchiolitis: A Systematic Review and Meta-analysis. In therapeutic trials for acute viral bronchiolitis, consistent clinical improvement in groups that received nebulized normal saline (NS) as placebo raises the question of whether nebulized NS acts as a treatment rather than a placebo.To measure the short-term association of nebulized NS with physiologic measures of respiratory status in children (...) with bronchiolitis by analyzing the changes in these measures between the use of nebulized NS and the use of other placebos and the changes before and after nebulized NS treatment.MEDLINE and Scopus were searched through March 2019, as were bibliographies of included studies and relevant systematic reviews, for randomized clinical trials evaluating nebulized therapies in bronchiolitis.Randomized clinical trials comparing children 2 years or younger with bronchiolitis who were treated with nebulized NS were

2020 JAMA pediatrics

14. Immune biomarkers predicting bronchiolitis disease severity: A systematic review. (Abstract)

Immune biomarkers predicting bronchiolitis disease severity: A systematic review. Bronchiolitis is one of the leading causes of hospitalisation in infancy, with highly variable clinical presentations ranging from mild disease safely managed at home to severe disease requiring invasive respiratory support. Identifying immune biomarkers that can predict and stratify this variable disease severity has important implications for clinical prognostication/disposition. A systematic literature search (...) of the databases Embase, PubMed, ScienceDirect, Web of Science, and Wiley Online Library was performed. English language studies that assessed the association between an immune biomarker and bronchiolitis disease severity among children aged less than 24 months were included. 252 distinct biomarkers were identified across 90 studies. A substantial degree of heterogeneity was observed in the bronchiolitis definitions, measures of disease severity, and study designs. 99 biomarkers showed some significant

2020 Paediatric Respiratory Reviews

15. Sporadic Obliterative Bronchiolitis: Case Series and Systematic Review of the Literature. (Full text)

Sporadic Obliterative Bronchiolitis: Case Series and Systematic Review of the Literature. To describe the clinical characteristics and outcomes of patients diagnosed with obliterative bronchiolitis (OB) not associated with transplantation or point-source exposures to inhaled toxins.We compiled all confirmed diagnoses of OB at our institution and analyzed their demographic characteristics, treatments, and outcomes as defined by pulmonary function tests (PFTs) and transplant-free mortality

2020 Mayo Clinic Proceedings. Innovations, Quality & Outcomes PubMed abstract

16. EXERCISE CAPACITY IN CHILDREN AND ADOLESCENTS WITH POST-INFECTIOUS BRONCHIOLITIS OBLITERANS: A SYSTEMATIC REVIEW. (Full text)

EXERCISE CAPACITY IN CHILDREN AND ADOLESCENTS WITH POST-INFECTIOUS BRONCHIOLITIS OBLITERANS: A SYSTEMATIC REVIEW. To evaluate exercise capacity in children and adolescents with post-infectious bronchiolitis obliterans.This is a systematic review based on data from PubMed, Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), Scientific Electronic Library Online (SciELO), and Physiotherapy Evidence Database (PEDro). We used the following search strategy: "Exercise capacity (...) OR Exercise Test OR Physical fitness OR Functional capacity OR Six-minute walk test OR Shuttle walk test OR Cardiopulmonary exercise test AND Bronchiolitis obliterans." We selected studies that evaluated exercise capacity through maximal/submaximal testing in children and adolescents with post-infectious bronchiolitis obliterans, and no other associated disease. We searched articles in English, Portuguese, and Spanish, without restrictions regarding the period of publication. The methodological quality

2020 Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo PubMed abstract

17. Efficacy of 3% hypertonic saline in bronchiolitis: A meta-analysis. (Full text)

Efficacy of 3% hypertonic saline in bronchiolitis: A meta-analysis. A meta-analysis was performed to analyze the efficacy of 3% hypertonic saline (HS) in bronchiolitis. Pubmed and MEDLINE databases were searched for relevant articles. A total of 2 authors selected the articles according to the inclusion criteria and then data were carefully extracted. Weighted mean difference (WMD) with 95% confidence interval (95% CI) values were used to pool continuous data, including length of stay (...) , with a WMD=-0.62 (95% CI=-0.90, -0.33). The results indicated a lower CSS score in the 3% HS group compared with the NS group (SMD=-0.80; 95% CI=-1.06, -0.54). The pooled outcome indicated a beneficial effect of 3% HS on decreasing re-admission rates compared with NS (RR=0.93; 95% CI=0.70, 1.23). No potential publication bias was observed (Begg's, P=0.133; Egger's, P=0.576). In conclusion, 3% HS was demonstrated to be a more successful therapy compared with NS for infants with bronchiolitis.

2020 Experimental and therapeutic medicine PubMed abstract

18. A systematic review protocol of Tuina for children with acute bronchitis: A protocol for systematic review. (Full text)

A systematic review protocol of Tuina for children with acute bronchitis: A protocol for systematic review. Acute bronchitis (AB) is a common cause of childhood morbidity. Tuina, a kind of Chinese massage, is frequently used for the treatment of AB in children by traditional Chinese medicine doctors. However, there is no relevant systematic review show its effectiveness and safety. The study aims to evaluate the effectiveness and safety of Tuina for children with AB.The following electronic (...) of interest only will be contained. Two independent researchers will operate article retrieval, duplication removing, screening, quality evaluation, and data analyses by Review Manager (V.5.3.5). Meta-analyses, subgroup analysis and/or descriptive analysis will be performed based on the included data conditions.High-quality synthesis and/or descriptive analysis of current evidence will be provided from the bronchitis severity score, symptom, and quality-of-life questionnaires, the questionnaire

2020 Medicine PubMed abstract

19. Efficacy of salbutamol in the treatment of infants with bronchiolitis: A meta-analysis of 13 studies. (Full text)

Efficacy of salbutamol in the treatment of infants with bronchiolitis: A meta-analysis of 13 studies. To systematically evaluate the clinical efficacy of salbutamol treatment in infants with bronchiolitis.A systematic review and meta-analysis of randomized controlled trials (RCTs) investigating the use of salbutamol in infants with bronchiolitis was performed. The Cochrane Risk of Bias Assessment Tool was used to evaluate the quality of RCTs. Data were extracted and meta-analyzed using STATA (...) version 12.0 (StataCorp, College Station, TX).Thirteen RCTs, including a total of 977 participants, were assessed in the present meta-analysis. Results indicated that salbutamol therapy for bronchiolitis in infants led to an increase in respiratory rate (weighted mean difference [WMD] 2.26 [95% confidence interval {CI} 0.36-4.16]) and higher heart rate (WMD 12.15 [95% CI 9.24-15.07]). However, as a selective β2-agonist, salbutamol did not improve the clinical severity score of infants

2020 Medicine PubMed abstract

20. The characteristics of the frequent exacerbators with chronic bronchitis phenotype and the asthma-chronic obstructive pulmonary disease overlap syndrome phenotype in chronic obstructive pulmonary disease patients: A meta-analysis and system review. (Full text)

The characteristics of the frequent exacerbators with chronic bronchitis phenotype and the asthma-chronic obstructive pulmonary disease overlap syndrome phenotype in chronic obstructive pulmonary disease patients: A meta-analysis and system review. To investigate the difference of clinical characteristics between chronic obstructive pulmonary disease (COPD) patients with the frequent exacerbators with chronic bronchitis (FE-CB) phenotype and those with the asthma-COPD overlap syndrome (ACO

2020 Medicine PubMed abstract