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Mitochondrial DNA copy number instability in ERBB2-amplified breastcancertumors 29743853 2018 11 14 1611-2156 17 2018 EXCLI journal EXCLI J Mitochondrial DNA copy number instability in ERBB2-amplified breastcancertumors. 149-158 10.17179/excli2017-819 Increase in the copy number of ERBB2 , a Tyrosine Kinase Receptor (TKR) leads to the overexpression of oncogene product and consequently uncontrolled cell proliferation which has been reported in different aggressive cancers with mitochondrial (...) malfunctions. Although, amplification of ERBB2 has been reported in different studies; however, the association between changes in mitochondrial DNA content and the ERBB2 gene copy number is poorly understood. The relative mitochondrial DNA content of breastcancertumor tissues of 70 patients who were referred to Imam Khomeini Hospital Complex was determined using quantitative Real-time PCR. Multiplex ligation-dependent probe amplification (MLPA) was conducted to evaluate the ERBB2 gene copy number
Faslodex for Locally Advanced or MetastaticBreastCancer – Details Faslodex for Locally Advanced or MetastaticBreastCancer – Details | CADTH.ca Français Français Find the information you need Faslodex for Locally Advanced or MetastaticBreastCancer – Details Faslodex for Locally Advanced or MetastaticBreastCancer – Details Project Number pCODR 10110 Brand Name Faslodex Generic Name Fulvestrant Tumour Type Breast Indication Locally Advanced or MetastaticBreastCancer Funding Request (...) For hormonal treatment of non-visceral locally advanced or metastaticbreastcancer in postmenopausal women, regardless of age, who have not been previously treated with endocrine therapy Review Status Pending Pre Noc Submission Yes NOC Date Manufacturer AstraZeneca Canada Inc. Submitter AstraZeneca Canada Inc. Submission Date (Target Date) July 17, 2017 Submission Type New Drug Prioritization Requested Stakeholder Input Deadline (target date based on target submission date) ‡ July 31, 2017 Check-point
Melatonin inhibits the proliferation of breastcancer cells induced by bisphenol A via targeting estrogen receptorâ€related pathways ORIGINAL ARTICLE Melatonin inhibits the proliferation of breastcancer cells induced by bisphenol A via targeting estrogen receptor-related pathways Tianjiao Wang 1,2* , Bowen Liu 1* , Yanan Guan 2 , Miaomiao Gong 2 , Weiying Zhang 1 , Jinjin Pan 2 , Yanan Liu 2 , Rui Liang 2† , Yuhui Yuan 2 & Lihong Ye 1 1 State Key Laboratory of Medicinal Chemical Biology (...) , Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin, China 2 Department of General Surgery, The Second Af?liated Hospital, Institute of Cancer Stem Cell, Dalian Medical University Cancer Center, Dalian, China Keywords Bisphenol A; breastneoplasms; estrogen response element; melatonin; steroid receptor coactivator. Correspondence Lihong Ye, State Key Laboratory of Medicinal Chemical Biology, Department of Cancer Research, Institute for Molecular Biology, College of Life
E2112: randomized phase iii trial of endocrine therapy plus entinostat/placebo in patients with hormone receptor-positive advanced breastcancer REVIEWARTICLE OPEN E2112: randomized phase iii trial of endocrine therapy plus entinostat/placebo in patients with hormone receptor-positive advanced breastcancer Sri Lakshmi Hyndavi Yeruva 1 , Fengmin Zhao 2 , Kathy D. Miller 3 , Amye J. Tevaarwerk 4 , Lynne I. Wagner 5 , Robert J. Gray 2 , Joseph A. Sparano 6 and Roisin M. Connolly 7 Endocrine (...) therapies are effective in the treatment of hormone receptor (HR)-positive breastcancer, however, de novo or acquired treatment resistance is a signi?cant clinical problem. A potential mechanism of resistance involves changes in gene expression secondary to epigenetic modi?cations, which might be reversed with the use of histone deacetylase (HDAC) inhibitors such as entinostat. The ENCORE 301 phase II randomized, placebo-controlled study demonstrated a signi?cant improvement in progression-free
Kisqali for MetastaticBreastCancer – Details Kisqali for MetastaticBreastCancer – Details | CADTH.ca Find the information you need Kisqali for MetastaticBreastCancer – Details Kisqali for MetastaticBreastCancer – Details Project Number pCODR 10112 Brand Name Kisqali Generic Name Ribociclib Tumour Type Breast Indication Advanced or MetastaticBreastCancer Funding Request For the treatment of postmenopausal women with hormone receptor (HR)-positive, human epidermal growth factor receptor (...) 2 (HER2)-negative advanced or metastaticbreastcancer, as an initial endocrine-based therapy Review Status Open for Input on Submission Pre Noc Submission Yes NOC Date Manufacturer Novartis Pharmaceuticals Canada Inc. Submitter Novartis Pharmaceuticals Canada Inc. Submission Date October 17, 2017 Submission Type New Drug Prioritization Requested Not Requested Stakeholder Input Deadline ‡ October 31, 2017 Check-point meeting (target date) pERC Meeting (target date) Initial Recommendation Issued
Association of Screening and Treatment With BreastCancer Mortality by Molecular Subtype in US Women, 2000-2012. Importance: Given recent advances in screening mammography and adjuvant therapy (treatment), quantifying their separate and combined effects on US breastcancer mortality reductions by molecular subtype could guide future decisions to reduce disease burden. Objective: To evaluate the contributions associated with screening and treatment to breastcancer mortality reductions (...) by molecular subtype based on estrogen-receptor (ER) and human epidermal growth factor receptor 2 (ERBB2, formerly HER2 or HER2/neu). Design, Setting, and Participants: Six Cancer Intervention and Surveillance Network (CISNET) models simulated US breastcancer mortality from 2000 to 2012 using national data on plain-film and digital mammography patterns and performance, dissemination and efficacy of ER/ERBB2-specific treatment, and competing mortality. Multiple US birth cohorts were simulated. Exposures
Manganeseâ€12 acetate suppresses the migration, invasion, and epithelialâ€“mesenchymal transition by inhibiting Wnt/Î²â€catenin and PI3K/AKT signaling pathways in breastcancer cells ORIGINAL ARTICLE Manganese-12 acetate suppresses the migration, invasion, and epithelial–mesenchymal transition by inhibiting Wnt/ß-catenin and PI3K/AKT signaling pathways in breastcancer cells Hongping Ju 1 , Yongxia Li 2 , Xiqian Xing 3 , Xisong Miao 1 , Yunping Feng 1 , Yunhui Ren 1 , Jing Qin 1 , Dian Liu 1 (...) , Zihao Chen 4 & Zhaoyu Yang 1 1 School of Medicine, Kunming University, Kunming, China 2 The Department of Respiratory Medicine, Second Ward, The Second Af?liated Hospital of Kunming Medical University, Kunming, China 3 The First Department of Respiratory Medicine, Yan’an Hospital Af?liated to Kunming Medical University, Kunming, China 4 The Graduate School, Hebei Medical University, Shijiazhuang, China Keywords Breastcancer; invasion; migration; manganese-12 acetate. Correspondence Zhaoyu Yang
Protocol for Moving On: a randomized controlled trial to increase outcome expectations and exercise among breastcancer survivors Nursing Open. 2018;5:101–108. | 101 wileyonlinelibrary.com/journal/nop2 R ec eiv ed: 16 F ebruary 2017 | A c c ep t ed: 21 O ct ober 2017 DOI: 10.1002/ nop2.119 STUDY PROTOCOL Protocol for Moving On: a randomized controlled trial to increase outcome expectations and exercise among breastcancer survivors Rachel Hirschey 1 | Gretchen Kimmick 2 | Marilyn Hockenberry 1 (...) sche y , D uk e U niv er sity S chool o f N ur sing, D urham, NC, US A. Email: firstname.lastname@example.org Funding Information T his r esear ch is funded b y NINR 1F31NR015690-01 and O nc olo gy N ur sing S ocie ty F ounda tion Abstract Aim : The aim of this study was to test the feasibility and fidelity of an intervention, Moving On, aimed to increase outcome expectations OEs (i.e. what one expects to obtain or avoid as a result of a behaviour) and exercise among breastcancer survivors. Design : Randomized
BreastCancer Screening Behaviors of First Degree Relatives of Women Receiving BreastCancer Treatment and the Affecting Factors Original Article Introduction Breastcancer is the most common cancer among females in Turkey. Incidence rate in the year 2008 was 40.7 in 100,000 and this rate increased to 43 in 2014 (1). Breastcancer incidence in Turkey is similar to the other developing countries but mortality is higher when compared with these countries (2). The best way to fight cancer (...) is to prevent its development by controlling the known risk factors. The most important risk factors for breastcancer are female gender, advancing age and family history. First-degree relatives (mother, sister and daughters) of women with breastcancer are at higher risk when compared with the general population and it has been reported that family history has a role in 5-10% of cases (3). Studies from T urkey have reported the genetic risk ranging from 5.4% to 25.9% (4-7). One study found that in all age
Granulomatous Mastitis Concurrence with BreastCancer Case Report Address for Correspondence : Hasan Çalis, e-mail: email@example.com Received: 01.10.2017 Accepted: 07.11.2017 Eur J Breast Health 2018; 14: 58-60 DOI: 10.5152/ejbh.2017.3804 58 Introduction Idiopathic Granulomatous Mastitis (IGM) is a rare, chronic, non-malignant and non-life-threatening breast disease (1). Clinically and radiologically, it mimics carcinoma of the breast. The most common complaints of patients (...) are unilaterally emerging breast pain or painless masses (2, 3). This case highlights the possibility that the concurrence of chronic granulomatous mastitis with breastcancer may be explained just as an adjunct situation or a coincidence and may be the difficulty in distinguishing one from the other. Case Presentation A 77-year-old female was admitted to our clinic with complaints of breast pain, accompanied by edema and thickening of the skin at 9 o’clock of the right breast, close to the areola. Initial
A Patient Advocacy Group Summit, Cancer Care in Turkey and The Society of Breast Health Editorial According to the World Health Organization (WHO), cancer now causes more deaths than all cardiac or all other diseases (1). The num- ber of new cases is expected to rise by about 70% over the next 2 decades. Globally, nearly 1 in 6 deaths is due to cancer, and approximately 70% of deaths from cancer occur in low- and middle-income countries (2). There is a significant disparity in cancer care (...) cancer scientists in a way similar to The Society of Breast Health to perform basic, reliable, and reasonable clinical projects based on the economic, socio-cultural and educational structure of a country. The number of PAGs should be increased and representatives of them should be participated in governmental organizations (such as National cancer Advisory Board, National Cancer Institute, etc.) to advocate and acquire their rights. Their participation abso- lutely provides integrity in health care
MONARCH 3: Abemaciclib As Initial Therapy for Advanced BreastCancer 28968163 2017 11 13 2017 11 13 1527-7755 35 32 2017 Nov 10 Journal of clinical oncology : official journal of the American Society of Clinical Oncology J. Clin. Oncol. MONARCH 3: Abemaciclib As Initial Therapy for Advanced BreastCancer. 3638-3646 10.1200/JCO.2017.75.6155 Purpose Abemaciclib, a cyclin-dependent kinase 4 and 6 inhibitor, demonstrated efficacy as monotherapy and in combination with fulvestrant in women (...) with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breastcancer previously treated with endocrine therapy. Methods MONARCH 3 is a double-blind, randomized phase III study of abemaciclib or placebo plus a nonsteroidal aromatase inhibitor in 493 postmenopausal women with HR-positive, HER2-negative advanced breastcancer who had no prior systemic therapy in the advanced setting. Patients received abemaciclib or placebo (150 mg twice daily continuous
Randomized, Multicenter, Placebo-Controlled Clinical Trial of Duloxetine Versus Placebo for Aromatase Inhibitor-Associated Arthralgias in Early-Stage BreastCancer: SWOG S1202 29136387 2017 12 19 1527-7755 2017 Nov 14 Journal of clinical oncology : official journal of the American Society of Clinical Oncology J. Clin. Oncol. Randomized, Multicenter, Placebo-Controlled Clinical Trial of Duloxetine Versus Placebo for Aromatase Inhibitor-Associated Arthralgias in Early-Stage BreastCancer: SWOG (...) S1202. JCO2017746651 10.1200/JCO.2017.74.6651 Purpose Adherence to aromatase inhibitor (AI) therapy for early-stage breastcancer is limited by AI-associated musculoskeletal symptoms (AIMSS). Duloxetine is US Food and Drug Administration approved for treatment of multiple chronic pain disorders. We hypothesized that treatment of AIMSS with duloxetine would improve average joint pain compared with placebo. Methods This randomized, double-blind, phase III trial included AI-treated postmenopausal women
MetastaticbreastcancerMetastaticbreastcancer - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search Metastaticbreastcancer Last reviewed: August 2018 Last updated: April 2018 Summary There is great heterogeneity in both the presentation and prognosis of metastaticbreastcancer. Multi-gene expression panels are being evaluated to determine which women with early stage breastcancer are more likely to develop (...) metastatic disease. Decisions on whether or not to treat a patient with metastaticbreastcancer and the aggressiveness of treatment must be individualised, based on patient prognosis, tumour characteristics, performance status, and the primary goals of treatment. Unlike stage I to III breastcancer, the primary goal of treatment in metastaticbreastcancer is often to improve quality of life, with extending life a secondary goal. Definition Breastcancer is considered metastaticbreastcancer (MBC