Latest & greatest articles for breast cancer

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Top results for breast cancer

181. Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer. Full Text available with Trip Pro

Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer. Unresectable locally advanced or metastatic triple-negative (hormone-receptor-negative and human epidermal growth factor receptor 2 [HER2]-negative) breast cancer is an aggressive disease with poor outcomes. Nanoparticle albumin-bound (nab)-paclitaxel may enhance the anticancer activity of atezolizumab.In this phase 3 trial, we randomly assigned (in a 1:1 ratio) patients with untreated metastatic triple-negative breast (...) tumors, the median overall survival was 25.0 months and 15.5 months, respectively (hazard ratio, 0.62; 95% CI, 0.45 to 0.86). No new adverse effects were identified. Adverse events that led to the discontinuation of any agent occurred in 15.9% of the patients who received atezolizumab plus nab-paclitaxel and in 8.2% of those who received placebo plus nab-paclitaxel.Atezolizumab plus nab-paclitaxel prolonged progression-free survival among patients with metastatic triple-negative breast cancer in both

2018 NEJM Controlled trial quality: predicted high

182. Molecular determinants of post-mastectomy breast cancer recurrence Full Text available with Trip Pro

signaling are associated with a more aggressive tumor phenotype. Validation of these associations in tissues from randomized trials may support targeted therapy to reduce breast cancer recurrence. (...) Molecular determinants of post-mastectomy breast cancer recurrence Breast cancer (BC) adjuvant therapy after mastectomy in the setting of 1-3 positive lymph nodes has been controversial. This retrospective Translational Breast Cancer Research Consortium study evaluated molecular aberrations in primary cancers associated with locoregional recurrence (LRR) or distant metastasis (DM) compared to non-recurrent controls. We identified 115 HER2 negative, therapy naïve, T 1-3 and N 0-1 BC patients

2018 NPJ breast cancer

183. Long term adjuvant endocrine therapy and risk of cardiovascular disease in female breast cancer survivors: systematic review. Full Text available with Trip Pro

Long term adjuvant endocrine therapy and risk of cardiovascular disease in female breast cancer survivors: systematic review. To investigate the effect of endocrine therapies on a wide range of specific clinical cardiovascular disease outcomes in women with a history of non-metastatic breast cancer.Systematic review and meta-analysis of randomised controlled trials and observational studies.Medline and Embase up until June 2018.Studies were included if they investigated the risk of a specific (...) thromboembolism and myocardial infarction, progressing knowledge. Although the choice of aromatase inhibitor or tamoxifen will primarily be based on the effectiveness against the recurrence of breast cancer, this review shows that the individual patient's risk of venous or arterial vascular disease should be an important secondary consideration.Prospero CRD42017065944.Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http

2018 BMJ

184. Axillary Lymph Node Dissection for Breast Cancer: Efficacy and Complication in Developing Countries Full Text available with Trip Pro

Axillary Lymph Node Dissection for Breast Cancer: Efficacy and Complication in Developing Countries Axillary lymph node dissection (ALND) frequently is performed as part of the surgical management of breast cancer as a therapeutic and prognostic index, but increasingly has been perceived as associated with significant complications. Data on efficacy and complications of ALND in Sudan are lacking. The aim of this study was to assess the efficacy and complications of ALND in patients with breast (...) cancer treated with mastectomy and breast-conserving surgery.We performed a prospective, hospital-based study in women with invasive breast cancer who underwent modified radical mastectomy or breast-conserving surgery with ALND between September 2014 and August 2015. The efficacy of ALND was defined as retrieval of ≥ 10 lymph nodes. Complications of ALND were assessed objectively and subjectively and defined as either present or absent.Of 96 patients with breast cancer included in the study, 40 (42

2018 Journal of global oncology

185. Should This Woman With Dense Breasts Receive Supplemental Breast Cancer Screening?: Grand Rounds Discussion From Beth Israel Deaconess Medical Center. (Abstract)

for breast cancer. In addition, for women with dense breasts, small tumors may be missed on mammography and the sensitivity of screening is diminished. At the time of publication, 35 states had passed laws mandating that breast density be reported in the letters that radiologists send to women with their mammogram results. The mandated language may be challenging for patients to understand, and such reporting may increase worry for women who are told that their risk for breast cancer is higher than (...) Should This Woman With Dense Breasts Receive Supplemental Breast Cancer Screening?: Grand Rounds Discussion From Beth Israel Deaconess Medical Center. Breast cancer will develop in 12% of women during their lifetime and is the second leading cause of cancer death among U.S. women. Mammography is the most commonly used tool to screen for breast cancer. Considerable uncertainty exists regarding the age at which to begin screening and the optimal screening interval. Breast density is a risk factor

2018 Annals of Internal Medicine

186. Blood Pressure Measurement as a Risk Factor for Lymphedema in Females Post Breast Cancer Treatment

included “blood pressure” and “lymphedema” and (“breast cancer” or “breast neoplasm”). The quality of evidence was assessed using the GRADE Working Group guidelines. Results: A total of 4 articles were included in this systematic review, all of which were prospective cohort studies. Three studies found no significantly increased risk of lymphedema with blood pressure measurements. One study measured lymphedema using 3 different techniques and found a significantly increased risk with one (...) of the techniques but not the others. Conclusion: This systematic review refutes the current guidelines that patients should avoid blood pressure monitoring in the affected arm. Further research that looks at how to define lymphedema and how to best diagnose it in the clinic will help with implementing earlier treatment. Keywords: Blood pressure, lymphedema, breast cancer, and breast neoplasm Recommended Citation Braesch, Chelsea, "Blood Pressure Measurement as a Risk Factor for Lymphedema in Females Post

2018 Pacific University EBM Capstone Project

187. Manual lymph drainage may not have a preventive effect on the development of breast cancer-related lymphoedema in the long term: a randomised trial Full Text available with Trip Pro

Manual lymph drainage may not have a preventive effect on the development of breast cancer-related lymphoedema in the long term: a randomised trial What are the short-term and long-term preventive effects of manual lymph drainage (MLD), when used in addition to information and exercise therapy, on the development of lymphoedema after axillary dissection for breast cancer?Randomised controlled trial with concealed allocation, blinded assessors and intention-to-treat analysis.Adults undergoing (...) unilateral dissection for breast cancer were recruited, with 79 allocated to the experimental group and 81 to the control group.The experimental group received guidelines about prevention of lymphoedema, exercise therapy and MLD. The control group received the same guidelines and exercise therapy, but no MLD. The interventions in both groups were delivered for 6 months.The primary outcome was cumulative incidence of arm lymphoedema defined in four ways (≥200ml,≥2cm,≥5%, and≥10% increase), which represent

2018 EvidenceUpdates

188. The Effect on Quality of Life and Body Image of Mastectomy Among Breast Cancer Survivors Full Text available with Trip Pro

The Effect on Quality of Life and Body Image of Mastectomy Among Breast Cancer Survivors The objective of the present study was to determine effect on quality of life (QoL) and body image level following mastectomy among breast cancer (BC) survivors.In this descriptive study was carried out between February 2015 and December 2016 with 57 women with modified radical mastectomy and who in stage II and stage III. Data were collected using the socio-demographic and body cathexis scale, Functional (...) Assessment of Cancer Therapy-Breast (FACT-B) to determine QoL. The study was carried out in home environment in which women lived.The average age of the women was 49.34 years (ranged 28-78 years). Most of the women had undergone mastectomy for more than 6 months.. Most of the women also received adjuvant chemotherapy and radiotherapy. The study showed that the mean FACT-B total score of the women was 68.47 (SD=22.44), and the body image score was 121.61(SD=21.96). According to the results of linear

2018 European journal of breast health

189. The Impact of Subtype Distribution in Inflammatory Breast Cancer Outcome Full Text available with Trip Pro

%) were triple negative (TNBC) by immunohistochemistry. There were no statistically significant differences between subtypes in terms of histological type, grade, tumour size and lymph node status. Median disease-free survival was 47 months (95% confidence interval [CI] 29.2-82.6) and median overall survival was 75 months (95% CI 64.7-90.8). Triple negative breast cancer showed poorer outcome than other subgroups. Presence of TNBC disease was associated with poorer outcome compared to luminal A (HR (...) between March 2000 and December 2015 were retrospectively reviewed. Patient demographics, clinical and pathological feature of the primary tumour, adjuvant treatment options and survival data were analysed. Intrinsic breast cancer subtypes were defined according to ER, PR, HER-2 and ki-67 status.We identified 129 non-metastatic inflammatory breast cancer patients. Median follow-up was 73 months. 10 (7.7%) were luminal A-like, 67 (51.9%) were luminal B-like, 37 (28.6%) were HER-2 positive, and 15 (11.6

2018 European journal of breast health

190. QOL Evaluation of Nab-Paclitaxel and Docetaxel for Early Breast Cancer Full Text available with Trip Pro

QOL Evaluation of Nab-Paclitaxel and Docetaxel for Early Breast Cancer A previous randomized phase II study showed that neoadjuvant nab-paclitaxel (nab-PTX) 100 mg/m2) was effective and well-tolerated in patients with HER2-negative early-stage breast cancer, compared with docetaxel (DTX). We evaluated patient outcomes in terms of the Functional Assessment of Cancer Therapy-Breast (FACT-B), as a measure of health-related quality of life (HRQoL).Stage I-III HER2-negative breast cancer patients

2018 European journal of breast health Controlled trial quality: uncertain

191. Impact of The Method of Diagnosis on The Stage of Breast Carcinoma Full Text available with Trip Pro

Impact of The Method of Diagnosis on The Stage of Breast Carcinoma Screening mammography is recommended to women at a certain age to achieve an early diagnosis. The purpose of this study is to find out how breast carcinoma was diagnosed and the impact of the method of diagnosis on the stage of the tumor.In this study, 903 operated breast cancer patients, between 2010-2016, in a large volume Marmara University Istanbul Pendik Education and Research Hospital were analyzed retrospectively (...) patients (65.7%) were diagnosed with a mass in the breast, while 241 (32.6%) patients were diagnosed with screening with mammography. Twelve patients (1.7%) presented with nipple discharge. Median tumor sizes measured in the resected specimen were 22 mm, 21 mm, and 21 mm in patients diagnosed with a mass, screening, and nipple discharge respectively. The difference among the groups were not significant (p=0.460).Axillary lymph nodes were positive in 210 (43.3%) of patients presenting with a mass

2018 European journal of breast health

192. Risk-Reducing Options for Women with a Hereditary Breast Cancer Predisposition Full Text available with Trip Pro

Risk-Reducing Options for Women with a Hereditary Breast Cancer Predisposition Genetic testing is now widely utilized to identify women with a hereditary predisposition for breast cancer. Women who carry mutations that increase breast cancer risk may consider three options to reduce risk: screening, chemoprevention, and prophylactic surgery. Yet, no randomized trials have specifically assessed the efficacy of these options in mutation carriers. In many developed countries, mammography (...) is regarded as the optimal means of screening for breast cancer in the general population. However, breast MRI is a more sensitive screening tool, and for mutation carriers, any breast cancer screening strategy should incorporate screening with MRI. In randomized trials of women at high risk for developing breast cancer, chemoprevention reduces that risk, but it has not been shown to reduce mortality. Finally, observational studies suggest that, in mutation carriers, prophylactic surgery may reduce

2018 European journal of breast health

193. The Significance of Extent of Extracapsular Extension in Patients with T1-2 and N1 Breast Cancer Full Text available with Trip Pro

The Significance of Extent of Extracapsular Extension in Patients with T1-2 and N1 Breast Cancer The prognostic importance of extracapsular extension (ECE) in breast cancer is not yet clear, especially in patients with pathological T1-2 and N1 (pT1-2N1) disease. We aimed to investigate whether the extent of ECE was an independent prognostic factor for survival outcomes in patients with pT1-2N1 breast cancer.A total number of 131 patients with pT1-2N1 breast cancer treated between 2009 and 2015 (...) in pT1-2N1 breast cancer patients and grade 3-4 ECE seems to be notably associated with a shorter OS and DFS.

2018 European journal of breast health

194. Evaluation of Breast Cancer (BC) Awareness among Female University Students in Zarqa University, Jordan Full Text available with Trip Pro

Evaluation of Breast Cancer (BC) Awareness among Female University Students in Zarqa University, Jordan The purposes of this study were to assess the level of Breast Cancer (BC) awareness of Jordanian female university students, measure their attitudes toward BC treatment, and compare the level of awareness and attitudes of students in the science and humanities faculties.The current study was cross-sectional and conducted among female students in Zarqa University in Jordan. Stratified random

2018 European journal of breast health

195. Androgen receptor expression in normal breast tissue and subsequent breast cancer risk Full Text available with Trip Pro

Androgen receptor expression in normal breast tissue and subsequent breast cancer risk Sex steroid hormone signaling is critical in the development of breast cancers, although the role of the androgen receptor remains unclear. This study evaluated androgen receptor (AR) expression in normal breast tissue as a potential marker of breast cancer risk. We conducted a nested case-control study of women with benign breast disease (BBD) within the Nurses' Health Studies. Epithelial AR expression (...) was assessed by immunohistochemistry in normal tissue from the BBD biopsy and the percent of positive nuclei was estimated in ordinal categories of 10% for 78 breast cancer cases and 276 controls. Logistic regression models adjusting for the matching factors and BBD lesion type were used to calculate odds ratios (ORs) for the association between AR expression (tertiles: ≤10%, 11-30%, and >30%) and breast cancer risk. AR expression in normal breast tissue was not associated with subsequent breast cancer

2018 NPJ breast cancer

196. Validation of CPS+EG, Neo‐Bioscore, and modified Neo‐Bioscore staging systems after preoperative systemic therapy of breast cancer: Protocol of a retrospective multicenter cohort study in China Full Text available with Trip Pro

trastuzumab treatment, to determine accurate prognosis. We propose a retrospective multicenter cohort study in China to validate CPS + EG, Neo-Bioscore, and the modified Neo-Bioscore system and determine the accuracy of prediction. Primary breast cancer patients without metastasis treated with PST and surgery in academic institutions or hospitals of provincial level in China will be included. Disease-free, disease specific, and overall survival will be calculated using the Kaplan-Meier Method, stratified (...) Validation of CPS+EG, Neo‐Bioscore, and modified Neo‐Bioscore staging systems after preoperative systemic therapy of breast cancer: Protocol of a retrospective multicenter cohort study in China Prognostic assessment after preoperative systemic therapy (PST) is critical to develop a therapeutic strategy for breast cancer management. Currently, a clinical-pathologic staging system that incorporates ER status and nuclear grading (CPS + EG), and the Neo-Bioscore system that includes HER2 status

2018 Thoracic cancer

197. Survival estimates stratified by the Nottingham Prognostic Index for early breast cancer: a systematic review and meta-analysis of observational studies. Full Text available with Trip Pro

Survival estimates stratified by the Nottingham Prognostic Index for early breast cancer: a systematic review and meta-analysis of observational studies. Estimates of survival for women diagnosed with early staged breast cancer are available based on stratification into prognostic categories defined using the Nottingham Prognostic Index (NPI). This review aimed to identify and summarize the estimated survival statistics from separate sources in the literature and to explore the extent (...) of between-study heterogeneity in survival estimates.Observational studies in women diagnosed with early and locally advanced breast cancer reporting overall survival by NPI category were identified using a systematic literature search. An exploratory meta-analysis was conducted to describe survival estimates and assess between-study heterogeneity.Twenty-eight studies were identified. Nineteen studies with sufficient data on overall survival were included in meta-analysis. A high level of heterogeneity

2018 Systematic Reviews

198. Prevalence of BRCA1 and BRCA2 Mutations Among High-Risk Saudi Patients With Breast Cancer Full Text available with Trip Pro

Prevalence of BRCA1 and BRCA2 Mutations Among High-Risk Saudi Patients With Breast Cancer Purpose Over the past three decades, the incidence rate of breast cancer (BC) among Arab women has continually increased. However, data on the prevalence of BRCA1/2 mutations are scarce. Although the population in Saudi Arabia is at large homogeneous and consanguinity is common, especially in the central, eastern, and southern regions of the country, the prevalence of BRCA1 and BRCA2 mutations

2018 Journal of global oncology

199. Genomic and expression profiling reveal molecular heterogeneity of disseminated tumor cells in bone marrow of early breast cancer Full Text available with Trip Pro

Genomic and expression profiling reveal molecular heterogeneity of disseminated tumor cells in bone marrow of early breast cancer Detection of disseminated tumor cells (DTCs) in bone marrow is an established negative prognostic factor. We isolated small pools of (~20) EPCAM-positive DTCs from early breast cancer patients for genomic profiling. Genome-wide copy number profiles of DTC pools (n = 45) appeared less aberrant than the corresponding primary tumors (PT, n = 16). PIK3CA mutations were (...) ). We observed high discordance between ESR1 (40%) and ERRB2 (43%) expression in DTC pools vs. the clinical ER and HER2 status of the corresponding primary tumors, suggesting plasticity of biomarker status during dissemination to the bone marrow. Comparison of expression profiles of DTC pools with available data from circulating tumor cells (CTCs) of metastatic breast cancer patients revealed gene expression signatures in DTCs that were unique from those of CTCs. For example, ALDH1A1, CAV1, and VIM

2018 NPJ breast cancer

200. Correlating nuclear morphometric patterns with estrogen receptor status in breast cancer pathologic specimens Full Text available with Trip Pro

Correlating nuclear morphometric patterns with estrogen receptor status in breast cancer pathologic specimens In this pilot study, we introduce a machine learning framework to identify relationships between cancer tissue morphology and hormone receptor pathway activation in breast cancer pathology hematoxylin and eosin (H&E)-stained samples. As a proof-of-concept, we focus on predicting clinical estrogen receptor (ER) status-defined as greater than one percent of cells positive for estrogen (...) receptor by immunohistochemistry staining-from spatial arrangement of nuclear features. Our learning pipeline segments nuclei from H&E images, extracts their position, shape and orientation descriptors, and then passes them to a deep neural network to predict ER status. After training on 57 tissue cores of invasive ductal carcinoma (IDC), our pipeline predicted ER status in an independent test set of patient samples (AUC ROC = 0.72, 95%CI = 0.55-0.89, n = 56). This proof of concept shows that machine

2018 NPJ breast cancer