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Latest & greatest articles for breast cancer
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on breast cancer or other clinical topics then use Trip today.
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BreastCancer Risk After Recent Childbirth: A Pooled Analysis of 15 Prospective Studies. Background: Parity is widely recognized as protective for breastcancer, but breastcancer risk may be increased shortly after childbirth. Whether this risk varies with breastfeeding, family history of breastcancer, or specific tumor subtype has rarely been evaluated. Objective: To characterize breastcancer risk in relation to recent childbirth. Design: Pooled analysis of individual-level data from 15 (...) prospective cohort studies. Setting: The international Premenopausal BreastCancer Collaborative Group. Participants: Women younger than 55 years. Measurements: During 9.6 million person-years of follow-up, 18 826 incident cases of breastcancer were diagnosed. Hazard ratios (HRs) and 95% CIs for breastcancer were calculated using Cox proportional hazards regression. Results: Compared with nulliparous women, parous women had an HR for breastcancer that peaked about 5 years after birth (HR, 1.80 [95% CI
Trastuzumab Emtansine for Residual Invasive HER2-Positive BreastCancer. BACKGROUND: Patients who have residual invasive breastcancer after receiving neoadjuvant chemotherapy plus human epidermal growth factor receptor 2 (HER2)-targeted therapy have a worse prognosis than those who have no residual cancer. Trastuzumab emtansine (T-DM1), an antibody-drug conjugate of trastuzumab and the cytotoxic agent emtansine (DM1), a maytansine derivative and microtubule inhibitor, provides benefit (...) in patients with metastaticbreastcancer that was previously treated with chemotherapy plus HER2-targeted therapy. METHODS: We conducted a phase 3, open-label trial involving patients with HER2-positive early breastcancer who were found to have residual invasive disease in the breast or axilla at surgery after receiving neoadjuvant therapy containing a taxane (with or without anthracycline) and trastuzumab. Patients were randomly assigned to receive adjuvant T-DM1 or trastuzumab for 14 cycles
HER2 Testing in BreastCancer - 2018 Focused Update HER2 Testing in BreastCancer -… | College of American Pathologists Cap icon Group CAP_logo_rgb User Toggle Navigation Menu Search Down Arrow Down Arrow Down Arrow Down Arrow Down Arrow Down Arrow Down Arrow HER2 Testing in BreastCancer - 2018 Focused Update HER2 Testing in BreastCancer - 2018 Focused Update To address new information made available since the 2013 “Human Epidermal Growth Factor Receptor 2 (HER2) Testing in BreastCancer (...) 2+ (equivocal) to the original FDA-approved criteria. Repeat HER2 testing on a surgical specimen if the initially tested core biopsy is negative is no longer stated as mandatory. A new HER2 test may (no longer should ) be ordered on the excision specimen on the basis of some criteria (such as tumor grade 3). A more rigorous interpretation criteria of the less common patterns that can be seen in about 5% of all cases when HER2 status in breastcancer is evaluated using a dual-probe ISH testing
Recommendations on screening for breastcancer in women 40-74 years of age who are not at increased risk Recommendations on screening for breastcancer in women aged 40–74 years who are not at increased risk for breastcancer | CMAJ Main menu User menu Search Search for this keyword Search for this keyword Guideline Recommendations on screening for breastcancer in women aged 40–74 years who are not at increased risk for breastcancer Scott Klarenbach , Nicki Sims-Jones , Gabriela Lewin (...) POINTS Low-certainty evidence indicates that screening for breastcancer with mammography results in a modest reduction in breastcancer mortality for women aged 40 to 74 years; the absolute benefit is lowest for women younger than 50 years. Screening may lead to overdiagnosis, resulting in unnecessary treatment of cancer that would not have caused harm in a woman’s lifetime and false-positive results that can lead to both physical and psychological consequences; overdiagnosis and false-positives
BreastCancer Risk Factors At a Glance Age 50 years old 30 years old Height 172 cm 162 cm ( average female height in Australia ) Reproductive factors Family history and genetic factors Lifestyle factors Personal factors VS. VS. 152 cm 162 cm ( average female height in Australia ) Mammographic breast density VS. Extremely dense breasts averagely dense breasts VS. Body mass index ( postmenopausal women ) VS. Adult weight gain ( postmenopausal women ) Weight gain (5kg) no weight gain VS. Weight (...) gain (10kg) Weight gain (20kg) Alcohol consumption 2 drinks per day no daily alcohol consumption VS. Physical activity Most active least active ( postmenopausal women ) VS. 4 drinks per day 6 drinks per day BreastCancer Risk Factors At a Glance Decreased risk Increased risk 1 2 3 4 5 6 7 8 910 0.5 0.33 0.25 0.2 0.125 0.1 10 1.17 0.85 2.14 1.12 1.25 1.40 1.06 1.12 1.26 1.15 1.31 1.50 0.87 VS. VS. no weight gain VS. no weight gain VS. no daily alcohol consumption VS. no daily alcohol consumption VS
Meta-analysis of sentinel lymph node biopsy after neoadjuvant chemotherapy in patients with initial biopsy-proven node-positive breastcancer 30311642 2018 10 12 1365-2168 105 12 2018 Nov The British journal of surgery Br J Surg Meta-analysis of sentinel lymph node biopsy after neoadjuvant chemotherapy in patients with initial biopsy-proven node-positive breastcancer. 1541-1552 10.1002/bjs.10986 Neoadjuvant chemotherapy for breastcancer has the potential to achieve a pathological complete (...) response in up to 40 per cent of patients, converting disease that was initially node-positive to node-negative. This has raised the question of whether sentinel lymph node biopsy could be an alternative to axillary lymph node dissection in these patients. The aim was to undertake a systematic review and meta-analysis of the accuracy and reliability of sentinel lymph node biopsy after neoadjuvant chemotherapy in patients with initial biopsy-proven node-positive breastcancer. A literature search
Limited Evidence Suggests Periodontal Disease Is Associated with a Slightly Increased Risk of BreastCancer UTCAT3364, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Limited Evidence Suggests Periodontal Disease Is Associated with a Slightly Increased Risk of BreastCancer Clinical Question In female patients with periodontal disease, is there an increased risk for breastcancer when compared to women without (...) periodontal disease? Clinical Bottom Line Patients with periodontitis have a slightly increased risk of breastcancer according to limited evidence from one meta-analysis and a prospective cohort study. History of smoking may play a role in this relationship and more evidence is required before specific recommendations can be made to patients with periodontitis. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1
Pertuzumab (Perjeta) - treatment of adult patients with HER2 positive, locally advanced, inflammatory, or early stage breastcancer at high risk of recurrence 1 Published 10 December 2018 1 SMC2119 pertuzumab 420mg concentrate for solution for infusion (Perjeta®) Roche Products Limited Resubmission 9 November 2018 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product and advises NHS Boards and Area Drug and Therapeutic Committees (ADTCs) on its use (...) in NHSScotland. The advice is summarised as follows: ADVICE: following a second resubmission assessed under the orphan medicine process pertuzumab (Perjeta ® ) is accepted for use within NHSScotland. Indication under review: for use in combination with trastuzumab and chemotherapy in the neoadjuvant treatment of adult patients with HER2-positive, locally advanced, inflammatory, or early stage breastcancer at high risk of recurrence. In a phase II study conducted in women with locally advanced, inflammatory
Diagnostic Accuracy of Different Surgical Procedures for Axillary Staging After Neoadjuvant Systemic Therapy in Node-positive BreastCancer: A Systematic Review and Meta-analysis 30312200 2018 10 12 1528-1140 2018 Oct 11 Annals of surgery Ann. Surg. Diagnostic Accuracy of Different Surgical Procedures for Axillary Staging After Neoadjuvant Systemic Therapy in Node-positive BreastCancer: A Systematic Review and Meta-analysis. 10.1097/SLA.0000000000003075 The aim of this study was to perform (...) a systematic review and meta-analysis to assess the accuracy of different surgical axillary staging procedures compared with ALND. Optimal axillary staging after neoadjuvant systemic therapy (NST) in node-positive breastcancer is an area of controversy. Several less invasive procedures, such as sentinel lymph node biopsy (SLNB), marking axillary lymph node with radioactive iodine seed (MARI), and targeted axillary dissection (a combination of SLNB and a MARI-like procedure), have been proposed to replace
Herceptin® (trastuzumab) in HER2-positive early breastcancer: a systematic review and cumulative network meta-analysis. BACKGROUND: Originator trastuzumab (Herceptin®; H) is an antibody-targeted therapy to treat patients with human epidermal growth factor receptor 2-positive (HER2+) early breastcancer (EBC). We investigated the overall survival (OS) advantage conferred by the addition of H to chemotherapy for HER2+ EBC patients and how the OS advantage changed over time. METHODS: A systematic
Axillary dissection versus no axillary dissection in patients with breastcancer and sentinel-node micrometastases (IBCSG 23-01): 10-year follow-up of a randomised, controlled phase 3 trial 30196031 2018 10 10 1474-5488 19 10 2018 Oct The Lancet. Oncology Lancet Oncol. Axillary dissection versus no axillary dissection in patients with breastcancer and sentinel-node micrometastases (IBCSG 23-01): 10-year follow-up of a randomised, controlled phase 3 trial. 1385-1393 S1470-2045(18)30380-2 (...) 10.1016/S1470-2045(18)30380-2 We previously reported the 5-year results of the phase 3 IBCSG 23-01 trial comparing disease-free survival in patients with breastcancer with one or more micrometastatic (≤2 mm) sentinel nodes randomly assigned to either axillary dissection or no axillary dissection. The results showed no difference in disease-free survival between the groups and showed non-inferiority of no axillary dissection relative to axillary dissection. The current analysis presents the results
First-Line Trastuzumab Plus an Aromatase Inhibitor, With or Without Pertuzumab, in Human Epidermal Growth Factor Receptor 2-Positive and Hormone Receptor-Positive Metastatic or Locally Advanced BreastCancer (PERTAIN): A Randomized, Open-Label Phase II Tr 30106636 2018 09 26 1527-7755 36 28 2018 Oct 01 Journal of clinical oncology : official journal of the American Society of Clinical Oncology J. Clin. Oncol. First-Line Trastuzumab Plus an Aromatase Inhibitor, With or Without Pertuzumab (...) , in Human Epidermal Growth Factor Receptor 2-Positive and Hormone Receptor-Positive Metastatic or Locally Advanced BreastCancer (PERTAIN): A Randomized, Open-Label Phase II Trial. 2826-2835 10.1200/JCO.2017.76.7863 To assess pertuzumab plus trastuzumab and an aromatase inhibitor (AI) in patients with human epidermal growth factor receptor 2 (HER2)-positive and hormone receptor-positive metastatic/locally advanced breastcancer (MBC/LABC). The PERTAIN trial (NCT01491737) is an ongoing randomized, open
Implant Based Breast Reconstruction With Acellular Dermal Matrix: Safety Data From an Open-label, Multicenter, Randomized, Controlled Trial in the Setting of BreastCancer Treatment 30308615 2018 10 19 1528-1140 2018 Oct 17 Annals of surgery Ann. Surg. Implant Based Breast Reconstruction With Acellular Dermal Matrix: Safety Data From an Open-label, Multicenter, Randomized, Controlled Trial in the Setting of BreastCancer Treatment. 10.1097/SLA.0000000000003054 To evaluate clinical outcomes (...) of using acellular dermal matrix (ADM) with implant based breast reconstructions (IBBRs) in a randomized controlled trial. The use of ADMs in IBBRs is widespread, but link between ADM and complications remain a controversial topic. In view of reports concerning harm, we present 6-months safety data of ADM-assisted IBBR in the setting of breastcancer treatment. An open-label, randomized, controlled trial recruiting patients from 4 centers in Sweden and 1 in UK. Eligible were women with breastcancer
Delaying chemotherapy after breastcancer surgery may reduce survival chances Signal - Delaying chemotherapy after breastcancer surgery may reduce survival chances Dissemination Centre Discover Portal NIHR DC Discover Delaying chemotherapy after breastcancer surgery may reduce survival chances Published on 31 January 2017 Delaying chemotherapy after breastcancer surgery may slightly decrease a woman’s chances of survival. A review found about a 5% increase in the relative risk of death. Many (...) women are offered chemotherapy soon after breastcancer surgery, called adjuvant chemotherapy. Chemotherapy is usually started after the surgical wounds have healed but the effect of any delay to this was unclear. These researchers calculated the risk from outcomes for almost 30,000 women treated with adjuvant chemotherapy, from studies in Europe and North America. The absolute risk of death for any woman will depend on her individual cancer stage and characteristics. A four week delay could add
Common osteoporosis drugs may prevent breastcancer spreading to bone Signal - Common osteoporosis drugs may prevent breastcancer spreading to bone Dissemination Centre Discover Portal NIHR DC Discover Common osteoporosis drugs may prevent breastcancer spreading to bone Published on 13 March 2018 Drugs commonly prescribed to prevent bone thinning probably help prevent the spread of early breastcancer to the bones in a few women, when taken in addition to standard cancer therapies. However (...) , the overall benefits may be small, for example preventing spread to bone or death in about one extra woman in every 100 treated for about five years. This is a complex area because many of the treatments for breastcancer are known to worsen bone thinning, but there are other bone strengthening benefits to these drugs. This large review of 44 studies with more than 37,000 participants looked at women with either early breastcancer or advanced breastcancer with or without bone involvement. The reviewers