Latest & greatest articles for babies

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Top results for babies

1. Premature babies have fewer complications if a lower platelet count is accepted

Premature babies have fewer complications if a lower platelet count is accepted Premature babies have fewer complications if a lower platelet count is accepted Dissemination Centre Discover Portal NIHR DC Discover Premature babies have fewer complications if a lower platelet count is accepted Published on 22 January 2019 doi: Fewer premature babies die or have major bleeding if platelet transfusions are withheld until platelet numbers drop to a lower level. At 28 days, death or new major (...) bleeding occurred in 19% of neonates transfused when they had less than 25,000/mm 3 platelets compared to 26% of neonates transfused when they had less than 50,000/mm 3 platelets. This trial, part-funded by the NIHR, included 660 premature babies with low platelet counts. The results suggest that in the absence of actual bleeding, platelet transfusions may be safer to give when blood platelet concentrations are lower than currently recommended trigger thresholds. It remains unclear why

NIHR Dissemination Centre2019

2. Domperidone increases breast milk production in mothers of premature babies

Domperidone increases breast milk production in mothers of premature babies Domperidone increases breast milk production in mothers of premature babies Dissemination Centre Discover Portal NIHR DC Discover Domperidone increases breast milk production in mothers of premature babies Published on 8 May 2018 The drug domperidone increases the amount of breast milk women produce. This review looked at its use for up to two weeks in women with premature babies being fed with expressed milk. Women had (...) a moderate increase in breast milk of about 88ml a day, a clinically important increase for these small babies. Domperidone is an anti-sickness medication. It has not been widely used to increase breast milk because of unknown effectiveness and concerns that it can cause an irregular heart rhythm with longer-term use in older people. This review found it can moderately increase milk production. Though no serious or cardiac side effects occurred in the studies, only 192 women participated in the trials

NIHR Dissemination Centre2019

3. Inducing labour in older women having their first baby does not increase the chance of caesarean delivery

Inducing labour in older women having their first baby does not increase the chance of caesarean delivery Signal - Inducing labour in older women having their first baby does not increase the chance of caesarean delivery Dissemination Centre Discover Portal NIHR DC Discover Inducing labour in older women having their first baby does not increase the chance of caesarean delivery Published on 26 April 2016 Planning to artificially start labour for older women, pregnant with their first child (...) , in the 39th week of pregnancy does not affect the chance of having a caesarean delivery, according to a new trial funded by NIHR. Older women having a first baby have a higher risk of stillbirth and other complications than younger mothers and inducing labour at or before the due date is thought to reduce this risk. However, there have been fears that inducing labour may raise the risk of a caesarean delivery. This study found that women aged 35 or over having their first child and who were induced at 39

NIHR Dissemination Centre2019

4. High-flow oxygen therapy may be a useful alternative to other forms of breathing support for preterm babies

High-flow oxygen therapy may be a useful alternative to other forms of breathing support for preterm babies Signal - High-flow oxygen therapy may be a useful alternative to other forms of breathing support for preterm babies Dissemination Centre Discover Portal NIHR DC Discover High-flow oxygen therapy may be a useful alternative to other forms of breathing support for preterm babies Published on 17 May 2016 This systematic review found high-flow oxygen delivered by nose was as effective (...) and safe as other non-invasive methods of breathing support for preterm babies. The numbers of treatment failures, deaths and rates of chronic lung disease were similar. Most studies were of high-flow oxygen for babies after tubes used for ventilation had been removed. For these babies use of high-flow techniques were less likely to cause nasal damage or a collapsed lung than other non-invasive methods. High-flow oxygen therapy delivers gas through thin tubes that sit just inside each nostril, whereas

NIHR Dissemination Centre2019

5. Links between antipsychotics in pregnancy and harmful outcomes for baby may be influenced by mother’s lifestyle

Links between antipsychotics in pregnancy and harmful outcomes for baby may be influenced by mother’s lifestyle Signal - Links between antipsychotics in pregnancy and harmful outcomes for baby may be influenced by mother’s lifestyle Dissemination Centre Discover Portal NIHR DC Discover Links between antipsychotics in pregnancy and harmful outcomes for baby may be influenced by mother’s lifestyle Published on 6 June 2016 This NIHR funded study found that antipsychotic use during pregnancy

NIHR Dissemination Centre2019

6. Preterm babies do not benefit from a new IV feeding regimen

Preterm babies do not benefit from a new IV feeding regimen Signal - Preterm babies do not benefit from a new IV feeding regimen Dissemination Centre Discover Portal NIHR DC Discover Preterm babies do not benefit from a new IV feeding regimen Published on 14 July 2016 Intravenous feeding solutions with a higher dose of amino acids or solutions containing fish oils do not provide better outcomes for preterm infants. Many preterm babies can’t feed normally for the first few weeks after birth so (...) they are given a mixture of protein, carbohydrate and lipid (oil or fat) intravenously. There is wide variation across the UK in terms of the type, composition and regimen of intravenous feeds. This NIHR-funded NEON trial looked at infants born before 31 weeks. It tested the theory that increasing the amount of amino acids provided in IV feeding fluids may improve lean body mass and that giving more fish oils rather than plant oils may reduce liver problems. The trial findings provide no evidence that higher

NIHR Dissemination Centre2019

7. Assisted reproduction using donated eggs has higher risk of complications for mothers and babies

Assisted reproduction using donated eggs has higher risk of complications for mothers and babies Signal - Assisted reproduction using donated eggs has higher risk of complications for mothers and babies Dissemination Centre Discover Portal NIHR DC Discover Assisted reproduction using donated eggs has higher risk of complications for mothers and babies Published on 13 December 2016 Assisted reproduction with donated eggs carries about double the chance of some risks for mothers and babies when (...) assisted reproduction involving donated eggs was in 1984. Since then, several studies have reported that high blood pressure during pregnancy, including pre-eclampsia, is more common in women who receive IVF using donor eggs. Pre-eclampsia is a major cause of maternal illness and mortality. Other studies have suggested that babies of egg donation pregnancies may also have poorer outcomes. This systematic review aimed to pool the results of these observational studies, to get a clearer picture

NIHR Dissemination Centre2019

8. Supplementary feeding of preterm babies by cup rather than bottle helps breastfeeding success

Supplementary feeding of preterm babies by cup rather than bottle helps breastfeeding success Signal - Supplementary feeding of preterm babies by cup rather than bottle helps breastfeeding success Dissemination Centre Discover Portal NIHR DC Discover Supplementary feeding of preterm babies by cup rather than bottle helps breastfeeding success Published on 13 December 2016 For women who chose to breastfeed their preterm baby, supplementary feeds with a cup, compared with a bottle, led (...) to improved breastfeeding rates at discharge and up to six months later. Preterm babies who are transitioning from being tube fed to breastfeeds have traditionally been given bottle feeds (of breast milk or formula) to supplement breastfeeding if the mother is unavailable or if additional feeds are thought necessary. This small Cochrane review found evidence that babies were more likely to be fully breastfed or to have at least some breastfeeds when cup feeds were used to supplement breastfeeding. In

NIHR Dissemination Centre2019

9. Antenatal corticosteroids reduce breathing problems in late preterm babies

Antenatal corticosteroids reduce breathing problems in late preterm babies Signal - Antenatal corticosteroids reduce breathing problems in late preterm babies Dissemination Centre Discover Portal NIHR DC Discover Antenatal corticosteroids reduce breathing problems in late preterm babies Published on 21 February 2017 Giving corticosteroids to women at risk of preterm birth at 34 weeks of pregnancy or later reduced the risk of severe breathing problems in the baby after birth from 1.9% to 1.1 (...) %. Steroids also reduced the risk for babies born by planned caesarean section after 37 weeks (so not premature). Steroids are known to be beneficial if given to pregnant women at risk of preterm birth before 34 weeks and are already advised for babies born by caesarean section. This meta-analysis of six large trials provides new evidence that steroids might also benefit premature babies born after the 34th week. However, the review also found steroids increased the risk of low blood sugar in the new-born

NIHR Dissemination Centre2019

10. Placing wet gauze on babies’ tummies speeds up urine collection

Placing wet gauze on babies’ tummies speeds up urine collection Signal - Placing wet gauze on babies’ tummies speeds up urine collection Dissemination Centre Discover Portal NIHR DC Discover Placing wet gauze on babies’ tummies speeds up urine collection Published on 17 October 2017 Almost a third of infants managed to urinate within five minutes after a painless, cheap technique that stimulates the skin, compared with 12% of infants observed only, as is standard practice. The ‘Quick-Wee (...) ’ method involved rubbing the babies’ abdomens gently with gauze soaked in cold saline before collecting urine. This trial was carried out with 354 babies aged one to 11 months in one Australian paediatrics emergency room. NICE guidelines recommend non-invasive ‘clean catch’ collection if possible but this can be difficult, especially in young children. They estimate that 20 minutes of staff time can be needed to obtain a sample. Hospital paediatrics settings and primary care may want to try

NIHR Dissemination Centre2019

11. Fewer large babies are born to pregnant woman with type 1 diabetes if their glucose was monitored continuously

Fewer large babies are born to pregnant woman with type 1 diabetes if their glucose was monitored continuously Signal - Fewer large babies are born to pregnant woman with type 1 diabetes if their glucose was monitored continuously Dissemination Centre Discover Portal NIHR DC Discover Fewer large babies are born to pregnant woman with type 1 diabetes if their glucose was monitored continuously Published on 12 December 2017 Pregnant women with type 1 diabetes who used a continuous glucose (...) monitoring system were half as likely to have a large baby compared with those using standard finger prick blood glucose measurements. Only 15% of infants needed intensive care admissions due to low blood glucose in the continuous glucose monitoring group, compared with 28% born to mothers in the standard finger prick control group. Pregnant women using continuous monitoring spent 7% more time in the target glucose range than those on standard measurements. However, their HbA1c levels, which indicate

NIHR Dissemination Centre2019

12. Breastfeeding reduces crying during baby immunisation

Breastfeeding reduces crying during baby immunisation Signal - Breastfeeding reduces crying during baby immunisation Dissemination Centre Discover Portal NIHR DC Discover Breastfeeding reduces crying during baby immunisation Published on 21 February 2017 Babies who were breastfed before and during routine childhood immunisations cried on average for 38 seconds less and had lower pain scores compared to babies not breastfed. This evidence review used data from 10 trials, with results for 1,066 (...) babies, mostly between one and six months old, following their normal immunisation schedule. Immunisation levels in England are below recommended levels and falling. Pain from injections causes distress to babies and parents, and may put parents off bringing their children for immunisation or finishing the course of treatment over a year. This is the first review to focus studies of breastfeeding for any painful procedure for older babies. The only trials found related to immunisations, and none

NIHR Dissemination Centre2019

13. Skin-to-skin contact improves breastfeeding of healthy babies

Skin-to-skin contact improves breastfeeding of healthy babies Signal - Skin-to-skin contact improves breastfeeding of healthy babies Dissemination Centre Discover Portal NIHR DC Discover Skin-to-skin contact improves breastfeeding of healthy babies Published on 28 March 2017 Early skin-to-skin contact improves breastfeeding of healthy full-term babies. Skin-to-skin contact is the direct contact between a naked baby and the mother’s bare chest. It can occur before or after the baby is cleaned (...) following birth. This review found that about a quarter more women who have this contact with their babies are still breastfeeding at one to four months after birth compared with those who don’t. The evidence that skin-to-skin contact may also help to stabilise the baby’s heart and breathing rates and blood sugar levels after birth was based on fewer trials and less strong. These findings support UK good practice to promote immediate skin-to-skin contact after birth to improve breastfeeding rates

NIHR Dissemination Centre2019

14. Fortified donor breast milk led to similar development for very-low-birthweight babies compared with formula milk

Fortified donor breast milk led to similar development for very-low-birthweight babies compared with formula milk Signal - Fortified donor breast milk led to similar development for very-low-birthweight babies compared with formula milk Dissemination Centre Discover Portal NIHR DC Discover Fortified donor breast milk led to similar development for very-low-birthweight babies compared with formula milk Published on 18 April 2017 Providing very-low-birthweight babies with fortified human donor (...) breast milk made no difference to their developmental neurological outcomes at 18 months compared with giving formula. This randomised controlled trial looked at 363 babies with birth weights of less than 1500g in neonatal intensive care units in Canada. When the mother’s own milk supply was limited, the babies were given either nutrient-enriched donor breast milk or formula developed for premature babies. There was no difference in their understanding, language, or ability to manipulate objects at 18

NIHR Dissemination Centre2019

15. Induction of labour may be considered in pregnant women with a large baby

Induction of labour may be considered in pregnant women with a large baby Signal - Induction of labour may be considered in pregnant women with a large baby Dissemination Centre Discover Portal NIHR DC Discover Induction of labour may be considered in pregnant women with a large baby Published on 20 June 2017 Induction of labour does not increase the risk of caesarean delivery in pregnant women with a larger than average baby. This is based on a review of four trials of 1190 women (...) with a suspected large baby who were allocated either to have labour induced from 38 weeks or to watchful waiting. Induction did not increase the risk of most negative outcomes for the baby, such as bleeding in the brain, or mother, such as major tearing. However, these outcomes are rare, so a larger number of women would need to be studied to be confident in these findings. When mothers were not induced babies were larger and born about a week later than if they were induced. They did suffer from more

NIHR Dissemination Centre2019

16. Oral ibuprofen may be an option for closing patent ductus arteriosus in premature babies

Oral ibuprofen may be an option for closing patent ductus arteriosus in premature babies Oral ibuprofen may be an option for closing patent ductus arteriosus in premature babies Dissemination Centre Discover Portal NIHR DC Discover Oral ibuprofen may be an option for closing patent ductus arteriosus in premature babies Published on 3 July 2018 doi: A high dose of oral ibuprofen was more likely to close a patent ductus arteriosus in premature babies when compared with standard doses (...) of intravenous ibuprofen or indometacin. Before birth, a baby's lungs aren't needed for breathing. Most blood bypasses the lungs through a large vessel called the ductus arteriosus directly from the pulmonary artery into the aorta to supply the main circulation. Once born, blood flows through the lungs, and the ductus arteriosus usually closes in the first few days. If it doesn't close it is referred to as "patent". This condition is much more common in premature babies and doesn't always need treatment

NIHR Dissemination Centre2019

17. Testing oxygen levels of newborn babies helps find serious heart defects

Testing oxygen levels of newborn babies helps find serious heart defects Testing oxygen levels of newborn babies helps find serious heart defects Dissemination Centre Discover Portal NIHR DC Discover Testing oxygen levels of newborn babies helps find serious heart defects Published on 17 July 2018 doi: Measuring oxygen levels in newborn babies as part of routine care can identify cases of critical congenital heart defects sooner than waiting until symptoms appear. If 10,000 babies were screened (...) , pulse oximetry could correctly identify about 5 of the 6 expected asymptomatic cases and might miss one. This international research suggests there would be about 14 false alarms. Waiting until babies are at least 24 hours old minimises the number of these false positives. Babies with critical heart defects often show no symptoms at birth. Early detection of these problems increases the chance of successful treatment. This systematic review looked at 21 studies of 457,202 babies where pulse oximetry

NIHR Dissemination Centre2019

18. A new method for monitoring baby’s heart beat during labour probably not justified

A new method for monitoring baby’s heart beat during labour probably not justified Signal - A new method for monitoring baby’s heart beat during labour probably not justified Dissemination Centre Discover Portal NIHR DC Discover A new method for monitoring baby’s heart beat during labour probably not justified Published on 1 March 2016 A new way of monitoring a baby’s distress during labour, called ST waveform analysis, did not improve outcomes for the baby or reduce the likelihood (...) of a caesarean section compared to current practice. Although monitoring of babies’ heartbeats during labour is common practice in the UK, additional ST analysis is not commonly used and on the basis of this evidence probably should not be promoted for routine use yet. The outcomes measured in this review included death of the baby before or after birth, fits and brain damage from low oxygen levels. Finding babies at risk of these rare events is important as urgent delivery may save the baby. However

NIHR Dissemination Centre2019

19. Kangaroo mother care may boost the survival of newborn, premature babies

Kangaroo mother care may boost the survival of newborn, premature babies Signal - Kangaroo mother care may boost the survival of newborn, premature babies Dissemination Centre Discover Portal NIHR DC Discover Kangaroo mother care may boost the survival of newborn, premature babies Published on 23 February 2016 Kangaroo mother care reduced the death rate of newborns by around a quarter compared with conventional care, according to a review of studies from around the world. Other positive (...) outcomes included lower risk of neonatal sepsis, hypothermia, hypoglycaemia, hospital readmission and higher exclusive breast feeding rates. Kangaroo care definitions vary by study, but typically promote mother and baby skin-to-skin contact, sometimes in combination with other elements like promoting breast feeding, and early supported discharge from hospital. Most of the studies in this review looked at premature babies born before 37 weeks and some studies were in low or middle income countries

NIHR Dissemination Centre2019

20. A trial of probiotics for treating sepsis in very premature babies poses more questions than it answers

A trial of probiotics for treating sepsis in very premature babies poses more questions than it answers Signal - A trial of probiotics for treating sepsis in very premature babies poses more questions than it answers Dissemination Centre Discover Portal NIHR DC Discover A trial of probiotics for treating sepsis in very premature babies poses more questions than it answers Published on 23 December 2015 Contrary to a previous review of trials, this large, NIHR-funded trial found that probiotic (...) treatment did not prevent two common life-threatening conditions in very premature babies. The conditions were necrotising enterocolitis, which is a severe gut inflammation/infection that can result in the death of intestinal tissue, and sepsis (blood poisoning) from bacteria that have crossed from the gut into the bloodstream. This trial used a single strain of a harmless bacterium, known as a “probiotic”, prepared to high quality standards fit for medicines, and chosen because it is commonly used

NIHR Dissemination Centre2018