Latest & greatest articles for autism

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on autism or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on autism and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Autism

Autism is a neurodevelopmental disorder (a type of mental disorder) characterised by difficult social interaction, impaired communication (both verbal and non-verbal), and restricted and repetitive behaviours. It forms part of the broader autism spectrum disorder (ASD), a range of similar conditions, including Asperger syndrome.

Autism is a condition that begins from early childhood and is often suspected and diagnosed by ages 1-3. It is a lifelong disability that affects how people interact with others.

Autism causes and treatment

There have been many misconceptions as to what causes autism in the past such as the MMR vaccine and diet. Extensive research and clinical trials have concluded that none of these factors cause autism or ASD. However, the real cause is little understood but research is starting to unpick potential factors such as genetics, pollution and other environmental factors. A current favoured idea is that genes inherited from a child’s parents can make them more vulnerable to developing autism, some researchers suggest that the disorder will only develop when triggered by environmental factors.

The exact cause of autism spectrum disorder is unknown, however research into the disorder suggest that it is caused by several genetic and environmental factors. Genes inherited from a child’s parents can make them more vulnerable to developing autism, some researchers suggest that the disorder will only develop when triggered by environmental factors. Read more in clinical papers on autism.

Autism can be managed with a combination of prescribed medicines and behavioural treatment, depending on the severity of the disorder. Read about clinical trials and medical advancements for the treatment of autism on Trip.

Hot topics in Trip

Users of Trip frequently look at topics around adolescents, therapies, behaviour and screening. They also explore such topics as omega-3 fatty acids, SSRIs and aripiprazole. All these topics, and more, can be easily searched for within Trip.

Top results for autism

1. Interventions Targeting Sensory Challenges in Children with Autism Spectrum Disorder - An Update

: 21220213.X-1 D-55 642. Ghanizadeh A. Can tactile sensory processing differentiate between children with autistic disorder and asperger's disorder? Innov Clin Neurosci. 2011 May;8(5):25-30. PMID: 21686145.X-1 643. Ghanizadeh A. A novel hypothesized clinical implication of zonisamide for autism...Ann Neurol. 2010 Feb;67(2):239- 49. Annals of Neurology. 2011;69(2):426- 1p. doi: 10.1002/ana.22153. PMID: 104841194. Language: English. Entry Date: 20110527. Revision Date: 20150711. Publication Type: Journal (...) insulin-like growth factor-1 in children with autism. Neuropediatrics. 2011 Oct;42(5):207-9. doi: 10.1055/s-0031-1291242. PMID: 22015434.X-1, X-3 736. Malisza KL, Clancy C, Shiloff D, et al. Functional evaluation of hidden figures object analysis in children with autistic disorder. Journal of Autism & Developmental Disorders. 2011;41(1):13-22 10p. doi: 10.1007/s10803-010-1013-z. PMID: 104970837. Language: English. Entry Date: 20110228. Revision Date: 20150711. Publication Type: Journal Article.X-1 737

2017 Effective Health Care Program (AHRQ)

2. Nutritional or dietary interventions for children and adolescents with autism spectrum disorder or ADHD

Nutritional or dietary interventions for children and adolescents with autism spectrum disorder or ADHD Nutritional or dietary interventions for children and adolescents with autism spectrum disorder or ADHD We use cookies on this website. By using this site, you agree that we may store and access cookies on your device. Swedish Agency for Health Technology Assessment and Assessment of Social Services Nutritional or dietary interventions for children and adolescents with autism spectrum (...) disorder or ADHD Share: Reading time approx. 6 minutes There are theories that different types of nutritional or dietary interventions, where specific food items are excluded from the diet or where nutritional supplements are added, may affect the symptoms of persons with Attention Deficit Hyperactivity Disorder (ADHD) or autism spectrum disorder. This applies, for example, to gluten-free and casein-free diet, ketogenic diet (a strict option of a low carbohydrate diet) or diet where sugar or various

2018 Swedish Council on Technology Assessement

3. Autism

search covered the period from 1991 to March 19, 2013 using the PubMed, PsycINFO, Cochrane, and CINAHL (EBSCO) databases. The initial searches were inclusive and sensitive. Search terms were a combination of MeSH headings and keywords, and the MeSH headings were adjusted to terms used by PsycINFO and CINAHL by using their thesauri. In PubMed the MeSH terms autistic disorder, childhood development disorders—pervasive, Asperger*, and Rett* and the keyword autism were searched. The initial search (...) OF CHILD & ADOLESCENT PSYCHIATRY VOLUME 53 NUMBER 2 FEBRUARY 2014 www.jaacap.org 237andvalidationstudies.There?nedPubMedsearch yielded3,613articles. In the PsycINFO database subject headings (focused) of autism, autistic thinking, pervasive developmental disorders, retts syndrome, aspergers, and keyword autism were searched. The initial search returned 24,875 articles and was then limited to English, childhood: birth to age 12yrs, adolescence: age 13-17 yrs, peer reviewed journal,and 1991 to March 19

2014 American Academy of Child and Adolescent Psychiatry

4. Sensory integration therapy for autism spectrum disorders: a systematic review

, O'Reilly M, Healy O, Rispoli M, Lydon H, Streusand W, Davis T, Kang S, Sigafoos J, Lancioni G, Didden R, Giesbers S. Sensory integration therapy for autism spectrum disorders: a systematic review. Research in Autism Spectrum Disorders 2012; 6(3): 1004-1018 DOI Original Paper URL Indexing Status Subject indexing assigned by CRD MeSH Autistic Disorder; Child; Humans; Occupational Therapy; Sensation; Sensation Disorders AccessionNumber 12012026826 Date bibliographic record published 29/08/2012 Date (...) Sensory integration therapy for autism spectrum disorders: a systematic review Sensory integration therapy for autism spectrum disorders: a systematic review Sensory integration therapy for autism spectrum disorders: a systematic review Lang R, O'Reilly M, Healy O, Rispoli M, Lydon H, Streusand W, Davis T, Kang S, Sigafoos J, Lancioni G, Didden R, Giesbers S CRD summary The authors concluded that sensory integration therapy had no consistently positive effect as a treatment for children

2012 DARE.

5. Future Research Needs: Interventions for Adolescents and Young Adults With Autism Spectrum Disorders

research focused on interventions for adolescents and young adults between the ages of 13 and 30 with autism spectrum disorder (ASD; autistic disorder, Asperger’s syndrome, pervasive developmental disorder–not otherwise specified). We addressed questions related to: the effectiveness of therapies targeting core symptoms of ASD (impairments in communication, social interaction, and behavior); common medical or mental health comorbidities, including associated symptoms such as irritability; the process (...) Future Research Needs: Interventions for Adolescents and Young Adults With Autism Spectrum Disorders Future Research Needs Paper Number 20 Future Research Needs: Interventions for Adolescents and Young Adults With Autism Spectrum Disorders Future Research Needs Paper Number 20 Future Research Needs: Interventions for Adolescents and Young Adults With Autism Spectrum Disorders Identification of Future Research Needs From Comparative Effectiveness Review No. 65 Prepared for: Agency for Healthcare

2013 Effective Health Care Program (AHRQ)

6. Motor Interventions for Autism Spectrum Disorder in Children

included studies. Randomized Controlled Trials Schaaf, 2014 2 Children (4-8 y) with autism (n = 32) Occupational therapy (manualized intervention) Improved Goal Attainment Scale scores, measures of caregiver assistance in self-care, and socialization compared with usual care. Chan, 2013 3 Children with ASD (n = 46) Nei Yang Gong Larger self-control improvements occurred in the treatment group compared with a Progressive Muscle Relaxation technique control group, parental reports of reduced autistic (...) symptoms. Pfeiffer, 2011 4 Children (6-12 y) with ASD Sensory integration The intervention successfully reduced autistic mannerisms compared with fine motor intervention. Both groups showed improved Goal Attainment Scaling scores. Silva, 2011 5 Children with Qigong massage Improved measures of autism, Motor Interventions for Autism Spectrum Disorder in Children 2 autism (n = 47) abnormal sensory responses, and self-regulation were reported in the treatment group. Piravej, 2009 6 Children (3-10 y

2014 Canadian Agency for Drugs and Technologies in Health - Rapid Review

7. Autism in under 19s: support and management

Autism in under 19s: support and management Autism spectrum disorder in under 19s: Autism spectrum disorder in under 19s: support and management support and management Clinical guideline Published: 28 August 2013 nice.org.uk/guidance/cg170 © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-of- rights).Y Y our responsibility our responsibility The recommendations in this guideline represent the view of NICE, arrived at after careful (...) in a way that would be inconsistent with complying with those duties. Commissioners and providers have a responsibility to promote an environmentally sustainable health and care system and should assess and reduce the environmental impact of implementing NICE recommendations wherever possible. Autism spectrum disorder in under 19s: support and management (CG170) © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 2

2013 National Institute for Health and Clinical Excellence - Clinical Guidelines

8. Autism spectrum disorder

acquired acquired language skills (regression). Rogers SJ. Developmental regression in autistic spectrum disorders. Ment Retard Dev Disabil Res Rev. 2004;10(2):139-43. http://www.ncbi.nlm.nih.gov/pubmed/15362172?tool=bestpractice.com Parr JR, Le Couteur A, Baird G, et al. Early developmental regression in autism spectrum disorder: evidence from an international multiplex sample. J Autism Dev Disord. 2011 Mar;41(3):332-40. http://www.ncbi.nlm.nih.gov/pubmed/20711649?tool=bestpractice.com Children who (...) Autism spectrum disorder Autism spectrum disorder - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Autism spectrum disorder Last reviewed: February 2019 Last updated: March 2018 Summary Children and adults with autism spectrum disorder (ASD) have social communication and interaction difficulties and show restricted, repetitive, and stereotyped patterns of behaviours, interests, or activities. Social communication

2018 BMJ Best Practice

9. Communication interventions for autism spectrum disorder in minimally verbal children. (Full text)

Communication interventions for autism spectrum disorder in minimally verbal children. Autism spectrum disorder (ASD) has an estimated prevalence of around 1.7% of the population. People with ASD often also have language difficulties, and about 25% to 30% of children with ASD either fail to develop functional language or are minimally verbal. The ability to communicate effectively is an essential life skill, and difficulties with communication can have a range of adverse outcomes, including (...) of Child Health and Human Development, the MIND Institute Research Program and a Professional Staff Congress-City University of New York grant. The PECS study included 84 minimally verbal participants (73 boys) aged 4 to 11 years who had a formal diagnosis of ASD and who were not using PECS beyond phase 1 at baseline. All children attended autism-specific classes or units, and most classes had a child to adult ratio of 2:1. Teachers and parents received PECS training (two-day workshop). PECS

2018 Cochrane PubMed abstract

10. Measles, Mumps, Rubella Vaccination and Autism: A Nationwide Cohort Study. (Full text)

Measles, Mumps, Rubella Vaccination and Autism: A Nationwide Cohort Study. The hypothesized link between the measles, mumps, rubella (MMR) vaccine and autism continues to cause concern and challenge vaccine uptake.To evaluate whether the MMR vaccine increases the risk for autism in children, subgroups of children, or time periods after vaccination.Nationwide cohort study.Denmark.657 461 children born in Denmark from 1999 through 31 December 2010, with follow-up from 1 year of age and through 31 (...) August 2013.Danish population registries were used to link information on MMR vaccination, autism diagnoses, other childhood vaccines, sibling history of autism, and autism risk factors to children in the cohort. Survival analysis of the time to autism diagnosis with Cox proportional hazards regression was used to estimate hazard ratios of autism according to MMR vaccination status, with adjustment for age, birth year, sex, other childhood vaccines, sibling history of autism, and autism risk factors

2019 Annals of Internal Medicine PubMed abstract

11. Autism in adults: diagnosis and management

with cognitive and behavioural flexibility, altered sensory sensitivity, sensory processing difficulties and emotional regulation difficulties. The features of autism may range from mild to severe and may fluctuate over time or in response to changes in circumstances. A significant proportion of adults with autism across the whole autistic spectrum experience social and economic exclusion. Their condition is often overlooked by healthcare, education and social care professionals, which creates barriers (...) -and- conditions#notice-of-rights). Page 5 of 50In this guideline 'autism' refers to 'autism spectrum disorders' encompassing autism, Asperger's syndrome and atypical autism (or pervasive developmental disorder not otherwise specified). The Guideline Development Group recognises, however, that different individuals and groups prefer a variety of terms for autism including autistic spectrum condition, autistic spectrum difference and neurodiversity (in recent Department of Health, National Audit Office

2012 National Institute for Health and Clinical Excellence - Clinical Guidelines

12. The Effect of Sensory Integration Therapy on Occupational Performance in Children With Autism. (Abstract)

The Effect of Sensory Integration Therapy on Occupational Performance in Children With Autism. Sensory processing problems and related dysfunctions are among the most common conditions in children with autism spectrum disorder (ASD). This study examined the effect of sensory integration therapy (SIT) on different aspects of occupational performance in children with ASD. The study was conducted on an intervention group ( n = 16) receiving SIT and a control group ( n = 15) with 3- to 8-year-old

2018 OTJR : occupation, participation and health Controlled trial quality: uncertain

13. Treatment for Insomnia and Disrupted Sleep Behavior in Children and Adolescents with Autism Spectrum Disorder

Treatment for Insomnia and Disrupted Sleep Behavior in Children and Adolescents with Autism Spectrum Disorder 1 1 Practice guideline: Treatment for insomnia and disrupted sleep behavior in children and 2 adolescents with autism spectrum disorder 3 4 Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the 5 American Academy of Neurology 6 7 Ashura Williams Buckley, MD, 1 Deborah Hirtz, MD, 2 Maryam Oskoui, MD, 3 Melissa J. 8 Armstrong, MD, MSc, 4 Anshu Batra (...) . Division of Developmental Medicine, Boston Children’s Hospital, Boston, MA 24 2 7. Departments of Pediatrics and Psychiatry, The Ohio State University College of 1 Medicine, Columbus 2 8. Duke Center for Autism and Brain Development, Duke Institute for Brain Sciences, and 3 Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, 4 Durham, NC 5 9. Northern Michigan Neurology, Traverse City 6 10. Department of Child and Behavioral Sciences, Johns Hopkins University

2020 American Academy of Neurology

14. Early intensive behavioral intervention (EIBI) for young children with autism spectrum disorders (ASD). (Full text)

Early intensive behavioral intervention (EIBI) for young children with autism spectrum disorders (ASD). The rising prevalence of autism spectrum disorders (ASD) increases the need for evidence-based behavioral treatments to lessen the impact of symptoms on children's functioning. At present, there are no curative or psychopharmacological therapies to effectively treat all symptoms of the disorders. Early intensive behavioral intervention (EIBI) is a treatment based on the principles of applied (...) behavior analysis. Delivered for multiple years at an intensity of 20 to 40 hours per week, it is one of the more well-established treatments for ASD. This is an update of a Cochrane review last published in 2012.To systematically review the evidence for the effectiveness of EIBI in increasing functional behaviors and skills, decreasing autism severity, and improving intelligence and communication skills for young children with ASD.We searched CENTRAL, MEDLINE, Embase, 12 additional electronic

2018 Cochrane PubMed abstract

15. Autism

Autism Evidence Maps - Trip Database or use your Google+ account Turning Research Into Practice ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4) Loading

2018 Trip Evidence Maps

16. Physical activity for persons with ADHD or autism

. 23672 6. 1 OR 2 OR 3 OR 4 OR 5 40896 7. "Autistic Disorder"/ or "Autism Spectrum Disorder"/ 26189 8. (Autism or Autistic* or "ASD" or "Autism spectrum disorder*").ti,ab,kw. 50587 9. 7 OR 8 53333 10. 6 OR 9 90701 Intervention: 11. Exercise/ 101551 12. ("Physical" adj6 ("Activit*" or "therap*" or "exercise" or “training”)).ti,ab,kw. 155219 13. (exercise* or physiotherapy or sport*).ti,ab. 345492 14. 11 OR 12 OR 13 466786 Limits: 15. (((comprehensive* or integrative or systematic*) adj3 (bibliographic (...) found Population: 1. [mh “Attention Deficit and Disruptive Behavior Disorders”] 2809 2. [mh “Attention Deficit Disorder with Hyperactivity”] 2482 3. (“Attention Deficit Disorder*”:ab,ti) 3751 4. ("Attention deficit*":ab,ti NEAR hyper*:ab,ti) 3529 5. (“adhd”:ti,ab,kw OR “addh”:ti,ab) 4168 6. 1 OR 2 OR 3 OR 4 OR 5 5506 7. [mh "Autistic Disorder"] 867 8. [mh "Autism Spectrum Disorder"] 1211 9. ("Autism" or Autist* or "ASD" OR "Autism spectrum*"):ti,ab 3467 10. 7 OR 8 OR 9 3523 11. 6 OR 10 8787

2019 Swedish Council on Technology Assessement

17. Autism

Autism Top results for autism - Trip Database or use your Google+ account Find evidence fast ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4) Loading (...) history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for autism The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest

2018 Trip Latest and Greatest

18. International multicentre randomised controlled trial of improvisational music therapy for children with autism spectrum disorder: TIME-A study

-assessed social responsiveness. Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Autism Spectrum Disorder; Autistic Disorder; Child; Child Development Disorders, Pervasive; Humans; Music Therapy Language Published English Country of organisation England English summary An English language summary is available. Address for correspondence NETSCC, Health Technology Assessment, Alpha House, University of Southampton Science Park, Southampton, SO16 7NS UK Tel: +44 23 8059 5586 (...) International multicentre randomised controlled trial of improvisational music therapy for children with autism spectrum disorder: TIME-A study International multicentre randomised controlled trial of improvisational music therapy for children with autism spectrum disorder: TIME-A study International multicentre randomised controlled trial of improvisational music therapy for children with autism spectrum disorder: TIME-A study Crawford M J, Gold C, Odell-Miller H, Thana L, Faber S, Assmus J

2018 Health Technology Assessment (HTA) Database.

19. Autism in adults

), especially when under stress or expressing emotion. If two or more of the above categories of behaviour are present, offer referral to an autism team if available (or if not, to a psychiatrist) for a comprehensive (diagnostic, needs, and risks) assessment for ASD. Provide verbal and written information on ASD. For example: The National Autistic Society website ( ) has information on available before diagnosis of ASD, the , , available , and what to do . Basis for recommendation Basis for recommendation (...) for people with ASD and how to decisions about benefits; services; and other (such as blue badges, bus passes, and Disabled Facilities Grants). The National Autistic Society Autism Helpline (0808 800 4104, ) — provides impartial, confidential information, advice, and support for people with ASD and their family, partners, and/or carers. It is available from 10am–4pm on Monday–Thursday, and 9am–3pm on Fridays. The NHS website ( ) — has a guide on , which is also available in an for people with a learning

2019 NICE Clinical Knowledge Summaries

20. Early detection for autism spectrum disorder in young children

Early detection for autism spectrum disorder in young children Autism spectrum disorder (ASD) is a life-long neurodevelopmental disorder, characterized by impairments in social communication, repetitive, restricted patterns of behaviour, and unusual sensory sensitivities or interests. ASD significantly impacts the lives of children and their families. Currently, the estimated prevalence of ASD is 1 in 66 Canadians aged 5 to 17 years. General paediatricians, family physicians, and other health (...) signs of ASD—an important step toward an accurate diagnosis and comprehensive needs assessment for intervention planning. Keywords: Autism spectrum disorder; Developmental surveillance; Early identification; Screening

2019 Canadian Paediatric Society