Latest & greatest articles for autism

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on autism or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on autism and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

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Autism

Autism is a neurodevelopmental disorder (a type of mental disorder) characterised by difficult social interaction, impaired communication (both verbal and non-verbal), and restricted and repetitive behaviours. It forms part of the broader autism spectrum disorder (ASD), a range of similar conditions, including Asperger syndrome.

Autism is a condition that begins from early childhood and is often suspected and diagnosed by ages 1-3. It is a lifelong disability that affects how people interact with others.

Autism causes and treatment

There have been many misconceptions as to what causes autism in the past such as the MMR vaccine and diet. Extensive research and clinical trials have concluded that none of these factors cause autism or ASD. However, the real cause is little understood but research is starting to unpick potential factors such as genetics, pollution and other environmental factors. A current favoured idea is that genes inherited from a child’s parents can make them more vulnerable to developing autism, some researchers suggest that the disorder will only develop when triggered by environmental factors.

The exact cause of autism spectrum disorder is unknown, however research into the disorder suggest that it is caused by several genetic and environmental factors. Genes inherited from a child’s parents can make them more vulnerable to developing autism, some researchers suggest that the disorder will only develop when triggered by environmental factors. Read more in clinical papers on autism.

Autism can be managed with a combination of prescribed medicines and behavioural treatment, depending on the severity of the disorder. Read about clinical trials and medical advancements for the treatment of autism on Trip.

Hot topics in Trip

Users of Trip frequently look at topics around adolescents, therapies, behaviour and screening. They also explore such topics as omega-3 fatty acids, SSRIs and aripiprazole. All these topics, and more, can be easily searched for within Trip.

Top results for autism

141. Cohort study: Prenatal exposure to sodium valproate is associated with increased risk of childhood autism and autistic spectrum disorder

Cohort study: Prenatal exposure to sodium valproate is associated with increased risk of childhood autism and autistic spectrum disorder Prenatal exposure to sodium valproate is associated with increased risk of childhood autism and autistic spectrum disorder | Evidence-Based Nursing We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log (...) in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Prenatal exposure to sodium valproate is associated with increased risk of childhood autism and autistic spectrum disorder Article Text

2014 Evidence-Based Nursing

142. Use of selective serotonin reuptake inhibitors during pregnancy and risk of autism. Full Text available with Trip Pro

Use of selective serotonin reuptake inhibitors during pregnancy and risk of autism. Studies have raised concern about an association between the use of selective serotonin reuptake inhibitors (SSRIs) during pregnancy and an increased risk of autism spectrum disorders in the offspring.We conducted a cohort study of all singleton live births in Denmark from 1996 through 2005 (626,875 births), with follow-up through 2009. Using Danish population registries, we linked information on maternal use (...) of SSRIs before and during pregnancy, autism spectrum disorders diagnosed in the offspring, and a range of potential confounders. We used a survival analysis of the time to diagnosis in the offspring with Poisson regression to estimate rate ratios of autism spectrum disorders according to maternal use of SSRIs.During 5,057,282 person-years of follow-up, we identified 3892 cases of autism spectrum disorder (incidence rate, 77.0 per 100,000 person-years). A total of 52 cases during 42,400 person-years

2013 NEJM

143. Autism. (Abstract)

Autism. Autism is a set of heterogeneous neurodevelopmental conditions, characterised by early-onset difficulties in social communication and unusually restricted, repetitive behaviour and interests. The worldwide population prevalence is about 1%. Autism affects more male than female individuals, and comorbidity is common (>70% have concurrent conditions). Individuals with autism have atypical cognitive profiles, such as impaired social cognition and social perception, executive dysfunction (...) , and atypical perceptual and information processing. These profiles are underpinned by atypical neural development at the systems level. Genetics has a key role in the aetiology of autism, in conjunction with developmentally early environmental factors. Large-effect rare mutations and small-effect common variants contribute to risk. Assessment needs to be multidisciplinary and developmental, and early detection is essential for early intervention. Early comprehensive and targeted behavioural interventions

2013 Lancet

144. Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum disorders (ASD). (Abstract)

Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum disorders (ASD). Autism spectrum disorders (ASD) are characterised by abnormalities in social interaction and communication skills, as well as stereotypic behaviours and restricted activities and interests. Selective serotonin reuptake inhibitors (SSRIs) are prescribed for the treatment of conditions often comorbid with ASD such as depression, anxiety and obsessive-compulsive behaviours.To determine if treatment with an SSRI:1 (...) . improves the core features of autism (social interaction, communication and behavioural problems);2. improves other non-core aspects of behaviour or function such as self-injurious behaviour;3. improves the quality of life of adults or children and their carers;4. has short- and long-term effects on outcome;5. causes harm.We searched the following databases up until March 2013: CENTRAL, Ovid MEDLINE, Embase, CINAHL, PsycINFO, ERIC and Sociological Abstracts. We also searched ClinicalTrials.gov

2013 Cochrane

145. Screening and Diagnostic Tools for Autism Spectrum Disorder in Children: A Review of Guidelines

Screening and Diagnostic Tools for Autism Spectrum Disorder in Children: A Review of Guidelines TITLE: Screening and Diagnostic Tools for Autism Spectrum Disorder in Children: A Review of Guidelines DATE: 03 July 2013 CONTEXT AND POLICY ISSUES Autism is a lifelong condition that involves impaired verbal and non-verbal communication, impaired socialization, and repetitive or restricted patterns of behaviour. 1-4 Autism spectrum disorders (ASD) refer to a range of disorders that include autistic (...) for additional research for better validation was indicated for the following second level screening tools, despite some of these being simultaneously recommended for use: Early Screening for Autistic Traits (ESAT), M-CHAT, Pervasive Developmental Disorder Screening Test-II (PDDST-II), the STAT, and the Social Communication Questionnaire (SCQ). 3 The Autism Behaviour Checklist (ASD) and Gilliam Autism Rating Scale (GARS) were not recommended for second level screening as these tools reported low sensitivity

2013 Canadian Agency for Drugs and Technologies in Health - Rapid Review

146. Genomic microarray analysis for intellectual disability, developmental delay, multiple congenital anomalies, and autism spectrum disorders

Genomic microarray analysis for intellectual disability, developmental delay, multiple congenital anomalies, and autism spectrum disorders Genomic microarray analysis for intellectual disability, developmental delay, multiple congenital anomalies, and autism spectrum disorders Genomic microarray analysis for intellectual disability, developmental delay, multiple congenital anomalies, and autism spectrum disorders Record Status This is a bibliographic record of a published health technology (...) assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Genomic microarray analysis for intellectual disability, developmental delay, multiple congenital anomalies, and autism spectrum disorders. Lansdale: HAYES, Inc.. Genetic Testing Publication. 2013 Authors' conclusions Chromosome abnormalities are a common cause of developmental delay (DD), intellectual disability (ID), multiple congenital anomalies (MCA), and other neurodevelopmental disorders

2013 Health Technology Assessment (HTA) Database.

147. Autism and mental retardation among offspring born after in vitro fertilization. Full Text available with Trip Pro

Autism and mental retardation among offspring born after in vitro fertilization. Between 1978 and 2010, approximately 5 million infants were born after in vitro fertilization (IVF) treatments. Yet limited information on neurodevelopment after IVF exists, especially after the first year of life.To examine the association between use of any IVF and different IVF procedures and the risk of autistic disorder and mental retardation in the offspring.A population-based, prospective cohort study using (...) Swedish national health registers. Offspring born between 1982 and 2007 were followed up for a clinical diagnosis of autistic disorder or mental retardation until December 31, 2009. The exposure of interest was IVF, categorized according to whether intracytoplasmic sperm injection (ICSI) for male infertility was used and whether embryos were fresh or frozen. For ICSI, whether sperm were ejaculated or surgically extracted was also considered.Relative risks (RRs) for autistic disorder and mental

2013 JAMA

148. Use of assistance and therapy dogs for children with autism spectrum disorders: a critical review of the current evidence Full Text available with Trip Pro

Use of assistance and therapy dogs for children with autism spectrum disorders: a critical review of the current evidence Use of assistance and therapy dogs for children with autism spectrum disorders: a critical review of the current evidence Use of assistance and therapy dogs for children with autism spectrum disorders: a critical review of the current evidence Berry A, Borgi M, Francia N, Alleva E, Cirulli F CRD summary This poorly reported review concluded that studies were encouraging (...) and indicated therapy or assistance dogs could promote positive behaviours in children diagnosed with autism spectrum disorders, but called for further research. The results cannot be considered reliable given the apparent variability in the small evidence base. Authors' objectives To provide a critical review of the literature assessing the effects of therapy and assistance dogs on children with autism spectrum disorders and their families. Searching PubMed, ERIC, Science Direct, Google Scholar, reference

2013 DARE.

149. Gestational age at birth and risk of autism spectrum disorders in Alberta, Canada (Abstract)

Gestational age at birth and risk of autism spectrum disorders in Alberta, Canada To examine the association between autism spectrum disorders (ASD) and each completed week of gestation using a graphical method of presenting results at all possible categorizations of gestational age (GA).The risk of ASD in a total of 218110 singleton live births with complete data from Alberta, Canada between 1998 and 2004 was examined through linkage to health insurance records. The relative risk of developing

2013 EvidenceUpdates

150. Future Research Needs: Interventions for Adolescents and Young Adults With Autism Spectrum Disorders

research focused on interventions for adolescents and young adults between the ages of 13 and 30 with autism spectrum disorder (ASD; autistic disorder, Asperger’s syndrome, pervasive developmental disorder–not otherwise specified). We addressed questions related to: the effectiveness of therapies targeting core symptoms of ASD (impairments in communication, social interaction, and behavior); common medical or mental health comorbidities, including associated symptoms such as irritability; the process (...) Future Research Needs: Interventions for Adolescents and Young Adults With Autism Spectrum Disorders Future Research Needs Paper Number 20 Future Research Needs: Interventions for Adolescents and Young Adults With Autism Spectrum Disorders Future Research Needs Paper Number 20 Future Research Needs: Interventions for Adolescents and Young Adults With Autism Spectrum Disorders Identification of Future Research Needs From Comparative Effectiveness Review No. 65 Prepared for: Agency for Healthcare

2013 Effective Health Care Program (AHRQ)

151. Association between maternal use of folic acid supplements and risk of autism spectrum disorders in children. Full Text available with Trip Pro

Association between maternal use of folic acid supplements and risk of autism spectrum disorders in children. Prenatal folic acid supplements reduce the risk of neural tube defects in children, but it has not been determined whether they protect against other neurodevelopmental disorders.To examine the association between maternal use of prenatal folic acid supplements and subsequent risk of autism spectrum disorders (ASDs) (autistic disorder, Asperger syndrome, pervasive developmental disorder (...) . Relative risks of ASDs were estimated by odds ratios (ORs) with 95% CIs in a logistic regression analysis. Analyses were adjusted for maternal education level, year of birth, and parity.Specialist-confirmed diagnosis of ASDs.At the end of follow-up, 270 children in the study sample had been diagnosed with ASDs: 114 with autistic disorder, 56 with Asperger syndrome, and 100 with PDD-NOS. In children whose mothers took folic acid, 0.10% (64/61,042) had autistic disorder, compared with 0.21% (50/24,134

2013 JAMA

152. Can we change the risk of autism? Full Text available with Trip Pro

Can we change the risk of autism? 23403688 2013 02 19 2018 12 02 1538-3598 309 6 2013 Feb 13 JAMA JAMA Periconceptional folic acid and risk of autism spectrum disorders. 611-3 10.1001/jama.2013.198 Berry Robert J RJ Crider Krista S KS Yeargin-Allsopp Marshalyn M eng CC999999 Intramural CDC HHS United States Editorial Research Support, U.S. Gov't, P.H.S. Comment United States JAMA 7501160 0098-7484 12001-76-2 Vitamin B Complex 935E97BOY8 Folic Acid AIM IM JAMA. 2013 Feb 13;309(6):570-7 23403681 (...) 19277892 Br J Psychiatry. 2009 Jul;195(1):7-14 19567888 J Nutr. 2010 May;140(5):1014-22 20335637 JAMA. 2010 Dec 22;304(24):2716-23 21177506 JAMA. 2011 Oct 12;306(14):1566-73 21990300 MMWR Surveill Summ. 2012 Mar 30;61(3):1-19 22456193 Am J Clin Nutr. 2012 Jul;96(1):80-9 22648721 Science. 2012 Oct 19;338(6105):342-3 23087240 Science. 2012 Dec 21;338(6114):1619-22 23160955 Autism Res. 2008 Feb;1(1):4-17 19360646 Pediatrics. 2005 Sep;116(3):703-8 16140711 Med Hypotheses. 2008 Sep;71(3):406-10 18514430

2013 JAMA

153. Pre?Graduation Transition Services for Improving Employment Outcomes among Persons with Autism Spectrum Disorders: A Systematic Review Full Text available with Trip Pro

Programs Recent conference programs and conference syntheses (2010‐2011) from relevant associations and conferences were used to identify unpublished studies eligible for review inclusion. Professional organizations/events that were examined included: Autism Society of America National Association of Rehabilitation Research and Training Centers International Society for Autism Research National Alliance for Autism Research Autism Research Institute National Autistic Society (UK) Autism Research Centre (...) Pre?Graduation Transition Services for Improving Employment Outcomes among Persons with Autism Spectrum Disorders: A Systematic Review Pre‐Graduation Transition Services for Improving Employment Outcomes among Persons with Autism Spectrum Disorders: A Systematic Review - Westbrook - 2013 - Campbell Systematic Reviews - Wiley Online Library By continuing to browse this site, you agree to its use of cookies as described in our . Search within Search term Search term SYSTEMATIC REVIEW Open Access

2013 Campbell Collaboration

154. Autism in under 19s: support and management

Autism in under 19s: support and management Autism spectrum disorder in under 19s: Autism spectrum disorder in under 19s: support and management support and management Clinical guideline Published: 28 August 2013 nice.org.uk/guidance/cg170 © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-of- rights).Y Y our responsibility our responsibility The recommendations in this guideline represent the view of NICE, arrived at after careful (...) in a way that would be inconsistent with complying with those duties. Commissioners and providers have a responsibility to promote an environmentally sustainable health and care system and should assess and reduce the environmental impact of implementing NICE recommendations wherever possible. Autism spectrum disorder in under 19s: support and management (CG170) © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 2

2013 National Institute for Health and Clinical Excellence - Clinical Guidelines

155. Review: more RCTs on early intensive behavioural intervention for young children with autism spectrum disorders needed

Review: more RCTs on early intensive behavioural intervention for young children with autism spectrum disorders needed Review: more RCTs on early intensive behavioural intervention for young children with autism spectrum disorders needed | Evidence-Based Mental Health We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your (...) username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Review: more RCTs on early intensive behavioural intervention for young children with autism spectrum disorders needed Article Text Therapeutics Review

2013 Evidence-Based Mental Health

156. Autism spectrum disorders are associated with fetal growth extremely below or above average for gestational age

Autism spectrum disorders are associated with fetal growth extremely below or above average for gestational age Autism spectrum disorders are associated with fetal growth extremely below or above average for gestational age | Evidence-Based Mental Health We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username (...) and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Autism spectrum disorders are associated with fetal growth extremely below or above average for gestational age Article Text Aetiology Autism spectrum disorders

2013 Evidence-Based Mental Health

157. Children of migrant parents may be at greater risk of low-functioning autism spectrum disorder, but lower risk of high-functioning autism spectrum disorder

Children of migrant parents may be at greater risk of low-functioning autism spectrum disorder, but lower risk of high-functioning autism spectrum disorder Children of migrant parents may be at greater risk of low-functioning autism spectrum disorder, but lower risk of high-functioning autism spectrum disorder | Evidence-Based Mental Health We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time (...) . To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Children of migrant parents may be at greater risk of low-functioning autism

2013 Evidence-Based Mental Health

158. Review: social skills groups may improve social competence in children and adolescents with autism spectrum disorder

Review: social skills groups may improve social competence in children and adolescents with autism spectrum disorder Review: social skills groups may improve social competence in children and adolescents with autism spectrum disorder | Evidence-Based Mental Health We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your (...) username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Review: social skills groups may improve social competence in children and adolescents with autism spectrum disorder Article Text Therapeutics Review

2013 Evidence-Based Mental Health

159. Cohort study: Maternal folic acid supplements associated with reduced autism risk in the child Full Text available with Trip Pro

Cohort study: Maternal folic acid supplements associated with reduced autism risk in the child Maternal folic acid supplements associated with reduced autism risk in the child | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers (...) of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Maternal folic acid supplements associated with reduced autism risk in the child Article Text Aetiology Cohort study Maternal folic acid supplements associated with reduced autism risk in the child Rebecca J Schmidt

2013 Evidence-Based Medicine

160. Autism ? complementary home-based care

Dev Disord, 40(12): 1447-58, 2010, [2a] http://www.ncbi.nlm.nih.gov/pubmed/20440639. Osborne, L. A.; McHugh, L.; Saunders, J.; and Reed, P.: Parenting stress reduces the effectiveness of early teaching interventions for autistic spectrum disorders. J Autism Dev Disord, 38(6): 1092-103, 2008, [4a] http://www.ncbi.nlm.nih.gov/pubmed/18027079. Rickards, A. L.; Walstab, J. E.; Wright-Rossi, R. A.; Simpson, J.; and Reddihough, D. S.: One-year follow-up of the outcome of a randomized controlled trial (...) Autism ? complementary home-based care Occupational Therapy and Physical Therapy/Autism/Home Based Services/BESt 131 Best Evidence Statement (BESt) Copyright © 2013 Cincinnati Children's Hospital Medical Center; all rights reserved Page 1 of 6 Date: 2/6/13 Title: Adding home based services to complement center based intervention for children with autism Clinical Question: Definitions for terms marked with * may be found in the Supporting Information section. Target Population

2013 Cincinnati Children's Hospital Medical Center