Latest & greatest articles for autism

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on autism or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on autism and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Autism

Autism is a neurodevelopmental disorder (a type of mental disorder) characterised by difficult social interaction, impaired communication (both verbal and non-verbal), and restricted and repetitive behaviours. It forms part of the broader autism spectrum disorder (ASD), a range of similar conditions, including Asperger syndrome.

Autism is a condition that begins from early childhood and is often suspected and diagnosed by ages 1-3. It is a lifelong disability that affects how people interact with others.

Autism causes and treatment

There have been many misconceptions as to what causes autism in the past such as the MMR vaccine and diet. Extensive research and clinical trials have concluded that none of these factors cause autism or ASD. However, the real cause is little understood but research is starting to unpick potential factors such as genetics, pollution and other environmental factors. A current favoured idea is that genes inherited from a child’s parents can make them more vulnerable to developing autism, some researchers suggest that the disorder will only develop when triggered by environmental factors.

The exact cause of autism spectrum disorder is unknown, however research into the disorder suggest that it is caused by several genetic and environmental factors. Genes inherited from a child’s parents can make them more vulnerable to developing autism, some researchers suggest that the disorder will only develop when triggered by environmental factors. Read more in clinical papers on autism.

Autism can be managed with a combination of prescribed medicines and behavioural treatment, depending on the severity of the disorder. Read about clinical trials and medical advancements for the treatment of autism on Trip.

Hot topics in Trip

Users of Trip frequently look at topics around adolescents, therapies, behaviour and screening. They also explore such topics as omega-3 fatty acids, SSRIs and aripiprazole. All these topics, and more, can be easily searched for within Trip.

Top results for autism

121. Equine therapy and other Equine-related therapies in developmental disorders, autism spectrum disorders and cerebral palsy

benefit. Healthcare sponsors surveyed do not cover this technology because they consider it experimental. Final publication URL www.iecs.org.ar Indexing Status Subject indexing assigned by CRD MeSH Autism Spectrum Disorder; Autistic Disorder; Cerebral Palsy; Developmental Disabilities; Equine-Assisted Therapy; Humans Language Published Spanish Country of organisation Argentina English summary An English language summary is available. Address for correspondence Institute for Clinical Effectiveness (...) Equine therapy and other Equine-related therapies in developmental disorders, autism spectrum disorders and cerebral palsy Equine therapy and other Equine-related therapies in developmental disorders, autism spectrum disorders and cerebral palsy Equine therapy and other Equine-related therapies in developmental disorders, autism spectrum disorders and cerebral palsy Oubiña M, Bardach A, Pichon-Riviere A, Augustovski F, García Martí S, Alcaraz A, Ciapponi A, López A, Rey-Ares L Record Status

2015 Health Technology Assessment (HTA) Database.

122. Growing evidence that maternal gestational diabetes increases risk of autism in offspring

Growing evidence that maternal gestational diabetes increases risk of autism in offspring Growing evidence that maternal gestational diabetes increases risk of autism in offspring | Evidence-Based Mental Health We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers (...) of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Growing evidence that maternal gestational diabetes increases risk of autism in offspring Article Text Causes and risk factors Growing evidence that maternal gestational diabetes increases risk of autism in offspring

2015 Evidence-Based Mental Health

123. Management of autism in children and young people: a good clinical practice guideline

Management of autism in children and young people: a good clinical practice guideline Management of autism in children and young people: a good clinical practice guideline Management of autism in children and young people: a good clinical practice guideline Veereman G, Holdt Henningsen K, Eyssen M, Benahmed N, Christiaens W, Bouchez M-H, De Roeck A, Deconinck N, De ligne G, Dewitte G, Gheysen T, Hendrix M, Kagan C, Magerotte G, Moonen M, Roeyers H, Schelstraete S, Soncarrieu M-V, Steyaert J (...) , Steyaert J, Tolfo F, Vrancken G, Willaye E, Wintgens A, Wouters S, Croonenberghs J. Management of autism in children and young people: a good clinical practice guideline. Brussels: Belgian Health Care Knowledge Centre (KCE). KCE Reports 233. 2014 Authors' conclusions The GDG worked diligently in order to demonstrate which interventions are meaningful to improve the lives of children and young people with autism and their families. The problems faced by children and adolescents with autism, caretakers

2015 Health Technology Assessment (HTA) Database.

124. Autism in adults

Autism in adults Autism in adults | Topics A to Z | CKS | NICE Search CKS… Menu Autism in adults Autism in adults Last revised in June 2019 Autism spectrum disorder is evidenced by difficulties in social interaction, communication, stereotypic behaviours, resistance to change, or restricted interests. Diagnosis Management Background information Autism in adults: Summary Autism spectrum disorder (ASD) is a lifelong neurodevelopmental condition characterized by persistent difficulties in social (...) with ASD include sensory problems, gastrointestinal disturbances (such as inflammatory bowel disease, coeliac disease, diarrhoea, and constipation), and epilepsy. The autism spectrum is very wide, ranging from people with limited self-help, independence, academic, or verbal skills through to those who are fully independent but have significant social difficulties. The features of ASD may range from mild to severe, and the presentation varies greatly in different people. The severity and impact of ASD

2015 NICE Clinical Knowledge Summaries

125. Addendum to the Notice on the Efficacy of Rehabilitative Interventions and Pharmacological Therapies for Children Aged 2 to 12 Years with Autism Spectrum Disorder (ASD)

Addendum to the Notice on the Efficacy of Rehabilitative Interventions and Pharmacological Therapies for Children Aged 2 to 12 Years with Autism Spectrum Disorder (ASD) Addenda à l'avis sur l'efficacité des interventions de réadaptation et des traitements pharmacologiques pour les enfants de 2 à 12 ans ayant un trouble du spectre de l'autisme (TSA) [Addendum to the notice on the efficacy of rehabilitative interventions and pharmacological therapies for children aged 2 to 12 Years with autism (...) spectrum disorder (ASD)] Addenda à l'avis sur l'efficacité des interventions de réadaptation et des traitements pharmacologiques pour les enfants de 2 à 12 ans ayant un trouble du spectre de l'autisme (TSA) [Addendum to the notice on the efficacy of rehabilitative interventions and pharmacological therapies for children aged 2 to 12 Years with autism spectrum disorder (ASD)] Mercier C, Beaudoin I Record Status This is a bibliographic record of a published health technology assessment from a member

2014 Health Technology Assessment (HTA) Database.

126. Therapies for Children With Autism Spectrum Disorder: Behavioral Interventions Update

Therapies for Children With Autism Spectrum Disorder: Behavioral Interventions Update Therapies for children with autism spectrum disorder: behavioral interventions update Therapies for children with autism spectrum disorder: behavioral interventions update Weitlauf AS, McPheeters ML, Peters B, Sathe N, Travis R, Aiello R, Williamson E, Veenstra-VanderWeele J, Krishnaswami S, Jerome R, Warren Z Record Status This is a bibliographic record of a published health technology assessment from (...) a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Weitlauf AS, McPheeters ML, Peters B, Sathe N, Travis R, Aiello R, Williamson E, Veenstra-VanderWeele J, Krishnaswami S, Jerome R, Warren Z. Therapies for children with autism spectrum disorder: behavioral interventions update. Rockville: Agency for Healthcare Research and Quality (AHRQ). Comparative Effectiveness Review No. 137. 2014 Authors' objectives We updated a prior systematic review

2014 Health Technology Assessment (HTA) Database.

127. Motor Interventions for Autism Spectrum Disorder in Children

included studies. Randomized Controlled Trials Schaaf, 2014 2 Children (4-8 y) with autism (n = 32) Occupational therapy (manualized intervention) Improved Goal Attainment Scale scores, measures of caregiver assistance in self-care, and socialization compared with usual care. Chan, 2013 3 Children with ASD (n = 46) Nei Yang Gong Larger self-control improvements occurred in the treatment group compared with a Progressive Muscle Relaxation technique control group, parental reports of reduced autistic (...) symptoms. Pfeiffer, 2011 4 Children (6-12 y) with ASD Sensory integration The intervention successfully reduced autistic mannerisms compared with fine motor intervention. Both groups showed improved Goal Attainment Scaling scores. Silva, 2011 5 Children with Qigong massage Improved measures of autism, Motor Interventions for Autism Spectrum Disorder in Children 2 autism (n = 47) abnormal sensory responses, and self-regulation were reported in the treatment group. Piravej, 2009 6 Children (3-10 y

2014 Canadian Agency for Drugs and Technologies in Health - Rapid Review

128. The familial risk of autism. Full Text available with Trip Pro

pairs, and 5,799,875 cousin pairs. Diagnoses of ASD to December 31, 2009 were ascertained.The relative recurrence risk (RRR) measures familial aggregation of disease. The RRR is the relative risk of autism in a participant with a sibling or cousin who has the diagnosis (exposed) compared with the risk in a participant with no diagnosed family member (unexposed). We calculated RRR for both ASD and autistic disorder adjusting for age, birth year, sex, parental psychiatric history, and parental age. We (...) The familial risk of autism. Autism spectrum disorder (ASD) aggregates in families, but the individual risk and to what extent this is caused by genetic factors or shared or nonshared environmental factors remains unresolved.To provide estimates of familial aggregation and heritability of ASD.A population-based cohort including 2,049,973 Swedish children born 1982 through 2006. We identified 37,570 twin pairs, 2,642,064 full sibling pairs, 432,281 maternal and 445,531 paternal half sibling

2014 JAMA

129. Sensory integration therapy for non-autistic children

Sensory integration therapy for non-autistic children Sensory integration therapy for non-autistic children Sensory integration therapy for non-autistic children Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Sensory integration therapy for non-autistic children. Lansdale: HAYES, Inc.. Directory Publication. 2014 Authors' conclusions Sensory integration therapy

2014 Health Technology Assessment (HTA) Database.

130. Dental Caries Prevalence is not Significantly Higher in Autistic Children Compared to Non-Autistic Children

Dental Caries Prevalence is not Significantly Higher in Autistic Children Compared to Non-Autistic Children UTCAT2693, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Dental Caries Prevalence is not Significantly Higher in Autistic Children Compared to Non-Autistic Children Clinical Question Is there a significantly higher prevalence of dental caries in children patients with autism than in children without (...) the disorder? Clinical Bottom Line Children with autism may have increased caries risk due to poor oral hygiene, modified dietary habits and decreased compliance, but do not necessarily have increased caries prevalence. Based on the limited information provided by literature, the studies on caries and autistic children are inconsistent. Results are in conflict between the studies possibly due to sample selection. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author

2014 UTHSCSA Dental School CAT Library

131. Patches of disorganization in the neocortex of children with autism. Full Text available with Trip Pro

Patches of disorganization in the neocortex of children with autism. Autism involves early brain overgrowth and dysfunction, which is most strongly evident in the prefrontal cortex. As assessed on pathological analysis, an excess of neurons in the prefrontal cortex among children with autism signals a disturbance in prenatal development and may be concomitant with abnormal cell type and laminar development.To systematically examine neocortical architecture during the early years after the onset (...) of autism, we used RNA in situ hybridization with a panel of layer- and cell-type-specific molecular markers to phenotype cortical microstructure. We assayed markers for neurons and glia, along with genes that have been implicated in the risk of autism, in prefrontal, temporal, and occipital neocortical tissue from postmortem samples obtained from children with autism and unaffected children between the ages of 2 and 15 years.We observed focal patches of abnormal laminar cytoarchitecture and cortical

2014 NEJM

132. Validation of the modified checklist for Autism in toddlers, revised with follow-up (M-CHAT-R/F) Full Text available with Trip Pro

Validation of the modified checklist for Autism in toddlers, revised with follow-up (M-CHAT-R/F) This study validates the Modified Checklist for Autism in Toddlers, Revised with Follow-up (M-CHAT-R/F), a screening tool for low-risk toddlers, and demonstrates improved utility compared with the original M-CHAT.Toddlers (N = 16,071) were screened during 18- and 24-month well-child care visits in metropolitan Atlanta and Connecticut. Parents of toddlers at risk on M-CHAT-R completed follow-up (...) ; those who continued to show risk were evaluated.The reliability and validity of the M-CHAT-R/F were demonstrated, and optimal scoring was determined by using receiver operating characteristic curves. Children whose total score was ≥ 3 initially and ≥ 2 after follow-up had a 47.5% risk of being diagnosed with autism spectrum disorder (ASD; confidence interval [95% CI]: 0.41-0.54) and a 94.6% risk of any developmental delay or concern (95% CI: 0.92-0.98). Total score was more effective than

2014 EvidenceUpdates

133. Chromosomal microarrays for the etiologic diagnosis in patients with intellectual disability, developmental delay or autism spectrum

Chromosomal microarrays for the etiologic diagnosis in patients with intellectual disability, developmental delay or autism spectrum Microarrays cromosómicos para diagnóstico etiológico en pacientes con discapacidad intelectual/retraso del desarrollo o trastornos del espectro autista [Chromosomal microarrays for the etiologic diagnosis in patients with intellectual disability, developmental delay or autism spectrum] Microarrays cromosómicos para diagnóstico etiológico en pacientes con (...) discapacidad intelectual/retraso del desarrollo o trastornos del espectro autista [Chromosomal microarrays for the etiologic diagnosis in patients with intellectual disability, developmental delay or autism spectrum] Pichon Riviere A, Augustovski F, Garcia Marti S, Alcaraz A, Glujovsky D, Lopez A, Rey-Ares L, Bardach A, Ciapponi A, Soto N Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been

2014 Health Technology Assessment (HTA) Database.

134. Screening and diagnostic tools for autism spectrum disorder in children: a review of guidelines

Autism Rating Scale (CARS) were the recommended tools for use when diagnosing ASD in those guidelines advocating their use. Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Autistic Disorders; Child; Mass Screening Language Published English Country of organisation Canada Province or state Ontario English summary An English language summary is available. Address for correspondence Canadian Agency for Drugs and Technologies in Health (CADTH), 865 Carling Avenue, Suite 600 (...) Screening and diagnostic tools for autism spectrum disorder in children: a review of guidelines Screening and diagnostic tools for autism spectrum disorder in children: a review of guidelines Screening and diagnostic tools for autism spectrum disorder in children: a review of guidelines CADTH Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database

2014 Health Technology Assessment (HTA) Database.

135. Theory of mind interventions can be effective in treating autism, although long-term success remains unproven Full Text available with Trip Pro

Theory of mind interventions can be effective in treating autism, although long-term success remains unproven Theory of mind interventions can be effective in treating autism, although long-term success remains unproven | Evidence-Based Mental Health We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username (...) and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Theory of mind interventions can be effective in treating autism, although long-term success remains unproven Article Text Miscellaneous Theory of mind interventions

2014 Evidence-Based Mental Health

136. Neonatal factors associated with autism spectrum disorders in infants Full Text available with Trip Pro

Neonatal factors associated with autism spectrum disorders in infants Neonatal factors associated with autism spectrum disorders in infants | Evidence-Based Mental Health We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username (...) * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Neonatal factors associated with autism spectrum disorders in infants Article Text Prevalence, assessment and diagnosis Neonatal factors associated with autism spectrum disorders in infants Sara Jane Webb Statistics from Altmetric.com What

2014 Evidence-Based Mental Health

137. Early Intensive Behavioral Intervention (EIBI) for Young Children with Autism Spectrum Disorders (ASD): A Systematic Review Full Text available with Trip Pro

of participants Young children with Autistic Disorder, Asperger's Disorder, Pervasive Developmental Disorder, not otherwise specified, or Atypical Autism ( ; )who are younger than six years old at the onset of treatment (that is, all participants within a group must be younger than six years old). Participants were not excluded based on IQ or presence of comorbidities. 3.1.3 Types of interventions EIBI as defined above, compared with no treatment, with waitlist controls, or treatment as usual (TAU). TAU often (...) specified children could have a diagnosis of autistic disorder or PDD‐NOS. The diagnoses of ASD were further confirmed in three of the five studies by using the ADI‐R. All studies specified that children could not have any other major medical conditions that would interfere with participation in the treatment. Two studies specified an IQ inclusion criterion. In children with autism had to have an IQ of 35 to 75 at treatment entry; in children with autism had to have an IQ of greater than 35. Across

2014 Campbell Collaboration

138. Autism traits may be more prevalent in ADHD than previously reported

Autism traits may be more prevalent in ADHD than previously reported Autism traits may be more prevalent in ADHD than previously reported | Evidence-Based Mental Health We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password (...) * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Autism traits may be more prevalent in ADHD than previously reported Article Text Prevalence, assessment and diagnosis Autism traits may be more prevalent in ADHD than previously reported Kevin Antshel Statistics from Altmetric.com What is already known

2014 Evidence-Based Mental Health

139. Labor Induction or Augmentation and Autism

Labor Induction or Augmentation and Autism Labor Induction or Augmentation and Autism - ACOG Menu ▼ Labor Induction or Augmentation and Autism Page Navigation ▼ Number 597, May 2014 (Reaffirmed 2018) Committee on Obstetric Practice The Society for Maternal-Fetal Medicine endorses this document. This document reflects emerging clinical and scientific advances as of the date issued and is subject to change. The information should not be construed as dictating an exclusive course of treatment (...) or procedure to be followed. Labor Induction or Augmentation and Autism Abstract: Functional oxytocin deficiency and a faulty oxytocin signaling pathway have been observed in conjunction with autism spectrum disorder (ASD). Because exogenous synthetic oxytocin commonly is administered for labor induction and augmentation, some have hypothesized that synthetic oxytocin used for these purposes may alter fetal oxytocin receptors and predispose exposed offspring to ASD. However, current evidence does

2014 American College of Obstetricians and Gynecologists

140. Autism

search covered the period from 1991 to March 19, 2013 using the PubMed, PsycINFO, Cochrane, and CINAHL (EBSCO) databases. The initial searches were inclusive and sensitive. Search terms were a combination of MeSH headings and keywords, and the MeSH headings were adjusted to terms used by PsycINFO and CINAHL by using their thesauri. In PubMed the MeSH terms autistic disorder, childhood development disorders—pervasive, Asperger*, and Rett* and the keyword autism were searched. The initial search (...) OF CHILD & ADOLESCENT PSYCHIATRY VOLUME 53 NUMBER 2 FEBRUARY 2014 www.jaacap.org 237andvalidationstudies.There?nedPubMedsearch yielded3,613articles. In the PsycINFO database subject headings (focused) of autism, autistic thinking, pervasive developmental disorders, retts syndrome, aspergers, and keyword autism were searched. The initial search returned 24,875 articles and was then limited to English, childhood: birth to age 12yrs, adolescence: age 13-17 yrs, peer reviewed journal,and 1991 to March 19

2014 American Academy of Child and Adolescent Psychiatry