Latest & greatest articles for autism

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Autism

Autism is a neurodevelopmental disorder (a type of mental disorder) characterised by difficult social interaction, impaired communication (both verbal and non-verbal), and restricted and repetitive behaviours. It forms part of the broader autism spectrum disorder (ASD), a range of similar conditions, including Asperger syndrome.

Autism is a condition that begins from early childhood and is often suspected and diagnosed by ages 1-3. It is a lifelong disability that affects how people interact with others.

Autism causes and treatment

There have been many misconceptions as to what causes autism in the past such as the MMR vaccine and diet. Extensive research and clinical trials have concluded that none of these factors cause autism or ASD. However, the real cause is little understood but research is starting to unpick potential factors such as genetics, pollution and other environmental factors. A current favoured idea is that genes inherited from a child’s parents can make them more vulnerable to developing autism, some researchers suggest that the disorder will only develop when triggered by environmental factors.

The exact cause of autism spectrum disorder is unknown, however research into the disorder suggest that it is caused by several genetic and environmental factors. Genes inherited from a child’s parents can make them more vulnerable to developing autism, some researchers suggest that the disorder will only develop when triggered by environmental factors. Read more in clinical papers on autism.

Autism can be managed with a combination of prescribed medicines and behavioural treatment, depending on the severity of the disorder. Read about clinical trials and medical advancements for the treatment of autism on Trip.

Hot topics in Trip

Users of Trip frequently look at topics around adolescents, therapies, behaviour and screening. They also explore such topics as omega-3 fatty acids, SSRIs and aripiprazole. All these topics, and more, can be easily searched for within Trip.

Top results for autism

81. Cognitive-behavioural group therapy for youth with high-functioning autism spectrum disorders demonstrates modest effects on social responsiveness

Cognitive-behavioural group therapy for youth with high-functioning autism spectrum disorders demonstrates modest effects on social responsiveness Cognitive-behavioural group therapy for youth with high-functioning autism spectrum disorders demonstrates modest effects on social responsiveness | Evidence-Based Mental Health We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about (...) how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Cognitive-behavioural group therapy for youth with high-functioning autism spectrum disorders

2017 Evidence-Based Mental Health

83. Thalamocortical dysconnectivity in autism spectrum disorder: An analysis of the Autism Brain Imaging Data Exchange Full Text available with Trip Pro

Thalamocortical dysconnectivity in autism spectrum disorder: An analysis of the Autism Brain Imaging Data Exchange Individuals with autism spectrum disorder (ASD) exhibit differences in basic sensorimotor processing as well as general cortical excitability. These observations converge to implicate thalamocortical connectivity as a potential unifying neural mechanism. The goal of this study was to clarify mixed findings on thalamocortical functional connectivity in a large sample of individuals (...) with ASD.Using the Autism Brain Imaging Data Exchange (ABIDE), we examined thalamocortical functional connectivity in 228 individuals with ASD and a matched comparison group of 228 typically developing individuals. In order to fully characterize thalamocortical functional networks, we employed complementary seed-based approaches that examined connectivity of major cortical divisions (e.g. prefrontal cortex, temporal lobe) with the thalamus and whole-brain connectivity of specific thalamic sub

2017 Biological psychiatry. Cognitive neuroscience and neuroimaging

84. Network organization is globally atypical in autism: A graph theory study of intrinsic functional connectivity Full Text available with Trip Pro

Network organization is globally atypical in autism: A graph theory study of intrinsic functional connectivity Despite abundant evidence of brain network anomalies in autism spectrum disorder (ASD), findings have varied from broad functional underconnectivity to broad overconnectivity. Rather than pursuing overly simplifying general hypotheses ('under' vs. 'over'), we tested the hypothesis of atypical network distribution in ASD (i.e., participation of unusual loci in distributed functional

2017 Biological psychiatry. Cognitive neuroscience and neuroimaging

85. Biomedical treatment for autism spectrum disorders

Status Subject indexing assigned by CRD MeSH Autism Spectrum Disorder; Autistic Disorder; Health Occupations; Humans Language Published Spanish Country of organisation Argentina English summary An English language summary is available. Address for correspondence Institute for Clinical Effectiveness and Health Policy, Viamonte 2146 - 3 Piso, C1056ABH Ciudad de Buenos Aires, Argentina Tel: +54 11 49 66 00 82 Fax:+54 11 49 53 40 58 Email: info@iecs.org.ar AccessionNumber 32016001124 Date abstract record (...) Biomedical treatment for autism spectrum disorders Biomedical treatment for autism spectrum disorders Biomedical treatment for autism spectrum disorders Mengarelli C, García Martí S, Pichon-Riviere A, Augustovski F, Alcaraz A, Bardach A, Ciapponi A, López A, Rey-Ares L Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Mengarelli C, García

2016 Health Technology Assessment (HTA) Database.

86. Prescription Drug Use and Polypharmacy Among Medicaid-Enrolled Adults with Autism: A Retrospective Cross-Sectional Analysis Full Text available with Trip Pro

Prescription Drug Use and Polypharmacy Among Medicaid-Enrolled Adults with Autism: A Retrospective Cross-Sectional Analysis A lack of gold standard treatment for autism spectrum disorders (ASD), no clear ASD management guidelines, and lack of evidence-based pharmacological interventions other than aripiprazole and risperidone elevate the risk of off-label prescribing and adverse effects among individuals with ASD, more so among adults.The aim of this study was to identify and compare the types

2016 Drugs - real world outcomes

87. "We Dance and Find Each Other"1: Effects of Dance/Movement Therapy on Negative Symptoms in Autism Spectrum Disorder. Full Text available with Trip Pro

"We Dance and Find Each Other"1: Effects of Dance/Movement Therapy on Negative Symptoms in Autism Spectrum Disorder. The treatment of deficits in social interaction, a shared symptom cluster in persons with schizophrenia (negative symptoms) and autism spectrum disorder (DSM-5 A-criterion), has so far remained widely unsuccessful in common approaches of psychotherapy. The alternative approach of embodiment brings to focus body-oriented intervention methods based on a theoretic framework (...) that explains the disorders on a more basic level than common theory of mind approaches. The randomized controlled trial at hand investigated the effects of a 10-week manualized dance and movement therapy intervention on negative symptoms in participants with autism spectrum disorder. Although the observed effects failed to reach significance at the conventional 0.05 threshold, possibly due to an undersized sample, an encouraging trend towards stronger symptom reduction in the treatment group for overall

2016 Behavioral sciences (Basel, Switzerland) Controlled trial quality: uncertain

88. Predictive Validity of the Modified Checklist for Autism in Toddlers (M-CHAT) Born Very Preterm Full Text available with Trip Pro

Predictive Validity of the Modified Checklist for Autism in Toddlers (M-CHAT) Born Very Preterm To examine the predictive validity of the Modified Checklist for Autism in Toddlers (M-CHAT) administered at age 24 months for autism spectrum disorder (ASD) diagnosed at 10 years of age in a US cohort of 827 extremely low gestational age newborns (ELGANs) followed from birth.We examined the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the M-CHAT

2016 EvidenceUpdates

89. Parent-mediated social communication therapy for young children with autism (PACT): long-term follow-up of a randomised controlled trial. Full Text available with Trip Pro

Parent-mediated social communication therapy for young children with autism (PACT): long-term follow-up of a randomised controlled trial. It is not known whether early intervention can improve long-term autism symptom outcomes. We aimed to follow-up the Preschool Autism Communication Trial (PACT), to investigate whether the PACT intervention had a long-term effect on autism symptoms and continued effects on parent and child social interaction.PACT was a randomised controlled trial of a parent (...) -mediated social communication intervention for children aged 2-4 years with core autism. Follow-up ascertainment was done at three specialised clinical services centres in the UK (London, Manchester, and Newcastle) at a median of 5·75 years (IQR 5·42-5·92) from the original trial endpoint. The main blinded outcomes were the comparative severity score (CSS) from the Autism Diagnostic Observation Schedule (ADOS), the Dyadic Communication Assessment Measure (DCMA) of the proportion of child initiatiations

2016 Lancet Controlled trial quality: predicted high

90. Hyperbaric oxygen therapy for people with autism spectrum disorder (ASD). Full Text available with Trip Pro

Hyperbaric oxygen therapy for people with autism spectrum disorder (ASD). The rising prevalence of autism spectrum disorder (ASD) has increased the need for evidence-based treatments to lessen the impact of symptoms. Presently, no therapies are available to effectively treat individuals with all of the symptoms of this disorder. It has been suggested that hyperbaric oxygen therapy may alleviate the biochemical dysfunction and clinical symptoms of ASD.To determine whether treatment

2016 Cochrane

91. Association of Labor Induction With Offspring Risk of Autism Spectrum Disorders Full Text available with Trip Pro

Association of Labor Induction With Offspring Risk of Autism Spectrum Disorders Induction of labor is a frequently performed obstetrical intervention. It would thus be of great concern if reported associations between labor induction and offspring risk of autism spectrum disorders (ASD) reflected causal influence.To assess the associations of labor induction with ASD, comparing differentially exposed relatives (siblings and cousins discordant for induction).Follow-up of all live births

2016 EvidenceUpdates

92. Genome-wide characteristics of de novo mutations in autism Full Text available with Trip Pro

Genome-wide characteristics of de novo mutations in autism De novo mutations (DNMs) are important in Autism Spectrum Disorder (ASD), but so far analyses have mainly been on the ~1.5% of the genome encoding genes. Here, we performed whole genome sequencing (WGS) of 200 ASD parent-child trios and characterized germline and somatic DNMs. We confirmed that the majority of germline DNMs (75.6%) originated from the father, and these increased significantly with paternal age only (p=4.2×10-10

2016 NPJ genomic medicine

93. Aberrant Oscillatory Synchrony Is Biased Toward Specific Frequencies and Processing Domains in the Autistic Brain Full Text available with Trip Pro

Aberrant Oscillatory Synchrony Is Biased Toward Specific Frequencies and Processing Domains in the Autistic Brain Prevailing theories suggest that autism spectrum disorder (ASD) results from impaired brain communication, causing aberrant synchrony among neuronal populations. However, it remains debated whether synchrony abnormalities are among local or long-range circuits, are circuit specific or are generalized, reflect hypersynchrony or reflect hyposynchrony, and are frequency band-specific

2016 Biological psychiatry. Cognitive neuroscience and neuroimaging

94. Maternal vitamin D deficiency and the risk of autism spectrum disorders: population-based study Full Text available with Trip Pro

Maternal vitamin D deficiency and the risk of autism spectrum disorders: population-based study Maternal vitamin D deficiency may increase risk of autism spectrum disorder (ASD), but direct evidence is lacking.To clarify the relationship between maternal vitamin D deficiency and offspring risk of ASD with and without intellectual disability.Using a register-based total population study (N=509 639), we calculated adjusted odds ratios (aORs) and 95% confidence intervals (CIs) of ASD

2016 BJPsych open

95. A microcosting and cost-consequence analysis of genomic testing strategies in autism spectrum disorder

A microcosting and cost-consequence analysis of genomic testing strategies in autism spectrum disorder A microcosting and cost-consequence analysis of genomic testing strategies in autism spectrum disorder A microcosting and cost-consequence analysis of genomic testing strategies in autism spectrum disorder Tsiplova K, Zur RM, Ungar WJ Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment (...) has been made for the HTA database. Citation Tsiplova K, Zur RM, Ungar WJ. A microcosting and cost-consequence analysis of genomic testing strategies in autism spectrum disorder. Toronto, ON: Technology Assessment at SickKids (TASK). 2016 Authors' conclusions This study is the first to estimate the cost of clinical exome and genome sequencing using a bottom-up microcosting approach, The WGS using older technology (HiSeq 2500) was the most expensive test, costing almost three times as much as WES

2016 Health Technology Assessment (HTA) Database.

96. Association of Psychiatric and Neurologic Comorbidity With Mortality Among Persons With Autism Spectrum Disorder in a Danish Population Full Text available with Trip Pro

Association of Psychiatric and Neurologic Comorbidity With Mortality Among Persons With Autism Spectrum Disorder in a Danish Population Increased mortality has been reported among persons with autism spectrum disorder (ASD), especially among those who also have the comorbid condition of epilepsy or intellectual disability. The effects of psychiatric and neurologic comorbidity on mortality among persons with ASD have not been rigorously examined in large, population-based studies.To investigate

2016 EvidenceUpdates

97. Screening for Autism Spectrum Disorder in Young Children: US Preventive Services Task Force Recommendation Statement. Full Text available with Trip Pro

Screening for Autism Spectrum Disorder in Young Children: US Preventive Services Task Force Recommendation Statement. New US Preventive Services Task Force (USPSTF) recommendation on screening for autism spectrum disorder (ASD) in young children.The USPSTF reviewed the evidence on the accuracy, benefits, and potential harms of brief, formal screening instruments for ASD administered during routine primary care visits and the benefits and potential harms of early behavioral treatment for young

2016 JAMA

98. Gender Variance Among Youth with Autism Spectrum Disorders: A Retrospective Chart Review Full Text available with Trip Pro

Gender Variance Among Youth with Autism Spectrum Disorders: A Retrospective Chart Review Purpose: Increasing clinical evidence suggests an overrepresentation of gender variance (GV) among patients with autism spectrum disorders (ASDs). This retrospective chart review aims to contribute to the existing literature on co-occurring ASD and gender dysphoria (GD). We compare the rate of parent-reported GV in patients with an ASD diagnosis to that of parent-reported GV in a normative nonreferred data

2016 Transgender health

99. Cohort study: Rate of epilepsy in people with autism and the rate of autism in people with epilepsy are high

Cohort study: Rate of epilepsy in people with autism and the rate of autism in people with epilepsy are high Rate of epilepsy in people with autism and the rate of autism in people with epilepsy are high | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal (...) accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Rate of epilepsy in people with autism and the rate of autism in people with epilepsy are high Article Text Prognosis Cohort study Rate of epilepsy in people with autism and the rate

2016 Evidence-Based Medicine

100. A microcosting and cost-consequence analysis of genomic testing strategies in autism spectrum disorder

A microcosting and cost-consequence analysis of genomic testing strategies in autism spectrum disorder The Hospital for Sick Children Technology Assessment at SickKids (TASK) FULL REPORT UPDATED A MICROCOSTING AND COST-CONSEQUENCE ANALYSIS OF GENOMIC TESTING STRATEGIES IN AUTISM SPECTRUM DISORDER Authors: Kate Tsiplova, MSc Research Project Manager, Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Canada Richard M. Zur, PhD Research Project Manager, Child Health (...) College of Medical Genetics and Genomics ASD Autism spectrum disorder CAD Canadian dollar CMA Chromosomal microarray analysis CGES Clinical genome and exome sequencing CIHI Canadian Institute for Health Information CNV Copy number variant DD Developmental delay DSA Deterministic sensitivity analysis FISH Fluorescence in situ hybridization GE 3 LS Genomics and its ethical, economic, environmental, legal, and social aspects HTA Health technology assessment ID Intellectual disability MCA Multiple

2016 SickKids Reports