Latest & greatest articles for autism

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This page lists the very latest high quality evidence on autism and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

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Autism

Autism is a neurodevelopmental disorder (a type of mental disorder) characterised by difficult social interaction, impaired communication (both verbal and non-verbal), and restricted and repetitive behaviours. It forms part of the broader autism spectrum disorder (ASD), a range of similar conditions, including Asperger syndrome.

Autism is a condition that begins from early childhood and is often suspected and diagnosed by ages 1-3. It is a lifelong disability that affects how people interact with others.

Autism causes and treatment

There have been many misconceptions as to what causes autism in the past such as the MMR vaccine and diet. Extensive research and clinical trials have concluded that none of these factors cause autism or ASD. However, the real cause is little understood but research is starting to unpick potential factors such as genetics, pollution and other environmental factors. A current favoured idea is that genes inherited from a child’s parents can make them more vulnerable to developing autism, some researchers suggest that the disorder will only develop when triggered by environmental factors.

The exact cause of autism spectrum disorder is unknown, however research into the disorder suggest that it is caused by several genetic and environmental factors. Genes inherited from a child’s parents can make them more vulnerable to developing autism, some researchers suggest that the disorder will only develop when triggered by environmental factors. Read more in clinical papers on autism.

Autism can be managed with a combination of prescribed medicines and behavioural treatment, depending on the severity of the disorder. Read about clinical trials and medical advancements for the treatment of autism on Trip.

Hot topics in Trip

Users of Trip frequently look at topics around adolescents, therapies, behaviour and screening. They also explore such topics as omega-3 fatty acids, SSRIs and aripiprazole. All these topics, and more, can be easily searched for within Trip.

Top results for autism

81. Parent-mediated social communication therapy for young children with autism (PACT): long-term follow-up of a randomised controlled trial. Full Text available with Trip Pro

Parent-mediated social communication therapy for young children with autism (PACT): long-term follow-up of a randomised controlled trial. It is not known whether early intervention can improve long-term autism symptom outcomes. We aimed to follow-up the Preschool Autism Communication Trial (PACT), to investigate whether the PACT intervention had a long-term effect on autism symptoms and continued effects on parent and child social interaction.PACT was a randomised controlled trial of a parent (...) -mediated social communication intervention for children aged 2-4 years with core autism. Follow-up ascertainment was done at three specialised clinical services centres in the UK (London, Manchester, and Newcastle) at a median of 5·75 years (IQR 5·42-5·92) from the original trial endpoint. The main blinded outcomes were the comparative severity score (CSS) from the Autism Diagnostic Observation Schedule (ADOS), the Dyadic Communication Assessment Measure (DCMA) of the proportion of child initiatiations

2016 Lancet Controlled trial quality: predicted high

82. Hyperbaric oxygen therapy for people with autism spectrum disorder (ASD). Full Text available with Trip Pro

Hyperbaric oxygen therapy for people with autism spectrum disorder (ASD). The rising prevalence of autism spectrum disorder (ASD) has increased the need for evidence-based treatments to lessen the impact of symptoms. Presently, no therapies are available to effectively treat individuals with all of the symptoms of this disorder. It has been suggested that hyperbaric oxygen therapy may alleviate the biochemical dysfunction and clinical symptoms of ASD.To determine whether treatment

2016 Cochrane

83. Association of Labor Induction With Offspring Risk of Autism Spectrum Disorders Full Text available with Trip Pro

Association of Labor Induction With Offspring Risk of Autism Spectrum Disorders Induction of labor is a frequently performed obstetrical intervention. It would thus be of great concern if reported associations between labor induction and offspring risk of autism spectrum disorders (ASD) reflected causal influence.To assess the associations of labor induction with ASD, comparing differentially exposed relatives (siblings and cousins discordant for induction).Follow-up of all live births

2016 EvidenceUpdates

84. Genome-wide characteristics of de novo mutations in autism Full Text available with Trip Pro

Genome-wide characteristics of de novo mutations in autism De novo mutations (DNMs) are important in Autism Spectrum Disorder (ASD), but so far analyses have mainly been on the ~1.5% of the genome encoding genes. Here, we performed whole genome sequencing (WGS) of 200 ASD parent-child trios and characterized germline and somatic DNMs. We confirmed that the majority of germline DNMs (75.6%) originated from the father, and these increased significantly with paternal age only (p=4.2×10-10

2016 NPJ genomic medicine

85. Aberrant Oscillatory Synchrony Is Biased Toward Specific Frequencies and Processing Domains in the Autistic Brain Full Text available with Trip Pro

Aberrant Oscillatory Synchrony Is Biased Toward Specific Frequencies and Processing Domains in the Autistic Brain Prevailing theories suggest that autism spectrum disorder (ASD) results from impaired brain communication, causing aberrant synchrony among neuronal populations. However, it remains debated whether synchrony abnormalities are among local or long-range circuits, are circuit specific or are generalized, reflect hypersynchrony or reflect hyposynchrony, and are frequency band-specific

2016 Biological psychiatry. Cognitive neuroscience and neuroimaging

86. Effects of augmentation agents in autistic disorder patients treated with risperidone: a systematic review and a meta-analysis. Full Text available with Trip Pro

Effects of augmentation agents in autistic disorder patients treated with risperidone: a systematic review and a meta-analysis. 27409138 2017 03 13 2018 12 02 2238-0019 38 2 2016 Apr-Jun Trends in psychiatry and psychotherapy Trends Psychiatry Psychother Effects of augmentation agents in autistic disorder patients treated with risperidone: a systematic review and a meta-analysis. 114-6 10.1590/2237-6089-2015-0068 S2237-60892016000200114 Soares Amanda A Laboratório de Neuromodulação Clínica (...) , Faculdade de Ciências Médicas da Santa Casa de São Paulo, São Paulo, SP, Brazil. Cordeiro Quirino Q Laboratório de Neuromodulação Clínica, Faculdade de Ciências Médicas da Santa Casa de São Paulo, São Paulo, SP, Brazil. eng Letter Meta-Analysis Review Systematic Review Brazil Trends Psychiatry Psychother 101610695 2237-6089 0 Psychotropic Drugs L6UH7ZF8HC Risperidone IM Autistic Disorder drug therapy Drug Therapy, Combination Humans Psychotropic Drugs therapeutic use Risperidone therapeutic use 2015 10

2016 Trends in psychiatry and psychotherapy

87. Assessment, diagnosis and interventions for autism spectrum disorders

. The inclusion of adults is in response to the increasing understanding that autism spectrum disorder (ASD) is a lifelong condition in which the core features of ASD persist whilst manifesting differently according to different age stages. Depending on the severity of autistic difficulties, ASD may not be evident as a presentation throughout preschool, primary, or secondary school years or in adulthood. It may not be recognised because of associated coexisting conditions. Variable environmental factors (...) on cognition. A study conducted in a gender clinic in London reported that among the 92 participants the prevalence of autistic traits, based on assessment with the Autism Spectrum Quotient (AQ) was 5.5% (3 male to female and 2 female to male transsexuals) compared to reports of clinical diagnoses of 0.5–2.0% in the general population. 49 Further indicators of possible ASD in adults are listed in Annex 2. Healthcare professionals should be aware of indicators for ASD in adults presenting with other

2016 SIGN

88. Aripiprazole for autism spectrum disorders (ASD). (Abstract)

Aripiprazole for autism spectrum disorders (ASD). Autism spectrum disorders (ASD) include autistic disorder, Asperger's disorder and pervasive developmental disorder - not otherwise specified (PDD-NOS). Antipsychotics have been used as a medication intervention for irritability related to ASD. Aripiprazole, a third-generation, atypical antipsychotic, is a relatively new drug that has a unique mechanism of action different from that of other antipsychotics. This review updates a previous

2016 Cochrane

89. Maternal vitamin D deficiency and the risk of autism spectrum disorders: population-based study Full Text available with Trip Pro

Maternal vitamin D deficiency and the risk of autism spectrum disorders: population-based study Maternal vitamin D deficiency may increase risk of autism spectrum disorder (ASD), but direct evidence is lacking.To clarify the relationship between maternal vitamin D deficiency and offspring risk of ASD with and without intellectual disability.Using a register-based total population study (N=509 639), we calculated adjusted odds ratios (aORs) and 95% confidence intervals (CIs) of ASD

2016 BJPsych open

90. A microcosting and cost-consequence analysis of genomic testing strategies in autism spectrum disorder

A microcosting and cost-consequence analysis of genomic testing strategies in autism spectrum disorder A microcosting and cost-consequence analysis of genomic testing strategies in autism spectrum disorder A microcosting and cost-consequence analysis of genomic testing strategies in autism spectrum disorder Tsiplova K, Zur RM, Ungar WJ Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment (...) has been made for the HTA database. Citation Tsiplova K, Zur RM, Ungar WJ. A microcosting and cost-consequence analysis of genomic testing strategies in autism spectrum disorder. Toronto, ON: Technology Assessment at SickKids (TASK). 2016 Authors' conclusions This study is the first to estimate the cost of clinical exome and genome sequencing using a bottom-up microcosting approach, The WGS using older technology (HiSeq 2500) was the most expensive test, costing almost three times as much as WES

2016 Health Technology Assessment (HTA) Database.

91. The broad autism phenotype in parents of individuals with autism: a systematic review of the literature. Full Text available with Trip Pro

The broad autism phenotype in parents of individuals with autism: a systematic review of the literature. The broad autism phenotype (BAP) is a milder manifestation of the defining symptoms of the syndrome in individuals without autism. This study conducted a systematic review of studies about behavioral characteristics of interpersonal relationships, communication and rigidity, as well as about three cognitive models, Theory of Mind, central coherence and executive function, in parents (...) of individuals with autism. The indexed databases were LILACS, IBECS, Web of Science, and MEDLINE, and the studies retrieved were published between 1991 and March 2012. Parents of individuals with autism have more difficulties in interpersonal relationships and in pragmatic language use and have more rigidity traits. The inclusions of the cognitive theories in the group of BAP characteristics were inconclusive.

2016 Trends in psychiatry and psychotherapy

92. Association of Psychiatric and Neurologic Comorbidity With Mortality Among Persons With Autism Spectrum Disorder in a Danish Population Full Text available with Trip Pro

Association of Psychiatric and Neurologic Comorbidity With Mortality Among Persons With Autism Spectrum Disorder in a Danish Population Increased mortality has been reported among persons with autism spectrum disorder (ASD), especially among those who also have the comorbid condition of epilepsy or intellectual disability. The effects of psychiatric and neurologic comorbidity on mortality among persons with ASD have not been rigorously examined in large, population-based studies.To investigate

2016 EvidenceUpdates

93. Screening for Autism Spectrum Disorder in Young Children: US Preventive Services Task Force Recommendation Statement. Full Text available with Trip Pro

Screening for Autism Spectrum Disorder in Young Children: US Preventive Services Task Force Recommendation Statement. New US Preventive Services Task Force (USPSTF) recommendation on screening for autism spectrum disorder (ASD) in young children.The USPSTF reviewed the evidence on the accuracy, benefits, and potential harms of brief, formal screening instruments for ASD administered during routine primary care visits and the benefits and potential harms of early behavioral treatment for young

2016 JAMA

94. Gender Variance Among Youth with Autism Spectrum Disorders: A Retrospective Chart Review Full Text available with Trip Pro

Gender Variance Among Youth with Autism Spectrum Disorders: A Retrospective Chart Review Purpose: Increasing clinical evidence suggests an overrepresentation of gender variance (GV) among patients with autism spectrum disorders (ASDs). This retrospective chart review aims to contribute to the existing literature on co-occurring ASD and gender dysphoria (GD). We compare the rate of parent-reported GV in patients with an ASD diagnosis to that of parent-reported GV in a normative nonreferred data

2016 Transgender health

95. Cohort study: Rate of epilepsy in people with autism and the rate of autism in people with epilepsy are high

Cohort study: Rate of epilepsy in people with autism and the rate of autism in people with epilepsy are high Rate of epilepsy in people with autism and the rate of autism in people with epilepsy are high | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal (...) accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Rate of epilepsy in people with autism and the rate of autism in people with epilepsy are high Article Text Prognosis Cohort study Rate of epilepsy in people with autism and the rate

2016 Evidence-Based Medicine

96. Autism Spectrum Disorder in Young Children: Screening

Autism Spectrum Disorder in Young Children: Screening Final Update Summary: Autism Spectrum Disorder in Young Children: Screening - US Preventive Services Task Force Search USPSTF Website Text size: Assembly version: 1.0.0.308 Last Build: 11/16/2018 6:27:19 PM You are here: Final Summary To watch a video about this final recommendation and learn more, click . Autism Spectrum Disorder in Young Children: Screening Release Date: February 2016 Recommendation Summary Population Recommendation Grade (...) Children aged 18 to 30 months The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for autism spectrum disorder (ASD) in young children for whom no concerns of ASD have been raised by their parents or a clinician. See the for suggestions for practice regarding the I statement. To read the recommendation statement in JAMA , click . ( ) Related Information for Consumers Related Information for Health Professionals There is no related

2016 U.S. Preventive Services Task Force

97. A microcosting and cost-consequence analysis of genomic testing strategies in autism spectrum disorder

A microcosting and cost-consequence analysis of genomic testing strategies in autism spectrum disorder The Hospital for Sick Children Technology Assessment at SickKids (TASK) FULL REPORT UPDATED A MICROCOSTING AND COST-CONSEQUENCE ANALYSIS OF GENOMIC TESTING STRATEGIES IN AUTISM SPECTRUM DISORDER Authors: Kate Tsiplova, MSc Research Project Manager, Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Canada Richard M. Zur, PhD Research Project Manager, Child Health (...) College of Medical Genetics and Genomics ASD Autism spectrum disorder CAD Canadian dollar CMA Chromosomal microarray analysis CGES Clinical genome and exome sequencing CIHI Canadian Institute for Health Information CNV Copy number variant DD Developmental delay DSA Deterministic sensitivity analysis FISH Fluorescence in situ hybridization GE 3 LS Genomics and its ethical, economic, environmental, legal, and social aspects HTA Health technology assessment ID Intellectual disability MCA Multiple

2016 SickKids Reports

98. Diagnosing autism spectrum disorder (ASD) among adults

Diagnosing autism spectrum disorder (ASD) among adults Diagnosing autism spectrum disorder (ASD) among adults | Evidence-Based Mental Health We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name (...) or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Diagnosing autism spectrum disorder (ASD) among adults Article Text Evidence-based case conference Diagnosing autism spectrum disorder (ASD) among adults Toshi A Furukawa Statistics from Altmetric.com Clinical case Patient: 18-year-old man Present illness : The patient

2016 Evidence-Based Mental Health

99. Air Pollution and Autism Spectrum Disorders: Causal or Confounded? Full Text available with Trip Pro

Air Pollution and Autism Spectrum Disorders: Causal or Confounded? In the last decade, several studies have examined the association between perinatal exposure to ambient air pollution and risk of autism spectrum disorder (ASD). These studies have largely been consistent, with associations seen with different aspects of air pollution, including hazardous air toxics, ozone, particulate, and traffic-related pollution. Confounding by socioeconomic status (SES) and place of residence

2015 Current environmental health reports

100. Special report: chromosomal microarray for the genetic evaluation of patients with global developmental delay, intellectual disability, and autism spectrum disorder

Special report: chromosomal microarray for the genetic evaluation of patients with global developmental delay, intellectual disability, and autism spectrum disorder Special report: chromosomal microarray for the genetic evaluation of patients with global developmental delay, intellectual disability, and autism spectrum disorder Special report: chromosomal microarray for the genetic evaluation of patients with global developmental delay, intellectual disability, and autism spectrum disorder (...) BlueCross BlueShield Association Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation BlueCross BlueShield Association. Special report: chromosomal microarray for the genetic evaluation of patients with global developmental delay, intellectual disability, and autism spectrum disorder. Chicago: BlueCross BlueShield Association (BCBS). TEC Assessment 30(2). 2015 Authors

2015 Health Technology Assessment (HTA) Database.