Latest & greatest articles for autism

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on autism or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on autism and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

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Autism

Autism is a neurodevelopmental disorder (a type of mental disorder) characterised by difficult social interaction, impaired communication (both verbal and non-verbal), and restricted and repetitive behaviours. It forms part of the broader autism spectrum disorder (ASD), a range of similar conditions, including Asperger syndrome.

Autism is a condition that begins from early childhood and is often suspected and diagnosed by ages 1-3. It is a lifelong disability that affects how people interact with others.

Autism causes and treatment

There have been many misconceptions as to what causes autism in the past such as the MMR vaccine and diet. Extensive research and clinical trials have concluded that none of these factors cause autism or ASD. However, the real cause is little understood but research is starting to unpick potential factors such as genetics, pollution and other environmental factors. A current favoured idea is that genes inherited from a child’s parents can make them more vulnerable to developing autism, some researchers suggest that the disorder will only develop when triggered by environmental factors.

The exact cause of autism spectrum disorder is unknown, however research into the disorder suggest that it is caused by several genetic and environmental factors. Genes inherited from a child’s parents can make them more vulnerable to developing autism, some researchers suggest that the disorder will only develop when triggered by environmental factors. Read more in clinical papers on autism.

Autism can be managed with a combination of prescribed medicines and behavioural treatment, depending on the severity of the disorder. Read about clinical trials and medical advancements for the treatment of autism on Trip.

Hot topics in Trip

Users of Trip frequently look at topics around adolescents, therapies, behaviour and screening. They also explore such topics as omega-3 fatty acids, SSRIs and aripiprazole. All these topics, and more, can be easily searched for within Trip.

Top results for autism

61. The Default Mode Network in Autism Full Text available with Trip Pro

The Default Mode Network in Autism Autism spectrum disorder (ASD) is characterized by deficits in social communication and interaction. Since its discovery as a major functional brain system, the default mode network (DMN) has been implicated in a number of psychiatric disorders, including ASD. Here we review converging multimodal evidence for DMN dysfunction in the context of specific components of social cognitive dysfunction in ASD: 'self-referential processing' - the ability to process

2017 Biological psychiatry. Cognitive neuroscience and neuroimaging

62. Autism, Attention, and Alpha Oscillations: An Electrophysiological Study of Attentional Capture Full Text available with Trip Pro

Autism, Attention, and Alpha Oscillations: An Electrophysiological Study of Attentional Capture Autism spectrum disorder (ASD) is associated with deficits in adaptively orienting attention to behaviorally-relevant information. Neural oscillatory activity plays a key role in brain function and provides a high-resolution temporal marker of attention dynamics. Alpha band (8-12 Hz) activity is associated with both selecting task-relevant stimuli and filtering task-irrelevant information.The present

2017 Biological psychiatry. Cognitive neuroscience and neuroimaging

63. Psychotropic medication use in autism spectrum disorders may affect functional brain connectivity Full Text available with Trip Pro

Psychotropic medication use in autism spectrum disorders may affect functional brain connectivity Prescription of psychotropic medications is common in autism spectrum disorders (ASDs), either off-label or to treat comorbid conditions such as ADHD or depression. Psychotropic medications are intended to alter brain function. Yet, studies investigating the functional brain organization in ASDs rarely take medication usage into account. This could explain some of the inconsistent findings (...) of atypical brain network connectivity reported in the autism literature.The current study tested whether functional connectivity patterns, as assessed with functional magnetic resonance imaging (fMRI), differed in a cohort of 49 children and adolescents with ASDs based on psychotropic medication status, and in comparison with 50 matched typically developing (TD) participants. Twenty-five participants in the ASD group (51%) reported current psychotropic medication usage, including stimulants

2017 Biological psychiatry. Cognitive neuroscience and neuroimaging

64. An altered scaffold for information processing: Cognitive control development in adolescents with autism Full Text available with Trip Pro

An altered scaffold for information processing: Cognitive control development in adolescents with autism We investigated how cognitive neuroscientific studies during the last decade have advanced understanding of cognitive control from adolescence to young adulthood in individuals with autism spectrum disorder (ASD). To do so, we conducted a selective review of the larger structural, resting state, and diffusion imaging studies of brain regions and networks related to cognitive control

2017 Biological psychiatry. Cognitive neuroscience and neuroimaging

65. Virtual Reality for the Diagnosis of Autism: Clinical Effectiveness

is the clinical effectiveness on the use of virtual reality to diagnose autism? What are the evidence-based guidelines regarding the use of virtual reality to diagnose autism? Key Message No relevant literature was identified regarding virtual reality for the diagnosis of autism. Tags asperger syndrome, autistic disorder, medical devices, Autism, Autistic, kanner syndrome, virtual reality, virtual environment, VR therapy, VRE, virtual therapy, augmented reality, Oculus, immersive technology Files Rapid (...) Virtual Reality for the Diagnosis of Autism: Clinical Effectiveness Virtual Reality for the Diagnosis of Autism: Clinical Effectiveness | CADTH.ca Find the information you need Virtual Reality for the Diagnosis of Autism: Clinical Effectiveness Virtual Reality for the Diagnosis of Autism: Clinical Effectiveness Published on: August 23, 2017 Project Number: RB1129-000 Product Line: Research Type: Devices and Systems Report Type: Summary of Abstracts Result type: Report Question What

2017 Canadian Agency for Drugs and Technologies in Health - Rapid Review

66. Subcortical Brain and Behavior Phenotypes Differentiate Infants with Autism versus Language Delay Full Text available with Trip Pro

Subcortical Brain and Behavior Phenotypes Differentiate Infants with Autism versus Language Delay Younger siblings of children with autism spectrum disorder (ASD) are themselves at increased risk for ASD and other developmental concerns. It is unclear if infants who display developmental concerns, but are unaffected by ASD, share similar or dissimilar behavioral and brain phenotypes to infants with ASD. Most individuals with ASD exhibit heterogeneous difficulties with language

2017 Biological psychiatry. Cognitive neuroscience and neuroimaging

67. Effects of Improvisational Music Therapy vs Enhanced Standard Care on Symptom Severity Among Children With Autism Spectrum Disorder: The TIME-A Randomized Clinical Trial. Full Text available with Trip Pro

Effects of Improvisational Music Therapy vs Enhanced Standard Care on Symptom Severity Among Children With Autism Spectrum Disorder: The TIME-A Randomized Clinical Trial. Music therapy may facilitate skills in areas affected by autism spectrum disorder (ASD), such as social interaction and communication.To evaluate effects of improvisational music therapy on generalized social communication skills of children with ASD.Assessor-blinded, randomized clinical trial, conducted in 9 countries (...) sang or played music with each child, attuned and adapted to the child's focus of attention, to help children develop affect sharing and joint attention.The primary outcome was symptom severity over 5 months, based on the Autism Diagnostic Observation Schedule (ADOS), social affect domain (range, 0-27; higher scores indicate greater severity; minimal clinically important difference, 1). Prespecified secondary outcomes included parent-rated social responsiveness. All outcomes were also assessed at 2

2017 JAMA Controlled trial quality: predicted high

68. Interventions Targeting Sensory Challenges in Children with Autism Spectrum Disorder - An Update

: 21220213.X-1 D-55 642. Ghanizadeh A. Can tactile sensory processing differentiate between children with autistic disorder and asperger's disorder? Innov Clin Neurosci. 2011 May;8(5):25-30. PMID: 21686145.X-1 643. Ghanizadeh A. A novel hypothesized clinical implication of zonisamide for autism...Ann Neurol. 2010 Feb;67(2):239- 49. Annals of Neurology. 2011;69(2):426- 1p. doi: 10.1002/ana.22153. PMID: 104841194. Language: English. Entry Date: 20110527. Revision Date: 20150711. Publication Type: Journal (...) insulin-like growth factor-1 in children with autism. Neuropediatrics. 2011 Oct;42(5):207-9. doi: 10.1055/s-0031-1291242. PMID: 22015434.X-1, X-3 736. Malisza KL, Clancy C, Shiloff D, et al. Functional evaluation of hidden figures object analysis in children with autistic disorder. Journal of Autism & Developmental Disorders. 2011;41(1):13-22 10p. doi: 10.1007/s10803-010-1013-z. PMID: 104970837. Language: English. Entry Date: 20110228. Revision Date: 20150711. Publication Type: Journal Article.X-1 737

2017 Effective Health Care Program (AHRQ)

69. Antidepressants during pregnancy and autism in offspring: population based cohort study. Full Text available with Trip Pro

Antidepressants during pregnancy and autism in offspring: population based cohort study. Objectives To study the association between maternal use of antidepressants during pregnancy and autism spectrum disorder (ASD) in offspring.Design Observational prospective cohort study with regression methods, propensity score matching, sibling controls, and negative control comparison.Setting Stockholm County, Sweden.Participants 254 610 individuals aged 4-17, including 5378 with autism, living (...) in Stockholm County in 2001-11 who were born to mothers who did not take antidepressants and did not have any psychiatric disorder, mothers who took antidepressants during pregnancy, or mothers with psychiatric disorders who did not take antidepressants during pregnancy. Maternal antidepressant use was recorded during first antenatal interview or determined from prescription records.Main outcome measure Offspring diagnosis of autism spectrum disorder, with and without intellectual disability.Results

2017 BMJ

70. [Cannabinoids in patients with autism spectrum disorders]

. The clinical practice guidelines consulted do not mention the use of this technology in autism spectrum disorders and no coverage policies considering its use were found. Final publication URL www.iecs.org.ar Indexing Status Subject indexing assigned by CRD MeSH Analgesics; Autism Spectrum Disorder; Autistic Disorder; Cannabinoids; Humans Language Published Spanish Country of organisation Argentina English summary There is no English language summary available. Address for correspondence Institute (...) [Cannabinoids in patients with autism spectrum disorders] [Cannabinoids in patients with autism spectrum disorders] [Cannabinoids in patients with autism spectrum disorders] Virgilio S, Alcaraz A, Pichon-Riviere A, Augustovski F, García Martí S, Bardach A, Ciapponi A Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Virgilio S, Alcaraz

2017 Health Technology Assessment (HTA) Database.

71. Developmental neurotoxicity of traffic-related air pollution: focus on autism Full Text available with Trip Pro

Developmental neurotoxicity of traffic-related air pollution: focus on autism Epidemiological and animal studies suggest that air pollution may negatively affect the central nervous system (CNS) and contribute to CNS diseases. Traffic-related air pollution is a major contributor to global air pollution, and diesel exhaust (DE) is its most important component.Several studies suggest that young individuals may be particularly susceptible to air pollution-induced neurotoxicity and that perinatal (...) exposure may cause or contribute to developmental disabilities and behavioral abnormalities. In particular, a number of recent studies have found associations between exposures to traffic-related air pollution and autism spectrum disorders (ASD), which are characterized by impairment in socialization and in communication and by the presence of repetitive and unusual behaviors. The cause(s) of ASD are unknown, and while it may have a hereditary component, environmental factors are increasingly suspected

2017 Current environmental health reports

72. Family therapy for autism spectrum disorders. Full Text available with Trip Pro

Family therapy for autism spectrum disorders. Autism spectrum disorders (ASDs) are characterised by impairments in communication and reciprocal social interaction. These impairments can impact on relationships with family members, augment stress and frustration, and contribute to behaviours that can be described as challenging. Family members of individuals with ASD can experience high rates of carer stress and burden, and poor parental efficacy. While there is evidence to suggest

2017 Cochrane

73. Variable phenotype expression in a family segregating microdeletions of the NRXN1 and MBD5 autism spectrum disorder susceptibility genes Full Text available with Trip Pro

Variable phenotype expression in a family segregating microdeletions of the NRXN1 and MBD5 autism spectrum disorder susceptibility genes Autism Spectrum Disorder (ASD) is a developmental condition of early childhood onset, which impacts socio-communicative functioning and is principally genetic in etiology. Currently, more than 50 genomic loci are deemed to be associated with susceptibility to ASD, showing de novo and inherited unbalanced copy number variants (CNVs) and smaller insertions

2017 NPJ genomic medicine

74. Associations of Maternal Antidepressant Use During the First Trimester of Pregnancy With Preterm Birth, Small for Gestational Age, Autism Spectrum Disorder, and Attention-Deficit/Hyperactivity Disorder in Offspring. Full Text available with Trip Pro

Associations of Maternal Antidepressant Use During the First Trimester of Pregnancy With Preterm Birth, Small for Gestational Age, Autism Spectrum Disorder, and Attention-Deficit/Hyperactivity Disorder in Offspring. Prenatal antidepressant exposure has been associated with adverse outcomes. Previous studies, however, may not have adequately accounted for confounding.To evaluate alternative hypotheses for associations between first-trimester antidepressant exposure and birth (...) weeks), small for gestational age (birth weight <2 SDs below the mean for gestational age), and first inpatient or outpatient clinical diagnosis of autism spectrum disorder and attention-deficit/hyperactivity disorder in offspring.Among 1 580 629 offspring (mean gestational age, 279 days; 48.6% female; 1.4% [n = 22 544] with maternal first-trimester self-reported antidepressant use) born to 943 776 mothers (mean age at childbirth, 30 years), 6.98% of exposed vs 4.78% of unexposed offspring were

2017 JAMA

75. Association Between Serotonergic Antidepressant Use During Pregnancy and Autism Spectrum Disorder in Children. (Abstract)

Association Between Serotonergic Antidepressant Use During Pregnancy and Autism Spectrum Disorder in Children. Previous observations of a higher risk of child autism spectrum disorder with serotonergic antidepressant exposure during pregnancy may have been confounded.To evaluate the association between serotonergic antidepressant exposure during pregnancy and child autism spectrum disorder.Retrospective cohort study. Health administrative data sets were used to study children born to mothers (...) who were receiving public prescription drug coverage during pregnancy in Ontario, Canada, from 2002-2010, reflecting 4.2% of births. Children were followed up until March 31, 2014.Serotonergic antidepressant exposure was defined as 2 or more consecutive maternal prescriptions for a selective serotonin or serotonin-norepinephrine reuptake inhibitor between conception and delivery.Child autism spectrum disorder identified after the age of 2 years. Exposure group differences were addressed by inverse

2017 JAMA

76. Gestational vitamin D deficiency and autism spectrum disorder Full Text available with Trip Pro

Gestational vitamin D deficiency and autism spectrum disorder There is growing interest in linking vitamin D deficiency with autism spectrum disorders (ASDs). The association between vitamin D deficiency during gestation, a critical period in neurodevelopment, and ASD is not well understood.To determine the association between gestational vitamin D status and ASD.Based on a birth cohort (n=4334), we examined the association between 25-hydroxyvitamin D (25OHD), assessed from both maternal mid

2017 BJPsych open

77. Negative valence in Autism Spectrum Disorder: the relationship between amygdala activity, selective attention, and co-occurring anxiety Full Text available with Trip Pro

Negative valence in Autism Spectrum Disorder: the relationship between amygdala activity, selective attention, and co-occurring anxiety A critical agenda of the National Institutes of Health Research Domain Criteria (RDoC) initiative is establishing whether domains within the RDoC matrix are truly transdiagnostic. Rates of anxiety disorders are elevated in autism spectrum disorder (ASD), but it is unclear whether the same mechanisms contribute to anxiety in individuals with and without ASD

2017 Biological psychiatry. Cognitive neuroscience and neuroimaging

78. Executive Dysfunction in Autism Spectrum Disorder Is Associated With a Failure to Modulate Frontoparietal-insular Hub Architecture Full Text available with Trip Pro

Executive Dysfunction in Autism Spectrum Disorder Is Associated With a Failure to Modulate Frontoparietal-insular Hub Architecture Comorbid executive dysfunction in autism spectrum disorder (ASD) is a barrier to adaptive functioning, despite remittance of core social-communication symptoms. Network models of ASD address core symptoms but not comorbid executive dysfunction. Following recent demonstrations in healthy adults that, with increasing executive demands, hubs embedded within

2017 Biological psychiatry. Cognitive neuroscience and neuroimaging

79. Miscellaneous: Spoken language shows some improvement following intervention for children with autism: but for which children and why?

Miscellaneous: Spoken language shows some improvement following intervention for children with autism: but for which children and why? Spoken language shows some improvement following intervention for children with autism: but for which children and why? | Evidence-Based Mental Health We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our (...) . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Spoken language shows some improvement following intervention for children with autism: but for which children and why? Article

2017 Evidence-Based Mental Health

80. Miscellaneous: Disruptive behaviour may hinder the acquisition of daily living skills for youth with autism spectrum disorder

Miscellaneous: Disruptive behaviour may hinder the acquisition of daily living skills for youth with autism spectrum disorder Disruptive behaviour may hinder the acquisition of daily living skills for youth with autism spectrum disorder | Evidence-Based Mental Health We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your (...) username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Disruptive behaviour may hinder the acquisition of daily living skills for youth with autism spectrum disorder Article Text Electronic pages Miscellaneous

2017 Evidence-Based Mental Health