Latest & greatest articles for autism

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This page lists the very latest high quality evidence on autism and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

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Autism

Autism is a neurodevelopmental disorder (a type of mental disorder) characterised by difficult social interaction, impaired communication (both verbal and non-verbal), and restricted and repetitive behaviours. It forms part of the broader autism spectrum disorder (ASD), a range of similar conditions, including Asperger syndrome.

Autism is a condition that begins from early childhood and is often suspected and diagnosed by ages 1-3. It is a lifelong disability that affects how people interact with others.

Autism causes and treatment

There have been many misconceptions as to what causes autism in the past such as the MMR vaccine and diet. Extensive research and clinical trials have concluded that none of these factors cause autism or ASD. However, the real cause is little understood but research is starting to unpick potential factors such as genetics, pollution and other environmental factors. A current favoured idea is that genes inherited from a child’s parents can make them more vulnerable to developing autism, some researchers suggest that the disorder will only develop when triggered by environmental factors.

The exact cause of autism spectrum disorder is unknown, however research into the disorder suggest that it is caused by several genetic and environmental factors. Genes inherited from a child’s parents can make them more vulnerable to developing autism, some researchers suggest that the disorder will only develop when triggered by environmental factors. Read more in clinical papers on autism.

Autism can be managed with a combination of prescribed medicines and behavioural treatment, depending on the severity of the disorder. Read about clinical trials and medical advancements for the treatment of autism on Trip.

Hot topics in Trip

Users of Trip frequently look at topics around adolescents, therapies, behaviour and screening. They also explore such topics as omega-3 fatty acids, SSRIs and aripiprazole. All these topics, and more, can be easily searched for within Trip.

Top results for autism

61. Variable phenotype expression in a family segregating microdeletions of the NRXN1 and MBD5 autism spectrum disorder susceptibility genes Full Text available with Trip Pro

Variable phenotype expression in a family segregating microdeletions of the NRXN1 and MBD5 autism spectrum disorder susceptibility genes Autism Spectrum Disorder (ASD) is a developmental condition of early childhood onset, which impacts socio-communicative functioning and is principally genetic in etiology. Currently, more than 50 genomic loci are deemed to be associated with susceptibility to ASD, showing de novo and inherited unbalanced copy number variants (CNVs) and smaller insertions

2017 NPJ genomic medicine

62. Associations of Maternal Antidepressant Use During the First Trimester of Pregnancy With Preterm Birth, Small for Gestational Age, Autism Spectrum Disorder, and Attention-Deficit/Hyperactivity Disorder in Offspring. Full Text available with Trip Pro

Associations of Maternal Antidepressant Use During the First Trimester of Pregnancy With Preterm Birth, Small for Gestational Age, Autism Spectrum Disorder, and Attention-Deficit/Hyperactivity Disorder in Offspring. Prenatal antidepressant exposure has been associated with adverse outcomes. Previous studies, however, may not have adequately accounted for confounding.To evaluate alternative hypotheses for associations between first-trimester antidepressant exposure and birth (...) weeks), small for gestational age (birth weight <2 SDs below the mean for gestational age), and first inpatient or outpatient clinical diagnosis of autism spectrum disorder and attention-deficit/hyperactivity disorder in offspring.Among 1 580 629 offspring (mean gestational age, 279 days; 48.6% female; 1.4% [n = 22 544] with maternal first-trimester self-reported antidepressant use) born to 943 776 mothers (mean age at childbirth, 30 years), 6.98% of exposed vs 4.78% of unexposed offspring were

2017 JAMA

63. Association Between Serotonergic Antidepressant Use During Pregnancy and Autism Spectrum Disorder in Children. (Abstract)

Association Between Serotonergic Antidepressant Use During Pregnancy and Autism Spectrum Disorder in Children. Previous observations of a higher risk of child autism spectrum disorder with serotonergic antidepressant exposure during pregnancy may have been confounded.To evaluate the association between serotonergic antidepressant exposure during pregnancy and child autism spectrum disorder.Retrospective cohort study. Health administrative data sets were used to study children born to mothers (...) who were receiving public prescription drug coverage during pregnancy in Ontario, Canada, from 2002-2010, reflecting 4.2% of births. Children were followed up until March 31, 2014.Serotonergic antidepressant exposure was defined as 2 or more consecutive maternal prescriptions for a selective serotonin or serotonin-norepinephrine reuptake inhibitor between conception and delivery.Child autism spectrum disorder identified after the age of 2 years. Exposure group differences were addressed by inverse

2017 JAMA

64. Gestational vitamin D deficiency and autism spectrum disorder Full Text available with Trip Pro

Gestational vitamin D deficiency and autism spectrum disorder There is growing interest in linking vitamin D deficiency with autism spectrum disorders (ASDs). The association between vitamin D deficiency during gestation, a critical period in neurodevelopment, and ASD is not well understood.To determine the association between gestational vitamin D status and ASD.Based on a birth cohort (n=4334), we examined the association between 25-hydroxyvitamin D (25OHD), assessed from both maternal mid

2017 BJPsych open

65. Negative valence in Autism Spectrum Disorder: the relationship between amygdala activity, selective attention, and co-occurring anxiety Full Text available with Trip Pro

Negative valence in Autism Spectrum Disorder: the relationship between amygdala activity, selective attention, and co-occurring anxiety A critical agenda of the National Institutes of Health Research Domain Criteria (RDoC) initiative is establishing whether domains within the RDoC matrix are truly transdiagnostic. Rates of anxiety disorders are elevated in autism spectrum disorder (ASD), but it is unclear whether the same mechanisms contribute to anxiety in individuals with and without ASD

2017 Biological psychiatry. Cognitive neuroscience and neuroimaging

66. Executive Dysfunction in Autism Spectrum Disorder Is Associated With a Failure to Modulate Frontoparietal-insular Hub Architecture Full Text available with Trip Pro

Executive Dysfunction in Autism Spectrum Disorder Is Associated With a Failure to Modulate Frontoparietal-insular Hub Architecture Comorbid executive dysfunction in autism spectrum disorder (ASD) is a barrier to adaptive functioning, despite remittance of core social-communication symptoms. Network models of ASD address core symptoms but not comorbid executive dysfunction. Following recent demonstrations in healthy adults that, with increasing executive demands, hubs embedded within

2017 Biological psychiatry. Cognitive neuroscience and neuroimaging

67. Miscellaneous: Spoken language shows some improvement following intervention for children with autism: but for which children and why?

Miscellaneous: Spoken language shows some improvement following intervention for children with autism: but for which children and why? Spoken language shows some improvement following intervention for children with autism: but for which children and why? | Evidence-Based Mental Health We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our (...) . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Spoken language shows some improvement following intervention for children with autism: but for which children and why? Article

2017 Evidence-Based Mental Health

68. Miscellaneous: Disruptive behaviour may hinder the acquisition of daily living skills for youth with autism spectrum disorder

Miscellaneous: Disruptive behaviour may hinder the acquisition of daily living skills for youth with autism spectrum disorder Disruptive behaviour may hinder the acquisition of daily living skills for youth with autism spectrum disorder | Evidence-Based Mental Health We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your (...) username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Disruptive behaviour may hinder the acquisition of daily living skills for youth with autism spectrum disorder Article Text Electronic pages Miscellaneous

2017 Evidence-Based Mental Health

69. Cognitive-behavioural group therapy for youth with high-functioning autism spectrum disorders demonstrates modest effects on social responsiveness

Cognitive-behavioural group therapy for youth with high-functioning autism spectrum disorders demonstrates modest effects on social responsiveness Cognitive-behavioural group therapy for youth with high-functioning autism spectrum disorders demonstrates modest effects on social responsiveness | Evidence-Based Mental Health We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about (...) how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Cognitive-behavioural group therapy for youth with high-functioning autism spectrum disorders

2017 Evidence-Based Mental Health

71. Thalamocortical dysconnectivity in autism spectrum disorder: An analysis of the Autism Brain Imaging Data Exchange Full Text available with Trip Pro

Thalamocortical dysconnectivity in autism spectrum disorder: An analysis of the Autism Brain Imaging Data Exchange Individuals with autism spectrum disorder (ASD) exhibit differences in basic sensorimotor processing as well as general cortical excitability. These observations converge to implicate thalamocortical connectivity as a potential unifying neural mechanism. The goal of this study was to clarify mixed findings on thalamocortical functional connectivity in a large sample of individuals (...) with ASD.Using the Autism Brain Imaging Data Exchange (ABIDE), we examined thalamocortical functional connectivity in 228 individuals with ASD and a matched comparison group of 228 typically developing individuals. In order to fully characterize thalamocortical functional networks, we employed complementary seed-based approaches that examined connectivity of major cortical divisions (e.g. prefrontal cortex, temporal lobe) with the thalamus and whole-brain connectivity of specific thalamic sub

2017 Biological psychiatry. Cognitive neuroscience and neuroimaging

72. Network organization is globally atypical in autism: A graph theory study of intrinsic functional connectivity Full Text available with Trip Pro

Network organization is globally atypical in autism: A graph theory study of intrinsic functional connectivity Despite abundant evidence of brain network anomalies in autism spectrum disorder (ASD), findings have varied from broad functional underconnectivity to broad overconnectivity. Rather than pursuing overly simplifying general hypotheses ('under' vs. 'over'), we tested the hypothesis of atypical network distribution in ASD (i.e., participation of unusual loci in distributed functional

2017 Biological psychiatry. Cognitive neuroscience and neuroimaging

73. Biomedical treatment for autism spectrum disorders

Status Subject indexing assigned by CRD MeSH Autism Spectrum Disorder; Autistic Disorder; Health Occupations; Humans Language Published Spanish Country of organisation Argentina English summary An English language summary is available. Address for correspondence Institute for Clinical Effectiveness and Health Policy, Viamonte 2146 - 3 Piso, C1056ABH Ciudad de Buenos Aires, Argentina Tel: +54 11 49 66 00 82 Fax:+54 11 49 53 40 58 Email: info@iecs.org.ar AccessionNumber 32016001124 Date abstract record (...) Biomedical treatment for autism spectrum disorders Biomedical treatment for autism spectrum disorders Biomedical treatment for autism spectrum disorders Mengarelli C, García Martí S, Pichon-Riviere A, Augustovski F, Alcaraz A, Bardach A, Ciapponi A, López A, Rey-Ares L Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Mengarelli C, García

2016 Health Technology Assessment (HTA) Database.

74. Prescription Drug Use and Polypharmacy Among Medicaid-Enrolled Adults with Autism: A Retrospective Cross-Sectional Analysis Full Text available with Trip Pro

Prescription Drug Use and Polypharmacy Among Medicaid-Enrolled Adults with Autism: A Retrospective Cross-Sectional Analysis A lack of gold standard treatment for autism spectrum disorders (ASD), no clear ASD management guidelines, and lack of evidence-based pharmacological interventions other than aripiprazole and risperidone elevate the risk of off-label prescribing and adverse effects among individuals with ASD, more so among adults.The aim of this study was to identify and compare the types

2016 Drugs - real world outcomes

75. "We Dance and Find Each Other"1: Effects of Dance/Movement Therapy on Negative Symptoms in Autism Spectrum Disorder. Full Text available with Trip Pro

"We Dance and Find Each Other"1: Effects of Dance/Movement Therapy on Negative Symptoms in Autism Spectrum Disorder. The treatment of deficits in social interaction, a shared symptom cluster in persons with schizophrenia (negative symptoms) and autism spectrum disorder (DSM-5 A-criterion), has so far remained widely unsuccessful in common approaches of psychotherapy. The alternative approach of embodiment brings to focus body-oriented intervention methods based on a theoretic framework (...) that explains the disorders on a more basic level than common theory of mind approaches. The randomized controlled trial at hand investigated the effects of a 10-week manualized dance and movement therapy intervention on negative symptoms in participants with autism spectrum disorder. Although the observed effects failed to reach significance at the conventional 0.05 threshold, possibly due to an undersized sample, an encouraging trend towards stronger symptom reduction in the treatment group for overall

2016 Behavioral sciences (Basel, Switzerland) Controlled trial quality: uncertain

76. Predictive Validity of the Modified Checklist for Autism in Toddlers (M-CHAT) Born Very Preterm Full Text available with Trip Pro

Predictive Validity of the Modified Checklist for Autism in Toddlers (M-CHAT) Born Very Preterm To examine the predictive validity of the Modified Checklist for Autism in Toddlers (M-CHAT) administered at age 24 months for autism spectrum disorder (ASD) diagnosed at 10 years of age in a US cohort of 827 extremely low gestational age newborns (ELGANs) followed from birth.We examined the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the M-CHAT

2016 EvidenceUpdates

77. Parent-mediated social communication therapy for young children with autism (PACT): long-term follow-up of a randomised controlled trial. Full Text available with Trip Pro

Parent-mediated social communication therapy for young children with autism (PACT): long-term follow-up of a randomised controlled trial. It is not known whether early intervention can improve long-term autism symptom outcomes. We aimed to follow-up the Preschool Autism Communication Trial (PACT), to investigate whether the PACT intervention had a long-term effect on autism symptoms and continued effects on parent and child social interaction.PACT was a randomised controlled trial of a parent (...) -mediated social communication intervention for children aged 2-4 years with core autism. Follow-up ascertainment was done at three specialised clinical services centres in the UK (London, Manchester, and Newcastle) at a median of 5·75 years (IQR 5·42-5·92) from the original trial endpoint. The main blinded outcomes were the comparative severity score (CSS) from the Autism Diagnostic Observation Schedule (ADOS), the Dyadic Communication Assessment Measure (DCMA) of the proportion of child initiatiations

2016 Lancet Controlled trial quality: predicted high

78. Hyperbaric oxygen therapy for people with autism spectrum disorder (ASD). Full Text available with Trip Pro

Hyperbaric oxygen therapy for people with autism spectrum disorder (ASD). The rising prevalence of autism spectrum disorder (ASD) has increased the need for evidence-based treatments to lessen the impact of symptoms. Presently, no therapies are available to effectively treat individuals with all of the symptoms of this disorder. It has been suggested that hyperbaric oxygen therapy may alleviate the biochemical dysfunction and clinical symptoms of ASD.To determine whether treatment

2016 Cochrane

79. Association of Labor Induction With Offspring Risk of Autism Spectrum Disorders Full Text available with Trip Pro

Association of Labor Induction With Offspring Risk of Autism Spectrum Disorders Induction of labor is a frequently performed obstetrical intervention. It would thus be of great concern if reported associations between labor induction and offspring risk of autism spectrum disorders (ASD) reflected causal influence.To assess the associations of labor induction with ASD, comparing differentially exposed relatives (siblings and cousins discordant for induction).Follow-up of all live births

2016 EvidenceUpdates

80. Genome-wide characteristics of de novo mutations in autism Full Text available with Trip Pro

Genome-wide characteristics of de novo mutations in autism De novo mutations (DNMs) are important in Autism Spectrum Disorder (ASD), but so far analyses have mainly been on the ~1.5% of the genome encoding genes. Here, we performed whole genome sequencing (WGS) of 200 ASD parent-child trios and characterized germline and somatic DNMs. We confirmed that the majority of germline DNMs (75.6%) originated from the father, and these increased significantly with paternal age only (p=4.2×10-10

2016 NPJ genomic medicine