Latest & greatest articles for autism

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on autism or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on autism and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

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Autism

Autism is a neurodevelopmental disorder (a type of mental disorder) characterised by difficult social interaction, impaired communication (both verbal and non-verbal), and restricted and repetitive behaviours. It forms part of the broader autism spectrum disorder (ASD), a range of similar conditions, including Asperger syndrome.

Autism is a condition that begins from early childhood and is often suspected and diagnosed by ages 1-3. It is a lifelong disability that affects how people interact with others.

Autism causes and treatment

There have been many misconceptions as to what causes autism in the past such as the MMR vaccine and diet. Extensive research and clinical trials have concluded that none of these factors cause autism or ASD. However, the real cause is little understood but research is starting to unpick potential factors such as genetics, pollution and other environmental factors. A current favoured idea is that genes inherited from a child’s parents can make them more vulnerable to developing autism, some researchers suggest that the disorder will only develop when triggered by environmental factors.

The exact cause of autism spectrum disorder is unknown, however research into the disorder suggest that it is caused by several genetic and environmental factors. Genes inherited from a child’s parents can make them more vulnerable to developing autism, some researchers suggest that the disorder will only develop when triggered by environmental factors. Read more in clinical papers on autism.

Autism can be managed with a combination of prescribed medicines and behavioural treatment, depending on the severity of the disorder. Read about clinical trials and medical advancements for the treatment of autism on Trip.

Hot topics in Trip

Users of Trip frequently look at topics around adolescents, therapies, behaviour and screening. They also explore such topics as omega-3 fatty acids, SSRIs and aripiprazole. All these topics, and more, can be easily searched for within Trip.

Top results for autism

61. Cohort study: Rate of epilepsy in people with autism and the rate of autism in people with epilepsy are high

Cohort study: Rate of epilepsy in people with autism and the rate of autism in people with epilepsy are high Rate of epilepsy in people with autism and the rate of autism in people with epilepsy are high | Evidence-Based Medicine This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search (...) for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Rate of epilepsy in people with autism and the rate of autism in people with epilepsy are high Article Text Prognosis Cohort study Rate of epilepsy in people with autism and the rate of autism in people with epilepsy are high Frank M C Besag Statistics from Altmetric.com Commentary on: Sundelin HE

Evidence-Based Medicine (Requires free registration)2016

62. Extended-Release Guanfacine for Hyperactivity in Children With Autism Spectrum Disorder

Extended-Release Guanfacine for Hyperactivity in Children With Autism Spectrum Disorder 26315981 2015 12 01 2016 03 24 2015 12 01 1535-7228 172 12 2015 Dec The American journal of psychiatry Am J Psychiatry Extended-Release Guanfacine for Hyperactivity in Children With Autism Spectrum Disorder. 1197-206 10.1176/appi.ajp.2015.15010055 Hyperactivity, impulsiveness, and distractibility are common problems in children with autism spectrum disorder (ASD). Extended-release guanfacine is approved (...) Children's Hospital, Seattle, Wash.; the Department of Child and Adolescent Psychiatry, Lurie Center for Autism, Massachusetts General Hospital, Lexington, Mass.; the Marcus Autism Center, Atlanta; the Department of Biostatistics, Yale University, New Haven, Conn.; the Department of Emergency Medicine, Yale University, New Haven, Conn.; the Department of Psychiatry, Massachusetts General Hospital, Boston; and the David Geffen School of Medicine, University of California, Los Angeles. McCracken James T JT

EvidenceUpdates2015

63. Special report: chromosomal microarray for the genetic evaluation of patients with global developmental delay, intellectual disability, and autism spectrum disorder

Special report: chromosomal microarray for the genetic evaluation of patients with global developmental delay, intellectual disability, and autism spectrum disorder Special report: chromosomal microarray for the genetic evaluation of patients with global developmental delay, intellectual disability, and autism spectrum disorder Special report: chromosomal microarray for the genetic evaluation of patients with global developmental delay, intellectual disability, and autism spectrum disorder (...) BlueCross BlueShield Association Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation BlueCross BlueShield Association. Special report: chromosomal microarray for the genetic evaluation of patients with global developmental delay, intellectual disability, and autism spectrum disorder. Chicago: BlueCross BlueShield Association (BCBS). TEC Assessment 30(2). 2015 Authors

Health Technology Assessment (HTA) Database.2015

64. Molecular Diagnostic Yield of Chromosomal Microarray Analysis and Whole-Exome Sequencing in Children With Autism Spectrum Disorder.

Molecular Diagnostic Yield of Chromosomal Microarray Analysis and Whole-Exome Sequencing in Children With Autism Spectrum Disorder. IMPORTANCE: The use of genome-wide tests to provide molecular diagnosis for individuals with autism spectrum disorder (ASD) requires more study. OBJECTIVE: To perform chromosomal microarray analysis (CMA) and whole-exome sequencing (WES) in a heterogeneous group of children with ASD to determine the molecular diagnostic yield of these tests in a sample typical

JAMA2015

65. Telehealth for Autism Spectrum Disorder Diagnosis in Pediatric Patients: Diagnostic Accuracy, Cost-Effectiveness, and Guidelines

Telehealth for Autism Spectrum Disorder Diagnosis in Pediatric Patients: Diagnostic Accuracy, Cost-Effectiveness, and Guidelines Telehealth for Autism Spectrum Disorder Diagnosis in Pediatric Patients: Diagnostic Accuracy, Cost-Effectiveness, and Guidelines | CADTH.ca Find the information you need Telehealth for Autism Spectrum Disorder Diagnosis in Pediatric Patients: Diagnostic Accuracy, Cost-Effectiveness, and Guidelines Telehealth for Autism Spectrum Disorder Diagnosis in Pediatric Patients (...) : Diagnostic Accuracy, Cost-Effectiveness, and Guidelines Published on: July 22, 2015 Project Number: RB0888-000 Product Line: Research Type: Devices and Systems Report Type: Summary of Abstracts Result type: Report Question What is the diagnostic accuracy of telehealth diagnosis of Autism Spectrum Disorder in pediatric patients? What is the cost-effectiveness of telehealth diagnosis of pediatric patients with suspected Autism Spectrum Disorder? What are the evidence-based guidelines regarding the use

Canadian Agency for Drugs and Technologies in Health - Rapid Review2015

66. Genetic testing for developmental disabilities, intellectual disability, and autism spectrum disorder

Genetic testing for developmental disabilities, intellectual disability, and autism spectrum disorder Genetic testing for developmental disabilities, intellectual disability, and autism spectrum disorder Genetic testing for developmental disabilities, intellectual disability, and autism spectrum disorder Sun F, Oristaglio J, Levy SE, Hakonarson H, Sullivan N, Fontanarosa J, Schoelles KM Record Status This is a bibliographic record of a published health technology assessment from a member (...) of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Sun F, Oristaglio J, Levy SE, Hakonarson H, Sullivan N, Fontanarosa J, Schoelles KM. Genetic testing for developmental disabilities, intellectual disability, and autism spectrum disorder. Rockville: Agency for Healthcare Research and Quality (AHRQ). Technical Brief No. 23. 2015 Authors' objectives This Technical Brief collects and summarizes information on genetic tests clinically available

Health Technology Assessment (HTA) Database.2015

67. [Efficacy of early intensive behavioral intervention in autism spectrum disorders]

[Efficacy of early intensive behavioral intervention in autism spectrum disorders] Eficacia de las terapias conductuales tempranas e intensivas en los Trastornos del Espectro Autista [Efficacy of early intensive behavioral intervention in autism spectrum disorders] Eficacia de las terapias conductuales tempranas e intensivas en los Trastornos del Espectro Autista [Efficacy of early intensive behavioral intervention in autism spectrum disorders] Gonzalez L, Pichon-Riviere A, Augustovski F (...) of early intensive behavioral intervention in autism spectrum disorders] Buenos Aires: Institute for Clinical Effectiveness and Health Policy (IECS). Informe de Respuesta Rapida No. 404. 2015 Authors' objectives To assess the available evidence on the efficacy, safety and issues related to coverage policies for the use of early intensive behavioral interventions in patients with autism spectrum disorder. Authors' conclusions The quality of the evidence found is low. It shows that an EIBI program could

Health Technology Assessment (HTA) Database.2015

69. Systematic review of tools to measure outcomes for young children with autism spectrum disorder

Systematic review of tools to measure outcomes for young children with autism spectrum disorder Systematic review of tools to measure outcomes for young children with autism spectrum disorder Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from the navigation or try a website search above to find the information you need. >> >> >> >> Issue (...) {{metadata .Issue }} Toolkit 1)"> 0)"> {{metadata.Title}} {{metadata.Headline}} The study found 12 tools among those reviewed which were the most valid overall in monitoring progress and measuring outcomes for young children with autism spectrum disorder, and provides a systematic evaluation of the measurement properties and qualities of these tools, along with recommendations of priority targets for research. {{author}} {{($index , , , , , , , , , , , , , , , , , , , , , & . Helen McConachie, 1

NIHR HTA programme2015

70. Chelation for autism spectrum disorder (ASD).

Chelation for autism spectrum disorder (ASD). BACKGROUND: It has been suggested that the severity of autism spectrum disorder (ASD) symptoms is positively correlated with the level of circulating or stored toxic metals, and that excretion of these heavy metals, brought about by the use of pharmaceutical chelating agents, results in improved symptoms. OBJECTIVES: To assess the potential benefits and adverse effects of pharmaceutical chelating agents (referred to as chelation therapy throughout (...) this review) for autism spectrum disorder (ASD) symptoms. SEARCH METHODS: We searched the following databases on 6 November 2014: CENTRAL, Ovid MEDLINE, Ovid MEDLINE In-Process, Embase,PsycINFO, Cumulative Index to Nursing and Allied Health Literature (CINAHL) and 15 other databases, including three trials registers. In addition we checked references lists and contacted experts. SELECTION CRITERIA: All randomised controlled trials of pharmaceutical chelating agents compared with placebo in individuals

Cochrane2015

71. Chelation for autism spectrum disorder (ASD).

Chelation for autism spectrum disorder (ASD). BACKGROUND: It has been suggested that the severity of autism spectrum disorder (ASD) symptoms is positively correlated with the level of circulating or stored toxic metals, and that excretion of these heavy metals, brought about by the use of pharmaceutical chelating agents, results in improved symptoms. OBJECTIVES: To assess the potential benefits and adverse effects of pharmaceutical chelating agents (referred to as chelation therapy throughout (...) this review) for autism spectrum disorder (ASD) symptoms. SEARCH METHODS: We searched the following databases on 6 November 2014: CENTRAL, Ovid MEDLINE, Ovid MEDLINE In-Process, Embase, PsycINFO, Cumulative Index to Nursing and Allied Health Literature (CINAHL) and 15 other databases, including three trials registers. In addition we checked references lists and contacted experts. SELECTION CRITERIA: All randomised controlled trials of pharmaceutical chelating agents compared with placebo in individuals

Cochrane2015

72. Special report: early intensive behavioral intervention and other behavioral interventions for autism spectrum disorder

Special report: early intensive behavioral intervention and other behavioral interventions for autism spectrum disorder Special report: early intensive behavioral intervention and other behavioral interventions for autism spectrum disorder Special report: early intensive behavioral intervention and other behavioral interventions for autism spectrum disorder BlueCross BlueShield Association Record Status This is a bibliographic record of a published health technology assessment. No evaluation (...) of the quality of this assessment has been made for the HTA database. Citation BlueCross BlueShield Association. Special report: early intensive behavioral intervention and other behavioral interventions for autism spectrum disorder. Chicago: BlueCross BlueShield Association (BCBS). TEC Assessment 30(1). 2015 Authors' objectives This Special Report has 2 goals: (1) to review comparative studies of EIBI and assess patient or intervention characteristics that might moderate treatment effects; and (2

Health Technology Assessment (HTA) Database.2015

73. Autism phenotype versus registered diagnosis in Swedish children: prevalence trends over 10 years in general population samples.

Autism phenotype versus registered diagnosis in Swedish children: prevalence trends over 10 years in general population samples. OBJECTIVE: To compare the annual prevalence of the autism symptom phenotype and of registered diagnoses for autism spectrum disorder during a 10 year period in children. DESIGN: Population based study. SETTING: Child and Adolescent Twin Study and national patient register, Sweden. PARTICIPANTS: 19, 993 twins (190 with autism spectrum disorder) and all children (n (...) =1,078,975; 4620 with autism spectrum disorder) born in Sweden over a 10 year period from 1993 to 2002. MAIN OUTCOME MEASURES: Annual prevalence of the autism symptom phenotype (that is, symptoms on which the diagnostic criteria are based) assessed by a validated parental telephone interview (the Autism-Tics, ADHD and other Comorbidities inventory), and annual prevalence of reported diagnoses of autism spectrum disorder in the national patient register. RESULTS: The annual prevalence of the autism

BMJ2015 Full Text: Link to full Text with Trip Pro

74. Effect of parent training vs parent education on behavioral problems in children with autism spectrum disorder: a randomized clinical trial.

Effect of parent training vs parent education on behavioral problems in children with autism spectrum disorder: a randomized clinical trial. 25898050 2015 04 22 2015 05 04 2016 11 16 1538-3598 313 15 2015 Apr 21 JAMA JAMA Effect of parent training vs parent education on behavioral problems in children with autism spectrum disorder: a randomized clinical trial. 1524-33 10.1001/jama.2015.3150 Disruptive behavior is common in children with autism spectrum disorder. Behavioral interventions (...) are used to treat disruptive behavior but have not been evaluated in large-scale randomized trials. To evaluate the efficacy of parent training for children with autism spectrum disorder and disruptive behavior. This 24-week randomized trial compared parent training (n = 89) to parent education (n = 91) at 6 centers (Emory University, Indiana University, Ohio State University, University of Pittsburgh, University of Rochester, Yale University). We screened 267 children; 180 children (aged 3-7 years

JAMA2015

75. Autism occurrence by MMR vaccine status among US children with older siblings with and without autism.

Autism occurrence by MMR vaccine status among US children with older siblings with and without autism. IMPORTANCE: Despite research showing no link between the measles-mumps-rubella (MMR) vaccine and autism spectrum disorders (ASD), beliefs that the vaccine causes autism persist, leading to lower vaccination levels. Parents who already have a child with ASD may be especially wary of vaccinations. OBJECTIVE: To report ASD occurrence by MMR vaccine status in a large sample of US children who have (...) OUTCOMES AND MEASURES: ASD status defined as 2 claims with a diagnosis code in any position for autistic disorder or other specified pervasive developmental disorder (PDD) including Asperger syndrome, or unspecified PDD (International Classification of Diseases, Ninth Revision, Clinical Modification 299.0x, 299.8x, 299.9x). RESULTS: Of 95,727 children with older siblings, 994 (1.04%) were diagnosed with ASD and 1929 (2.01%) had an older sibling with ASD. Of those with older siblings with ASD, 134 (6.9

JAMA2015

76. Association of maternal diabetes with autism in offspring.

Association of maternal diabetes with autism in offspring. IMPORTANCE: Information about the association of maternal diabetes and autism spectrum disorders (ASDs) in offspring is limited, with no report on the importance of timing of exposure during gestation. OBJECTIVE: To assess ASD risk associated with intrauterine exposure to preexisting type 2 diabetes and gestational diabetes mellitus (GDM) by gestational age at GDM diagnosis. DESIGN, SETTING, AND PATIENTS: Retrospective longitudinal

JAMA2015

77. Parent-Implemented Social Intervention for Toddlers With Autism: An RCT

Parent-Implemented Social Intervention for Toddlers With Autism: An RCT 25367544 2014 12 02 2015 02 09 2017 02 20 1098-4275 134 6 2014 Dec Pediatrics Pediatrics Parent-implemented social intervention for toddlers with autism: an RCT. 1084-93 10.1542/peds.2014-0757 To compare the effects of two 9-month parent-implemented interventions within the Early Social Interaction (ESI) Project. Both individual-ESI, offered 2 or 3 times per week at home or in the community, and group-ESI, offered once per (...) week in a clinic, taught parents how to embed strategies to support social communication throughout everyday activities. Participants in the randomized controlled trial included 82 children diagnosed with autism spectrum disorder at 16 to 20 months. Children were matched on pretreatment nonverbal developmental level and pairs were randomly assigned to treatment condition. Child outcomes included measures of social communication, autism symptoms, adaptive behavior, and developmental level. Child

EvidenceUpdates2015

78. Management of autism in children and young people: a good clinical practice guideline

Management of autism in children and young people: a good clinical practice guideline Management of autism in children and young people: a good clinical practice guideline Management of autism in children and young people: a good clinical practice guideline Veereman G, Holdt Henningsen K, Eyssen M, Benahmed N, Christiaens W, Bouchez M-H, De Roeck A, Deconinck N, De ligne G, Dewitte G, Gheysen T, Hendrix M, Kagan C, Magerotte G, Moonen M, Roeyers H, Schelstraete S, Soncarrieu M-V, Steyaert J (...) , Steyaert J, Tolfo F, Vrancken G, Willaye E, Wintgens A, Wouters S, Croonenberghs J. Management of autism in children and young people: a good clinical practice guideline. Brussels: Belgian Health Care Knowledge Centre (KCE). KCE Reports 233. 2014 Authors' conclusions The GDG worked diligently in order to demonstrate which interventions are meaningful to improve the lives of children and young people with autism and their families. The problems faced by children and adolescents with autism, caretakers

Health Technology Assessment (HTA) Database.2015

79. Growing evidence that maternal gestational diabetes increases risk of autism in offspring

Growing evidence that maternal gestational diabetes increases risk of autism in offspring Growing evidence that maternal gestational diabetes increases risk of autism in offspring | Evidence-Based Mental Health This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search (...) for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Growing evidence that maternal gestational diabetes increases risk of autism in offspring Article Text Causes and risk factors Growing evidence that maternal gestational diabetes increases risk of autism in offspring Andrea L Roberts , Vy T Nguyen Statistics from Altmetric.com No Altmetric data available for this article

Evidence-Based Mental Health2015

80. Quantitative autistic traits are transmitted intergenerationally and increase risk for autism spectrum disorders

Quantitative autistic traits are transmitted intergenerationally and increase risk for autism spectrum disorders Quantitative autistic traits are transmitted intergenerationally and increase risk for autism spectrum disorders | Evidence-Based Mental Health This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name (...) or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Quantitative autistic traits are transmitted intergenerationally and increase risk for autism spectrum disorders Article Text Causes and risk factors Quantitative autistic traits are transmitted intergenerationally and increase risk for autism spectrum disorders Loren Martin

Evidence-Based Mental Health2015