Latest & greatest articles for autism

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on autism or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on autism and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

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Autism

Autism is a neurodevelopmental disorder (a type of mental disorder) characterised by difficult social interaction, impaired communication (both verbal and non-verbal), and restricted and repetitive behaviours. It forms part of the broader autism spectrum disorder (ASD), a range of similar conditions, including Asperger syndrome.

Autism is a condition that begins from early childhood and is often suspected and diagnosed by ages 1-3. It is a lifelong disability that affects how people interact with others.

Autism causes and treatment

There have been many misconceptions as to what causes autism in the past such as the MMR vaccine and diet. Extensive research and clinical trials have concluded that none of these factors cause autism or ASD. However, the real cause is little understood but research is starting to unpick potential factors such as genetics, pollution and other environmental factors. A current favoured idea is that genes inherited from a child’s parents can make them more vulnerable to developing autism, some researchers suggest that the disorder will only develop when triggered by environmental factors.

The exact cause of autism spectrum disorder is unknown, however research into the disorder suggest that it is caused by several genetic and environmental factors. Genes inherited from a child’s parents can make them more vulnerable to developing autism, some researchers suggest that the disorder will only develop when triggered by environmental factors. Read more in clinical papers on autism.

Autism can be managed with a combination of prescribed medicines and behavioural treatment, depending on the severity of the disorder. Read about clinical trials and medical advancements for the treatment of autism on Trip.

Hot topics in Trip

Users of Trip frequently look at topics around adolescents, therapies, behaviour and screening. They also explore such topics as omega-3 fatty acids, SSRIs and aripiprazole. All these topics, and more, can be easily searched for within Trip.

Top results for autism

41. Autism

Autism Top results for autism - Trip Database or use your Google+ account Find evidence fast ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4) Loading (...) history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for autism The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest

2018 Trip Latest and Greatest

42. Diagnostic tests for autism spectrum disorder (ASD) in preschool children. Full Text available with Trip Pro

Diagnostic tests for autism spectrum disorder (ASD) in preschool children. Autism spectrum disorder (ASD) is a behaviourally diagnosed condition. It is defined by impairments in social communication or the presence of restricted or repetitive behaviours, or both. Diagnosis is made according to existing classification systems. In recent years, especially following publication of the Diagnostic and Statistical Manual of Mental Disorders - Fifth Edition (DSM-5; APA 2013), children are given (...) the diagnosis of ASD, rather than subclassifications of the spectrum such as autistic disorder, Asperger syndrome, or pervasive developmental disorder - not otherwise specified. Tests to diagnose ASD have been developed using parent or carer interview, child observation, or a combination of both.Primary objectives1. To identify which diagnostic tools, including updated versions, most accurately diagnose ASD in preschool children when compared with multi-disciplinary team clinical judgement.2. To identify

2018 Cochrane

43. Autism

Autism Evidence Maps - Trip Database or use your Google+ account Turning Research Into Practice ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4) Loading

2018 Trip Evidence Maps

44. Crossing the divide: a longitudinal study of effective treatments for people with autism and attention deficit hyperactivity disorder across the lifespan Full Text available with Trip Pro

Crossing the divide: a longitudinal study of effective treatments for people with autism and attention deficit hyperactivity disorder across the lifespan Crossing the divide: a longitudinal study of effective treatments for people with autism and attention deficit hyperactivity disorder across the lifespan Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please

2018 NIHR HTA programme

45. Autism spectrum disorder: advances in diagnosis and evaluation. (Abstract)

Autism spectrum disorder: advances in diagnosis and evaluation. Autism spectrum disorder (ASD) has a variety of causes, and its clinical expression is generally associated with substantial disability throughout the lifespan. Recent advances have led to earlier diagnosis, and deep phenotyping efforts focused on high risk infants have helped advance the characterization of early behavioral trajectories. Moreover, biomarkers that measure early structural and functional connectivity, visual (...) orienting, and other biological processes have shown promise in detecting the risk of autism spectrum disorder even before the emergence of overt behavioral symptoms. Despite these advances, the mean age of diagnosis is still 4-5 years. Because of the broad consistency in published guidelines, parameters for high quality comprehensive assessments are available; however, such models are resource intensive and high demand can result in greatly increased waiting times. This review describes advances

2018 BMJ

46. ‘How deep are your pockets?’ Autoethnographic reflections on the cost of raising a child with autism Full Text available with Trip Pro

‘How deep are your pockets?’ Autoethnographic reflections on the cost of raising a child with autism In this article, we reflected on our experience of the cost of parenting a child with autism, including our ongoing search for educational and therapeutic intervention.We aimed to give an academic insight into the state of autism education and care in South Africa as seen by us, with special attention to its cost and sustainability.Using evocative autoethnography as storied scholarship (...) together with critical autism studies, we reflected on stories of the past 5 years since our son's diagnosis.Our experiences agree with international studies that establish autism as the most expensive disability. In addition to the high costs of diagnosis, existing intervention and support approaches are unaffordable for the majority of South Africans. We recommend that teachers should be trained to participate in early screening and diagnosis, as well as co-therapists, to strengthen

2018 African journal of disability

47. International multicentre randomised controlled trial of improvisational music therapy for children with autism spectrum disorder: TIME-A study

-assessed social responsiveness. Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Autism Spectrum Disorder; Autistic Disorder; Child; Child Development Disorders, Pervasive; Humans; Music Therapy Language Published English Country of organisation England English summary An English language summary is available. Address for correspondence NETSCC, Health Technology Assessment, Alpha House, University of Southampton Science Park, Southampton, SO16 7NS UK Tel: +44 23 8059 5586 (...) International multicentre randomised controlled trial of improvisational music therapy for children with autism spectrum disorder: TIME-A study International multicentre randomised controlled trial of improvisational music therapy for children with autism spectrum disorder: TIME-A study International multicentre randomised controlled trial of improvisational music therapy for children with autism spectrum disorder: TIME-A study Crawford M J, Gold C, Odell-Miller H, Thana L, Faber S, Assmus J

2018 Health Technology Assessment (HTA) Database.

48. A symptom-based approach to treatment of psychosis in autism spectrum disorder Full Text available with Trip Pro

A symptom-based approach to treatment of psychosis in autism spectrum disorder The optimal management of autism with psychosis remains unclear. This report describes a 22-year-old man with autism and psychosis who was referred to a tertiary-level specialist psychosis service, following a 6-year history of deterioration in mental health starting around the time of sitting GCSE examinations and an episode of bullying at school. We describe the individualised symptom-based approach

2018 BJPsych open

49. Prevalence of Autism Spectrum Disorder Among US Children and Adolescents, 2014-2016 Full Text available with Trip Pro

Prevalence of Autism Spectrum Disorder Among US Children and Adolescents, 2014-2016 29297068 2018 01 08 2018 11 13 1538-3598 319 1 2018 01 02 JAMA JAMA Prevalence of Autism Spectrum Disorder Among US Children and Adolescents, 2014-2016. 81-82 10.1001/jama.2017.17812 Xu Guifeng G Department of Epidemiology, University of Iowa College of Public Health, Iowa City. Strathearn Lane L Center for Disabilities and Development, University of Iowa Stead Family Children's Hospital, Iowa City. Liu Buyun B (...) Department of Epidemiology, University of Iowa College of Public Health, Iowa City. Bao Wei W Department of Epidemiology, University of Iowa College of Public Health, Iowa City. eng Journal Article United States JAMA 7501160 0098-7484 AIM IM JAMA. 2018 Feb 6;319(5):505 29305599 JAMA. 2018 Feb 6;319(5):505 29305598 Adolescent Autism Spectrum Disorder epidemiology Child Child, Preschool Female Health Surveys Humans Male Prevalence United States epidemiology 2018 1 4 6 0 2018 1 4 6 0 2018 1 9 6 0 ppublish

2018 JAMA

50. Autism spectrum disorder: Warning signs, detection, diagnosis and assessment in children and adolescents

Autism spectrum disorder: Warning signs, detection, diagnosis and assessment in children and adolescents Haute Autorité de Santé - Autism spectrum disorder: Warning signs, detection, diagnosis and assessment in children and adolescents Fermer Choose language Accessibility Change contrast : Standards Reinforced icone Chercher icone plus Chercher My account My account Please fill in your email address to retrieve your email alerts subscriptions. Please fill in your email address to retrieve your (...) guide Date : 08 February 2018 Autism spectrum disorder: Warning signs, detection, diagnosis and assessment in children and adolescents Practice guidelines - Posted on Feb 19 2018 This Best Practice Guideline updates the “Professional practice guidelines for the diagnosis of autism” which were developed in 2005 by the French Federation of Psychiatry (FFP) in partnership with HAS. The central issue in detection and then early diagnosis is the opportunity to implement interventions suitable for ASD

2018 HAS Guidelines

51. Autism spectrum disorder

acquired acquired language skills (regression). Rogers SJ. Developmental regression in autistic spectrum disorders. Ment Retard Dev Disabil Res Rev. 2004;10(2):139-43. http://www.ncbi.nlm.nih.gov/pubmed/15362172?tool=bestpractice.com Parr JR, Le Couteur A, Baird G, et al. Early developmental regression in autism spectrum disorder: evidence from an international multiplex sample. J Autism Dev Disord. 2011 Mar;41(3):332-40. http://www.ncbi.nlm.nih.gov/pubmed/20711649?tool=bestpractice.com Children who (...) Autism spectrum disorder Autism spectrum disorder - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Autism spectrum disorder Last reviewed: February 2019 Last updated: March 2018 Summary Children and adults with autism spectrum disorder (ASD) have social communication and interaction difficulties and show restricted, repetitive, and stereotyped patterns of behaviours, interests, or activities. Social communication

2018 BMJ Best Practice

52. A microcosting and cost-consequence analysis of genomic testing strategies (including trios) in autism spectrum disorder: An update

A microcosting and cost-consequence analysis of genomic testing strategies (including trios) in autism spectrum disorder: An update The Hospital for Sick Children Technology Assessment at SickKids (TASK) FULL REPORT A MICROCOSTING AND COST-CONSEQUENCE ANALYSIS OF GENOMIC TESTING STRATEGIES (INCLUDING TRIOS) IN AUTISM SPECTRUM DISORDER: AN UPDATE Authors: Jathishinie Jegathisawaran, MHEcon Clinical Research Project Coordinator, Child Health Evaluative Sciences, The Hospital for Sick Children (...) with quality checks. i List of Abbreviations aCGH Array-based comparative genomic hybridization ACMG American College of Medical Genetics and Genomics ASD Autism spectrum disorder CAD Canadian dollar CGES Clinical genome and exome sequencing CIHI Canadian Institute for Health Information CMA Chromosomal microarray analysis CNV Copy number variant DD Developmental delay DPLM Department of pediatric laboratory medicine DSA Deterministic sensitivity analysis FISH Fluorescence in situ hybridization GATK Genome

2018 SickKids Reports

53. Autism in children: What else might it be?

Autism in children: What else might it be? Differential diagnosis | Diagnosis | Autism in children | CKS | NICE Search CKS… Menu Differential diagnosis Autism in children: What else might it be? Last revised in October 2018 What else might it be? Conditions that may present with similar features to autism spectrum disorder (ASD) include: Neurodevelopmental disorders, including: Specific language delay or disorder — they will usually develop compensatory non-verbal communication and have normal (...) a history of appropriate quality of communication and interaction in some circumstances, typically at home, where the child or young person usually talks normally. Child maltreatment — children with a history of maltreatment can present with a marked change in behaviour which can be linked back to maltreatment. See the section on in the CKS topic for more information. Basis for recommendation This information on the differential diagnosis of autism spectrum disorder is taken from the National Institute

2018 NICE Clinical Knowledge Summaries

54. Autism in children: Scenario: How should I manage a child with confirmed autism spectrum disorder in primary care?

of the general public. The National Autistic Society ( ) — the is aimed at all health professionals who may come into contact with a child or adult with autism for reasons other than autism. The National Institute for Health and Care Excellence (NICE, ): The guideline on covers interventions and support for children, young people, and adults with a learning disability and behaviour that challenges. It also covers support and intervention for family members and/or carers. The guideline on covers services (...) , for example, abdominal pain, earache, or eczema. Levels of activity and exercise during the day. Emotional upset. The National Autistic Society website ( ) has information on . Give advice on good sleep hygiene. See the section on in the CKS topic on for more information. If the problem persists, consider referral to a paediatric sleep specialist or an autism team if available (or if not, to a paediatrician or a child and adolescent psychiatrist). Be aware that pharmacological intervention to aid sleep

2018 NICE Clinical Knowledge Summaries

55. Disorder-Specific and Shared Brain Abnormalities During Vigilance in Autism and Obsessive-Compulsive Disorder Full Text available with Trip Pro

Disorder-Specific and Shared Brain Abnormalities During Vigilance in Autism and Obsessive-Compulsive Disorder Autism spectrum disorder (ASD) and obsessive-compulsive disorder (OCD) are often comorbid and share similarities across some cognitive phenotypes, including certain aspects of attention. However, no functional magnetic resonance imaging studies have compared the underlying neural mechanisms contributing to these shared phenotypes.Age- and IQ-matched boys (11-17 years old) with ASD (n

2017 Biological psychiatry. Cognitive neuroscience and neuroimaging

56. Autism spectrum disorder and Li-Fraumeni syndrome: purely coincidental or mechanistically associated? Full Text available with Trip Pro

Autism spectrum disorder and Li-Fraumeni syndrome: purely coincidental or mechanistically associated? Autism spectrum disorders (ASDs) are neurodevelopmental disorders with impaired social interactions and communication and restrictive, repetitive patterns of behaviors, interests, and activities. A recent epidemiological study suggests that children with ASD might have an increased cancer risk.The 14.5-year-old boy, previously diagnosed with ASD, was referred with persistent bone pain (...) cancer.Some of the oncogenes and tumor suppressor genes causing cancer susceptibility syndromes overlap with those involved in autism. This functional overlap between autism and cancer is novel and particularly compelling. The surprising coincidence of LFS and ASD in our patient raises the question whether this is purely coincidental or mechanistically associated.

2017 Molecular and cellular pediatrics

57. Antenatal nutritional supplementation and autism spectrum disorders in the Stockholm youth cohort: population based cohort study. Full Text available with Trip Pro

Antenatal nutritional supplementation and autism spectrum disorders in the Stockholm youth cohort: population based cohort study. Objective To determine whether nutritional supplementation during pregnancy is associated with a reduced risk of autism spectrum disorder (ASD) with and without intellectual disability in offspring.Design Observational prospective cohort study using multivariable logistic regression, sibling controls, and propensity score matching.Setting Stockholm County (...) nutrition and its role in the cause of autism is recommended.Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

2017 BMJ

58. Atypical autism in a boy with double duplication of 22q11.2: implications of increasing dosage Full Text available with Trip Pro

Atypical autism in a boy with double duplication of 22q11.2: implications of increasing dosage Duplication of chromosome 22q11.2 (LCR A-D) has been reported at higher frequencies in clinical samples than the general population, but phenotypes vary widely. Triplication (4 copies) is rare, but studying the associated phenotype may provide insight into dosage-sensitivity of the genes in this chromosomal interval. We describe a proband with a triplication, specifically a "double duplication" (two

2017 NPJ genomic medicine

59. The Heritability of Autism Spectrum Disorder Full Text available with Trip Pro

The Heritability of Autism Spectrum Disorder 28973605 2017 10 19 2018 11 13 1538-3598 318 12 2017 09 26 JAMA JAMA The Heritability of Autism Spectrum Disorder. 1182-1184 10.1001/jama.2017.12141 Sandin Sven S Department of Psychiatry, Ichan School of Medicine at Mount Sinai, New York, New York. Lichtenstein Paul P Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Kuja-Halkola Ralf R Department of Medical Epidemiology and Biostatistics, Karolinska (...) Institutet, Stockholm, Sweden. Hultman Christina C Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Larsson Henrik H School of Medical Sciences, Örebro University, Örebro, Sweden. Reichenberg Abraham A Department of Psychiatry, Ichan School of Medicine at Mount Sinai, New York, New York. eng Journal Article Research Support, Non-U.S. Gov't United States JAMA 7501160 0098-7484 AIM IM Autism Spectrum Disorder genetics Child Cohort Studies Genetic

2017 JAMA

60. Study of the C677T and 1298AC polymorphic genotypes of MTHFR Gene in autism spectrum disorder Full Text available with Trip Pro

and to make a phenotype-genotype correlation for the autistic patients.This case-control study was carried out from 2013 through 2015. The study included 31 children with autism and 39 children in a normal control group, the mean age of patients and control was comparable (4.5 years± 2) with males predominant in both groups. We used DSM-V-TR criteria, Stanford-Binet intelligence scale V and childhood autism rating scale (CARS) for assessments. Genotyping for MTHFR gene polymorphic loci C677T and 1298AC (...) Study of the C677T and 1298AC polymorphic genotypes of MTHFR Gene in autism spectrum disorder Autism is currently known as "a behaviorally defined syndrome" manifested as impairment in social communication, repetitive routines and restricted interests. There is an increased risk of ASDs associated with common mutations affecting the folate/methylation cycle.The aim of this study was to identify C677T and 1298AC polymorphic genotypes of MTHFR gene among a sample of Egyptian children with autism

2017 Electronic physician