Latest & greatest articles for autism

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Autism

Autism is a neurodevelopmental disorder (a type of mental disorder) characterised by difficult social interaction, impaired communication (both verbal and non-verbal), and restricted and repetitive behaviours. It forms part of the broader autism spectrum disorder (ASD), a range of similar conditions, including Asperger syndrome.

Autism is a condition that begins from early childhood and is often suspected and diagnosed by ages 1-3. It is a lifelong disability that affects how people interact with others.

Autism causes and treatment

There have been many misconceptions as to what causes autism in the past such as the MMR vaccine and diet. Extensive research and clinical trials have concluded that none of these factors cause autism or ASD. However, the real cause is little understood but research is starting to unpick potential factors such as genetics, pollution and other environmental factors. A current favoured idea is that genes inherited from a child’s parents can make them more vulnerable to developing autism, some researchers suggest that the disorder will only develop when triggered by environmental factors.

The exact cause of autism spectrum disorder is unknown, however research into the disorder suggest that it is caused by several genetic and environmental factors. Genes inherited from a child’s parents can make them more vulnerable to developing autism, some researchers suggest that the disorder will only develop when triggered by environmental factors. Read more in clinical papers on autism.

Autism can be managed with a combination of prescribed medicines and behavioural treatment, depending on the severity of the disorder. Read about clinical trials and medical advancements for the treatment of autism on Trip.

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Users of Trip frequently look at topics around adolescents, therapies, behaviour and screening. They also explore such topics as omega-3 fatty acids, SSRIs and aripiprazole. All these topics, and more, can be easily searched for within Trip.

Top results for autism

21. Post-diagnostic management and follow-up care for autism spectrum disorder

Post-diagnostic management and follow-up care for autism spectrum disorder Paediatricians and other primary care providers are well positioned to provide or coordinate ongoing medical and psychosocial care and support services for children with autism spectrum disorder (ASD). This statement provides recommendations and information on a range of interventions and resources, to help paediatric care providers optimize care for children with ASD and support their families. The management of ASD (...) includes treating medical and psychiatric co-morbidities, behavioural and developmental interventions, and providing supportive social care services to enhance quality of life for affected children and families. Keywords: Autism spectrum disorder; Behavioural interventions; Complementary and alternative medicine; Developmental interventions; Pharmacological management

2019 Canadian Paediatric Society

22. Standards of diagnostic assessment for autism spectrum disorder

Standards of diagnostic assessment for autism spectrum disorder The rising prevalence of autism spectrum disorder (ASD) has created a need to expand ASD diagnostic capacity by community-based paediatricians and other primary care providers. Although evidence suggests that some children can be definitively diagnosed by 2 years of age, many are not diagnosed until 4 to 5 years of age. Most clinical guidelines recommend multidisciplinary team involvement in the ASD diagnostic process. Although (...) on referral for a comprehensive needs assessment both for treatment and intervention planning, using a flexible, multilevel approach. Keywords: Autism spectrum disorder; Diagnostic evaluation; Intervention planning

2019 Canadian Paediatric Society

23. Effect of Fluoxetine on Obsessive-Compulsive Behaviors in Children and Adolescents With Autism Spectrum Disorders: A Randomized Clinical Trial. Full Text available with Trip Pro

Effect of Fluoxetine on Obsessive-Compulsive Behaviors in Children and Adolescents With Autism Spectrum Disorders: A Randomized Clinical Trial. Selective serotonin receptor inhibitors are prescribed to reduce the severity of core behaviors of autism spectrum disorders, but their efficacy remains uncertain.To determine the efficacy of fluoxetine for reducing the frequency and severity of obsessive-compulsive behaviors in autism spectrum disorders.Multicenter, randomized, placebo-controlled (...) clinical trial. Participants aged 7.5-18 years with autism spectrum disorders and a total score of 6 or higher on the Children's Yale-Brown Obsessive Compulsive Scale, modified for pervasive developmental disorder (CYBOCS-PDD) were recruited from 3 tertiary health centers across Australia. Enrollment began November 2010 and ended April 2017. Follow-up ended August 2017.Participants were randomized to receive fluoxetine (n = 75) or placebo (n = 71). Study medication was commenced at 4 or 8 mg/d

2019 JAMA

24. Fecal Microbiota Transplantation for Autism: Clinical Effectiveness, Cost-Effectiveness, and Guidelines

Fecal Microbiota Transplantation for Autism: Clinical Effectiveness, Cost-Effectiveness, and Guidelines Fecal Microbiota Transplantation for Autism: Clinical Effectiveness, Cost-Effectiveness, and Guidelines | CADTH.ca Find the information you need Fecal Microbiota Transplantation for Autism: Clinical Effectiveness, Cost-Effectiveness, and Guidelines Fecal Microbiota Transplantation for Autism: Clinical Effectiveness, Cost-Effectiveness, and Guidelines Last updated: June 13, 2019 Project Number (...) : RB1353-000 Product Line: Research Type: Devices and Systems Report Type: Summary of Abstracts Result type: Report Question What is the clinical effectiveness of fecal microbiota transplantation for the treatment of individuals with autism spectrum disorder? What is the cost-effectiveness of fecal microbiota transplantation for the treatment of individuals with autism spectrum disorder? What are the evidence-based guidelines regarding the use of fecal microbiota transplantation for the treatment

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

25. Melatonin (Slenyto) - Treatment of insomnia in children and adolescents aged 2 to 18 years with autism spectrum disorder and / or Smith-Magenis syndrome

Melatonin (Slenyto) - Treatment of insomnia in children and adolescents aged 2 to 18 years with autism spectrum disorder and / or Smith-Magenis syndrome 1 Published 9 September 2019 1 SMC2168 melatonin 1mg and 5mg prolonged-release tablets (Slenyto®) Flynn Pharma Ltd 9 August 2019 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product and advises NHS Boards and Area Drug and Therapeutic Committees (ADTCs) on its use in NHSScotland. The advice is summarised (...) as follows: ADVICE: following a full submission melatonin prolonged-release (Slenyto ® ) is not recommended for use within NHSScotland. Indication under review: Treatment of insomnia in children and adolescents aged 2 to 18 years with autism spectrum disorder and / or Smith-Magenis syndrome, where sleep hygiene measures have been insufficient. Melatonin prolonged-release (Slenyto ® ), compared with placebo, increased total sleep time and sleep onset latency in children aged 2 to 17.5 years with sleep

2019 Scottish Medicines Consortium

26. Psychotropic drugs and people with learning disabilities or autism

Psychotropic drugs and people with learning disabilities or autism Psychotropic drugs and people with learning disabilities or autism: executive summary - GOV.UK GOV.UK uses cookies to make the site simpler. Accept cookies You’ve accepted all cookies. You can at any time. Hide Search Guidance Psychotropic drugs and people with learning disabilities or autism: executive summary Published 22 March 2019 Contents © Crown copyright 2019 This publication is licensed under the terms of the Open (...) Government Licence v3.0 except where otherwise stated. To view this licence, visit or write to the Information Policy Team, The National Archives, Kew, London TW9 4DU, or email: . Where we have identified any third party copyright information you will need to obtain permission from the copyright holders concerned. This publication is available at https://www.gov.uk/government/publications/psychotropic-drugs-and-people-with-learning-disabilities-or-autism/psychotropic-drugs-and-people-with-learning

2019 Public Health England

27. WITHDRAWN: Gluten- and casein-free diets for autistic spectrum disorder. Full Text available with Trip Pro

WITHDRAWN: Gluten- and casein-free diets for autistic spectrum disorder. It has been suggested that peptides from gluten and casein may have a role in the origins of autism and that the physiology and psychology of autism might be explained by excessive opioid activity linked to these peptides. Research has reported abnormal levels of peptides in the urine and cerebrospinal fluid of people with autism.To determine the efficacy of gluten and/or casein free diets as an intervention to improve (...) programmes which eliminated gluten, casein or both gluten and casein from the diets of individuals diagnosed with an autistic spectrum disorder.Abstracts of studies identified in searches of electronic databases were assessed to determine inclusion by two independent authors The included trials did not share common outcome measures and therefore no meta-analysis was possible. Data are presented in narrative form.Two small RCTs were identified (n = 35). No meta-analysis was possible. There were only three

2019 Cochrane

28. Prenatal and infant exposure to ambient pesticides and autism spectrum disorder in children: population based case-control study. Full Text available with Trip Pro

Prenatal and infant exposure to ambient pesticides and autism spectrum disorder in children: population based case-control study. To examine associations between early developmental exposure to ambient pesticides and autism spectrum disorder.Population based case-control study.California's main agricultural region, Central Valley, using 1998-2010 birth data from the Office of Vital Statistics.2961 individuals with a diagnosis of autism spectrum disorder based on the Diagnostic and Statistical (...) and autism spectrum disorder (with or without intellectual disabilities) in offspring, adjusting for confounders.Risk of autism spectrum disorder was associated with prenatal exposure to glyphosate (odds ratio 1.16, 95% confidence interval 1.06 to 1.27), chlorpyrifos (1.13, 1.05 to 1.23), diazinon (1.11, 1.01 to 1.21), malathion (1.11, 1.01 to 1.22), avermectin (1.12, 1.04 to 1.22), and permethrin (1.10, 1.01 to 1.20). For autism spectrum disorder with intellectual disability, estimated odds ratios were

2019 BMJ

29. Measles, Mumps, Rubella Vaccination and Autism: A Nationwide Cohort Study. Full Text available with Trip Pro

Measles, Mumps, Rubella Vaccination and Autism: A Nationwide Cohort Study. The hypothesized link between the measles, mumps, rubella (MMR) vaccine and autism continues to cause concern and challenge vaccine uptake.To evaluate whether the MMR vaccine increases the risk for autism in children, subgroups of children, or time periods after vaccination.Nationwide cohort study.Denmark.657 461 children born in Denmark from 1999 through 31 December 2010, with follow-up from 1 year of age and through 31 (...) August 2013.Danish population registries were used to link information on MMR vaccination, autism diagnoses, other childhood vaccines, sibling history of autism, and autism risk factors to children in the cohort. Survival analysis of the time to autism diagnosis with Cox proportional hazards regression was used to estimate hazard ratios of autism according to MMR vaccination status, with adjustment for age, birth year, sex, other childhood vaccines, sibling history of autism, and autism risk factors

2019 Annals of Internal Medicine

30. Autism in children: When should I suspect autism spectrum disorder in a primary school child?

Autism in children: When should I suspect autism spectrum disorder in a primary school child? When to suspect autism in a primary school child | Diagnosis | Autism in children | CKS | NICE Search CKS… Menu When to suspect autism in a primary school child Autism in children: When should I suspect autism spectrum disorder in a primary school child? Last revised in October 2018 When should I suspect autism spectrum disorder in a primary school child? Suspect autism spectrum disorder (ASD (...) difficult in: Children with a learning disability — the intellectual age, not the biological age, of the child needs to be considered when making the diagnosis. Children from very deprived backgrounds and in those with a history of maltreatment — care needs be taken to distinguish the features of ASD from behaviours caused by maltreatment or deprivation. Basis for recommendation These recommendations are based on the National Institute for Health and Care Excellence (NICE) guidelines Autism: recognition

2019 NICE Clinical Knowledge Summaries

31. Autism in children: When should I suspect autism spectrum disorder in a secondary school child?

Autism in children: When should I suspect autism spectrum disorder in a secondary school child? When to suspect autism in a secondary school child | Diagnosis | Autism in children | CKS | NICE Search CKS… Menu When to suspect autism in a secondary school child Autism in children: When should I suspect autism spectrum disorder in a secondary school child? Last revised in October 2018 When should I suspect autism spectrum disorder in a secondary school child? Suspect autism spectrum disorder (...) be taken to distinguish the features of ASD from behaviours caused by maltreatment or deprivation. Basis for recommendation These recommendations are based on the National Institute for Health and Care Excellence (NICE) guidelines Autism: recognition, referral and diagnosis of children and young people on the autism spectrum [ ] and Autism spectrum disorder in under 19s: recognition, referral and diagnosis [ ], and are based largely on the expert opinion of the NICE guideline development group as NICE

2019 NICE Clinical Knowledge Summaries

32. Autism in children: When should I suspect autism spectrum disorder in a preschool child?

Autism in children: When should I suspect autism spectrum disorder in a preschool child? When to suspect autism in a preschool child | Diagnosis | Autism in children | CKS | NICE Search CKS… Menu When to suspect autism in a preschool child Autism in children: When should I suspect autism spectrum disorder in a preschool child? Last revised in October 2018 When should I suspect autism spectrum disorder in a preschool child? Suspect autism spectrum disorder (ASD) in a preschool child if any (...) for Health and Care Excellence (NICE) guidelines Autism: recognition, referral and diagnosis of children and young people on the autism spectrum [ ] and Autism spectrum disorder in under 19s: recognition, referral and diagnosis [ ], and are based largely on the expert opinion of the NICE guideline development group as NICE found limited good-quality evidence to inform recommendations on when to suspect autism spectrum disorder. The recommendations are in line with those in the Scottish Intercollegiate

2019 NICE Clinical Knowledge Summaries

33. Neuropsychiatric profile and psychotropic medication use in adults with autism spectrum disorder: results from the Australian Longitudinal Study of Adults with Autism Full Text available with Trip Pro

Neuropsychiatric profile and psychotropic medication use in adults with autism spectrum disorder: results from the Australian Longitudinal Study of Adults with Autism Children and adolescents with autism spectrum disorder (ASD) are a highly medicated group. Few studies have examined the neuropsychiatric profile and patterns of psychotropic medication use among adults with ASD.To describe and compare the neuropsychiatric profile and psychotropic medication use in a cohort of adults with ASD (...) and non-autistic controls.Baseline data from a survey-based, longitudinal study of adults with ASD in Australia. Participants were 188 adults with ASD and 115 controls aged 25-80 years.ASD was associated with increased odds of psychotropic medication use even when controlling for the presence of any neurological or psychiatric disorder. There were no corresponding indications for 14.4% of psychotropic medications prescribed to adults with ASD.This study found substantial psychotropic prescribing

2018 BJPsych open

34. Stem cell transplantation as treatment for children with autism

Stem cell transplantation as treatment for children with autism Stem cell transplantation as treatment for children with autism We use cookies on this website. By using this site, you agree that we may store and access cookies on your device. Swedish Agency for Health Technology Assessment and Assessment of Social Services Stem cell transplantation as treatment for children with autism Share: Reading time approx. 1 minute Stem cell transplantations are performed to treat certain forms of cancer (...) but also to treat some other rarer disorders. Today stem cell clinics advertise stem cell transplantation as a treatment to disorders like autism at high costs. There are however doubts about the efficacy and safety of these treatments. Question Which scientific studies have investigated stem cell transplantation as treatment for children with autism? Identified literature Chez M, Lepage C, Parise C, Dang-Chu A, Hankins A, Carroll M. Safety and Observations from a Placebo-Controlled, Crossover Study

2018 Swedish Council on Technology Assessement

35. Nutritional or dietary interventions for children and adolescents with autism spectrum disorder or ADHD

Nutritional or dietary interventions for children and adolescents with autism spectrum disorder or ADHD Nutritional or dietary interventions for children and adolescents with autism spectrum disorder or ADHD We use cookies on this website. By using this site, you agree that we may store and access cookies on your device. Swedish Agency for Health Technology Assessment and Assessment of Social Services Nutritional or dietary interventions for children and adolescents with autism spectrum (...) disorder or ADHD Share: Reading time approx. 6 minutes There are theories that different types of nutritional or dietary interventions, where specific food items are excluded from the diet or where nutritional supplements are added, may affect the symptoms of persons with Attention Deficit Hyperactivity Disorder (ADHD) or autism spectrum disorder. This applies, for example, to gluten-free and casein-free diet, ketogenic diet (a strict option of a low carbohydrate diet) or diet where sugar or various

2018 Swedish Council on Technology Assessement

36. A National Guideline for the Assessment and Diagnosis of Autism Spectrum Disorders in Australia

A National Guideline for the Assessment and Diagnosis of Autism Spectrum Disorders in Australia A National Guideline for the Assessment and Diagnosis of Autism Spectrum Disorder in Australia | Autism CRC Menu Breadcrumb A National Guideline for the Assessment and Diagnosis of Autism Spectrum Disorder in Australia Download the National Guideline Developed and published by Autism CRC with the financial support of the National Disability Insurance Agency (NDIA), the Guideline aims to create (...) greater consistency in diagnostic practices across the country to ensure individuals on the autism spectrum and their families can receive the optimal clinical care. The Guideline also emphasises the importance of listening to individuals and their families about the impact of the behaviours on family life. The community has been requesting a national and consistent guideline for autism assessment and diagnosis for many years, and we are pleased to release a guideline that responds to this need

2018 Clinical Practice Guidelines Portal

37. Prenatal Tetanus, Diphtheria, Acellular Pertussis Vaccination and Autism Spectrum Disorder Full Text available with Trip Pro

Prenatal Tetanus, Diphtheria, Acellular Pertussis Vaccination and Autism Spectrum Disorder : media-1vid110.1542/5803567555001PEDS-VA_2018-0120Video Abstract BACKGROUND: Increasing vaccination of pregnant women makes it important to assess safety events potentially linked to prenatal vaccination. This study investigates the association between prenatal tetanus, diphtheria, acellular pertussis (Tdap) vaccination and autism spectrum disorder (ASD) risk in offspring.This is a retrospective cohort

2018 EvidenceUpdates

38. Autism spectrum disorder: Warning signs, detection, diagnosis and assessment in children and adolescents

Autism spectrum disorder: Warning signs, detection, diagnosis and assessment in children and adolescents Haute Autorité de Santé - Trouble du spectre de l’autisme - Signes d’alerte, repérage, diagnostic et évaluation chez l’enfant et l’adolescent Développer la qualité dans le champ sanitaire, social et médico-social Recherche La HAS Accréditation & Certification Outils, Guides & Méthodes Recommandation de bonne pratique Trouble du spectre de l’autisme - Signes d’alerte, repérage, diagnostic et

2018 HAS Guidelines

39. Heterogeneity in clinical sequencing tests marketed for autism spectrum disorders Full Text available with Trip Pro

Heterogeneity in clinical sequencing tests marketed for autism spectrum disorders 30275975 2018 11 14 2056-7944 3 2018 NPJ genomic medicine NPJ Genom Med Heterogeneity in clinical sequencing tests marketed for autism spectrum disorders. 27 10.1038/s41525-018-0066-3 Hoang Ny N 1Department of Genetic Counselling, The Hospital for Sick Children, Toronto, ON Canada. 0000 0004 0473 9646 grid.42327.30 2Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON Canada. 0000 0004 0473 (...) 2938 grid.17063.33 4The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON Canada. 0000 0004 0473 9646 grid.42327.30 5McLaughlin Centre and Department of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, ON Canada. 0000 0001 2157 2938 grid.17063.33 eng Journal Article 2018 09 19 England NPJ Genom Med 101685193 2056-7944 S.W.S. and SickKids Hospital has licensed intellectual property for genetic testing in autism to Athena Diagnostics, Lineagen

2018 NPJ genomic medicine

40. Autism spectrum disorder. (Abstract)

Autism spectrum disorder. Autism spectrum disorder is a term used to describe a constellation of early-appearing social communication deficits and repetitive sensory-motor behaviours associated with a strong genetic component as well as other causes. The outlook for many individuals with autism spectrum disorder today is brighter than it was 50 years ago; more people with the condition are able to speak, read, and live in the community rather than in institutions, and some will be largely free (...) for adults with autism spectrum disorder. Clinicians can make a difference by providing timely and individualised help to families navigating referrals and access to community support systems, by providing accurate information despite often unfiltered media input, and by anticipating transitions such as family changes and school entry and leaving.Copyright © 2018 Elsevier Ltd. All rights reserved.

2018 Lancet