Latest & greatest articles for autism

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on autism or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on autism and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

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Autism

Autism is a neurodevelopmental disorder (a type of mental disorder) characterised by difficult social interaction, impaired communication (both verbal and non-verbal), and restricted and repetitive behaviours. It forms part of the broader autism spectrum disorder (ASD), a range of similar conditions, including Asperger syndrome.

Autism is a condition that begins from early childhood and is often suspected and diagnosed by ages 1-3. It is a lifelong disability that affects how people interact with others.

Autism causes and treatment

There have been many misconceptions as to what causes autism in the past such as the MMR vaccine and diet. Extensive research and clinical trials have concluded that none of these factors cause autism or ASD. However, the real cause is little understood but research is starting to unpick potential factors such as genetics, pollution and other environmental factors. A current favoured idea is that genes inherited from a child’s parents can make them more vulnerable to developing autism, some researchers suggest that the disorder will only develop when triggered by environmental factors.

The exact cause of autism spectrum disorder is unknown, however research into the disorder suggest that it is caused by several genetic and environmental factors. Genes inherited from a child’s parents can make them more vulnerable to developing autism, some researchers suggest that the disorder will only develop when triggered by environmental factors. Read more in clinical papers on autism.

Autism can be managed with a combination of prescribed medicines and behavioural treatment, depending on the severity of the disorder. Read about clinical trials and medical advancements for the treatment of autism on Trip.

Hot topics in Trip

Users of Trip frequently look at topics around adolescents, therapies, behaviour and screening. They also explore such topics as omega-3 fatty acids, SSRIs and aripiprazole. All these topics, and more, can be easily searched for within Trip.

Top results for autism

181. Effectiveness of intensive autism programmes Full Text available with Trip Pro

Effectiveness of intensive autism programmes 20189018 2010 03 15 2018 11 13 1474-547X 375 9716 2010 Feb 27 Lancet (London, England) Lancet Effectiveness of intensive autism programmes. 722-3; author reply 723 10.1016/S0140-6736(10)60299-1 Dawson Michelle M Gernsbacher Morton Ann MA eng F33 DC005365 DC NIDCD NIH HHS United States R01 DC007223 DC NIDCD NIH HHS United States R01 MH069793 MH NIMH NIH HHS United States Comment Letter England Lancet 2985213R 0140-6736 AIM IM Lancet. 2009 Nov 7;374 (...) (9701):1627-38 19819542 Lancet. 2011 Nov 19;378(9805):1778 Autistic Disorder diagnosis therapy Behavior Therapy methods Child Humans Randomized Controlled Trials as Topic Treatment Outcome 2010 3 2 6 0 2010 3 2 6 0 2010 3 17 6 0 ppublish 20189018 S0140-6736(10)60299-1 10.1016/S0140-6736(10)60299-1 PMC4301441 NIHMS655565 Am J Ment Retard. 2000 Jul;105(4):269-85 10934569 Am J Ment Retard. 2005 Nov;110(6):417-38 16212446 J Clin Child Adolesc Psychol. 2008 Jan;37(1):8-38 18444052 Lancet. 2009 Nov 7;374

2010 Lancet

182. Randomized, controlled trial of an intervention for toddlers with autism: the Early Start Denver Model Full Text available with Trip Pro

Randomized, controlled trial of an intervention for toddlers with autism: the Early Start Denver Model To conduct a randomized, controlled trial to evaluate the efficacy of the Early Start Denver Model (ESDM), a comprehensive developmental behavioral intervention, for improving outcomes of toddlers diagnosed with autism spectrum disorder (ASD).Forty-eight children diagnosed with ASD between 18 and 30 months of age were randomly assigned to 1 of 2 groups: (1) ESDM intervention, which is based (...) on developmental and applied behavioral analytic principles and delivered by trained therapists and parents for 2 years; or (2) referral to community providers for intervention commonly available in the community.Compared with children who received community-intervention, children who received ESDM showed significant improvements in IQ, adaptive behavior, and autism diagnosis. Two years after entering intervention, the ESDM group on average improved 17.6 standard score points (1 SD: 15 points) compared

2010 EvidenceUpdates Controlled trial quality: uncertain

183. Risk of autism and increasing maternal and paternal age in a large north American population Full Text available with Trip Pro

Risk of autism and increasing maternal and paternal age in a large north American population Previous studies are inconsistent regarding whether there are independent effects of maternal and paternal age on the risk of autism. Different biologic mechanisms are suggested by maternal and paternal age effects. The study population included all California singletons born in 1989-2002 (n = 7,550,026). Children with autism (n = 23,311) were identified through the California Department (...) of Developmental Services and compared with the remainder of the study population, with parental ages and covariates obtained from birth certificates. Adjusted odds ratios and 95% confidence intervals were used to evaluate the risk of autism associated with increasing maternal and paternal age. In adjusted models that included age of the other parent and demographic covariates, a 10-year increase in maternal age was associated with a 38% increase in the odds ratio for autism (odds ratio = 1.38, 95% confidence

2010 EvidenceUpdates

184. Autism and X-linked hypophosphatemia: A possible association? Full Text available with Trip Pro

Autism and X-linked hypophosphatemia: A possible association? We herein report the joint occurrence of an autistic disorder (AD) and X-linked hypophosphatemia. X-linked hypophosphatemia (XLH), an X-linked dominant disorder, is the most common of the inherited renal phosphate wasting disorders. Autism is a pervasive developmental disorder that occurs mainly due to genetic causes. In approximately 6-15% of cases, the autistic phenotype is a part of a broader genetic condition called syndromic (...) autism.Therefore, reports of cases with the joint occurrence of a known genetic syndrome and a diagnosis of ASD by a child psychiatrist are relevant. A joint occurrence does not, however, mean that there is always a causal link between the genetic syndrome and the autistic behavioural phenotype. In this case, there are a number of arguments countering a causal link.

2010 Indian journal of human genetics

185. Parent-mediated communication-focused treatment in children with autism (PACT): a randomised controlled trial. Full Text available with Trip Pro

Parent-mediated communication-focused treatment in children with autism (PACT): a randomised controlled trial. Results of small trials suggest that early interventions for social communication are effective for the treatment of autism in children. We therefore investigated the efficacy of such an intervention in a larger trial.Children with core autism (aged 2 years to 4 years and 11 months) were randomly assigned in a one-to-one ratio to a parent-mediated communication-focused (Preschool (...) Autism Communication Trial [PACT]) intervention or treatment as usual at three specialist centres in the UK. Those assigned to PACT were also given treatment as usual. Randomisation was by use of minimisation of probability in the marginal distribution of treatment centre, age (42 months), and autism severity (Autism Diagnostic Observation Schedule-Generic [ADOS-G] algorithm score 12-17 or 18-24). Primary outcome was severity of autism symptoms (a total score of social communication

2010 Lancet Controlled trial quality: predicted high

186. Estimated prevalence of autism spectrum conditions in Cambridgeshire is over 1%

Estimated prevalence of autism spectrum conditions in Cambridgeshire is over 1% Estimated prevalence of autism spectrum conditions in Cambridgeshire is over 1% | Evidence-Based Mental Health We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional (...) accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Estimated prevalence of autism spectrum conditions in Cambridgeshire is over 1% Article Text Prevalence Estimated prevalence of autism spectrum conditions in Cambridgeshire is over 1% Statistics from Altmetric.com Question

2010 Evidence-Based Mental Health

187. Citalopram not effective for repetitive behaviour in autistic spectrum disorders Full Text available with Trip Pro

Citalopram not effective for repetitive behaviour in autistic spectrum disorders Citalopram not effective for repetitive behaviour in autistic spectrum disorders | Evidence-Based Mental Health We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional (...) accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Citalopram not effective for repetitive behaviour in autistic spectrum disorders Article Text Therapeutics Citalopram not effective for repetitive behaviour in autistic spectrum disorders Statistics from Altmetric.com Question

2010 Evidence-Based Mental Health

188. Gluten-free and casein-free diets in the treatment of autism spectrum disorders: a systematic review

Not stated. Bibliographic details Mulloy A, Lang R, O'Reilly M, Sigafoos J, Lancioni G, Rispoli M. Gluten-free and casein-free diets in the treatment of autism spectrum disorders: a systematic review. Research in Autism Spectrum Disorders 2010; 4(3): 328-339 DOI Original Paper URL Indexing Status Subject indexing assigned by CRD MeSH Adolescent; Autistic Disorder /diet therapy; Caseins; Child; Complementary Therapies; Diet, Gluten-Free; Glutens; Humans AccessionNumber 12010003744 Date bibliographic (...) Gluten-free and casein-free diets in the treatment of autism spectrum disorders: a systematic review Gluten-free and casein-free diets in the treatment of autism spectrum disorders: a systematic review Gluten-free and casein-free diets in the treatment of autism spectrum disorders: a systematic review Mulloy A, Lang R, O'Reilly M, Sigafoos J, Lancioni G, Rispoli M CRD summary This review concluded that the evidence did not support use of gluten-free and/or casein-free diets in the treatment

2010 DARE.

189. Is video-based instruction effective in the rehabilitation of children with autism spectrum disorders?

Is video-based instruction effective in the rehabilitation of children with autism spectrum disorders? Is video-based instruction effective in the rehabilitation of children with autism spectrum disorders? Is video-based instruction effective in the rehabilitation of children with autism spectrum disorders? Kagohara DM CRD summary This review assessed the effectiveness of video-based instruction for teaching adaptive behaviours to children with autism spectrum disorders. Included studies were (...) small case series or single cases in which introduction and removal of the intervention provided the control. The evidence provided by these studies was not adequate to support the author's conclusion that video-based instruction was an empirically supported intervention. Authors' objectives To assess the effectiveness of video-based instruction for teaching adaptive behaviours to children with autism spectrum disorders. Searching ERIC, SpringerLink, PsycINFO and ProQuest were searched from

2010 DARE.

190. Applied behavior analytic intervention for autism in early childhood: meta-analysis, meta-regression and dose-response meta-analysis of multiple outcomes

Applied behavior analytic intervention for autism in early childhood: meta-analysis, meta-regression and dose-response meta-analysis of multiple outcomes Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2010 DARE.

191. Intensive behavioral intervention therapy for autism

Intensive behavioral intervention therapy for autism Intensive behavioral intervention therapy for autism Intensive behavioral intervention therapy for autism Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Intensive behavioral intervention therapy for autism. Lansdale: HAYES, Inc.. Directory Publication. 2010 Authors' objectives

Intensive behavioral (...) intervention (IBI) therapy, also known as Lovaas therapy, applied behavior analysis (ABA), or early intensive behavioral intervention (EIBI), is an intensive behavioral treatment program that attempts to improve the cognitive and social functioning of children with autism.

Timeliness warning This report has been archived and may contain outdated information. To request a copy of the report please contact the organisation directly. Final publication URL Indexing Status Subject indexing assigned by CRD

2010 Health Technology Assessment (HTA) Database.

192. Fluconazole and pharmaceuticals without inactive ingredients for autism: a review of the clinical effectiveness

Fluconazole and pharmaceuticals without inactive ingredients for autism: a review of the clinical effectiveness Fluconazole and pharmaceuticals without inactive ingredients for autism: a review of the clinical effectiveness Fluconazole and pharmaceuticals without inactive ingredients for autism: a review of the clinical effectiveness Canadian Agency for Drugs and Technologies in Health Record Status This is a bibliographic record of a published health technology assessment from a member (...) of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Canadian Agency for Drugs and Technologies in Health. Fluconazole and pharmaceuticals without inactive ingredients for autism: a review of the clinical effectiveness. Ottawa: Canadian Agency for Drugs and Technologies in Health (CADTH). 2010 Authors' conclusions The efficacy of antifungal agents for the treatment of autism has not been demonstrated in published clinical trials or observational studies

2010 Health Technology Assessment (HTA) Database.

193. Extremely preterm children at increased risk of autism spectrum disorders

Extremely preterm children at increased risk of autism spectrum disorders Extremely preterm children at increased risk of autism spectrum disorders | Evidence-Based Mental Health We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username (...) * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Extremely preterm children at increased risk of autism spectrum disorders Article Text Prevalence Extremely preterm children at increased risk of autism spectrum disorders Statistics from Altmetric.com Question Question What is the prevalence

2010 Evidence-Based Mental Health

194. Autism. Full Text available with Trip Pro

Autism. Autism spectrum disorders are characterised by severe deficits in socialisation, communication, and repetitive or unusual behaviours. Increases over time in the frequency of these disorders (to present rates of about 60 cases per 10,000 children) might be attributable to factors such as new administrative classifications, policy and practice changes, and increased awareness. Surveillance and screening strategies for early identification could enable early treatment and improved outcomes (...) . Autism spectrum disorders are highly genetic and multifactorial, with many risk factors acting together. Genes that affect synaptic maturation are implicated, resulting in neurobiological theories focusing on connectivity and neural effects of gene expression. Several treatments might address core and comorbid symptoms. However, not all treatments have been adequately studied. Improved strategies for early identification with phenotypic characteristics and biological markers (eg, electrophysiological

2009 Lancet

195. Association of Family History of Autoimmune Diseases and Autism Spectrum Disorders Full Text available with Trip Pro

Association of Family History of Autoimmune Diseases and Autism Spectrum Disorders Recent studies suggest that familial autoimmunity plays a part in the pathogenesis of ASDs. In this study we investigated the association between family history of autoimmune diseases (ADs) and ASDs/infantile autism. We perform confirmatory analyses based on results from previous studies, as well as various explorative analyses.The study cohort consisted of all of the children born in Denmark from 1993 through (...) 2004 (689 196 children). Outcome data consisted of both inpatient and outpatient diagnoses reported to the Danish National Psychiatric Registry. Information on ADs in parents and siblings of the cohort members was obtained from the Danish National Hospital Register. The incidence rate ratio of autism was estimated by using log-linear Poisson regression.A total of 3325 children were diagnosed with ASDs, of which 1089 had an infantile autism diagnosis. Increased risk of ASDs was observed for children

2009 EvidenceUpdates

196. Lack of efficacy of citalopram in children with autism spectrum disorders and high levels of repetitive behavior: citalopram ineffective in children with autism Full Text available with Trip Pro

Lack of efficacy of citalopram in children with autism spectrum disorders and high levels of repetitive behavior: citalopram ineffective in children with autism Selective serotonin reuptake inhibitors are widely prescribed for children with autism spectrum disorders.To determine the efficacy and safety of citalopram hydrobromide therapy for repetitive behavior in children with autism spectrum disorders.National Institutes of Health-sponsored randomized controlled trial.Six academic centers (...) , including Mount Sinai School of Medicine, North Shore-Long Island Jewish Health System, University of North Carolina at Chapel Hill, University of California at Los Angeles, Yale University, and Dartmouth Medical School.One hundred forty-nine volunteers 5 to 17 years old (mean [SD] age, 9.4 [3.1] years) were randomized to receive citalopram (n = 73) or placebo (n = 76). Participants had autistic spectrum disorders, Asperger disorder, or pervasive developmental disorder, not otherwise specified; had

2009 EvidenceUpdates Controlled trial quality: predicted high

197. Birth defects in children with autism spectrum disorders: a population-based, nested case-control study Full Text available with Trip Pro

Birth defects in children with autism spectrum disorders: a population-based, nested case-control study The causes of autism spectrum disorders (ASDs) are unknown, although genetic and environmental influences have been implicated. Previous studies have suggested an association with birth defects, but most investigators have not addressed associations with specific diagnostic categories of ASD. In this study, the authors investigated the associations between birth defects and autism, Asperger (...) ratios for birth defects were similar for autism (odds ratio (OR) = 2.0, 95% confidence interval (CI): 1.3, 3.0) and pervasive developmental disorder not otherwise specified (OR = 2.2, 95% CI: 1.1, 4.3) but not for Asperger syndrome (OR = 0.5, 95% CI: 0.1, 1.9). Birth defects in case siblings were not significantly different from those in cases and population controls. The association between birth defects and ASD may be due to underlying genetic and/or environmental factors common to both ASD

2009 EvidenceUpdates

198. Should Fragile X be tested for in boys with a diagnosis of autistic spectrum disorder?

Completed: 5th May 2009 Last Modified: 5th May 2009 Status: Green (complete) Three Part Question In [boys with a diagnosis of autism] and [no family history of learning disability - negative test result] what is [the risk of fragile X syndrome]? Clinical Scenario You diagnose a 5-year-old boy with autistic spectrum disorder. His examination is unremarkable and there is no family history of learning difficulties. Should you perform a molecular genetic screen for fragile X? Search Strategy PubMed (...) : the search was limited to 1991–2008, as molecular genetic testing was routinely used to test for this condition from 1991 onwards.Secondary sources Clinical Evidence: no relevant items. Cochrane Library: no relevant items. EMBASE: no relevant items. Searches were carried out using "Autism", "Autistic spectrum disorder" combined with "FRAX" and "fragile X". Search Outcome Thirty articles were retrieved and the abstracts were reviewed. Four relevant articles were included. No papers were specific to boys

2009 BestBETS

199. A nationwide study on the risk of autism after prenatal stress exposure to maternal bereavement Full Text available with Trip Pro

A nationwide study on the risk of autism after prenatal stress exposure to maternal bereavement Prenatal stress has been linked to several adverse neurobehavioral outcomes, which may share a common pathophysiology with autism. We aimed to examine whether prenatal stress exposure after maternal bereavement is associated with an increased risk of autism later in life.We conducted a nationwide population-based cohort study of all 1492709 singletons in Denmark born from 1978 to 2003. A total (...) of 37275 children were born to women who lost a close relative during pregnancy or up to 1 year before pregnancy. These children were included in the exposed group, and the remaining children were in the unexposed group. All children were followed up from birth until their death, migration, onset of autism, or the end of 2006. Information on autism was obtained from the Danish Psychiatric Central Register. We used Cox regression models to estimate hazard ratios in the exposed group compared with those

2009 EvidenceUpdates

200. [Autism treatment with orthomolecular therapy]

the efficacy and safety of orthomolecular therapies in autism treatment.

Authors' conclusions Included studies have important methodologic deficiencies that limit the validity of the results. Efficacy and safety of the assessed nutritional supplements are not proved. Rigorous double blinded randomized clinical trials are required in order to assess this kind of therapy. Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Autistic Disorders; Orthomolecular Therapy Language (...) [Autism treatment with orthomolecular therapy] Tratamiento del autismo mediante medicina ortomolecular [Autism treatment with orthomolecular therapy] Tratamiento del autismo mediante medicina ortomolecular [Autism treatment with orthomolecular therapy] Reza M Citation Reza M. Tratamiento del autismo mediante medicina ortomolecular. [Autism treatment with orthomolecular therapy] Madrid: Unidad de Evaluacion de Tecnologias Sanitarias (UETS). IT02/2009. 2009 Authors' objectives

To assess

2009 Health Technology Assessment (HTA) Database.