Latest & greatest articles for autism

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on autism or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on autism and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

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Autism

Autism is a neurodevelopmental disorder (a type of mental disorder) characterised by difficult social interaction, impaired communication (both verbal and non-verbal), and restricted and repetitive behaviours. It forms part of the broader autism spectrum disorder (ASD), a range of similar conditions, including Asperger syndrome.

Autism is a condition that begins from early childhood and is often suspected and diagnosed by ages 1-3. It is a lifelong disability that affects how people interact with others.

Autism causes and treatment

There have been many misconceptions as to what causes autism in the past such as the MMR vaccine and diet. Extensive research and clinical trials have concluded that none of these factors cause autism or ASD. However, the real cause is little understood but research is starting to unpick potential factors such as genetics, pollution and other environmental factors. A current favoured idea is that genes inherited from a child’s parents can make them more vulnerable to developing autism, some researchers suggest that the disorder will only develop when triggered by environmental factors.

The exact cause of autism spectrum disorder is unknown, however research into the disorder suggest that it is caused by several genetic and environmental factors. Genes inherited from a child’s parents can make them more vulnerable to developing autism, some researchers suggest that the disorder will only develop when triggered by environmental factors. Read more in clinical papers on autism.

Autism can be managed with a combination of prescribed medicines and behavioural treatment, depending on the severity of the disorder. Read about clinical trials and medical advancements for the treatment of autism on Trip.

Hot topics in Trip

Users of Trip frequently look at topics around adolescents, therapies, behaviour and screening. They also explore such topics as omega-3 fatty acids, SSRIs and aripiprazole. All these topics, and more, can be easily searched for within Trip.

Top results for autism

181. [Autism treatment with orthomolecular therapy]

[Autism treatment with orthomolecular therapy] Tratamiento del autismo mediante medicina ortomolecular [Autism treatment with orthomolecular therapy] Tratamiento del autismo mediante medicina ortomolecular [Autism treatment with orthomolecular therapy] Reza M Citation Reza M. Tratamiento del autismo mediante medicina ortomolecular. [Autism treatment with orthomolecular therapy] Madrid: Unidad de Evaluacion de Tecnologias Sanitarias (UETS). IT02/2009. 2009 Authors' objectives

To assess (...) the efficacy and safety of orthomolecular therapies in autism treatment.

Authors' conclusions Included studies have important methodologic deficiencies that limit the validity of the results. Efficacy and safety of the assessed nutritional supplements are not proved. Rigorous double blinded randomized clinical trials are required in order to assess this kind of therapy. Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Autistic Disorders; Orthomolecular Therapy Language

Health Technology Assessment (HTA) Database.2009

182. Hyperbaric oxygen therapy for autism: a review of the clinical and cost-effectiveness

Hyperbaric oxygen therapy for autism: a review of the clinical and cost-effectiveness Hyperbaric oxygen therapy for autism: a review of the clinical and cost-effectiveness Hyperbaric oxygen therapy for autism: a review of the clinical and cost-effectiveness Perras C, Cunningham J Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Perras C (...) , Cunningham J. Hyperbaric oxygen therapy for autism: a review of the clinical and cost-effectiveness. Ottawa: Canadian Agency for Drugs and Technologies in Health (CADTH). 2009 Authors' conclusions Prior to 2009, there was a lack of RCTs on the efficacy of HBOT in autism. ABC-C and ATEC aggregate mean scores were improved within the group of children treated with hyperbaric oxygen (but not within the control group). Specifically, improvements were noted in the subscales of irritability, stereotypy

Health Technology Assessment (HTA) Database.2009

183. Meta-analysis of early intensive behavioral intervention for children with autism

Meta-analysis of early intensive behavioral intervention for children with autism Meta-analysis of early intensive behavioral intervention for children with autism Meta-analysis of early intensive behavioral intervention for children with autism Eldevik S, Hastings RP, Hughes JC, Jahr E, Eikeseth S, Cross S CRD summary The authors concluded that early intensive behavioural intervention was associated with large to moderate improvements in IQ (intelligence quotient) and adaptive behaviour (...) in children with autism compared to no intervention or eclectic treatment. Given the paucity of randomised controlled trials and the unclear quality of the included trials, the reliability of the authors' conclusions is unclear. Authors' objectives To evaluate the effectiveness of early intensive behavioural intervention (EIBI) for children with autism. Searching PsycINFO, PubMed and ERIC were searched to March 2008. Search terms were reported. Bibliographies of retrieved studies were handsearched

DARE.2009

184. Promoting the social and communicative behavior of young children with autism spectrum disorders: a review of parent-implemented intervention studies

Promoting the social and communicative behavior of young children with autism spectrum disorders: a review of parent-implemented intervention studies Promoting the social and communicative behavior of young children with autism spectrum disorders: a review of parent-implemented intervention studies Promoting the social and communicative behavior of young children with autism spectrum disorders: a review of parent-implemented intervention studies Meadan H, Ostrosky MM, Zaghlawan HY, Yu SY CRD (...) of young children with autism spectrum disorders (ASD). Searching ERIC and PsycINFO were searched for articles published in peer-reviewed articles between 1997 to 2007. Search terms were reported. Bibliographies of retrieved articles, reviews and book chapters were handsearched. Study selection Studies of parent-implemented interventions aimed at improving social and communication skills in children with ASD and that contained at least one child aged six years or less were eligible for inclusion

DARE.2009

185. CPG for the Management of Patients with Autism Spectrum Disorders in Primary Care

CPG for the Management of Patients with Autism Spectrum Disorders in Primary Care

GuiaSalud2009

186. Milieu therapy as a communication intervention: a review of the literature related to children with autism spectrum disorder

Milieu therapy as a communication intervention: a review of the literature related to children with autism spectrum disorder Milieu therapy as a communication intervention: a review of the literature related to children with autism spectrum disorder Milieu therapy as a communication intervention: a review of the literature related to children with autism spectrum disorder Mancil GR CRD summary The author of this review concluded that milieu therapy improved the communication skills of children (...) with autism spectrum disorder. This overall conclusion appears appropriate given the evidence presented, but some caution should be exercised given a number of limitations identified in the review. Authors' objectives To examine the characteristics of milieu therapy and to assess its effectiveness for children with autistic spectrum disorder. Searching ERIC, Education, PsycINFO and Academic Search Premier databases were searched for eligible studies using keywords documented in the report. Dates were

DARE.2009

187. Systematic review of early intensive behavioral interventions for children with autism

Systematic review of early intensive behavioral interventions for children with autism Systematic review of early intensive behavioral interventions for children with autism Systematic review of early intensive behavioral interventions for children with autism Howlin P, Magiati I, Charman T CRD summary This review concluded that there was strong evidence that early intensive behavioural interventions were effective for some but not all children with autism spectrum disorders. There was wide (...) variability in response to treatment. Poor reporting of the review process, lack of validity assessment and possible inappropriate pooling of included studies indicated that these conclusions should be interpreted with caution. Authors' objectives To evaluate the effectiveness of early intensive behavioural interventions (EIBI) for young children with autism. Searching MEDLINE, EMBASE, The Cochrane Library, PsycINFO, CINAHL and ERIC were searched between 1985 and May 2007. Search terms were reported

DARE.2009

188. Efficacy of applied behavioral intervention in preschool children with autism for improving cognitive, language, and adaptive behavior: a systematic review and meta-analysis

Efficacy of applied behavioral intervention in preschool children with autism for improving cognitive, language, and adaptive behavior: a systematic review and meta-analysis Efficacy of applied behavioral intervention in preschool children with autism for improving cognitive, language, and adaptive behavior: a systematic review and meta-analysis Efficacy of applied behavioral intervention in preschool children with autism for improving cognitive, language, and adaptive behavior: a systematic (...) review and meta-analysis Spreckley M, Boyd R CRD summary This review concluded that, according to available evidence, applied behavioural intervention programmes did not have better outcomes than standard care for children with autism. The results of this review should be treated with some caution given the high variability of included studies and problems with the overall analysis. Authors' objectives To assess the effectiveness of applied behaviour intervention programmes for preschool children

DARE.2009

189. Comprehensive synthesis of early intensive behavioral interventions for young children with autism based on the UCLA young autism project model

Comprehensive synthesis of early intensive behavioral interventions for young children with autism based on the UCLA young autism project model Comprehensive synthesis of early intensive behavioral interventions for young children with autism based on the UCLA young autism project model Comprehensive synthesis of early intensive behavioral interventions for young children with autism based on the UCLA young autism project model Reichow B, Wolery M CRD summary This review found that early (...) intensive behavioural interventions were on average an effective treatment for children with autism, but the authors advised caution in interpreting the results due to gaps and limitations in the evidence base. The authors' cautious conclusions appear to be justified. Authors' objectives To synthesise the studies on early intensive behavioural interventions based on the University of California at Los Angeles Young Autism Project model for young children with autism Searching The authors searched

DARE.2009

190. The use of weighted vests with children with autism spectrum disorders and other disabilities

The use of weighted vests with children with autism spectrum disorders and other disabilities The use of weighted vests with children with autism spectrum disorders and other disabilities The use of weighted vests with children with autism spectrum disorders and other disabilities Stephenson J, Carter M CRD summary The authors concluded that weighted vests were ineffective in remediating behaviour problems of children with autism spectrum disorders and other behavioural disabilities. Despite (...) concerns about aspects of the review methods, the authors conclusions were appropriate given the limited and poor-quality evidence that was identified. Authors' objectives To assess the effectiveness of the use of weighted vests for children with autism spectrum disorders and other behavioural disabilities. Searching PsychINFO, ERIC and CINAHL were searched and studies looked for using Google Scholar. Search terms were reported, but search dates were not. The reference lists of retrieved publications

DARE.2009

191. PTEN sequence variants in macrocephaly / autism syndrome

PTEN sequence variants in macrocephaly / autism syndrome PTEN sequence variants in macrocephaly / autism syndrome PTEN sequence variants in macrocephaly / autism syndrome Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Report may be purchased from Citation PTEN sequence variants in macrocephaly / autism syndrome . Lansdale: HAYES, Inc.. 2009 Authors' objectives Autism (...) research has focused on autism/ASD and macrocephaly related to PTEN sequence variants. Project page URL Indexing Status Subject indexing assigned by CRD MeSH Autistic Disorder; Genetic Predisposition to Diseases; Risk Factors Language Published English Country of organisation United States Address for correspondence 157 S. Broad Street, Suite 200, Lansdale, PA 19446, USA. Tel: 215 855 0615; Fax: 215 855 5218 Email: mwinkler@hayesinc.com AccessionNumber 32010000914 Date abstract record published 01/09

Health Technology Assessment (HTA) Database.2009

192. Selective serotonin reuptake inhibitors for the treatment of autism

Selective serotonin reuptake inhibitors for the treatment of autism Selective serotonin reuptake inhibitors for the treatment of autism Selective serotonin reuptake inhibitors for the treatment of autism Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Report may be purchased from . Citation Selective serotonin reuptake inhibitors for the treatment of autism . Lansdale (...) : HAYES, Inc.. 2009 Authors' objectives Serotonergic abnormalities may contribute to the underlying etiology of autism. Therefore, selective serotonin reuptake inhibitors (SSRIs) are increasingly being prescribed as an off-label treatment for children and adults with autism. The goal of SSRI treatment is to minimize the severity of core behavioral deficits and associated behaviors, maximize functionality, and improve quality of life for autistic individuals and their families. Project page URL

Health Technology Assessment (HTA) Database.2009

193. Do children with autism and developmental regression need EEG investigation in the absence of clinical seizures?

Do children with autism and developmental regression need EEG investigation in the absence of clinical seizures? BestBets: Do children with autism and developmental regression need EEG investigation in the absence of clinical seizures? Do children with autism and developmental regression need EEG investigation in the absence of clinical seizures? Report By: Dr Choong Yi Fong - Paediatric Neurology Specialist Registrar Search checked by G. Baird, E Wraige - Institution: Evelina Children's (...) Hospital, London, UK and Guy's Hospital Date Submitted: 31st July 2007 Last Modified: 5th November 2008 Status: Green (complete) Three Part Question In [a seizure-free child with autism presenting with developmental regression] is [EEG] necessary to [rule out subclinical epilepsy]? Clinical Scenario A child presents to your developmental clinic at 30 months old. His mother reports developmental regression of previously acquired developmental milestones. He has now lost his previously acquired language

BestBETS2008

194. Evidence-Based Review of Interventions for Autism Used in or of Relevance to Occupational Therapy

Evidence-Based Review of Interventions for Autism Used in or of Relevance to Occupational Therapy 18712004 2008 08 20 2008 12 19 2012 08 27 0272-9490 62 4 2008 Jul-Aug The American journal of occupational therapy : official publication of the American Occupational Therapy Association Am J Occup Ther Evidence-based review of interventions for autism used in or of relevance to occupational therapy. 416-29 Occupational therapy practitioners are among the professionals who provide services (...) to children and adults with autism spectrum disorder (ASD), embracing both leadership and supportive roles in service delivery. The study's primary aims were as follows: (1) to identify, evaluate, and synthesize the research literature on interventions for ASD of relevance to occupational therapy and (2) to interpret and apply the research literature to occupational therapy. A total of 49 articles met the authors' criteria and were included in the review. Six categories of research topics were identified

EvidenceUpdates2008

195. Birth weight and gestational age characteristics of children with autism, including a comparison with other developmental disabilities

Birth weight and gestational age characteristics of children with autism, including a comparison with other developmental disabilities 18519485 2008 06 03 2008 08 11 2008 06 03 1098-4275 121 6 2008 Jun Pediatrics Pediatrics Birth weight and gestational age characteristics of children with autism, including a comparison with other developmental disabilities. 1155-64 10.1542/peds.2007-1049 The objectives of this study were to compare the birth weight and gestational age distributions (...) and prevalence rates of autism with those of other developmental disabilities and to estimate the birth weight-and gestational age-specific risks for autism. For the first objective, a retrospective cohort of children born in Atlanta, Georgia, in 1981-1993 who survived to 3 years of age was identified through vital records. Children in the cohort who had developmental disabilities (autism, mental retardation, cerebral palsy, hearing loss, or vision impairment) and were still residing in metropolitan Atlanta

EvidenceUpdates2008

196. Parental psychiatric disorders associated with autism spectrum disorders in the offspring

Parental psychiatric disorders associated with autism spectrum disorders in the offspring 18450879 2008 05 02 2008 06 04 2008 11 03 1098-4275 121 5 2008 May Pediatrics Pediatrics Parental psychiatric disorders associated with autism spectrum disorders in the offspring. e1357-62 10.1542/peds.2007-2296 Autism is a developmental disorder defined by impaired social interaction, communication, and behavior. Causes and correlates of autism are largely unknown, but elevated frequencies of psychiatric (...) disorders and distinct personality traits have been reported among the family members of individuals with autism. Linkage of data from Swedish registries was used to investigate whether hospitalization for psychiatric conditions was higher among parents of children with autism compared with control subjects. Data sources included the Swedish Medical Birth Register (child's birth), the Swedish Multi-Generation Register (linking parents to children), and Swedish Hospital Discharge Register

EvidenceUpdates2008

197. Positive screening for autism in ex-preterm infants: prevalence and risk factors

Positive screening for autism in ex-preterm infants: prevalence and risk factors 18381541 2008 04 02 2008 04 30 2016 11 22 1098-4275 121 4 2008 Apr Pediatrics Pediatrics Positive screening for autism in ex-preterm infants: prevalence and risk factors. 758-65 10.1542/peds.2007-2158 The survival of very low birth weight infants has increased markedly in recent years. Unfortunately, the prevalence of significant and lifelong motor, cognitive, and behavioral dysfunction has remained a major problem (...) confronting these children. The objective of this study was to perform screening tests for early autistic features in children with a history of very low birth weight and to identify risk factors associated with a positive screening result. We studied 91 ex-preterm infants < or = 1500 g at birth. Infants underwent conventional MRI studies at preterm and/or term-adjusted age. We collected pertinent demographic, prenatal, intrapartum, acute postnatal, and short-term outcome data for all infants. Follow-up

EvidenceUpdates2008 Full Text: Link to full Text with Trip Pro

198. Interventions targeting joint attention and symbolic play can improve aspects of these skills in young children with autism

Interventions targeting joint attention and symbolic play can improve aspects of these skills in young children with autism Interventions targeting joint attention and symbolic play can improve aspects of these skills in young children with autism | Evidence-Based Mental Health This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password (...) * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Interventions targeting joint attention and symbolic play can improve aspects of these skills in young children with autism Article Text Therapeutics Interventions targeting joint attention and symbolic play can improve aspects of these skills in young

Evidence-Based Mental Health2008

199. Association between Microdeletion and Microduplication at 16p11.2 and Autism.

Association between Microdeletion and Microduplication at 16p11.2 and Autism. BACKGROUND: Autism spectrum disorder is a heritable developmental disorder in which chromosomal abnormalities are thought to play a role. METHODS: As a first component of a genomewide association study of families from the Autism Genetic Resource Exchange (AGRE), we used two novel algorithms to search for recurrent copy-number variations in genotype data from 751 multiplex families with autism. Specific recurrent de (...) novo events were further evaluated in clinical-testing data from Children's Hospital Boston and in a large population study in Iceland. RESULTS: Among the AGRE families, we observed five instances of a de novo deletion of 593 kb on chromosome 16p11.2. Using comparative genomic hybridization, we observed the identical deletion in 5 of 512 children referred to Children's Hospital Boston for developmental delay, mental retardation, or suspected autism spectrum disorder, as well as in 3 of 299 persons

NEJM2008

200. Social skills interventions for children with Asperger's syndrome or high-functioning autism: a review and recommendations

Social skills interventions for children with Asperger's syndrome or high-functioning autism: a review and recommendations Social skills interventions for children with Asperger's syndrome or high-functioning autism: a review and recommendations Social skills interventions for children with Asperger's syndrome or high-functioning autism: a review and recommendations Rao P A, Beidel D C, Murray M J CRD summary This review assessed the effectiveness of Social Skills Training (SST) programs (...) for children with Asperger's Syndrome (AS) or high-functioning autism (HFA) and found little empirical support for them. Given doubts about the review process these results should be considered with caution. Authors' objectives To review the literature on the effectiveness of Social Skills Training (SST) programs for children with Asperger's Syndrome (AS) or high-functioning autism (HFA). Searching PsycINFO, PsycARTICLES, ERIC, Psychology and Behavioural Sciences and Academic Search Primer were searched

DARE.2008