Latest & greatest articles for autism

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on autism or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on autism and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

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Autism

Autism is a neurodevelopmental disorder (a type of mental disorder) characterised by difficult social interaction, impaired communication (both verbal and non-verbal), and restricted and repetitive behaviours. It forms part of the broader autism spectrum disorder (ASD), a range of similar conditions, including Asperger syndrome.

Autism is a condition that begins from early childhood and is often suspected and diagnosed by ages 1-3. It is a lifelong disability that affects how people interact with others.

Autism causes and treatment

There have been many misconceptions as to what causes autism in the past such as the MMR vaccine and diet. Extensive research and clinical trials have concluded that none of these factors cause autism or ASD. However, the real cause is little understood but research is starting to unpick potential factors such as genetics, pollution and other environmental factors. A current favoured idea is that genes inherited from a child’s parents can make them more vulnerable to developing autism, some researchers suggest that the disorder will only develop when triggered by environmental factors.

The exact cause of autism spectrum disorder is unknown, however research into the disorder suggest that it is caused by several genetic and environmental factors. Genes inherited from a child’s parents can make them more vulnerable to developing autism, some researchers suggest that the disorder will only develop when triggered by environmental factors. Read more in clinical papers on autism.

Autism can be managed with a combination of prescribed medicines and behavioural treatment, depending on the severity of the disorder. Read about clinical trials and medical advancements for the treatment of autism on Trip.

Hot topics in Trip

Users of Trip frequently look at topics around adolescents, therapies, behaviour and screening. They also explore such topics as omega-3 fatty acids, SSRIs and aripiprazole. All these topics, and more, can be easily searched for within Trip.

Top results for autism

181. A meta-analytic study on the effectiveness of comprehensive ABA-based early intervention programs for children with autism spectrum disorders

/post-test design and that evaluating EIBI in young children aged 10 years or under at treatment onset and diagnosed with autism spectrum disorders (Diagnostic and Statistical Manual of Mental Disorders (DSM) -III, DSM-III-R, DSM-IV or International Classification of Diseases Autistic Disorder and Pervasive Developmental Disorder-Not Otherwise Specified) were eligible for inclusion. EIBI had to address all three core deficits in autism using applied behaviour analysis. Eligible outcomes were (...) , Sturmey P. A meta-analytic study on the effectiveness of comprehensive ABA-based early intervention programs for children with autism spectrum disorders. Research in Autism Spectrum Disorders 2011; 5(1): 60-69 DOI Original Paper URL Indexing Status Subject indexing assigned by CRD MeSH Autistic Disorder; Behavior Therapy; Child; Child Behavior Disorders; Child Development Disorders, Pervasive; Child, Preschool; Early Intervention (Education); Humans AccessionNumber 12010007347 Date bibliographic

2011 DARE.

182. SHANK3, the Synapse, and Autism. Full Text available with Trip Pro

SHANK3, the Synapse, and Autism. 21751912 2011 07 22 2012 11 15 1533-4406 365 2 2011 Jul 14 The New England journal of medicine N. Engl. J. Med. SHANK3, the synapse, and autism. 173-5 10.1056/NEJMcibr1104261 Herbert Martha R MR Massachusetts General Hospital and Harvard Medical School, Boston, USA. eng Journal Article United States N Engl J Med 0255562 0028-4793 0 Carrier Proteins 0 Mutant Proteins 0 Nerve Tissue Proteins 0 Shank3 protein, mouse AIM IM N Engl J Med. 2011 Nov 10;365(19):1848 (...) Animals Autistic Disorder genetics pathology physiopathology Carrier Proteins genetics metabolism Corpus Striatum pathology physiopathology Dendrites physiology Mice Mutant Proteins genetics metabolism Nerve Tissue Proteins Synapses genetics metabolism 2011 7 15 6 0 2011 7 15 6 0 2011 7 23 6 0 ppublish 21751912 10.1056/NEJMcibr1104261

2011 NEJM

183. A systematic review of early intensive intervention for autism spectrum disorders. Full Text available with Trip Pro

A systematic review of early intensive intervention for autism spectrum disorders. Early intensive behavioral and developmental interventions for young children with autism spectrum disorders (ASDs) may enhance developmental outcomes.To systematically review evidence regarding such interventions for children aged 12 and younger with ASDs.We searched Medline, PsycINFO, and ERIC (Education Resources Information Center) from 2000 to May 2010. Two reviewers independently assessed studies against

2011 EvidenceUpdates

184. A systematic review of secretin for children with autism spectrum disorders. Full Text available with Trip Pro

A systematic review of secretin for children with autism spectrum disorders. As many as 1 in every 110 children in the United States has an autism spectrum disorder (ASD). Secretin is 1 of many medical treatments studied for treating the symptoms of ASDs, but there is currently no consensus regarding which interventions are most effective.To systematically review evidence regarding the use of secretin in children with ASDs who are aged 12 years and younger.We searched the Medline, PsycINFO (...) supports a lack of effectiveness of secretin for the treatment of ASD symptoms including language and communication impairment, symptom severity, and cognitive and social skill deficits. No studies have resulted in significantly greater improvements in measures of language, cognition, or autistic symptoms when compared with placebo; study authors who reported improvement over time did so equally for both the intervention and placebo groups.Secretin has been studied extensively in multiple randomized

2011 EvidenceUpdates

185. A systematic review of medical treatments for children with autism spectrum disorders. Full Text available with Trip Pro

A systematic review of medical treatments for children with autism spectrum disorders. As many as 1 in every 110 children in the United States has an autism spectrum disorder (ASD). Many medical treatments for ASDs have been proposed and studied, but there is currently no consensus regarding which interventions are most effective.To systematically review evidence regarding medical treatments for children aged 12 years and younger with ASDs.We searched the Medline, PsycInfo, and ERIC (Education

2011 EvidenceUpdates

186. Autism in under 19s: recognition, referral and diagnosis

in both cause and manifestation. DSM-5 refers to autism spectrum disorder as a single condition with different levels of symptom severity in 2 core domains: 1) deficits in social communication and social interaction and 2) restricted repetitive behaviours (RRBs), interests, and activities and sensory anomalies. Autism spectrum disorder encompasses the 4 separate disorders from the previous DSM-IV: autistic disorder (autism), Asperger's disorder, childhood disintegrative disorder and pervasive (...) developmental disorder not otherwise specified. Because both components are required for diagnosis of autism spectrum disorder, social (pragmatic) communication disorder is diagnosed if no RRBs are present. Note that childhood disintegrative disorder is excluded from ASD in DSM-5. The guideline development group recognised that individuals and groups prefer a variety of terms, including autism spectrum disorder, autistic spectrum condition, autistic spectrum difference and neuro-diversity. For clarity

2011 National Institute for Health and Clinical Excellence - Clinical Guidelines

187. Social skills training for autistic spectrum disorders

for autism spectrum disorders (ASDs) are nonpharmacological interventions intended to reduce the negative impact of ASD on the child or adolescent and his/her family. Social skills training teaches children or adolescents with ASD to interact, share, and play and work with others, thereby enhancing participation in family, school, and community activities. Final publication URL The report may be purchased from: Indexing Status Subject indexing assigned by CRD MeSH Autistic Disorder; Behavior Therapys (...) Social skills training for autistic spectrum disorders Social skills training for autistic spectrum disorders Social skills training for autistic spectrum disorders Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Social skills training for autistic spectrum disorders. Lansdale: HAYES, Inc.. Directory Publication. 2011 Authors' conclusions Social skills trainings

2011 Health Technology Assessment (HTA) Database.

188. Intensive behavioral intervention therapy for autism

intervention (IBI) therapy, also known as Lovaas therapy, applied behavior analysis (ABA), or early intensive behavioral intervention (EIBI), is an intensive behavioral treatment program that attempts to improve the cognitive and social functioning of children, primarily young children, with autism. Final publication URL The report may be purchased from: Indexing Status Subject indexing assigned by CRD MeSH Autistic Disorder; Behavior Therapy; Child Behavior; Child Behavior Disorders; Childs Language (...) Intensive behavioral intervention therapy for autism Intensive behavioral intervention therapy for autism Intensive behavioral intervention therapy for autism Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Intensive behavioral intervention therapy for autism. Lansdale: HAYES, Inc.. Directory Publication. 2011 Authors' conclusions Intensive behavioral

2011 Health Technology Assessment (HTA) Database.

189. For toddlers with autism spectrum disorders, supplementing a comprehensive intervention with interpersonal synchrony improves socially engaged imitation

For toddlers with autism spectrum disorders, supplementing a comprehensive intervention with interpersonal synchrony improves socially engaged imitation For toddlers with autism spectrum disorders, supplementing a comprehensive intervention with interpersonal synchrony improves socially engaged imitation | Evidence-Based Mental Health We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn (...) more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here For toddlers with autism spectrum disorders, supplementing a comprehensive

2011 Evidence-Based Mental Health

190. Review: little evidence of clear benefit for most medical treatments for children with autism spectrum disorders

Review: little evidence of clear benefit for most medical treatments for children with autism spectrum disorders Review: little evidence of clear benefit for most medical treatments for children with autism spectrum disorders | Evidence-Based Mental Health We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username (...) and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Review: little evidence of clear benefit for most medical treatments for children with autism spectrum disorders Article Text Therapeutics Review: little evidence

2011 Evidence-Based Mental Health

191. Review: secretin is not effective for the treatment of children with autism spectrum disorders

Review: secretin is not effective for the treatment of children with autism spectrum disorders Review: secretin is not effective for the treatment of children with autism spectrum disorders | Evidence-Based Mental Health We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts (...) OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Review: secretin is not effective for the treatment of children with autism spectrum disorders Article Text Therapeutics Review: secretin is not effective for the treatment of children with autism

2011 Evidence-Based Mental Health

192. Review: possible benefits from early intensive behavioural and developmental interventions in children with autism spectrum disorders, but more research needed Full Text available with Trip Pro

, in these times of financial restraint, ensuring that treatments are focused and individually appropriate becomes even more essential. References Lovaas OI . Behavioral treatment and normal educational and intellectual functioning in young autistic children . Howlin P , Magiati I , Charman T . Systematic review of early intensive behavioral interventions for children with autism . Carter AS , Messinger DS , Stone WL , et al . A randomized controlled trial of Hanen's ‘More Than Words’ in toddlers with early (...) Review: possible benefits from early intensive behavioural and developmental interventions in children with autism spectrum disorders, but more research needed Review: possible benefits from early intensive behavioural and developmental interventions in children with autism spectrum disorders, but more research needed | Evidence-Based Mental Health We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any

2011 Evidence-Based Mental Health

193. Just under 1% of adults living in the community in England are estimated to have autism spectrum disorders Full Text available with Trip Pro

Just under 1% of adults living in the community in England are estimated to have autism spectrum disorders Just under 1% of adults living in the community in England are estimated to have autism spectrum disorders | Evidence-Based Mental Health We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password (...) For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Just under 1% of adults living in the community in England are estimated to have autism spectrum disorders Article Text Prevalence Just under 1% of adults living in the community

2011 Evidence-Based Mental Health

194. Mitochondrial dysfunction in autism. Full Text available with Trip Pro

Mitochondrial dysfunction in autism. Impaired mitochondrial function may influence processes highly dependent on energy, such as neurodevelopment, and contribute to autism. No studies have evaluated mitochondrial dysfunction and mitochondrial DNA (mtDNA) abnormalities in a well-defined population of children with autism.To evaluate mitochondrial defects in children with autism.Observational study using data collected from patients aged 2 to 5 years who were a subset of children participating (...) in the Childhood Autism Risk From Genes and Environment study in California, which is a population-based, case-control investigation with confirmed autism cases and age-matched, genetically unrelated, typically developing controls, that was launched in 2003 and is still ongoing. Mitochondrial dysfunction and mtDNA abnormalities were evaluated in lymphocytes from 10 children with autism and 10 controls.Oxidative phosphorylation capacity, mtDNA copy number and deletions, mitochondrial rate of hydrogen peroxide

2010 JAMA

195. Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum disorders (ASD). (Abstract)

Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum disorders (ASD). Autism spectrum disorders (ASD) are characterised by abnormalities in social interaction and communication skills, as well as stereotypic behaviours and restricted activities and interests. Selective serotonin reuptake inhibitors (SSRIs) are prescribed for the treatment of co-morbidity associated with ASD such as depression, anxiety and obsessive-compulsive behaviours.To determine if treatment with an SSRI: 1 (...) . improves the core features of autism (social interaction, communication and behavioural problems); 2. improves other non-core aspects of behaviour or function such as self-injurious behaviour; 3. improves the quality of life of children and their carers; 4. has short and long term effects on outcome; 5. causes harms.We searched the Cochrane Central Register of Controlled Trials (The Cochrane Library 2009, Issue 4), MEDLINE ( December 2009), EMBASE (December 2009), CINAHL (December 2009), PsycINFO

2010 Cochrane

196. Effectiveness of intensive autism programmes Full Text available with Trip Pro

Effectiveness of intensive autism programmes 20189018 2010 03 15 2018 11 13 1474-547X 375 9716 2010 Feb 27 Lancet (London, England) Lancet Effectiveness of intensive autism programmes. 722-3; author reply 723 10.1016/S0140-6736(10)60299-1 Dawson Michelle M Gernsbacher Morton Ann MA eng F33 DC005365 DC NIDCD NIH HHS United States R01 DC007223 DC NIDCD NIH HHS United States R01 MH069793 MH NIMH NIH HHS United States Comment Letter England Lancet 2985213R 0140-6736 AIM IM Lancet. 2009 Nov 7;374 (...) (9701):1627-38 19819542 Lancet. 2011 Nov 19;378(9805):1778 Autistic Disorder diagnosis therapy Behavior Therapy methods Child Humans Randomized Controlled Trials as Topic Treatment Outcome 2010 3 2 6 0 2010 3 2 6 0 2010 3 17 6 0 ppublish 20189018 S0140-6736(10)60299-1 10.1016/S0140-6736(10)60299-1 PMC4301441 NIHMS655565 Am J Ment Retard. 2000 Jul;105(4):269-85 10934569 Am J Ment Retard. 2005 Nov;110(6):417-38 16212446 J Clin Child Adolesc Psychol. 2008 Jan;37(1):8-38 18444052 Lancet. 2009 Nov 7;374

2010 Lancet

197. Randomized, controlled trial of an intervention for toddlers with autism: the Early Start Denver Model Full Text available with Trip Pro

Randomized, controlled trial of an intervention for toddlers with autism: the Early Start Denver Model To conduct a randomized, controlled trial to evaluate the efficacy of the Early Start Denver Model (ESDM), a comprehensive developmental behavioral intervention, for improving outcomes of toddlers diagnosed with autism spectrum disorder (ASD).Forty-eight children diagnosed with ASD between 18 and 30 months of age were randomly assigned to 1 of 2 groups: (1) ESDM intervention, which is based (...) on developmental and applied behavioral analytic principles and delivered by trained therapists and parents for 2 years; or (2) referral to community providers for intervention commonly available in the community.Compared with children who received community-intervention, children who received ESDM showed significant improvements in IQ, adaptive behavior, and autism diagnosis. Two years after entering intervention, the ESDM group on average improved 17.6 standard score points (1 SD: 15 points) compared

2010 EvidenceUpdates Controlled trial quality: uncertain

198. Risk of autism and increasing maternal and paternal age in a large north American population Full Text available with Trip Pro

Risk of autism and increasing maternal and paternal age in a large north American population Previous studies are inconsistent regarding whether there are independent effects of maternal and paternal age on the risk of autism. Different biologic mechanisms are suggested by maternal and paternal age effects. The study population included all California singletons born in 1989-2002 (n = 7,550,026). Children with autism (n = 23,311) were identified through the California Department (...) of Developmental Services and compared with the remainder of the study population, with parental ages and covariates obtained from birth certificates. Adjusted odds ratios and 95% confidence intervals were used to evaluate the risk of autism associated with increasing maternal and paternal age. In adjusted models that included age of the other parent and demographic covariates, a 10-year increase in maternal age was associated with a 38% increase in the odds ratio for autism (odds ratio = 1.38, 95% confidence

2010 EvidenceUpdates

199. Extremely preterm children at increased risk of autism spectrum disorders

Extremely preterm children at increased risk of autism spectrum disorders Extremely preterm children at increased risk of autism spectrum disorders | Evidence-Based Mental Health We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username (...) * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Extremely preterm children at increased risk of autism spectrum disorders Article Text Prevalence Extremely preterm children at increased risk of autism spectrum disorders Statistics from Altmetric.com Question Question What is the prevalence

2010 Evidence-Based Mental Health

200. Intensive behavioral intervention therapy for autism

Intensive behavioral intervention therapy for autism Intensive behavioral intervention therapy for autism Intensive behavioral intervention therapy for autism Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Intensive behavioral intervention therapy for autism. Lansdale: HAYES, Inc.. Directory Publication. 2010 Authors' objectives

Intensive behavioral (...) intervention (IBI) therapy, also known as Lovaas therapy, applied behavior analysis (ABA), or early intensive behavioral intervention (EIBI), is an intensive behavioral treatment program that attempts to improve the cognitive and social functioning of children with autism.

Timeliness warning This report has been archived and may contain outdated information. To request a copy of the report please contact the organisation directly. Final publication URL Indexing Status Subject indexing assigned by CRD

2010 Health Technology Assessment (HTA) Database.