Latest & greatest articles for autism

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on autism or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on autism and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

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Autism

Autism is a neurodevelopmental disorder (a type of mental disorder) characterised by difficult social interaction, impaired communication (both verbal and non-verbal), and restricted and repetitive behaviours. It forms part of the broader autism spectrum disorder (ASD), a range of similar conditions, including Asperger syndrome.

Autism is a condition that begins from early childhood and is often suspected and diagnosed by ages 1-3. It is a lifelong disability that affects how people interact with others.

Autism causes and treatment

There have been many misconceptions as to what causes autism in the past such as the MMR vaccine and diet. Extensive research and clinical trials have concluded that none of these factors cause autism or ASD. However, the real cause is little understood but research is starting to unpick potential factors such as genetics, pollution and other environmental factors. A current favoured idea is that genes inherited from a child’s parents can make them more vulnerable to developing autism, some researchers suggest that the disorder will only develop when triggered by environmental factors.

The exact cause of autism spectrum disorder is unknown, however research into the disorder suggest that it is caused by several genetic and environmental factors. Genes inherited from a child’s parents can make them more vulnerable to developing autism, some researchers suggest that the disorder will only develop when triggered by environmental factors. Read more in clinical papers on autism.

Autism can be managed with a combination of prescribed medicines and behavioural treatment, depending on the severity of the disorder. Read about clinical trials and medical advancements for the treatment of autism on Trip.

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Users of Trip frequently look at topics around adolescents, therapies, behaviour and screening. They also explore such topics as omega-3 fatty acids, SSRIs and aripiprazole. All these topics, and more, can be easily searched for within Trip.

Top results for autism

1. Measles, Mumps, Rubella Vaccination and Autism: A Nationwide Cohort Study. (PubMed)

Measles, Mumps, Rubella Vaccination and Autism: A Nationwide Cohort Study. The hypothesized link between the measles, mumps, rubella (MMR) vaccine and autism continues to cause concern and challenge vaccine uptake.To evaluate whether the MMR vaccine increases the risk for autism in children, subgroups of children, or time periods after vaccination.Nationwide cohort study.Denmark.657 461 children born in Denmark from 1999 through 31 December 2010, with follow-up from 1 year of age and through 31 (...) August 2013.Danish population registries were used to link information on MMR vaccination, autism diagnoses, other childhood vaccines, sibling history of autism, and autism risk factors to children in the cohort. Survival analysis of the time to autism diagnosis with Cox proportional hazards regression was used to estimate hazard ratios of autism according to MMR vaccination status, with adjustment for age, birth year, sex, other childhood vaccines, sibling history of autism, and autism risk factors

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2019 Annals of Internal Medicine

2. Parent-focused therapy has some long-term benefits for children with autism

Parent-focused therapy has some long-term benefits for children with autism Parent-focused therapy has some long-term benefits for children with autism Discover Portal Discover Portal Parent-focused therapy has some long-term benefits for children with autism Published on 14 February 2017 doi: A parent-focused therapy for young children with autism continues to have beneficial effects on symptoms and communication almost six years after the end of treatment. This UK randomised controlled trial (...) investigated the effects of a one-year social communication therapy in 152 UK children aged two to four years with severe autism. The therapy, partly delivered by parents, aimed to help them adapt their style of interacting with their child. Children who received the intervention had less severe symptoms at the end of the initial one-year intervention period than those who received treatment as usual. When these children were followed up nearly six years later at age seven to 11 years, children who had

2019 NIHR Dissemination Centre

3. Neuropsychiatric profile and psychotropic medication use in adults with autism spectrum disorder: results from the Australian Longitudinal Study of Adults with Autism (PubMed)

Neuropsychiatric profile and psychotropic medication use in adults with autism spectrum disorder: results from the Australian Longitudinal Study of Adults with Autism Children and adolescents with autism spectrum disorder (ASD) are a highly medicated group. Few studies have examined the neuropsychiatric profile and patterns of psychotropic medication use among adults with ASD.To describe and compare the neuropsychiatric profile and psychotropic medication use in a cohort of adults with ASD

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2018 BJPsych open

4. Communication interventions for autism spectrum disorder in minimally verbal children. (PubMed)

Communication interventions for autism spectrum disorder in minimally verbal children. Autism spectrum disorder (ASD) has an estimated prevalence of around 1.7% of the population. People with ASD often also have language difficulties, and about 25% to 30% of children with ASD either fail to develop functional language or are minimally verbal. The ability to communicate effectively is an essential life skill, and difficulties with communication can have a range of adverse outcomes, including (...) of Child Health and Human Development, the MIND Institute Research Program and a Professional Staff Congress-City University of New York grant. The PECS study included 84 minimally verbal participants (73 boys) aged 4 to 11 years who had a formal diagnosis of ASD and who were not using PECS beyond phase 1 at baseline. All children attended autism-specific classes or units, and most classes had a child to adult ratio of 2:1. Teachers and parents received PECS training (two-day workshop). PECS

2018 Cochrane

5. Weight management interventions for youth with autism spectrum disorder: a systematic review

Weight management interventions for youth with autism spectrum disorder: a systematic review In response to the elevated levels of overweight and obesity among children with autism spectrum disorder (ASD), this article provides a systematic review of the extant empirical literature reporting the effect of weight management interventions (including exercise, diet, and medication) for youth with ASD.A systematic review of published studies. The databases CINAHL, Web of Science, ERIC, Pubmed

2018 EvidenceUpdates

6. A National Guideline for the Assessment and Diagnosis of Autism Spectrum Disorders in Australia

A National Guideline for the Assessment and Diagnosis of Autism Spectrum Disorders in Australia A National Guideline for the Assessment and Diagnosis of Autism Spectrum Disorder in Australia | Autism CRC Menu Breadcrumb A National Guideline for the Assessment and Diagnosis of Autism Spectrum Disorder in Australia Download the National Guideline Developed and published by Autism CRC with the financial support of the National Disability Insurance Agency (NDIA), the Guideline aims to create (...) greater consistency in diagnostic practices across the country to ensure individuals on the autism spectrum and their families can receive the optimal clinical care. The Guideline also emphasises the importance of listening to individuals and their families about the impact of the behaviours on family life. The community has been requesting a national and consistent guideline for autism assessment and diagnosis for many years, and we are pleased to release a guideline that responds to this need

2018 Clinical Practice Guidelines Portal

7. Stem cell transplantation as treatment for children with autism

Stem cell transplantation as treatment for children with autism Stem cell transplantation as treatment for children with autism We use cookies on this website. By using this site, you agree that we may store and access cookies on your device. Swedish Agency for Health Technology Assessment and Assessment of Social Services Stem cell transplantation as treatment for children with autism Share: Reading time approx. 1 minute Stem cell transplantations are performed to treat certain forms of cancer (...) but also to treat some other rarer disorders. Today stem cell clinics advertise stem cell transplantation as a treatment to disorders like autism at high costs. There are however doubts about the efficacy and safety of these treatments. Question Which scientific studies have investigated stem cell transplantation as treatment for children with autism? Identified literature Chez M, Lepage C, Parise C, Dang-Chu A, Hankins A, Carroll M. Safety and Observations from a Placebo-Controlled, Crossover Study

2018 Swedish Council on Technology Assessement

8. Nutritional or dietary interventions for children and adolescents with autism spectrum disorder or ADHD

Nutritional or dietary interventions for children and adolescents with autism spectrum disorder or ADHD Nutritional or dietary interventions for children and adolescents with autism spectrum disorder or ADHD We use cookies on this website. By using this site, you agree that we may store and access cookies on your device. Swedish Agency for Health Technology Assessment and Assessment of Social Services Nutritional or dietary interventions for children and adolescents with autism spectrum (...) disorder or ADHD Share: Reading time approx. 6 minutes There are theories that different types of nutritional or dietary interventions, where specific food items are excluded from the diet or where nutritional supplements are added, may affect the symptoms of persons with Attention Deficit Hyperactivity Disorder (ADHD) or autism spectrum disorder. This applies, for example, to gluten-free and casein-free diet, ketogenic diet (a strict option of a low carbohydrate diet) or diet where sugar or various

2018 Swedish Council on Technology Assessement

9. Prenatal Tetanus, Diphtheria, Acellular Pertussis Vaccination and Autism Spectrum Disorder

Prenatal Tetanus, Diphtheria, Acellular Pertussis Vaccination and Autism Spectrum Disorder : media-1vid110.1542/5803567555001PEDS-VA_2018-0120Video Abstract BACKGROUND: Increasing vaccination of pregnant women makes it important to assess safety events potentially linked to prenatal vaccination. This study investigates the association between prenatal tetanus, diphtheria, acellular pertussis (Tdap) vaccination and autism spectrum disorder (ASD) risk in offspring.This is a retrospective cohort

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2018 EvidenceUpdates

10. Autism spectrum disorder: Warning signs, detection, diagnosis and assessment in children and adolescents

Autism spectrum disorder: Warning signs, detection, diagnosis and assessment in children and adolescents Haute Autorité de Santé - Trouble du spectre de l’autisme - Signes d’alerte, repérage, diagnostic et évaluation chez l’enfant et l’adolescent Développer la qualité dans le champ sanitaire, social et médico-social Recherche La HAS Accréditation & Certification Outils, Guides & Méthodes Recommandation de bonne pratique Trouble du spectre de l’autisme - Signes d’alerte, repérage, diagnostic et

2018 HAS Guidelines

11. Heterogeneity in clinical sequencing tests marketed for autism spectrum disorders (PubMed)

Heterogeneity in clinical sequencing tests marketed for autism spectrum disorders 30275975 2018 11 14 2056-7944 3 2018 NPJ genomic medicine NPJ Genom Med Heterogeneity in clinical sequencing tests marketed for autism spectrum disorders. 27 10.1038/s41525-018-0066-3 Hoang Ny N 1Department of Genetic Counselling, The Hospital for Sick Children, Toronto, ON Canada. 0000 0004 0473 9646 grid.42327.30 2Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON Canada. 0000 0004 0473 (...) 2938 grid.17063.33 4The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON Canada. 0000 0004 0473 9646 grid.42327.30 5McLaughlin Centre and Department of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, ON Canada. 0000 0001 2157 2938 grid.17063.33 eng Journal Article 2018 09 19 England NPJ Genom Med 101685193 2056-7944 S.W.S. and SickKids Hospital has licensed intellectual property for genetic testing in autism to Athena Diagnostics, Lineagen

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2018 NPJ genomic medicine

12. Specialist-led improvised music therapy did not improve children’s symptoms of autism

Specialist-led improvised music therapy did not improve children’s symptoms of autism Specialist-led improvised music therapy did not improve children’s symptoms of autism Discover Portal Discover Portal Specialist-led improvised music therapy did not improve children’s symptoms of autism Published on 28 November 2017 doi: After five months, improvised music therapy added to enhanced usual care was no better than enhanced usual care alone for young children with an autism spectrum disorder (ASD (...) care comprised a wide range of local services including communication therapies. The enhanced care was three counselling and support sessions provided to all parents in the study. Though music itself may be useful for some children with an ASD, this specialist delivered therapy did not show any detectable benefit. Share your views on the research. Why was this study needed? Autism spectrum disorders (ASDs) are lifelong neurodevelopmental conditions affecting social interaction, communication

2018 NIHR Dissemination Centre

13. Autism spectrum disorder. (PubMed)

Autism spectrum disorder. Autism spectrum disorder is a term used to describe a constellation of early-appearing social communication deficits and repetitive sensory-motor behaviours associated with a strong genetic component as well as other causes. The outlook for many individuals with autism spectrum disorder today is brighter than it was 50 years ago; more people with the condition are able to speak, read, and live in the community rather than in institutions, and some will be largely free (...) for adults with autism spectrum disorder. Clinicians can make a difference by providing timely and individualised help to families navigating referrals and access to community support systems, by providing accurate information despite often unfiltered media input, and by anticipating transitions such as family changes and school entry and leaving.Copyright © 2018 Elsevier Ltd. All rights reserved.

2018 Lancet

14. Autism

Autism Top results for autism - Trip Database or use your Google+ account Find evidence fast ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4) Loading (...) history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for autism The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest

2018 Trip Latest and Greatest

15. Diagnostic tests for autism spectrum disorder (ASD) in preschool children. (PubMed)

Diagnostic tests for autism spectrum disorder (ASD) in preschool children. Autism spectrum disorder (ASD) is a behaviourally diagnosed condition. It is defined by impairments in social communication or the presence of restricted or repetitive behaviours, or both. Diagnosis is made according to existing classification systems. In recent years, especially following publication of the Diagnostic and Statistical Manual of Mental Disorders - Fifth Edition (DSM-5; APA 2013), children are given (...) tools: Autism Diagnostic Interview - Revised (ADI-R), Gilliam Autism Rating Scale (GARS), Diagnostic Interview for Social and Communication Disorder (DISCO), Developmental, Dimensional, and Diagnostic Interview (3di), Autism Diagnostic Observation Schedule - Generic (ADOS), and Childhood Autism Rating Scale (CARS); 2. include children of preschool age (under six years of age) suspected of having an ASD; and 3. have a multi-disciplinary assessment, or similar, as the reference standard.Eligible

2018 Cochrane

16. Autism

Autism Evidence Maps - Trip Database or use your Google+ account Turning Research Into Practice ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4) Loading

2018 Trip Evidence Maps

17. Autism spectrum disorder: advances in diagnosis and evaluation. (PubMed)

Autism spectrum disorder: advances in diagnosis and evaluation. Autism spectrum disorder (ASD) has a variety of causes, and its clinical expression is generally associated with substantial disability throughout the lifespan. Recent advances have led to earlier diagnosis, and deep phenotyping efforts focused on high risk infants have helped advance the characterization of early behavioral trajectories. Moreover, biomarkers that measure early structural and functional connectivity, visual (...) orienting, and other biological processes have shown promise in detecting the risk of autism spectrum disorder even before the emergence of overt behavioral symptoms. Despite these advances, the mean age of diagnosis is still 4-5 years. Because of the broad consistency in published guidelines, parameters for high quality comprehensive assessments are available; however, such models are resource intensive and high demand can result in greatly increased waiting times. This review describes advances

2018 BMJ

18. Early intensive behavioral intervention (EIBI) for young children with autism spectrum disorders (ASD). (PubMed)

Early intensive behavioral intervention (EIBI) for young children with autism spectrum disorders (ASD). The rising prevalence of autism spectrum disorders (ASD) increases the need for evidence-based behavioral treatments to lessen the impact of symptoms on children's functioning. At present, there are no curative or psychopharmacological therapies to effectively treat all symptoms of the disorders. Early intensive behavioral intervention (EIBI) is a treatment based on the principles of applied (...) behavior analysis. Delivered for multiple years at an intensity of 20 to 40 hours per week, it is one of the more well-established treatments for ASD. This is an update of a Cochrane review last published in 2012.To systematically review the evidence for the effectiveness of EIBI in increasing functional behaviors and skills, decreasing autism severity, and improving intelligence and communication skills for young children with ASD.We searched CENTRAL, MEDLINE, Embase, 12 additional electronic

2018 Cochrane

19. Parent-focused therapy has some long-term benefits for children with autism

Parent-focused therapy has some long-term benefits for children with autism Parent-focused therapy has some long-term benefits for children with autism Discover Portal Discover Portal Parent-focused therapy has some long-term benefits for children with autism Published on 14 February 2017 doi: A parent-focused therapy for young children with autism continues to have beneficial effects on symptoms and communication almost six years after the end of treatment. This UK randomised controlled trial (...) investigated the effects of a one-year social communication therapy in 152 UK children aged two to four years with severe autism. The therapy, partly delivered by parents, aimed to help them adapt their style of interacting with their child. Children who received the intervention had less severe symptoms at the end of the initial one-year intervention period than those who received treatment as usual. When these children were followed up nearly six years later at age seven to 11 years, children who had

2018 NIHR Dissemination Centre

20. Specialist-led improvised music therapy did not improve children’s symptoms of autism

Specialist-led improvised music therapy did not improve children’s symptoms of autism Specialist-led improvised music therapy did not improve children’s symptoms of autism Discover Portal Discover Portal Specialist-led improvised music therapy did not improve children’s symptoms of autism Published on 28 November 2017 doi: After five months, improvised music therapy added to enhanced usual care was no better than enhanced usual care alone for young children with an autism spectrum disorder (ASD (...) care comprised a wide range of local services including communication therapies. The enhanced care was three counselling and support sessions provided to all parents in the study. Though music itself may be useful for some children with an ASD, this specialist delivered therapy did not show any detectable benefit. Share your views on the research. Why was this study needed? Autism spectrum disorders (ASDs) are lifelong neurodevelopmental conditions affecting social interaction, communication

2018 NIHR Dissemination Centre