Latest & greatest articles for atrial fibrillation

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Top results for atrial fibrillation

121. Digoxin and Mortality in Patients With Atrial Fibrillation Full Text available with Trip Pro

Digoxin and Mortality in Patients With Atrial Fibrillation Digoxin is widely used in patients with atrial fibrillation (AF).The goal of this paper was to explore whether digoxin use was independently associated with increased mortality in patients with AF and if the association was modified by heart failure and/or serum digoxin concentration.The association between digoxin use and mortality was assessed in 17,897 patients by using a propensity score-adjusted analysis and in new digoxin users

2018 EvidenceUpdates

122. Apixaban in patients at risk of stroke undergoing atrial fibrillation ablation Full Text available with Trip Pro

Apixaban in patients at risk of stroke undergoing atrial fibrillation ablation It is recommended to perform atrial fibrillation ablation with continuous anticoagulation. Continuous apixaban has not been tested.We compared continuous apixaban (5 mg b.i.d.) to vitamin K antagonists (VKA, international normalized ratio 2-3) in atrial fibrillation patients at risk of stroke a prospective, open, multi-centre study with blinded outcome assessment. Primary outcome was a composite of death, stroke (...) , or bleeding (Bleeding Academic Research Consortium 2-5). A high-resolution brain magnetic resonance imaging (MRI) sub-study quantified acute brain lesions. Cognitive function was assessed by Montreal Cognitive Assessment (MoCA) at baseline and at end of follow-up. Overall, 674 patients (median age 64 years, 33% female, 42% non-paroxysmal atrial fibrillation, 49 sites) were randomized; 633 received study drug and underwent ablation; 335 undertook MRI (25 sites, 323 analysable scans). The primary outcome

2018 EvidenceUpdates

123. How to Prevent, Detect and Manage Complications Caused by Cryoballoon Ablation of Atrial Fibrillation Full Text available with Trip Pro

How to Prevent, Detect and Manage Complications Caused by Cryoballoon Ablation of Atrial Fibrillation Atrial fibrillation is the most common cardiac arrhythmia and the prevalence is increasing every year. Patients who fail to maintain sinus rhythm with use of anti-arrhythmic drug therapy are referred for catheter ablation. Cryoballoon (CB) ablation has emerged as an effective and alternative treatment option to traditional point-by-point radiofrequency ablation, but there can be complications (...) . This article reviews the incidence, presentation, risk factors, management and preventative strategies of three major complications associated with CB ablation: phrenic nerve injury, atrial oesophageal fistula and bronchial injury. Although these complications are rare, electrophysiologists should institute measures to identify high-risk patients, implement best-practice techniques to minimise risks and maintain a high index of suspicion to recognise the complications quickly and implement correct

2018 Arrhythmia & electrophysiology review

124. Drivers of Atrial Fibrillation: Theoretical Considerations and Practical Concerns Full Text available with Trip Pro

Drivers of Atrial Fibrillation: Theoretical Considerations and Practical Concerns Understanding the mechanisms responsible for driving AF is key to improving the procedural success for AF ablation. In this review, we look at some of the proposed drivers of AF, the disagreement between experts and the challenges confronted in attempting to map AF. Defining a 'driver' is also controversial, but for the purposes of this review we will consider an AF driver to be either a focal or localised source

2018 Arrhythmia & electrophysiology review

125. Authors’ Reply: Hybrid Approach for Atrial Fibrillation Ablation: the Jury is Still Out Full Text available with Trip Pro

Authors’ Reply: Hybrid Approach for Atrial Fibrillation Ablation: the Jury is Still Out 29686873 2018 11 14 2050-3369 7 1 2018 Mar Arrhythmia & electrophysiology review Arrhythm Electrophysiol Rev Authors' Reply: Hybrid Approach for Atrial Fibrillation Ablation: the Jury is Still Out. 65-66 10.15420/aer.2017.7.1.L3.R3 Pearman Charles M CM Liverpool Heart and Chest Hospital, Liverpool and Manchester Academic Health Science Centre, University of Manchester Manchester, UK. Liverpool Heart

2018 Arrhythmia & electrophysiology review

126. Hybrid Approach for Atrial Fibrillation Ablation: the Jury is Still Out Full Text available with Trip Pro

Hybrid Approach for Atrial Fibrillation Ablation: the Jury is Still Out 29636976 2018 11 14 2050-3369 7 1 2018 Mar Arrhythmia & electrophysiology review Arrhythm Electrophysiol Rev Hybrid Approach for Atrial Fibrillation Ablation: the Jury is Still Out. 65 10.15420/aer.2017.7.1.L3 Giannopoulos Georgios G Yale School of MedicineNew Haven, CT, USA. Deftereos Spyridon S Yale School of MedicineNew Haven, CT, USA. eng Journal Article England Arrhythm Electrophysiol Rev 101637930 2050-3369 2018 4 12

2018 Arrhythmia & electrophysiology review

127. Systematic Screening for Atrial Fibrillation in the Community: Evidence and Obstacles Full Text available with Trip Pro

Systematic Screening for Atrial Fibrillation in the Community: Evidence and Obstacles With an ageing population globally, the burden of atrial fibrillation (AF) and its consequent complication of stroke and risk of mortality will continue to increase. Although opportunistic screening for AF by pulse check or ECG rhythm strip for people >65 years of age is currently recommended, data are now emerging that demonstrate the possible benefits of systematic community screening. Such screening

2018 Arrhythmia & electrophysiology review

128. Stroke Risk in Patients With Reduced Ejection Fraction After Myocardial Infarction Without Atrial Fibrillation Full Text available with Trip Pro

Stroke Risk in Patients With Reduced Ejection Fraction After Myocardial Infarction Without Atrial Fibrillation Stroke can occur after myocardial infarction (MI) in the absence of atrial fibrillation (AF).This study sought to identify risk factors (excluding AF) for the occurrence of stroke and to develop a calibrated and validated stroke risk score in patients with MI and heart failure (HF) and/or systolic dysfunction.The datasets included in this pooling initiative were derived from 4 trials

2018 EvidenceUpdates

129. New-Onset Atrial Fibrillation After PCI or CABG for Left Main Disease: The EXCEL Trial Full Text available with Trip Pro

New-Onset Atrial Fibrillation After PCI or CABG for Left Main Disease: The EXCEL Trial There is limited information on the incidence and prognostic impact of new-onset atrial fibrillation (NOAF) following percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) for left main coronary artery disease (LMCAD).This study sought to determine the incidence of NOAF following PCI and CABG for LMCAD and its effect on 3-year cardiovascular outcomes.In the EXCEL (Evaluation (...) of XIENCE Versus Coronary Artery Bypass Surgery for Effectiveness of Left Main Revascularization) trial, 1,905 patients with LMCAD and low or intermediate SYNTAX scores were randomized to PCI with everolimus-eluting stents versus CABG. Outcomes were analyzed according to the development of NOAF during the initial hospitalization following revascularization.Among 1,812 patients without atrial fibrillation on presentation, NOAF developed at a mean of 2.7 ± 2.5 days after revascularization in 162 patients

2018 EvidenceUpdates

130. Female Sex Is a Risk Modifier Rather Than a Risk Factor for Stroke in Atrial Fibrillation: Should We Use a CHA2DS2-VA Score Rather Than CHA2DS2-VASc? Full Text available with Trip Pro

Female Sex Is a Risk Modifier Rather Than a Risk Factor for Stroke in Atrial Fibrillation: Should We Use a CHA2DS2-VA Score Rather Than CHA2DS2-VASc? Stroke risk in atrial fibrillation is assessed by using the CHA2DS2-VASc score. Sex category (Sc, ie, female sex) confers 1 point on CHA2DS2-VASc. We hypothesized that female sex is a stroke risk modifier, rather than an overall risk factor, when added to a CHA2DS2-VA (sex-independent thromboembolism risk) score scale.Using 3 nationwide registries (...) , we identified patients with incident nonvalvular atrial fibrillation from January 1, 1997, through December 31, 2015. Patients receiving oral anticoagulant treatment at baseline were excluded, and person-time was censored at the time of treatment initiation (if any). CHA2DS2-VA scores were calculated for men and women, and were followed for up to 1 year in the Danish National Patient Registry. The primary outcome was a primary hospital code for ischemic stroke or systemic embolism

2018 EvidenceUpdates

131. Targeted therapy of underlying conditions improves sinus rhythm maintenance in patients with persistent atrial fibrillation: results of the RACE 3 trial Full Text available with Trip Pro

Targeted therapy of underlying conditions improves sinus rhythm maintenance in patients with persistent atrial fibrillation: results of the RACE 3 trial Atrial fibrillation (AF) is a progressive disease. Targeted therapy of underlying conditions refers to interventions aiming to modify risk factors in order to prevent AF. We hypothesised that targeted therapy of underlying conditions improves sinus rhythm maintenance in patients with persistent AF.We randomized patients with early persistent AF

2018 EvidenceUpdates

132. Lifetime Risks, Projected Numbers, and Adverse Outcomes in Asian Patients With Atrial Fibrillation: A Report From the Taiwan Nationwide AF Cohort Study Full Text available with Trip Pro

Lifetime Risks, Projected Numbers, and Adverse Outcomes in Asian Patients With Atrial Fibrillation: A Report From the Taiwan Nationwide AF Cohort Study Most data on the clinical epidemiology of atrial fibrillation (AF) come from Western populations, and data for Asians are limited. We investigated the lifetime risk and projected number of AF among Asians. The annual risks of adverse events among patients with AF, time trends, and the risks compared with patients without AF were analyzed.Between

2018 EvidenceUpdates

133. In-hospital direct costs for thromboembolism and bleeding in Chinese patients with atrial fibrillation Full Text available with Trip Pro

In-hospital direct costs for thromboembolism and bleeding in Chinese patients with atrial fibrillation Limited data are available on the direct costs of hospitalization owing to thromboembolism and bleeding in patients with atrial fibrillation (AF) in China. Such data are essential for policy development, service planning, and cost-effectiveness analysis of new therapeutic strategies. This study aimed to provide detailed data regarding in-hospital direct costs for these patients, compare

2018 Chronic diseases and translational medicine

134. Ischaemic stroke, haemorrhage, and mortality in older patients with chronic kidney disease newly started on anticoagulation for atrial fibrillation: a population based study from UK primary care. Full Text available with Trip Pro

Ischaemic stroke, haemorrhage, and mortality in older patients with chronic kidney disease newly started on anticoagulation for atrial fibrillation: a population based study from UK primary care. To assess the association between anticoagulation, ischaemic stroke, gastrointestinal and cerebral haemorrhage, and all cause mortality in older people with atrial fibrillation and chronic kidney disease.Propensity matched, population based, retrospective cohort analysis from January 2006 through (...) December 2016.The Royal College of General Practitioners Research and Surveillance Centre database population of almost 2.73 million patients from 110 general practices across England and Wales.Patients aged 65 years and over with a new diagnosis of atrial fibrillation and estimated glomerular filtration rate (eGFR) of <50 mL/min/1.73m2, calculated using the chronic kidney disease epidemiology collaboration creatinine equation. Patients with a previous diagnosis of atrial fibrillation or receiving

2018 BMJ

135. Reveal LINQ insertable cardiac monitor to detect atrial fibrillation after cryptogenic stroke

Reveal LINQ insertable cardiac monitor to detect atrial fibrillation after cryptogenic stroke Re Rev veal LINQ insertable cardiac monitor to detect eal LINQ insertable cardiac monitor to detect atrial fibrillation after cryptogenic strok atrial fibrillation after cryptogenic stroke e Medtech innovation briefing Published: 16 February 2018 nice.org.uk/guidance/mib141 pathways Summary Summary The technology technology described in this briefing is Reveal LINQ insertable cardiac monitor (ICM (...) ) with CareLink service for detecting suspected asymptomatic atrial fibrillation (AF) after cryptogenic stroke. The inno innovativ vative aspects e aspects are: a proprietary AF detection algorithm, which is designed to reduce false positive detections; small device size, which allows insertion outside a catheterisation lab; and memory capacity offering sufficient recording time to establish symptom–rhythm correlations. The intended place in ther intended place in therap apy y is in addition to standard care

2018 National Institute for Health and Clinical Excellence - Advice

136. Prediction of Incident Atrial Fibrillation According to Gender in Patients With Ischemic Stroke From a Nationwide Cohort Full Text available with Trip Pro

Prediction of Incident Atrial Fibrillation According to Gender in Patients With Ischemic Stroke From a Nationwide Cohort The CHA2DS2-VASc score may identify patients at higher risk of atrial fibrillation (AF) following ischemic stroke (IS) in patients without known AF. We compared gender-related differences in items from CHA2DS2-VASc score and their relation with AF occurrence after IS. This French cohort study was based on the database covering hospital care from 2009 to 2012 for the entire

2018 EvidenceUpdates

137. Predictors of Mortality in Patients With Atrial Fibrillation (from the Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events [ACTIVE A]) (Abstract)

Predictors of Mortality in Patients With Atrial Fibrillation (from the Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events [ACTIVE A]) The mortality rate of most patients with atrial fibrillation (AF) exceeds the stroke rate, but predictors of mortality have not been well defined. The Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events (ACTIVE A) recruited patients with AF who were unsuitable to receive vitamin K

2018 EvidenceUpdates

138. [Trancatheter ablation with cryoballoon for the treatment of atrial fibrillation. A rapid assessment]

[Trancatheter ablation with cryoballoon for the treatment of atrial fibrillation. A rapid assessment] Ablazione transcatetere mediante criopallone per il trattamento della fibrillazione atriale. Valutazione rapida [Trancatheter ablation with cryoballoon for the treatment of atrial fibrillation. A rapid assessment] Ablazione transcatetere mediante criopallone per il trattamento della fibrillazione atriale. Valutazione rapida [Trancatheter ablation with cryoballoon for the treatment of atrial (...) fibrillation. A rapid assessment] Negro A, Maltoni S, Pecoraro V, Camerlingo M, Falasca G, Lauretti F. Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Negro A, Maltoni S, Pecoraro V, Camerlingo M, Falasca G, Lauretti F.. Ablazione transcatetere mediante criopallone per il trattamento della fibrillazione atriale. Valutazione rapida. [Trancatheter

2018 Health Technology Assessment (HTA) Database.

139. Catheter Ablation for Atrial Fibrillation with Heart Failure. Full Text available with Trip Pro

Catheter Ablation for Atrial Fibrillation with Heart Failure. Mortality and morbidity are higher among patients with atrial fibrillation and heart failure than among those with heart failure alone. Catheter ablation for atrial fibrillation has been proposed as a means of improving outcomes among patients with heart failure who are otherwise receiving appropriate treatment.We randomly assigned patients with symptomatic paroxysmal or persistent atrial fibrillation who did not have a response (...) to antiarrhythmic drugs, had unacceptable side effects, or were unwilling to take these drugs to undergo either catheter ablation (179 patients) or medical therapy (rate or rhythm control) (184 patients) for atrial fibrillation in addition to guidelines-based therapy for heart failure. All the patients had New York Heart Association class II, III, or IV heart failure, a left ventricular ejection fraction of 35% or less, and an implanted defibrillator. The primary end point was a composite of death from any

2018 NEJM Controlled trial quality: predicted high

140. Comparative effectiveness of direct oral anticoagulants and warfarin in patients with cancer and atrial fibrillation Full Text available with Trip Pro

Comparative effectiveness of direct oral anticoagulants and warfarin in patients with cancer and atrial fibrillation Randomized clinical trials comparing direct oral anticoagulants (DOACs) to warfarin in cancer patients have not been performed. We evaluated the effectiveness and associated risk of DOACs vs warfarin, as well as comparisons of DOACs, in a large population of cancer patients with nonvalvular atrial fibrillation (AF). Using the MarketScan databases, we identified 16 096 AF patients

2018 Blood advances