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Latest & greatest articles for atrial fibrillation
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on atrial fibrillation or other clinical topics then use Trip today.
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Lixiana (edoxaban) - for the prevention of embolism in patients with nonvalvular atrialfibrillation OR treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE) and prevention of recurrent DVT and PE. Lixiana (edoxaban) × Insert searchphrase to search the website Insert searchphrase to search the website > > > Lixiana (edoxaban) Conclusion Lixiana (edoxaban) is the fourth Non-vitamin K Oral Anticoagulant (NOAC) in Denmark after Eliques (apixaban), Xarelto (rivaroxaban) and Pradaxa (...) (dabigatran). Lixiana is indicated for the prevention of embolism in patients with nonvalvular atrialfibrillation (NVAF) with one or more risk factors and treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE) and prevention of recurrent DVT and PE. For either indication, Lixiana is not inferior to warfarin when it comes to preventing embolism and has a statistically significantly lower occurrence of major bleeding. The lower risk of bleeding is particularly evident in comparisons
Assessment of Remote Heart Rhythm Sampling Using the AliveCor Heart Monitor to Screen for AtrialFibrillation: The REHEARSE-AF Study Asymptomatic atrialfibrillation (AF) is increasingly common in the aging population and implicated in many ischemic strokes. Earlier identification of AF with appropriate anticoagulation may decrease stroke morbidity and mortality.We conducted a randomized controlled trial of AF screening using an AliveCor Kardia monitor attached to a WiFi-enabled iPod to obtain
Bleeding-related hospital admissions and 30-day readmissions in patients with non-valvular atrialfibrillation treated with dabigatran versus warfarin Essentials Bleeding is a common cause of hospital admission and readmission in oral anticoagulant users. Patients with dabigatran and warfarin were included to assess hospital admission risk. Dabigatran users had a higher risk of 30-day readmission with bleeding than warfarin users. Close monitoring following hospital discharge for dabigatran (...) . warfarin in patients with non-valvular atrialfibrillation (NVAF). Methods This was a retrospective cohort study using a population-wide database managed by the Hong Kong Hospital Authority. Patients newly diagnosed with NVAF from 2010 through to 2014 and prescribed dabigatran or warfarin were 1:1 matched by propensity score. The incidence rate of hospital admission with bleeding (a composite of gastrointestinal bleeding, intracranial hemorrhage and bleeding at other sites) was assessed. Results Among
Impact of creatinine clearance on outcomes in patients with non-valvular atrialfibrillation: a subanalysis of the J-RHYTHM Registry To clarify the influence of renal function on adverse outcomes in patients with non-valvular atrialfibrillation (NVAF), a post hoc analysis of the J-RHYTHM Registry was performed.A consecutive series of outpatients with atrialfibrillation (AF) were enrolled from 158 institutions and followed for 2 years or until the occurrence of an event. Among 7406 patients
Dual Antithrombotic Therapy with Dabigatran after PCI in AtrialFibrillation. Triple antithrombotic therapy with warfarin plus two antiplatelet agents is the standard of care after percutaneous coronary intervention (PCI) for patients with atrialfibrillation, but this therapy is associated with a high risk of bleeding.In this multicenter trial, we randomly assigned 2725 patients with atrialfibrillation who had undergone PCI to triple therapy with warfarin plus a P2Y12 inhibitor (clopidogrel (...) ; 95% CI, 0.84 to 1.29; P=0.005 for noninferiority). The rate of serious adverse events did not differ significantly among the groups.Among patients with atrialfibrillation who had undergone PCI, the risk of bleeding was lower among those who received dual therapy with dabigatran and a P2Y12 inhibitor than among those who received triple therapy with warfarin, a P2Y12 inhibitor, and aspirin. Dual therapy was noninferior to triple therapy with respect to the risk of thromboembolic events. (Funded
A multifaceted intervention to improve treatment with oral anticoagulants in atrialfibrillation (IMPACT-AF): an international, cluster-randomised trial. Oral anticoagulation is underused in patients with atrialfibrillation. We assessed the impact of a multifaceted educational intervention, versus usual care, on oral anticoagulant use in patients with atrial fibrillation.This study was a two-arm, prospective, international, cluster-randomised, controlled trial. Patients were included who had (...) atrialfibrillation and an indication for oral anticoagulation. Clusters were randomised (1:1) to receive a quality improvement educational intervention (intervention group) or usual care (control group). Randomisation was carried out centrally, using the eClinicalOS electronic data capture system. The intervention involved education of providers and patients, with regular monitoring and feedback. The primary outcome was the change in the proportion of patients treated with oral anticoagulants from
2017LancetControlled trial quality: predicted high
Association of a Family History of AtrialFibrillation With Incidence and Outcomes of AtrialFibrillation: A Population-Based Family Cohort Study The heritability of atrialfibrillation (AF), the contribution of genetic and environmental factors, and the association of a family history of AF with prognosis are unclear.To measure genetic and environmental factors in the familial aggregation of AF and to estimate the association of a family history of AF with major adverse cardiovascular events
Effectiveness and Safety of Standard-Dose Nonvitamin K Antagonist Oral Anticoagulants and Warfarin Among Patients With AtrialFibrillation With a Single Stroke Risk Factor: A Nationwide Cohort Study The randomized clinical trials comparing nonvitamin K antagonist oral anticoagulants (NOACs) vs warfarin largely focused on recruiting high-risk patients with atrialfibrillation with more than 2 stroke risk factors, with only the trials testing dabigatran or apixaban including few patients with 1 (...) stroke risk factor. Despite this, regulatory approvals of all NOACs have been based on stroke prevention for patients with atrialfibrillation with 1 or more stroke risk factors.To compare the effectiveness and safety study of standard-dose NOACs (dabigatran at 150 mg twice daily, rivaroxaban at 20 mg once daily, and apixaban at 5 mg twice daily) and warfarin in patients with atrialfibrillation with 1 low-risk, nonsex-related stroke risk factor.This nationwide observational cohort study used data
Influence of renal function on anticoagulation control in patients with non-valvular atrialfibrillation taking vitamin K antagonists Chronic kidney disease (CKD) has been related to poor anticoagulation control and an increased risk of bleeding. This study aims to evaluate the association between impaired renal function (eGFR <60 mL/min/1.73 m2 ) and anticoagulation control in patients with non-valvular atrialfibrillation (AF) on vitamin K antagonists (VKA) therapy. We also assessed whether
Notification of international normalized ratio test in atrialfibrillation patients treated with warfarin via short message service: Study protocol for a randomized controlled trial AtrialFibrillation (AF) is the most common abnormal heart rhythm. AF patients usually use warfarin therapy. Safety and efficacy of warfarin are dependent on maintaining the International Normalized Ratio (INR) within the therapeutic range.We will use a Short Message Service (SMS) to evaluate the effect
Randomized clinical trial of landiolol hydrochloride for the prevention of atrialfibrillation and postoperative complications after oesophagectomy for cancer Atrialfibrillation is common after oesophageal surgery. The aim of this study was to evaluate whether landiolol hydrochloride was effective and safe in the prevention of atrialfibrillation after oesophagectomy, and to see whether a reduction in incidence of atrialfibrillation would reduce other postoperative complications.This single (...) -centre study enrolled patients scheduled for transthoracic oesophagectomy in a randomized, double-blind, placebo-controlled trial between March 2013 and January 2016. Enrolled patients were randomized with a 1 : 1 parallel allocation ratio to either landiolol prophylaxis or placebo. The primary endpoint was the occurrence of atrialfibrillation after oesophagectomy. Secondary endpoints were incidence of postoperative complications, and effects on haemodynamic and inflammatory indices.One hundred
[Cryoablation for the treatment of persistent or symptomatic paroxysmal atrialfibrillation] [Cryoablation for the treatment of persistent or symptomatic paroxysmal atrialfibrillation] [Cryoablation for the treatment of persistent or symptomatic paroxysmal atrialfibrillation] Hernández-Vásquez A, Alcaraz A, Pichon-Riviere A, Augustovski F, García Martí S, Bardach A, Ciapponi A, López A, Rey-Ares L Record Status This is a bibliographic record of a published health technology assessment from (...) a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Hernández-Vásquez A, Alcaraz A, Pichon-Riviere A, Augustovski F, García Martí S, Bardach A, Ciapponi A, López A, Rey-Ares L. [Cryoablation for the treatment of persistent or symptomatic paroxysmal atrialfibrillation] Buenos Aires: Institute for Clinical Effectiveness and Health Policy (IECS). Documentos de Evaluación de Tecnologías Sanitarias, Informe de Respuesta Rapida No 517. 2017
Atrialfibrillation following therapy with high-dose i.v. methylprednisolone: A brief case-based review Atrialfibrillation following high-dose i.v. steroids for treatment of severe immune-mediated diseases has been rarely reported in the literature. Here we report a further case of atrialfibrillation following high-dose i.v. methylprednisolone (HDIVMP) therapy of severe thrombocytopenia in a female patient with a flare-up of systemic lupus erythematosus (SLE). The available literature
Practical Implementation of Anticoagulation Strategy for Patients Undergoing Cardioversion of AtrialFibrillation Anticoagulation is routinely prescribed to patients with persistent AF before cardioversion to reduce the risk of thromboembolic events. As direct oral anticoagulants (DOACs) have a rapid onset of action, a consistent anticoagulant effect, if taken correctly, and do not need monitoring or dose adjustments, there is considerable interest in their use for patients with AF undergoing
AtrialFibrillation and Anticoagulation in Hypertrophic Cardiomyopathy Hypertrophic cardiomyopathy (HCM) represents a common inherited cardiac disorder with well-known complications Including stroke and sudden cardiac death. There is a recognised association between HCM and the development of AF. This review describes the epidemiology of AF within the HCM population and analyses the risk factors for the development of AF. It further discusses the outcomes associated with AF in this population
CHA2DS2-VASc Score (Congestive Heart Failure, Hypertension, Age >/=75 [Doubled], Diabetes Mellitus, Prior Stroke or Transient Ischemic Attack [Doubled], Vascular Disease, Age 65-74, Female) for Stroke in Asian Patients With AtrialFibrillation: A Korean N The CHA2DS2-VASc stroke score (congestive heart failure, hypertension, age ≥75 (doubled), diabetes mellitus, prior stroke or transient ischemic attack (doubled), vascular disease, age 65-74, female) is used in most guidelines for risk (...) stratification in atrialfibrillation (AF), but most data for this score have been derived in Western populations. Ethnic differences in stroke risk may be present. Our objective was to investigate risk factors for stroke in AF and application of the CHA2DS2-VASc score in an Asian AF population from Korea.A total of 5855 oral anticoagulant-naive nonvalvular AF patients aged ≥20 years were enrolled from Korea National Health Insurance Service Sample cohort from 2002 to 2008 and were followed up until December
Atrialfibrillation as a risk factor for cognitive decline and dementia To assess whether AF is a risk factor for cognitive dysfunction we used prospective data on AF, repeat cognitive scores, and dementia incidence in adults followed over 45 to 85 years.Data are drawn from the Whitehall II study, N = 10 308 at study recruitment in 1985. A battery of cognitive tests was administered four times (1997-2013) to 7428 participants (414 cases of AF), aged 45-69 years in 1997. Compared with AF-free
CHAD65 and CHA2DS2-VASc Risk Stratification Tools for Patients with AtrialFibrillation: A Review of Clinical Effectiveness and Guidelines CHAD65 and CHA2DS2-VASc Risk Stratification Tools for Patients with AtrialFibrillation: A Review of Clinical Effectiveness and Guidelines | CADTH.ca Find the information you need CHAD65 and CHA2DS2-VASc Risk Stratification Tools for Patients with AtrialFibrillation: A Review of Clinical Effectiveness and Guidelines CHAD65 and CHA2DS2-VASc Risk (...) Stratification Tools for Patients with AtrialFibrillation: A Review of Clinical Effectiveness and Guidelines Published on: May 12, 2017 Project Number: RC0883-000 Product Line: Research Type: Devices and Systems Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of the CHAD65 and CHA2DS2-VASc risk stratification tools to determine the need for pharmacological treatment in patients with atrialfibrillation? What are the evidence-based guidelines
Risk of stroke in chronic heart failure patients with preserved ejection fraction, but without atrialfibrillation: analysis of the CHARM-Preserved and I-Preserve trials The incidence and predictors of stroke in patients with heart failure and preserved ejection fraction (HF-PEF), but without atrialfibrillation (AF), are unknown. We described the incidence of stroke in HF-PEF patients with and without AF and predictors of stroke in those without AF.We pooled data from the CHARM-Preserved and I
Exercise Training in Patients With Chronic Heart Failure and AtrialFibrillation The safety and efficacy of aerobic exercise in heart failure (HF) patients with atrialfibrillation (AF) has not been well evaluated.This study examined whether outcomes with exercise training in HF vary according to AF status.HF-ACTION (Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training) randomized 2,331 ambulatory HF patients with ejection fraction ≤35% to exercise training or usual