Latest & greatest articles for asthma

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Top results for asthma

1181. Effect of long-term salmeterol treatment on exercise-induced asthma.

Effect of long-term salmeterol treatment on exercise-induced asthma. 9664089 1998 07 16 1998 07 16 2015 11 19 0028-4793 339 3 1998 Jul 16 The New England journal of medicine N. Engl. J. Med. Effect of long-term salmeterol treatment on exercise-induced asthma. 141-6 With long-term administration of salmeterol, the extent of protection afforded by the drug against experimental precipitants of asthma such as methacholine and adenosine may decrease. Whether this effect extends to a clinically (...) relevant stimulus such as exercise is unknown. We performed a random-order, double-blind, crossover trial in 20 patients with exercise-induced asthma. Each patient received inhaled salmeterol or placebo twice daily for a month, with a one-week washout period between treatments. The patients performed cycle ergometry while breathing frigid air 30 minutes after the morning dose and 9 hours later on the 1st, 14th, and 29th study days. The primary end point was the extent of the decrease in forced

NEJM1998

1182. Effects of antihistamines in adult asthma: a meta-analysis of clinical trials

Effects of antihistamines in adult asthma: a meta-analysis of clinical trials Effects of antihistamines in adult asthma: a meta-analysis of clinical trials Effects of antihistamines in adult asthma: a meta-analysis of clinical trials Van Ganse E, Kaufman L, Derde M P, Yernault J C, Delaunois L, Vincken W Authors' objectives To investigate the positive and negative effects of antihistamines in asthma. Searching MEDLINE, Ringdoc, and Excerpta Medica: DRUGS, were searched for studies published (...) to other asthma medication were not used. Participants included in the review Patients with mild, moderate or severe asthma were included in the review. All asthma definitions given by the authors were accepted; these usually defined asthma as a history of reversible airflow obstruction, with impaired lung function that improved considerably after the use of inhaled bronchodilators. The age of the participants in the included studies ranged from 7 to 74 years, and over 50% of the patients in each study

DARE.1997

1183. Effectiveness of prophylactic inhaled steroids in childhood asthma: a systematic review of the literature

Effectiveness of prophylactic inhaled steroids in childhood asthma: a systematic review of the literature Effectiveness of prophylactic inhaled steroids in childhood asthma: a systematic review of the literature Effectiveness of prophylactic inhaled steroids in childhood asthma: a systematic review of the literature Calpin C, Macarthur C, Stephens D, Feldman W, Parkin P C Authors' objectives To evaluate the effectiveness of prophylactic inhaled steroids in childhood asthma. Searching MEDLINE (...) was searched from January 1966 to December 1996 using the following MeSH terms: 'asthma', 'drug therapy', 'glucocorticoid', 'inhaled corticosteroid', 'inhaled steroid', 'clinical trial' and 'randomised controlled trial' (RCT). In addition, Current Contents and selected paediatric and respiratory journals were searched manually, and the reference lists of the retrieved papers were examined. Only publications in the English language were retrieved. Study selection Study designs of evaluations included

DARE.1997

1184. Zafirlukast: the first leukotriene-receptor antagonist approved for the treatment of asthma

Zafirlukast: the first leukotriene-receptor antagonist approved for the treatment of asthma Zafirlukast: the first leukotriene-receptor antagonist approved for the treatment of asthma Zafirlukast: the first leukotriene-receptor antagonist approved for the treatment of asthma Kelloway JS Authors' objectives To review the pharmacology, pharmacokinetics, clinical efficacy, and adverse effects of zafirlukast for the treatment of asthma. Searching MEDLINE was searched, but no details of the search (...) strategy were provided. Study selection Study designs of evaluations included in the review Double-blind, placebo-controlled trials were included. Specific interventions included in the review Zafirlukast (both oral and aerosol). Participants included in the review Patients with asthma were included. Outcomes assessed in the review Asthma symptoms, concomitant beta-agonist use, pulmonary function, and the safety profile were assessed. How were decisions on the relevance of primary studies made

DARE.1997

1185. Metered-dose inhaler accessory devices in acute asthma. Efficacy and comparison with nebulizers: a literature review

Metered-dose inhaler accessory devices in acute asthma. Efficacy and comparison with nebulizers: a literature review Metered-dose inhaler accessory devices in acute asthma. Efficacy and comparison with nebulizers: a literature review Metered-dose inhaler accessory devices in acute asthma. Efficacy and comparison with nebulizers: a literature review Amirav I, Newhouse M T Authors' objectives To evaluate the efficacy of metered-dose inhalers (MDIs) and accessory devices (ADs) in the management (...) of acute asthma in children, and to compare the outcome with small volume nebulisers (SVNs), which represent the current standard of care. Searching MEDLINE was searched from 1980 to 1996 for publications in the English language, using the keywords 'acute asthma', 'children', 'aerosols' and 'nebulizers'. The reference lists of the retrieved studies were examined, and citation searches were made using the Science Citation Index. The authors of the primary studies were also contacted for additional

DARE.1997

1186. Cost effectiveness of an allergy consultation in the management of asthma

Cost effectiveness of an allergy consultation in the management of asthma Cost effectiveness of an allergy consultation in the management of asthma Cost effectiveness of an allergy consultation in the management of asthma Westley C R, Spiecher B, Starr L, Simons P, Sanders B, Marsh W, Comer C, Harvey R Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results (...) and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Use of an allergist consultation (asthma/allergy specialist evaluation) for moderately severe and severe asthma patients in the framework of a large staff-model health maintenance organization (HMO). Some of the components reported to be incorporated in the asthma/allergy consultation were as follows: attempts to identify triggers, individualising home care plans with use

NHS Economic Evaluation Database.1997

1187. Cost-effective management of malignant potentially fatal asthma

Cost-effective management of malignant potentially fatal asthma Cost-effective management of malignant potentially fatal asthma Cost-effective management of malignant potentially fatal asthma Levenson T, Grammar L C, Yarnold P R, Patterson R Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment (...) on the reliability of the study and the conclusions drawn. Health technology Asthma management intervention programme tailored for specific patients with malignant potentially fatal asthma. The programme included regular clinic visits, patient and family education, 24-hour telephone access, simplified medical regimens, adequate anti-inflammatory medication and, if indicated, psychiatric referral. These measures included the building of doctor/patient relations and, for some, the use of depot injections

NHS Economic Evaluation Database.1997

1188. Care of asthma: allergy clinic versus emergency room

Care of asthma: allergy clinic versus emergency room Care of asthma: allergy clinic versus emergency room Care of asthma: allergy clinic versus emergency room Moore C M, Ahmed I, Mouallem R, May W, Ehlayel M, Sorensen R U Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study (...) and the conclusions drawn. Health technology Allergy clinics and emergency room treatment for asthma. Type of intervention Secondary prevention. Economic study type Cost-effectiveness analysis. Study population Asthmatic patients (children) from an inner-city area in the USA. All patients came from low income, working families without medical insurance and were ineligible for Medicaid. Setting Hospital. The study was carried out at the Medical Center of Louisiana in New Orleans, USA. Dates to which data relate

NHS Economic Evaluation Database.1997

1189. Cost effectiveness analysis of a dry powder inhaler (Turbuhaler) versus a pressurised metered dose inhaler in patients with asthma

Cost effectiveness analysis of a dry powder inhaler (Turbuhaler) versus a pressurised metered dose inhaler in patients with asthma Cost effectiveness analysis of a dry powder inhaler (Turbuhaler) versus a pressurised metered dose inhaler in patients with asthma Cost effectiveness analysis of a dry powder inhaler (Turbuhaler) versus a pressurised metered dose inhaler in patients with asthma Liljas B, Stahl E, Pauwels R A Record Status This is a critical abstract of an economic evaluation (...) that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Two different kinds of inhalers: using an aerosol pressurised metered dose inhaler (pMDI) or a dry powder inhaler (Turbuhaler) in patients with asthma. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population

NHS Economic Evaluation Database.1997

1190. Randomised placebo-controlled trial of inhaled sodium cromoglycate in 1-4-year-old children with moderate asthma.

Randomised placebo-controlled trial of inhaled sodium cromoglycate in 1-4-year-old children with moderate asthma. 10213547 1999 04 27 1999 04 27 2015 06 16 0140-6736 350 9084 1997 Oct 11 Lancet (London, England) Lancet Randomised placebo-controlled trial of inhaled sodium cromoglycate in 1-4-year-old children with moderate asthma. 1060-4 Inhalation therapy with sodium cromoglycate is recommended as the first-line prophylactic treatment for moderate asthma in children. The availability of spacer (...) devices with face-masks has extended the applicability of metered-dose inhalers to younger children. We studied the feasibility and effects of this therapy compared with placebo in children aged 1-4 years. 218 children aged 1-4 years with moderate asthma were recruited through 151 general practitioners between March, 1995, and March, 1996. They were randomly assigned sodium cromoglycate (10 mg three times daily) or placebo, given by inhaler with spacer device and face-mask for 5 months. Rescue

Lancet1997

1191. A controlled trial of immunotherapy for asthma in allergic children.

A controlled trial of immunotherapy for asthma in allergic children. 9011784 1997 02 06 1997 02 06 2007 11 14 0028-4793 336 5 1997 Jan 30 The New England journal of medicine N. Engl. J. Med. A controlled trial of immunotherapy for asthma in allergic children. 324-31 Injections of allergens are widely prescribed for patients with asthma, but little is known about the effectiveness of immunotherapy. We conducted a double-blind, placebo-controlled trial of multiple-allergen immunotherapy in 121 (...) allergic children with moderate-to-severe, perennial asthma. The children, who required daily medication for their asthma, were randomly assigned to receive subcutaneous injections of either a mixture of up to seven aeroallergen extracts or a placebo. Maintenance injections were continued for 18 months or longer. Medications were adjusted every two to three weeks on the basis of peak flow rates and symptoms. The principal outcome was the daily medication score. Bronchial sensitivity to methacholine

NEJM1997

1192. Randomised trial of intravenous salbutamol in early management of acute severe asthma in children.

Randomised trial of intravenous salbutamol in early management of acute severe asthma in children. 9024371 1997 02 28 1997 02 28 2015 06 16 0140-6736 349 9048 1997 Feb 01 Lancet (London, England) Lancet Randomised trial of intravenous salbutamol in early management of acute severe asthma in children. 301-5 The mainstay of treatment for acute asthma in children is nebulised beta 2-adrenergic agents such as salbutamol, given with corticosteroids. However, penetration of the drug to the small (...) airways is impeded by obstruction so intravenous salbutamol may be more effective. We assessed the use of intravenous salbutamol in the management of children with acute severe asthma in a double-blind randomised study. Children who presented to the Emergency Department of Westmead Hospital, Sydney, Australia with asthma were assessed with a clinical assessment scale, and those with severe acute asthma were given nebulised salbutamol at a dose of 2.5 mg (age < or = 2 years) or 5.0 mg (age > 2 years

Lancet1997

1193. Effect of inhaled formoterol and budesonide on exacerbations of asthma. Formoterol and Corticosteroids Establishing Therapy (FACET) International Study Group.

Effect of inhaled formoterol and budesonide on exacerbations of asthma. Formoterol and Corticosteroids Establishing Therapy (FACET) International Study Group. 9358137 1997 11 13 1997 11 13 2015 11 19 0028-4793 337 20 1997 Nov 13 The New England journal of medicine N. Engl. J. Med. Effect of inhaled formoterol and budesonide on exacerbations of asthma. Formoterol and Corticosteroids Establishing Therapy (FACET) International Study Group. 1405-11 The role of long-acting, inhaled beta2-agonists (...) in treating asthma is uncertain. In a double-blind study, we evaluated the effects of adding inhaled formoterol to both lower and higher doses of the inhaled glucocorticoid budesonide. After a four-week run-in period of treatment with budesonide (800 microg twice daily), 852 patients being treated with glucocorticoids were randomly assigned to one of four treatments given twice daily by means of a dry-powder inhaler (Turbuhaler): 100 microg of budesonide plus placebo, 100 microg of budesonide plus 12

NEJM1997

1194. A comparison of low-dose inhaled budesonide plus theophylline and high-dose inhaled budesonide for moderate asthma.

A comparison of low-dose inhaled budesonide plus theophylline and high-dose inhaled budesonide for moderate asthma. 9358138 1997 11 13 1997 11 13 2013 11 21 0028-4793 337 20 1997 Nov 13 The New England journal of medicine N. Engl. J. Med. A comparison of low-dose inhaled budesonide plus theophylline and high-dose inhaled budesonide for moderate asthma. 1412-8 Inhaled glucosteroids and oral theophylline are widely used to treat asthma. We compared the benefits of adding theophylline to inhaled (...) and similar reductions in beta2-agonist use and the variability of peak expiratory flow, a correlate of bronchial hyperresponsiveness and the severity of asthma. Serum cortisol concentrations were significantly reduced in the group given high-dose budesonide (from a mean [+/-SE] of 18.4+/-2.4 microg per deciliter to 15.9+/-2.1 microg per deciliter, P=0.02) but were unchanged in the other group. The median serum theophylline concentration was 8.7 microg per milliliter (therapeutic range, 10 to 20) among

NEJM1997

1195. A comparison of beclomethasone, salmeterol, and placebo in children with asthma. Canadian Beclomethasone Dipropionate-Salmeterol Xinafoate Study Group.

A comparison of beclomethasone, salmeterol, and placebo in children with asthma. Canadian Beclomethasone Dipropionate-Salmeterol Xinafoate Study Group. 9385125 1997 12 04 1997 12 04 2015 11 19 0028-4793 337 23 1997 Dec 04 The New England journal of medicine N. Engl. J. Med. A comparison of beclomethasone, salmeterol, and placebo in children with asthma. Canadian Beclomethasone Dipropionate-Salmeterol Xinafoate Study Group. 1659-65 An inhaled glucocorticoid is currently the medication of choice (...) for long-term control of persistent asthma in children. The role of long-acting beta2-adrenergic-receptor agonists, such as salmeterol, needs to be defined. We conducted a randomized, double-blind, placebo-controlled, parallel-group, one-year study of 241 children (mean [+/-SD] age, 9.3+/-2.4 years) with clinically stable asthma and less than one month of prior glucocorticoid use. We compared inhaled beclomethasone dipropionate (200 microg twice daily) with salmeterol xinafoate (50 microg twice daily

NEJM1997

1196. Effect of long-term treatment with salmeterol on asthma control: a double blind, randomised crossover study.

Effect of long-term treatment with salmeterol on asthma control: a double blind, randomised crossover study. 9167559 1997 06 11 1997 06 11 2015 11 19 0959-8138 314 7092 1997 May 17 BMJ (Clinical research ed.) BMJ Effect of long-term treatment with salmeterol on asthma control: a double blind, randomised crossover study. 1441-6 To determine the effect of adding salmeterol 50 micrograms twice daily for six months to current treatment in subjects with asthma who control their inhaled (...) corticosteroid dose according to a management plan. A double blind, randomised crossover study. Nottingham. 101 subjects with mild or moderate asthma taking at least 200 micrograms twice daily of beclomethasone dipropionate or budesonide. Salmeterol 50 micrograms twice daily and placebo for six months each, with a one month washout. Subjects adjusted inhaled steroid dose according to guidelines. Reduction in inhaled steroid use, exacerbations of asthma, and use of oral steroids. Data were available for 87

BMJ1997 Full Text: Link to full Text with Trip Pro

1197. Zafirlukast (Accolate) in asthma

Zafirlukast (Accolate) in asthma Zafirlukast (Accolate) in asthma Zafirlukast (Accolate) in asthma Booth-Clibborn N, Best L, Stevens A Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Booth-Clibborn N, Best L, Stevens A. Zafirlukast (Accolate) in asthma. Southampton: Wessex Institute for Health Research and Development (WIHRD) 1996 Authors (...) ' objectives The author evaluates whether zafirlukast should be offered to patients with mild to moderate asthma, who are currently treated at Step 2 of the British Thoracic Society guidelines, ie. prescribed bronchodilators and corticosteroids. Authors' conclusions The authors conclude that corticosteroids are likely to remain the major treatment for mild to moderate asthma patients for the near future. There is insufficient evidence of zafirlukast's effectiveness in long-term management and for routine

Health Technology Assessment (HTA) Database.1996

1198. Organisation of asthma care: what difference does it make. A systematic review of the literature

Organisation of asthma care: what difference does it make. A systematic review of the literature Organisation of asthma care: what difference does it make. A systematic review of the literature Organisation of asthma care: what difference does it make. A systematic review of the literature Eastwood A J, Sheldon T A Authors' objectives To evaluate the effectiveness of different forms of delivery of asthma care. Searching MEDLINE was searched from 1976 to the first quarter of 1995 using (...) the search terms provided in the Appendix. CINAHL, HELMIS, Manchester Primary and Secondary Care Interface, Health Planning and Administration, and DHSS databases were also searched. Additional material was located by examining relevant citations from identified articles, and by contacting members of the National Asthma Guidelines working party. Study selection Study designs of evaluations included in the review The review included all type of studies assessing organisational methods of asthma management

DARE.1996

1199. Meta-analysis of the effects of psychoeducational care in adults with asthma

Meta-analysis of the effects of psychoeducational care in adults with asthma Meta-analysis of the effects of psychoeducational care in adults with asthma Meta-analysis of the effects of psychoeducational care in adults with asthma Devine E C Authors' objectives To carry out a meta-analysis of relevant intervention studies examining the treatment effects of psychoeducational care in adults with asthma. Searching CINAHL, MEDLINE, Dissertation Abstracts International and PsycLIT searched using (...) the following keywords: 'asthma', 'patient/client education', 'counselling', 'behavioural therapy', 'pulmonary rehabilitation' and 'relaxation therapy'. Additional material was identified by examining conference proceedings from relevant conferences, dissertations obtained graduate programmes in nursing and from University Microfilms International, and the reference lists of relevant studies and reviews. Study selection Study designs of evaluations included in the review Experimental, quasi-experimental

DARE.1996

1200. Impact of inhaled corticosteroids on acute asthma hospitalization in Sweden

Impact of inhaled corticosteroids on acute asthma hospitalization in Sweden Impact of inhaled corticosteroids on acute asthma hospitalization in Sweden Impact of inhaled corticosteroids on acute asthma hospitalization in Sweden Gerdtham U G, Hertzman P, Jonsson B, Boman G Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed (...) critical assessment on the reliability of the study and the conclusions drawn. Health technology Inhaled corticosteroids in the treatment of asthmatic patients. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population Swedish inhabitants. Setting Clinic. The economic study was carried out in Sweden. Dates to which data relate The effectiveness and resource utilisation data were collected between 1978 and 1991 (except for 1984 in-patient care data which were

NHS Economic Evaluation Database.1996