Latest & greatest articles for asthma

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Top results for asthma

61. Randomized Trial of Dexamethasone Versus Prednisone for Children with Acute Asthma Exacerbations

Randomized Trial of Dexamethasone Versus Prednisone for Children with Acute Asthma Exacerbations 29173304 2017 12 11 2017 12 11 1097-6833 191 2017 Dec The Journal of pediatrics J. Pediatr. Randomized Trial of Dexamethasone Versus Prednisone for Children with Acute Asthma Exacerbations. 190-196.e1 S0022-3476(17)31090-9 10.1016/j.jpeds.2017.08.030 To determine whether 2 doses of dexamethasone is as effective as 5 days of prednisolone/prednisone therapy in improving symptoms and quality (...) of life of children with asthma exacerbations admitted to the emergency department (ED). We conducted a randomized, noninferiority trial including patients aged 1-14 years who presented to the ED with acute asthma to compare the efficacy of 2 doses of dexamethasone (0.6 mg/kg/dose, experimental treatment) vs a 5-day course of prednisolone/prednisone (1.5 mg/kg/d, followed by 1 mg/kg/d on days 2-5, conventional treatment). Two follow-up telephone interviews were completed at 7 and 15 days. The primary outcome

EvidenceUpdates2018

62. Effect of the School-Based Telemedicine Enhanced Asthma Management (SB-TEAM) Program on Asthma Morbidity: A Randomized Clinical Trial

Effect of the School-Based Telemedicine Enhanced Asthma Management (SB-TEAM) Program on Asthma Morbidity: A Randomized Clinical Trial 29309483 2018 02 07 2168-6211 2018 Jan 08 JAMA pediatrics JAMA Pediatr Effect of the School-Based Telemedicine Enhanced Asthma Management (SB-TEAM) Program on Asthma Morbidity: A Randomized Clinical Trial. e174938 10.1001/jamapediatrics.2017.4938 Poor adherence to recommended preventive asthma medications is common, leading to preventable morbidity. We developed (...) the School-Based Telemedicine Enhanced Asthma Management (SB-TEAM) program to build on school-based supervised therapy programs by incorporating telemedicine at school to overcome barriers to preventive asthma care. To evaluate the effect of the SB-TEAM program on asthma morbidity among urban children with persistent asthma. In this randomized clinical trial, children with persistent asthma aged 3 to 10 years in the Rochester City School District in Rochester, New York, were stratified by preventive

EvidenceUpdates2018

63. Effect of an Intervention to Promote Breastfeeding on Asthma, Lung Function, and Atopic Eczema at Age 16 Years: Follow-up of the PROBIT Randomized Trial

Effect of an Intervention to Promote Breastfeeding on Asthma, Lung Function, and Atopic Eczema at Age 16 Years: Follow-up of the PROBIT Randomized Trial 29131887 2018 01 03 2168-6211 172 1 2018 Jan 02 JAMA pediatrics JAMA Pediatr Effect of an Intervention to Promote Breastfeeding on Asthma, Lung Function, and Atopic Eczema at Age 16 Years: Follow-up of the PROBIT Randomized Trial. e174064 10.1001/jamapediatrics.2017.4064 Atopic diseases, including asthma and atopic eczema, are the most common (...) chronic conditions of childhood. To investigate whether an intervention to promote prolonged and exclusive breastfeeding protects against asthma, atopic eczema, and low lung function in adolescence. Follow-up of the Promotion of Breastfeeding Intervention Trial (PROBIT), a cluster randomized trial in 30 Belarusian maternity hospitals and affiliated polyclinics; recruitment of 17 046 healthy term infants took place from June 15, 1996, to December 31, 1997. Data analysis was conducted from May 9, 2016

EvidenceUpdates2018

64. Benralizumab (Fasenra) - For add-on maintenance treatment of patients with severe asthma aged 12 years and older, and with an eosinophilic phenotype

Benralizumab (Fasenra) - For add-on maintenance treatment of patients with severe asthma aged 12 years and older, and with an eosinophilic phenotype Fasenra (benralizumab) 30 mg/mL Injection U.S. Department of Health and Human Services Search FDA Submit search Fasenra (benralizumab) 30 mg/mL Injection Fasenra Company: AstraZeneca Pharmaceuticals LP Application No.: 761070 Approval Date: 11/14/2017 Persons with disabilities having problems accessing the PDF files below may call (301) 796-3634

FDA - Drug Approval Package2018

65. Omalizumab (Xolair) PBS listed for use in children with asthma

Omalizumab (Xolair) PBS listed for use in children with asthma Omalizumab (Xolair) PBS listed for use in children with asthma | RADAR 20 Years Of Helping Australians Make Better Decisions About Medicines, Medical Tests And Other Health Technologies. Log in Facebook Twitter LinkedIn Google Signing you in Use another account OR Login Form Email Password Log in to NPS MedicineWise Don't have an account? Forgot password Forgot password Email Send reset instructions Set new password Reset Password (...) the and accept the Subscribe Breadcrumbs Omalizumab (Xolair) PBS listed for use in children with asthma Article Sections Omalizumab (Xolair) PBS listed for use in children with asthma 12 Jan 2017 3 min read Share Share to: Print Larger text Smaller text Omalizumab is a last-line therapy. a. omalizumab 150 mg/mL injection, 1 mL syringe (Xolair) omalizumab 75 mg/0.5 mL injection, 0.5 mL syringe (Xolair) Omalizumab for asthma Omalizumab is a recombinant, DNA-derived, monoclonal anti-immunoglobulin E antibody

National Prescribing Service Limited (Australia)2018

66. Association Between Inhaled Corticosteroid Use and Bone Fracture in Children With Asthma

Association Between Inhaled Corticosteroid Use and Bone Fracture in Children With Asthma 29131874 2018 01 03 2168-6211 172 1 2018 Jan 01 JAMA pediatrics JAMA Pediatr Association Between Inhaled Corticosteroid Use and Bone Fracture in Children With Asthma. 57-64 10.1001/jamapediatrics.2017.3579 Daily use of inhaled corticosteroids is a widely recommended treatment for mild persistent asthma in children. There is concern that, similar to systemic corticosteroids, inhaled corticosteroids may have (...) adverse effects on bone health. To determine whether there is an increased risk of bone fracture associated with inhaled corticosteroid use in children with asthma. In this population-based nested case-control study, we used health administrative databases to identify a cohort of children aged 2 to 18 years with a physician diagnosis of asthma between April 1, 2003, and March 31, 2014, who were eligible for public drug coverage through the Ontario Drug Benefit Program (Ontario, Canada). We matched

EvidenceUpdates2018

67. The Clinical Utility of Fractional Exhaled Nitric Oxide (FeNO) in Asthma Management

The Clinical Utility of Fractional Exhaled Nitric Oxide (FeNO) in Asthma Management Comparative Effectiveness Review Number 197 The Clinical Utility of Fractional Exhaled Nitric Oxide (FeNO) in Asthma Management Evidence Summary Objectives and Rationale for the Review This report summarizes a systematic review on “The Clinical Utility of Fractional Exhaled Nitric Oxide in Asthma Management”. This was one of the 6 high priority topics within asthma identified by an NHLBI Advisory Council Asthma (...) Expert Working group. 1 Background The diagnosis of asthma is a clinical diagnosis and is challenging without a criterion standard test. Fractional exhaled nitric oxide (FeNO) testing has been suggested as a diagnostic test for asthma. It has also been studied as a tool that aids in selecting asthma treatments, predicting response to therapy (e.g., inhaled corticosteroids) and for monitoring the response to therapy. In young children with recurrent wheezing, FeNO may predict the ones who are likely

Effective Health Care Program (AHRQ)2018

68. Asthma in children

Asthma in children Asthma in children - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Asthma in children Last reviewed: August 2018 Last updated: July 2018 Summary As paediatric asthma differs from adult asthma, child-specific asthma guidelines should be used and adult and adolescent guidelines should not be extrapolated to younger age groups. The prevalence of childhood asthma appears to have plateaued in many (...) affluent countries. However, asthma remains a significant cause of childhood morbidity and mortality, and is still a common problem managed in ambulatory and emergency care settings. Most children with asthma have mild intermittent asthma and do not require daily therapy. Minimum doses and medications for maximal control should be used in those who require preventative therapies. Therapy should be individualised. A number of important differential diagnoses, adherence and environmental issues should

BMJ Best Practice2018

69. Occupational asthma

Occupational asthma Occupational asthma - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Occupational asthma Last reviewed: August 2018 Last updated: September 2018 Summary Should be suspected in all adult patients with asthma. An occupational history should be taken to identify work-related causes. Details of work exposures should be obtained from material safety data sheets and other material available (...) to the patient from their workplace. Objective evidence of asthma should be obtained from spirometry, a bronchodilator response, and/or a methacholine challenge. Tests should be performed when the patient is symptomatic and/or within days of having exposure to a suspected aetiological agent. If sensitiser-induced occupational asthma is suspected, additional testing of asthma should be done, preferably while the patient is still working. Whenever possible an immunological response to a suspected work

BMJ Best Practice2018

70. Acute asthma exacerbation in children

Acute asthma exacerbation in children Acute asthma exacerbation in children - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Acute asthma exacerbation in children Last reviewed: August 2018 Last updated: July 2018 Summary Asthma exacerbations present with acute or sub-acute onset of wheeze and respiratory distress, the symptoms and signs of which vary depending on the developmental and maturational age of the child (...) , intravenous bronchodilators, and intramuscular adrenaline (if anaphylaxis is present). Severe and life-threatening cases may require non-invasive ventilation or intubation, and the intensive care team should be involved as early as possible. In children not responding to standard asthmatic treatment, other differential diagnoses should be considered. On discharge from hospital, a clear asthma management plan and asthma education is essential to optimise asthma control and prevent future exacerbations

BMJ Best Practice2018

71. Acute asthma exacerbation in adults

Acute asthma exacerbation in adults Acute asthma exacerbation in adults - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Acute asthma exacerbation in adults Last reviewed: August 2018 Last updated: June 2018 Summary Presents as an acute or subacute episode of progressive worsening of symptoms, such as shortness of breath, wheezing, cough, and chest tightness. Pulse rate, respiratory rate, subjective assessment (...) , mechanical ventilation. Pneumonia, pneumothorax, pneumomediastinum, and respiratory failure are complications. Definition An asthma exacerbation is an acute or subacute episode of progressive worsening of symptoms of asthma, including shortness of breath, wheezing, cough, and chest tightness. Exacerbations are marked by decreases from baseline in objective measures of pulmonary function, such as peak expiratory flow rate and FEV1. History and exam presence of risk factors cough wheezing

BMJ Best Practice2018

72. Asthma in adults

Asthma in adults Asthma in adults - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Asthma in adults Last reviewed: August 2018 Last updated: June 2018 Summary Patients present with recurrent episodes of shortness of breath, chest tightness, wheezing, or coughing. Examination typically demonstrates an expiratory wheeze; however, in severe asthma there is poor air entry and the chest is silent. Treatment is step-wise (...) , based on symptoms. Patients may need to monitor their peak expiratory flow daily and should be aware of the warning signs of a severe attack. Some patients may develop progressive, irreversible obstructive lung disease. Definition Asthma is a chronic inflammatory airway disease characterised by intermittent airway obstruction and hyper-reactivity. Many cellular components are involved in the asthmatic pathway, including mast cells, eosinophils, T lymphocytes, macrophages, neutrophils, and epithelial

BMJ Best Practice2018

73. Breaking through Restricting Bottleneck for Better Asthma Control

Breaking through Restricting Bottleneck for Better Asthma Control JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE / OCT-DEC 2017 / VOL 5 | ISSUE 4 192 Address for Correspondence: Dr. Huahao Shen and Songmin Ying, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, Institute of Respiratory Diseases, Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, China. Email: huahaoshen@zju.edu.cn (Huahao Shen); yings@zju.edu.cn (Songmin Ying) Access (...) this article online Website: www.intern-med.com DOI: 10.1515/jtim-2017-0032 Quick Response Code: Commentary Breaking through restricting bottleneck for better asthma control Ding Zhu, Chao Zhang, Huahao Shen, Songmin Ying Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, Institute of Respiratory Diseases, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China Asthma is characterized by chronic bronchial inflammation, airway hyperresponsiveness induced

Journal of translational internal medicine2017 Full Text: Link to full Text with Trip Pro

74. Evaluation of anxiety and depression in mothers of children with asthma

Evaluation of anxiety and depression in mothers of children with asthma Electronic Physician (ISSN: 2008-5842) http://www.ephysician.ir December 2017, Volume: 9, Issue: 12, Pages: 6058-6062, DOI: http://dx.doi.org/10.19082/6058 Corresponding author: Assistant Professor Dr. Elahe Heidari, Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Tel: +98.9155574738, Email: heidarie@mums.ac.ir Received: March 08, 2017, Accepted: August 04, 2017 (...) of children with asthma Fatemeh Behmanesh 1 , Fatemeh Moharreri 2 , Atefeh Soltanifar 2 , Mahdis Hamzeh 3 , Elahe Heidari 4 1 MD., Associate Professor, Allergy Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran 2 Associate Professor, Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran 3 MD., Psychiatrist, Mashhad, Iran 4 MD., Assistant Professor, Department of Pediatrics, Faculty of Medicine, Mashhad University

Electronic physician2017 Full Text: Link to full Text with Trip Pro

75. Asthma.

Asthma. Asthma-one of the most common chronic, non-communicable diseases in children and adults-is characterised by variable respiratory symptoms and variable airflow limitation. Asthma is a consequence of complex gene-environment interactions, with heterogeneity in clinical presentation and the type and intensity of airway inflammation and remodelling. The goal of asthma treatment is to achieve good asthma control-ie, to minimise symptom burden and risk of exacerbations. Anti-inflammatory (...) and bronchodilator treatments are the mainstay of asthma therapy and are used in a stepwise approach. Pharmacological treatment is based on a cycle of assessment and re-evaluation of symptom control, risk factors, comorbidities, side-effects, and patient satisfaction by means of shared decisions. Asthma is classed as severe when requiring high-intensity treatment to keep it under control, or if it remains uncontrolled despite treatment. New biological therapies for treatment of severe asthma, together

Lancet2017

76. Stormy weather: a retrospective analysis of demand for emergency medical services during epidemic thunderstorm asthma.

Stormy weather: a retrospective analysis of demand for emergency medical services during epidemic thunderstorm asthma. OBJECTIVES: To describe the demand for emergency medical assistance during the largest outbreak of thunderstorm asthma reported globally, which occurred on 21 November 2016. DESIGN: A time series analysis was conducted of emergency medical service caseload between 1 January 2015 and 31 December 2016. Demand during the thunderstorm asthma event was compared to historical trends (...) by paramedics as having acute respiratory distress on 21 November, compared with a daily average of 52 during the historical period. After adjustment for temporal trends, thunderstorm asthma was associated with a 42% (95% confidence interval 40% to 44%) increase in overall caseload for the emergency medical service and a 432% increase in emergency medical attendances for acute respiratory distress symptoms. Emergency transports to hospital increased by 17% (16% to 19%) and time critical referrals from

BMJ2017 Full Text: Link to full Text with Trip Pro

77. Breathing training for dysfunctional breathing in asthma: taking a multidimensional approach

Breathing training for dysfunctional breathing in asthma: taking a multidimensional approach Breathing training for dysfunctional breathing in asthma: taking a multidimensional approach Rosalba Courtney Affiliation: School of Health Science, Southern Cross University, Lismore, Australia. Correspondence: Rosalba Courtney, School of Health Science, Southern Cross University, 11 Binburra Avenue, Avalon, NSW 2107, Australia. E-mail: courtney2107@optusnet.com.au ABSTRACT Various breathing training (...) programmes may be helpful for adults with asthma. The main therapeutic aim for many of these programmes is the correction of dysfunctional breathing. Dysfunctional breathing can be viewed practically as a multidimensional entity with the three key dimensions being biochemical, biomechanical and psychophysiological. The objectives of this review are to explore how each of these dimensions might impact on asthma sufferers, to review how various breathing therapy protocols target these dimensions

ERJ open research2017 Full Text: Link to full Text with Trip Pro

79. Effectiveness and Safety of Bronchial Thermoplasty in Management of Asthma

Effectiveness and Safety of Bronchial Thermoplasty in Management of Asthma Comparative Effectiveness Review Number 202 Effectiveness and Safety of Bronchial Thermoplasty in Management of Asthma eComparative Effectiveness Review Number 202 Effectiveness and Safety of Bronchial Thermoplasty in Management of Asthma Prepared for: Agency for Healthcare Research and Quality U.S. Department of Health and Human Services 5600 Fishers Lane Rockville, MD 20857 www.ahrq.gov Contract No. 290-2015-00005-I (...) and safety of bronchial thermoplasty (BT), a procedure that uses heat to remove muscle tissue from the airways of adults with moderate to severe asthma. BT is usually given as three treatments 3 weeks apart. Key Messages • BT along with standard medical management, compared to medical management alone, may improve asthma control and quality of life, but evidence is insufficient to determine impact on asthma exacerbations. • BT along with standard medical management, compared to a similar procedure

Effective Health Care Program (AHRQ)2017

80. International Variation in Asthma and Bronchiolitis Guidelines

International Variation in Asthma and Bronchiolitis Guidelines 29070533 2017 11 13 2017 11 13 1098-4275 140 5 2017 Nov Pediatrics Pediatrics International Variation in Asthma and Bronchiolitis Guidelines. e20170092 10.1542/peds.2017-0092 Guideline recommendations for the same clinical condition may vary. The purpose of this study was to determine the degree of agreement among comparable asthma and bronchiolitis treatment recommendations from guidelines. National and international guidelines (...) 7 guidelines for asthma and 4 guidelines for bronchiolitis. For asthma, there were 166 recommendation topics, with 69 recommendation topics given in ≥2 guidelines. For bronchiolitis, there were 46 recommendation topics, with 21 recommendation topics provided in ≥2 guidelines. The overall κ for asthma was 0.03, both unweighted (95% confidence interval [CI]: -0.01 to 0.07) and weighted (95% CI: -0.01 to 0.10); for bronchiolitis, it was 0.32 unweighted (95% CI: 0.16 to 0.52) and 0.15 weighted (95

EvidenceUpdates2017