Latest & greatest articles for asthma

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Top results for asthma

203. Exhaled nitric oxide levels to guide treatment for adults with asthma.

Exhaled nitric oxide levels to guide treatment for adults with asthma. BACKGROUND: Asthma guidelines aim to guide health practitioners to optimise treatment for patients so as to minimise symptoms, improve or maintain good lung function, and prevent acute exacerbations or flare-ups. The principle of asthma guidelines is based on a step-up or step-down regimen of asthma medications to maximise good health outcomes using minimum medications. Asthma maintenance therapies reduce airway inflammation (...) that is usually eosinophilic. Tailoring asthma medications in accordance with airway eosinophilic levels may improve asthma outcomes such as indices of control or reduce exacerbations or both. Fractional exhaled nitric oxide (FeNO) is a marker of eosinophilic inflammation, and as it is easy to measure, has an advantage over other measurements of eosinophilic inflammation (for example sputum eosinophils). OBJECTIVES: To evaluate the efficacy of tailoring asthma interventions based on exhaled nitric oxide (FeNO

Cochrane2016

204. Vilanterol and fluticasone furoate for asthma.

Vilanterol and fluticasone furoate for asthma. BACKGROUND: Vilanterol (VI) is a long-acting beta 2 -agonist (LABA) that binds to the beta 2 -adrenoceptor on the airway smooth muscle, producing bronchodilation. LABA therapy, which is well established in adults as part of the British Thoracic Society (BTS) Guidelines for the Management of Asthma, leads to improvement in symptoms and lung function and reduction in exacerbations. At present, the commonly used LABAs licensed for use in asthma (...) management (formoterol and salmeterol) require twice-daily administration, whereas VI is a once-daily therapy.Fluticasone furoate (FF) is an inhaled corticosteroid (ICS), and ICS therapy is recommended by the BTS asthma guidelines. ICSs, the mainstay of asthma treatment, lead to a reduction in both airway inflammation and airway hyper-responsiveness. Regular use leads to improvement in symptoms and lung function. ICSs are currently recommended as 'preventer' therapy for patients who use a 'reliever

Cochrane2016

205. “Management of the patient with eosinophilic asthma: a new era begins” Jantina C. de Groot, Anneke ten Brinke and Elisabeth H.D. Bel. ERJ Open Res 2015; 1: 00024-2016.

“Management of the patient with eosinophilic asthma: a new era begins” Jantina C. de Groot, Anneke ten Brinke and Elisabeth H.D. Bel. ERJ Open Res 2015; 1: 00024-2016. 27808286 2017 08 16 2312-0541 2 3 2016 Jul ERJ open research ERJ Open Res Erratum: "Management of the patient with eosinophilic asthma: a new era begins" Jantina C. de Groot, Anneke ten Brinke and Elisabeth H.D. Bel. ERJ Open Res 2015; 1: 00024-2016. 00024-2015-ERR [This corrects the article DOI: 10.1183/23120541.00024-2015

ERJ open research2016 Full Text: Link to full Text with Trip Pro

206. Acetaminophen and Asthma - A Small Sigh of Relief?

Acetaminophen and Asthma - A Small Sigh of Relief? Acetaminophen and Asthma--A Small Sigh of Relief? - PubMed - NCBI Warning: The NCBI web site requires JavaScript to function. Search database Search term Search Result Filters Format Summary Summary (text) Abstract Abstract (text) MEDLINE XML PMID List Apply Choose Destination File Clipboard Collections E-mail Order My Bibliography Citation manager Format Create File 1 selected item: 27532835 Format MeSH and Other Data E-mail Subject Additional (...) text E-mail Add to Clipboard Add to Collections Order articles Add to My Bibliography Generate a file for use with external citation management software. Create File 2016 Aug 18;375(7):684-5. doi: 10.1056/NEJMe1607629. Acetaminophen and Asthma--A Small Sigh of Relief? 1 . 1 From the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School - both in Boston. Comment on [N Engl J Med. 2016] PMID: 27532835 DOI: [Indexed for MEDLINE] Free

NEJM2016

207. Decline in Lung Function in Childhood Asthma.

Decline in Lung Function in Childhood Asthma. Decline in Lung Function in Childhood Asthma. - PubMed - NCBI Warning: The NCBI web site requires JavaScript to function. Search database Search term Search Result Filters Format Summary Summary (text) Abstract Abstract (text) MEDLINE XML PMID List Apply Choose Destination File Clipboard Collections E-mail Order My Bibliography Citation manager Format Create File 1 selected item: 27532852 Format MeSH and Other Data E-mail Subject Additional text E (...) -mail Add to Clipboard Add to Collections Order articles Add to My Bibliography Generate a file for use with external citation management software. Create File 2016 Aug 18;375(7):e13. doi: 10.1056/NEJMc1608228. Decline in Lung Function in Childhood Asthma. , . Comment on [N Engl J Med. 2016] [N Engl J Med. 2016] [N Engl J Med. 2016] PMID: 27532852 DOI: [Indexed for MEDLINE] Free full text Publication types MeSH terms Substance Full Text Sources Medical PubMed Commons 0 comments How to cite

NEJM2016

208. Decline in Lung Function in Childhood Asthma.

Decline in Lung Function in Childhood Asthma. Decline in Lung Function in Childhood Asthma. - PubMed - NCBI Warning: The NCBI web site requires JavaScript to function. Search database Search term Search Result Filters Format Summary Summary (text) Abstract Abstract (text) MEDLINE XML PMID List Apply Choose Destination File Clipboard Collections E-mail Order My Bibliography Citation manager Format Create File 1 selected item: 27532853 Format MeSH and Other Data E-mail Subject Additional text E (...) -mail Add to Clipboard Add to Collections Order articles Add to My Bibliography Generate a file for use with external citation management software. Create File 2016 Aug 18;375(7):e13. doi: 10.1056/NEJMc1608228#SA1. Decline in Lung Function in Childhood Asthma. 1 , 2 , 2 . 1 Nepean Hospital, Sydney, NSW, Australia. 2 University of Sydney, Sydney, NSW, Australia. Comment in [N Engl J Med. 2016] Comment on [N Engl J Med. 2016] PMID: 27532853 DOI: [Indexed for MEDLINE] Publication types MeSH terms

NEJM2016 Full Text: Link to full Text with Trip Pro

209. Decline in Lung Function in Childhood Asthma.

Decline in Lung Function in Childhood Asthma. Decline in Lung Function in Childhood Asthma. - PubMed - NCBI Warning: The NCBI web site requires JavaScript to function. Search database Search term Search Result Filters Format Summary Summary (text) Abstract Abstract (text) MEDLINE XML PMID List Apply Choose Destination File Clipboard Collections E-mail Order My Bibliography Citation manager Format Create File 1 selected item: 27532854 Format MeSH and Other Data E-mail Subject Additional text E (...) -mail Add to Clipboard Add to Collections Order articles Add to My Bibliography Generate a file for use with external citation management software. Create File 2016 Aug 18;375(7):e13. doi: 10.1056/NEJMc1608228#SA2. Decline in Lung Function in Childhood Asthma. 1 , 1 , 1 . 1 University of Trieste, Trieste, Italy. Comment in [N Engl J Med. 2016] Comment on [N Engl J Med. 2016] PMID: 27532854 DOI: [Indexed for MEDLINE] Publication types MeSH terms Substance Full Text Sources Medical PubMed Commons 0

NEJM2016 Full Text: Link to full Text with Trip Pro

210. Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma.

Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma. BACKGROUND: Studies have suggested an association between frequent acetaminophen use and asthma-related complications among children, leading some physicians to recommend that acetaminophen be avoided in children with asthma; however, appropriately designed trials evaluating this association in children are lacking. METHODS: In a multicenter, prospective, randomized, double-blind, parallel-group trial, we enrolled 300 (...) children (age range, 12 to 59 months) with mild persistent asthma and assigned them to receive either acetaminophen or ibuprofen when needed for the alleviation of fever or pain over the course of 48 weeks. The primary outcome was the number of asthma exacerbations that led to treatment with systemic glucocorticoids. Children in both groups received standardized asthma-controller therapies that were used in a simultaneous, factorially linked trial. RESULTS: Participants received a median of 5.5 doses

NEJM2016

211. Early origins of asthma (and allergy)

Early origins of asthma (and allergy) 27510897 2016 08 11 2018 11 13 2194-7791 3 1 2016 Dec Molecular and cellular pediatrics Mol Cell Pediatr Early origins of asthma (and allergy). 31 10.1186/s40348-016-0056-4 Asthma is the most common chronic disease starting in childhood and persisting into adulthood in many cases. During childhood, different forms of asthma and wheezing disorders exist that can be discriminated by the mechanisms they are caused by. Specific genetic constellations (...) and exposure against environmental factors during early childhood and in utero play a decisive role in the early development of the disease. Epigenetic mechanisms which are master regulators of gene transcription and thus govern the accessibility and use of genome information, have recently been identified as a "third power" determining many features in the early development of asthma and allergy. Kabesch Michael M http://orcid.org/0000-0003-0697-1871 Department of Pediatric Pneumology and Allergy

Molecular and cellular pediatrics2016 Full Text: Link to full Text with Trip Pro

212. Innate Immunity in Asthma.

Innate Immunity in Asthma. Innate Immunity in Asthma. - PubMed - NCBI Warning: The NCBI web site requires JavaScript to function. Search database Search term Search Result Filters Format Summary Summary (text) Abstract Abstract (text) MEDLINE XML PMID List Apply Choose Destination File Clipboard Collections E-mail Order My Bibliography Citation manager Format Create File 1 selected item: 27518667 Format MeSH and Other Data E-mail Subject Additional text E-mail Add to Clipboard Add (...) to Collections Order articles Add to My Bibliography Generate a file for use with external citation management software. Create File 2016 Aug 4;375(5):477-9. doi: 10.1056/NEJMe1607438. Innate Immunity in Asthma. 1 . 1 From the Division of Immunology, Boston Children's Hospital, and the Department of Pediatrics, Harvard Medical School, Boston. Comment on [N Engl J Med. 2016] PMID: 27518667 PMCID: DOI: [Indexed for MEDLINE] Images from this publication. Figure 1 Farming Lifestyle, the Activation of Innate

NEJM2016

213. Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children.

Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children. BACKGROUND: The Amish and Hutterites are U.S. agricultural populations whose lifestyles are remarkably similar in many respects but whose farming practices, in particular, are distinct; the former follow traditional farming practices whereas the latter use industrialized farming practices. The populations also show striking disparities in the prevalence of asthma, and little is known about the immune responses underlying (...) were assessed in a murine model of experimental allergic asthma. RESULTS: Despite the similar genetic ancestries and lifestyles of Amish and Hutterite children, the prevalence of asthma and allergic sensitization was 4 and 6 times as low in the Amish, whereas median endotoxin levels in Amish house dust was 6.8 times as high. Differences in microbial composition were also observed in dust samples from Amish and Hutterite homes. Profound differences in the proportions, phenotypes, and functions

NEJM2016

214. Maternal smoking in pregnancy and its influence on childhood asthma

Maternal smoking in pregnancy and its influence on childhood asthma 27730206 2018 11 13 2312-0541 2 3 2016 Jul ERJ open research ERJ Open Res Maternal smoking in pregnancy and its influence on childhood asthma. 00042-2016 Maternal smoking in pregnancy (MSP) is a large modifiable risk factor for pregnancy related mortality and morbidity and also the most important known modifiable risk factor for asthma. This review summarises the effects of MSP throughout infancy, childhood and adolescence (...) with regards to asthma (development and severity). Firstly, the direct damage caused by nicotine on fetal lung development, fetal growth and neuronal differentiation is discussed, as well as the indirect effects of nicotine on placental functioning. Secondly, the effects of MSP on later immune functioning resulting in increased infection rate are summarised and details are given on the effects of MSP modulating airway hyperreactivity, reducing lung function and therefore increasing asthma morbidity

ERJ open research2016 Full Text: Link to full Text with Trip Pro

215. A multidisciplinary team case management approach reduces the burden of frequent asthma admissions

A multidisciplinary team case management approach reduces the burden of frequent asthma admissions 27730207 2018 11 13 2312-0541 2 3 2016 Jul ERJ open research ERJ Open Res A multidisciplinary team case management approach reduces the burden of frequent asthma admissions. 00039-2016 Up to 10% of asthmatics have "difficult asthma"; however, they account for 80% of asthma-related expenditure and run the highest risk of acute severe exacerbations. An estimated 75% of admissions for asthma (...) are avoidable. Guidelines advise that these patients be managed by an experienced specialist multidisciplinary team (MDT). We aimed to assess the impact of a case management strategy delivered via specialist MDTs on acute healthcare utilisation of patients with frequent asthma admissions. An MDT (consultant, specialist nurse, physiotherapist and psychologist) case management strategy was introduced in 2010 at University Hospital Southampton Foundation Trust (Southampton, UK) to support patients

ERJ open research2016 Full Text: Link to full Text with Trip Pro

216. The puzzle of immune phenotypes of childhood asthma

The puzzle of immune phenotypes of childhood asthma 27468754 2016 07 29 2018 11 13 2194-7791 3 1 2016 Dec Molecular and cellular pediatrics Mol Cell Pediatr The puzzle of immune phenotypes of childhood asthma. 27 10.1186/s40348-016-0057-3 Asthma represents the most common chronic childhood disease worldwide. Whereas preschool children present with wheezing triggered by different factors (multitrigger and viral wheeze), clinical asthma manifestation in school children has previously been (...) classified as allergic and non-allergic asthma. For both, the underlying immunological mechanisms are not yet understood in depth in children. Treatment is still prescribed regardless of underlying mechanisms, and children are not always treated successfully. This review summarizes recent key findings on the complex mechanisms of the development and manifestation of childhood asthma. Whereas traditional classification of childhood asthma is primarily based on clinical symptoms like wheezing and atopy

Molecular and cellular pediatrics2016 Full Text: Link to full Text with Trip Pro

218. Risk of congenital anomalies after exposure to asthma medication in the first trimester of pregnancy - a cohort linkage study

Risk of congenital anomalies after exposure to asthma medication in the first trimester of pregnancy - a cohort linkage study 27172856 2016 08 17 2017 02 20 1471-0528 123 10 2016 Sep BJOG : an international journal of obstetrics and gynaecology BJOG Risk of congenital anomalies after exposure to asthma medication in the first trimester of pregnancy - a cohort linkage study. 1609-18 10.1111/1471-0528.14026 To examine the effect of maternal exposure to asthma medications on the risk of congenital (...) anomalies. Meta-analysis of aggregated data from three cohort studies. Linkage between healthcare databases and EUROCAT congenital anomaly registries. 519 242 pregnancies in Norway (2004-2010), Wales (2000-2010) and Funen, Denmark (2000-2010). Exposure defined as having at least one prescription for asthma medications issued (Wales) or dispensed (Norway, Denmark) from 91 days before to 91 days after the pregnancy start date. Odds ratios (ORs) were estimated separately for each register and combined

EvidenceUpdates2016

219. Severe angina pectoris in asthma attack: a case report

Severe angina pectoris in asthma attack: a case report 27504177 2016 08 09 2018 11 13 2008-5842 8 6 2016 Jun Electronic physician Electron Physician Severe angina pectoris in asthma attack: a case report. 2591-4 10.19082/2591 Asthma is a chronic inflammatory disorder of the airways related to the obstruction of reversible airflow. Asthma presents as recurrent attacks of cough and dyspnea. Poor control causes recurrent admissions to the ICU, and mortality is related to poor drug compliance (...) and follow-up. Angina pectoris is a syndrome of recurrent chest discomfort related to myocardial ischemia. The presence of these two disorders rarely has been reported. We reported a 12-year-old boy who was referred with exacerbation of asthma and developed angina pectoris during hospitalization. He had labored breathing and diffuse wheezing. During treatment of the asthma, the patient developed severe chest pain due to shunt formation and coronary hypoxia, caused by the sole administration of ventolin

Electronic physician2016 Full Text: Link to full Text with Trip Pro

220. The intersection between asthma and acute chest syndrome in children with sickle-cell anaemia.

The intersection between asthma and acute chest syndrome in children with sickle-cell anaemia. Acute chest syndrome is a frequent cause of acute lung disease in children with sickle-cell disease. Asthma is common in children with sickle-cell disease and is associated with increased incidence of vaso-occlusive pain events, acute chest syndrome episodes, and earlier death. Risk factors for asthma exacerbation and an acute chest syndrome episode are similar, and both can present (...) with shortness of breath, chest pain, cough, and wheezing. Despite overlapping risk factors and symptoms, an acute exacerbation of asthma or an episode of acute chest syndrome are two distinct entities that need disease-specific management strategies. Although understanding has increased about asthma as a comorbidity in sickle-cell disease and its effects on morbidity, substantial gaps remain in knowledge about best management. Copyright © 2016 Elsevier Ltd. All rights reserved.

Lancet2016