Latest & greatest articles for asthma

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Top results for asthma

1. Study shows no benefit of an antibiotic for acute asthma

Study shows no benefit of an antibiotic for acute asthma Signal - Study shows no benefit of an antibiotic for acute asthma Dissemination Centre Discover Portal NIHR DC Discover Study shows no benefit of an antibiotic for acute asthma Published on 21 December 2016 The antibiotic azithromycin did not reduce symptoms or change other outcomes in adults seeking emergency care for an acute asthma attack. However people not already taking antibiotics were hard to find and the trial failed to enrol (...) enough people to answer the research question. In this UK-based trial, people with asthma who received azithromycin on top of standard treatment with corticosteroids had no better symptoms ten days later than people who received corticosteroids alone. Almost half of almost 4,600 potential participants had already been given antibiotics. This study shows that many people are being prescribed antibiotics to treat an asthma attack despite British guidance stating that antibiotics should not be routinely

NIHR Dissemination Centre2018

2. The nitric oxide breath test offers little benefit when monitoring asthma

The nitric oxide breath test offers little benefit when monitoring asthma Signal - The nitric oxide breath test offers little benefit when monitoring asthma Dissemination Centre Discover Portal NIHR DC Discover The nitric oxide breath test offers little benefit when monitoring asthma Published on 10 January 2017 Using exhaled nitric oxide levels to guide the dose of asthma medication at regular clinic visits may reduce flare-ups but does not improve overall symptoms or quality (...) of life. In this review hospitalisations and the total inhaled steroid doses were unaffected by the intervention. Measuring the amount of fractional exhaled nitric oxide (FeNO) in the breath of people with asthma detects lung inflammation. If inflammation increases, this may indicate that a flare-up is likely and preventative action can be taken. The aim is to ensure medication corresponds to symptom severity, the ideal being the minimum dose needed to control symptoms. The usual monitoring strategy consists

NIHR Dissemination Centre2018

3. GP letter to improve medication adherence did not reduce unplanned care for children with asthma

GP letter to improve medication adherence did not reduce unplanned care for children with asthma Signal - GP letter to improve medication adherence did not reduce unplanned care for children with asthma Dissemination Centre Discover Portal NIHR DC Discover GP letter to improve medication adherence did not reduce unplanned care for children with asthma Published on 14 March 2017 A one-off GP letter reminding parents of children with asthma to use their medications over the August summer holiday (...) did not prevent a characteristic annual peak in unplanned care on returning to school in September, but did lead to more prescriptions. Unplanned care represents visits to the GP or accident and emergency that is not part of the child’s asthma care plan. They do not include scheduled medical review or visits for repeat prescriptions. The letter prompted about a third more parents to collect inhaler prescriptions in August than parents receiving no letter. But this failed to reduce the high

NIHR Dissemination Centre2018

4. Combination inhaler treatment in emergency departments may reduce admissions for asthma attacks

Combination inhaler treatment in emergency departments may reduce admissions for asthma attacks Signal - Combination inhaler treatment in emergency departments may reduce admissions for asthma attacks Dissemination Centre Discover Portal NIHR DC Discover Combination inhaler treatment in emergency departments may reduce admissions for asthma attacks Published on 30 May 2017 Using a combination of two inhaled drugs to open the airways may modestly reduce the need to admit an adult with asthma (...) attack to hospital, though the underlying evidence is weak. The first-line treatment for an asthma attack is an inhaled β2 agonist, like salbutamol. This Cochrane review compared emergency department treatment with this drug alone, or combined with an inhaled short-acting anticholinergic, like ipratropium bromide. Pooled results from 16 trials included found that combination therapy would mean about 65 fewer patients per 1000 are admitted to hospital. As most underlying trials were conducted outside

NIHR Dissemination Centre2018

5. Asthma self-management programmes can reduce unscheduled care

Asthma self-management programmes can reduce unscheduled care Signal - Asthma self-management programmes can reduce unscheduled care Dissemination Centre Discover Portal NIHR DC Discover Asthma self-management programmes can reduce unscheduled care Published on 20 June 2017 People with asthma who receive supported self-management are less likely to attend A&E or be admitted to hospital. The interventions are unlikely to increase overall costs for healthcare services. Those who self-manage (...) are also likely to have more controlled asthma and a better quality of life. This extensive overview of systematic reviews included evidence from 270 randomised controlled trials exploring the effects of asthma self-management on healthcare utilisation and costs. Self-management programmes were slightly more expensive, but this cost was likely to be offset by reducing unplanned medical visits and improving patient quality of life. Trials covered different self-care education programmes delivered

NIHR Dissemination Centre2018

6. Breathing exercises improve asthma and can be learned by DVD

Breathing exercises improve asthma and can be learned by DVD Signal - Breathing exercises improve asthma and can be learned by DVD Dissemination Centre Discover Portal NIHR DC Discover Breathing exercises improve asthma and can be learned by DVD Published on 7 November 2017 Breathing exercises taught by a physiotherapist in person or on DVD both improved the quality of life of adults with poorly controlled asthma to a small but similar extent. The DVD was the cheapest option, and it could lead (...) to inexpensive internet delivery in the future. This NIHR-funded trial recruited 655 UK adults with poorly controlled asthma. It showed about 63% of those receiving the breathing exercises had clinically important improvements in their asthma-related quality of life over a year, compared to 56% who improved receiving usual care. Exercises did not improve formally measured lung function, suggesting the underlying biology of the asthma was unchanged. The findings imply that breathing exercise programmes

NIHR Dissemination Centre2018

7. Intermittent inhaled steroids reduce asthma attacks in wheezing preschool children

Intermittent inhaled steroids reduce asthma attacks in wheezing preschool children Signal - Intermittent inhaled steroids reduce asthma attacks in wheezing preschool children Dissemination Centre Discover Portal NIHR DC Discover Intermittent inhaled steroids reduce asthma attacks in wheezing preschool children Published on 22 November 2016 Regular daily steroid inhalers reduce the number of severe asthma exacerbations requiring soluble tablets or injections in wheezing preschool children (...) by about a third. Intermittent high-dose steroid inhalers, given only when symptoms of a cold begin, were also effective for children with occasional asthma or wheezing triggered by a virus. This strategy may reduce the overall dose of steroids given to these children, though adverse effects may still occur. Wheezing is initially treated with a β2 agonist inhaler which opens up the airways. UK guidelines recommend adding in a daily low-dose steroid inhaler if symptoms are persistent, which

NIHR Dissemination Centre2018

8. Vitamin D supplements can reduce risk of asthma attacks

Vitamin D supplements can reduce risk of asthma attacks Signal - Vitamin D supplements can reduce risk of asthma attacks Dissemination Centre Discover Portal NIHR DC Discover Vitamin D supplements can reduce risk of asthma attacks Published on 6 December 2016 People with mild to moderate asthma experience fewer severe asthma attacks if they take vitamin D supplements. This review found that the average number of asthma attacks was equivalent to about one every four years in those taking vitamin (...) D, compared to nearly one every two years in those taking a placebo. Half as many people attended hospital for asthma treatment each year when taking vitamin D (3%) compared with those not taking vitamin D (6%). These reductions were clinically and statistically significant. There are a few unknowns still. It’s not clear if these results apply to everyone or just those with low levels of vitamin D. Also, these results apply to adults with mild to moderate asthma when taken alongside their usual

NIHR Dissemination Centre2018

9. Increasing inhaled steroids for short periods reduces asthma exacerbations

Increasing inhaled steroids for short periods reduces asthma exacerbations Asthma exacerbations can be reduced by increasing inhaled steroids for short periods Dissemination Centre Discover Portal NIHR DC Discover Increasing inhaled steroids for short periods reduces asthma exacerbations Published on 17 July 2018 doi: Taking four times the usual dose of inhaled corticosteroids for up to two weeks can modestly reduce the chance of asthma worsening. This NIHR-funded trial assessed increasing (...) the inhaled corticosteroid dose compared with staying on the usual dose, as part of a self-management plan. Participants were adults and adolescents with uncontrolled asthma and had at least one exacerbation needing additional medical attention in the year before the trial. Quadrupling the inhaled corticosteroid dose when asthma worsens is already recommended by NICE guidance, but previously there was little research evidence to support the clinical practice. What there was, suggested that doubling

NIHR Dissemination Centre2018

10. Inhaled steroids with and without regular salmeterol for asthma: serious adverse events.

Inhaled steroids with and without regular salmeterol for asthma: serious adverse events. BACKGROUND: Epidemiological evidence has suggested a link between use of beta₂-agonists and increased asthma mortality. Much debate has surrounded possible causal links for this association, and whether regular (daily) long-acting beta₂-agonists (LABAs) are safe, particularly when used in combination with inhaled corticosteroids (ICSs). This is an update of a Cochrane Review that now includes data from two (...) large trials including 11,679 adults and 6208 children; both were mandated by the US Food and Drug Administration (FDA). OBJECTIVES: To assess risks of mortality and non-fatal serious adverse events (SAEs) in trials that randomised participants with chronic asthma to regular salmeterol and ICS versus the same dose of ICS. SEARCH METHODS: We identified randomised trials using the Cochrane Airways Group Specialised Register of trials. We checked websites of clinical trials registers for unpublished

Cochrane2018

11. Tiotropium (Spiriva Respimat) add-on maintenance bronchodilator treatment in patients aged 6 years and older with severe asthma

Tiotropium (Spiriva Respimat) add-on maintenance bronchodilator treatment in patients aged 6 years and older with severe asthma Tiotropium (Spiriva ® Respimat ® ). Reference number 1882. Page 1 of 3 AWMSG Secretariat Assessment Report – Limited submission Tiotropium (Spiriva ® Respimat ® ) 2.5 microgram, inhalation solution Company: Boehringer Ingelheim Ltd Licensed indication under consideration: add-on maintenance bronchodilator treatment in patients aged 6 years to < 18 years with severe (...) asthma who experienced one or more severe asthma exacerbations in the preceding year Date of licence extension: 12 April 2018 Comparator(s) The company stated that there is no comparator and that tiotropium (Spiriva ® Respimat ® ) is an add-on treatment. Limited submission details ? The limited submission criteria were met based on a minor licence extension. Clinical effectiveness ? Tiotropium (Spiriva ® Respimat ® ) was recommended by the All Wales Medicines Strategy Group in 2017 as an add

All Wales Medicines Strategy Group2018

12. Temporarily quadrupling the dose of inhaled steroid to prevent asthma exacerbations: FAST

Temporarily quadrupling the dose of inhaled steroid to prevent asthma exacerbations: FAST Temporarily quadrupling the dose of inhaled steroid to prevent asthma exacerbations: FAST Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from the navigation or try a website search above to find the information you need. >> >> >> >> Issue {{metadata (...) .Issue }} Toolkit 1)"> 0)"> 1)"> {{metadata.Title}} {{metadata.Headline}} An asthma self-management plan that advised patients to temporarily quadruple their dose of inhaled corticosteroid reduced asthma exacerbations, with fewer serious adverse events and at lower cost. {{author}} {{($index , , , , , , , , , , , , , , , & . Tricia McKeever 1 , Kevin Mortimer 2 , Lucy Bradshaw 3 , Rebecca Haydock 3 , Ian Pavord 4 , Bernard Higgins 5 , Samantha Walker 6 , Andrew Wilson 7 , David Price 8, 9 , Mike

NIHR HTA programme2018

13. Consequences of long-term oral corticosteroid therapy and its side-effects in severe asthma in adults: a focused review of the impact data in the literature

Consequences of long-term oral corticosteroid therapy and its side-effects in severe asthma in adults: a focused review of the impact data in the literature 30190274 2018 10 26 1399-3003 52 4 2018 Oct The European respiratory journal Eur. Respir. J. Consequences of long-term oral corticosteroid therapy and its side-effects in severe asthma in adults: a focused review of the impact data in the literature. 1800703 10.1183/13993003.00703-2018 This review provides an overview of the role of long (...) -term treatment of severe asthma with oral corticosteroids (OCS) and its associated side-effects in adults. It is based on a systematic literature search conducted in MEDLINE, Embase and the Cochrane Library to identify relevant studies. After a short overview of severe asthma and its treatment we present studies showing a dose-response relationship in asthmatic patients treated with OCS and then consider by organ systems the undesired effects demonstrated in clinical and epidemiological studies

EvidenceUpdates2018

14. Limited clinical value of exhaled volatile organic compound measurements in childhood asthma

Limited clinical value of exhaled volatile organic compound measurements in childhood asthma 30443556 2018 12 07 2312-0541 4 4 2018 Oct ERJ open research ERJ Open Res Limited clinical value of exhaled volatile organic compound measurements in childhood asthma. 00026-2018 10.1183/23120541.00026-2018 Exhaled volatile organic compound measurements do not aid the clinician diagnosing asthma in children http://ow.ly/Z2d930lpZ60. Fuglsbjerg Maria G MG COPSAC, Copenhagen Prospective Studies on Asthma (...) in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. Rasmussen Morten A MA COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. Dept of Food Science, Faculty of Science, University of Copenhagen, Denmark. Hansen Kirsten S KS The Pediatric Dept, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. Smolinska Agnieszka A Dept of Pharmacology and Toxicology

ERJ open research2018 Full Text: Link to full Text with Trip Pro

15. Asthma severity and fertility outcome in women with polycystic ovary syndrome: a registry-based study

Asthma severity and fertility outcome in women with polycystic ovary syndrome: a registry-based study 30406126 2018 11 14 2312-0541 4 4 2018 Oct ERJ open research ERJ Open Res Asthma severity and fertility outcome in women with polycystic ovary syndrome: a registry-based study. 00138-2017 10.1183/23120541.00138-2017 Recent research suggests that women with polycystic ovary syndrome (PCOS) have a higher risk of asthma. However, the severity of asthma, use of antiasthma medication and effect (...) on fertility have yet to be investigated. In a case-control cross-sectional registry study using the Danish National Patient Register and other Danish registries, asthma prevalence, asthma severity, antiasthma medication use and fertility outcome were investigated among two groups of women with PCOS (n=1358 and n=17 123) and a healthy control group (n=5340). Both asthma prevalence (OR 1.45, 95% CI 1.24-1.70) and mean daily inhaled corticosteroid dose were higher among women with PCOS compared with healthy

ERJ open research2018 Full Text: Link to full Text with Trip Pro

16. Inhaler Technique Education and Exacerbation Risk in Older Adults with Asthma or Chronic Obstructive Pulmonary Disease: A Meta-Analysis

Inhaler Technique Education and Exacerbation Risk in Older Adults with Asthma or Chronic Obstructive Pulmonary Disease: A Meta-Analysis 30291745 2018 10 06 1532-5415 2018 Oct 06 Journal of the American Geriatrics Society J Am Geriatr Soc Inhaler Technique Education and Exacerbation Risk in Older Adults with Asthma or Chronic Obstructive Pulmonary Disease: A Meta-Analysis. 10.1111/jgs.15602 To evaluate the effect of inhaler education programs on clinical outcomes and exacerbation rates in older (...) adults with asthma or chronic obstructive pulmonary disease (COPD). Systematic review and meta-analysis. Older adults with asthma or COPD, either in primary or secondary health care and pharmacy setting. We searched the Medline, Embase, and Central databases according to the main eligibility criteria for inclusion: systematic reviews, meta-analysis, clinical trials and quasi-experimental studies; participants aged 65 and older; education on inhaler technique and reporting of disease control

EvidenceUpdates2018

17. Does early onset asthma increase childhood obesity risk? A pooled analysis of 16 European cohorts

Does early onset asthma increase childhood obesity risk? A pooled analysis of 16 European cohorts 30209194 2018 10 12 1399-3003 52 3 2018 Sep The European respiratory journal Eur. Respir. J. Does early onset asthma increase childhood obesity risk? A pooled analysis of 16 European cohorts. 1800504 10.1183/13993003.00504-2018 The parallel epidemics of childhood asthma and obesity over the past few decades have spurred research into obesity as a risk factor for asthma. However, little is known (...) regarding the role of asthma in obesity incidence. We examined whether early-onset asthma and related phenotypes are associated with the risk of developing obesity in childhood.This study includes 21 130 children born from 1990 to 2008 in Denmark, France, Germany, Greece, Italy, The Netherlands, Spain, Sweden and the UK. We followed non-obese children at 3-4 years of age for incident obesity up to 8 years of age. Physician-diagnosed asthma, wheezing and allergic rhinitis were assessed up to 3-4 years

EvidenceUpdates2018

18. Comprehensive Community-Based Intervention and Asthma Outcomes in African American Adolescents

Comprehensive Community-Based Intervention and Asthma Outcomes in African American Adolescents 30185428 2018 10 02 1098-4275 142 4 2018 Oct Pediatrics Pediatrics Comprehensive Community-Based Intervention and Asthma Outcomes in African American Adolescents. e20173737 10.1542/peds.2017-3737 : media-1vid110.1542/5804911922001PEDS-VA_2017-3737 Video Abstract BACKGROUND: African American adolescents appear to be the most at risk for asthma morbidity and mortality even compared with other minority (...) groups, yet there are few successful interventions for this population that are used to target poorly controlled asthma. African American adolescents (age 12-16 years) with moderate-to-severe persistent asthma and ≥1 inpatient hospitalization or ≥2 emergency department visits in 12 months were randomly assigned to Multisystemic Therapy-Health Care or an attention control group ( N = 167). Multisystemic Therapy-Health Care is a 6-month home- and community-based treatment that has been shown to improve

EvidenceUpdates2018

19. FeNO-based asthma management results in faster improvement of airway hyperresponsiveness

FeNO-based asthma management results in faster improvement of airway hyperresponsiveness 30302333 2018 11 14 2312-0541 4 4 2018 Oct ERJ open research ERJ Open Res F eNO -based asthma management results in faster improvement of airway hyperresponsiveness. 00147-2017 10.1183/23120541.00147-2017 Asthma is characterised by inflammation and respiratory symptoms. Current asthma treatment is based on severity of asthma symptoms only. Exhaled nitric oxide fraction ( F eNO ) is not recommended (...) by the Global Initiative for Asthma guidelines. The aim was to compare the usefulness of a F eNO guided versus symptom-based treatment in achieving improved asthma control assessed by airway hyperresponsiveness (AHR). 80 asthmatic patients were included in a double-blinded, parallel, randomised controlled trial with follow-up visits after 8, 24 and 36 weeks. Treatment was tailored using either a F eNO or Asthma Control Questionnaire (ACQ) based algorithm. Inclusion criteria were asthma symptoms

ERJ open research2018 Full Text: Link to full Text with Trip Pro

20. The Relationship Between Fish Oil Supplementation During Pregnancy and Incidence of Asthma in Children

The Relationship Between Fish Oil Supplementation During Pregnancy and Incidence of Asthma in Children "The Relationship Between Fish Oil Supplementation During Pregnancy and" by JesAnne Tageson-Ramirez < > > > > > Title Author Date of Graduation Summer 8-11-2018 Degree Type Capstone Project Degree Name Master of Science in Physician Assistant Studies Rights . Abstract Background: The incidence of asthma is increasing in the United States. Some researchers believe this rise is due to higher (...) levels of n-6 fatty acids in relation to n-3 fatty acids that are found in cold-water fish. Several studies over the years have tried to discern if increasing fish oil in the diet or by supplementation can decrease the incidence of asthma in children. However, the results of these studies are not in agreement. Methods: A comprehensive search of available medical literature was performed using MEDLINE-Ovid, CINAHL, and Web of Science using the keywords: fatty acids, omega-3s, fish oil, LCPUFAs

Pacific University EBM Capstone Project2018