Latest & greatest articles for aspirin

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Aspirin

Acetylsalicylic acid (ASA) more commonly known as aspirin is a painkiller that has a wide range of uses. It is frequently used to treat fever, mild pain, tooth aches, headaches and muscle aches. Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) and can be used in the management of conditions such as heart attack, arthritis, blood clots and stroke. Aspirin, has been used for thousands of years, initially extracted from the leaves of willow trees.

Aspirin works in much the same way as other NSAIDs but has additional properties, such as antiplatelet activity which can make it additionally useful. More recently aspirin has been linked with cancer prevention. But the potential benefits of aspirin need to be weighed against the potential side effects, which includes gastrointestinal bleeding and Reye’s syndrome. It should be noted that aspirin should not be used in people who are allergic to drugs such as ibuprofen or a more generalized intolerance to NSAIDs. It should also be used cautiously in asthmatics and/or those with bronchospasm associated with NSAID use.

Research evidence, clinical trials and guidelines on Aspirin

The Trip Database has an extensive collection of articles on aspirin ranging from clinical trials, systematic reviews, clinical guidelines and case reports. These can be found via searching the site.

Top results for aspirin

101. Dietary Omega-3 Fatty Acids and Aspirin are Effective as Adjunctive Therapy During Non-Surgical Treatment of Chronic Periodontitis

Dietary Omega-3 Fatty Acids and Aspirin are Effective as Adjunctive Therapy During Non-Surgical Treatment of Chronic Periodontitis UTCAT2871, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Dietary Omega-3 Fatty Acids and Aspirin are Effective as Adjunctive Therapy During Non-Surgical Treatment of Chronic Periodontitis Clinical Question In patients with chronic periodontitis, does combined dietary omega-3 fatty acids (...) and aspirin reduce the symptoms of periodontitis when compared to a placebo? Clinical Bottom Line Dietary omega-3 fatty acids and aspirin with or without scaling and root planing have been shown to improve clinical parameters of periodontitis, such as reducing probing depths and increasing clinical attachment, in patients with chronic periodontitis. While more long-term studies with comparison to the gold-standard (scaling and root planing) are needed, this combination of drugs shows potential to arrest

UTHSCSA Dental School CAT Library2015

102. Association of aspirin and NSAID use with risk of colorectal cancer according to genetic variants.

Association of aspirin and NSAID use with risk of colorectal cancer according to genetic variants. IMPORTANCE: Use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with lower risk of colorectal cancer. OBJECTIVE: To identify common genetic markers that may confer differential benefit from aspirin or NSAID chemoprevention, we tested gene × environment interactions between regular use of aspirin and/or NSAIDs and single-nucleotide polymorphisms (SNPs) in relation (...) to risk of colorectal cancer. DESIGN, SETTING, AND PARTICIPANTS: Case-control study using data from 5 case-control and 5 cohort studies initiated between 1976 and 2003 across the United States, Canada, Australia, and Germany and including colorectal cancer cases (n=8634) and matched controls (n=8553) ascertained between 1976 and 2011. Participants were all of European descent. EXPOSURES: Genome-wide SNP data and information on regular use of aspirin and/or NSAIDs and other risk factors. MAIN OUTCOMES

JAMA2015 Full Text: Link to full Text with Trip Pro

103. Systematic review: Updated review identifies no adverse impact on mother or offspring during the perinatal period of aspirin use for prevention of preeclampsia

Systematic review: Updated review identifies no adverse impact on mother or offspring during the perinatal period of aspirin use for prevention of preeclampsia Updated review identifies no adverse impact on mother or offspring during the perinatal period of aspirin use for prevention of preeclampsia | Evidence-Based Medicine This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in using your username and password For personal accounts OR managers (...) of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Updated review identifies no adverse impact on mother or offspring during the perinatal period of aspirin use for prevention of preeclampsia Article Text Therapeutics/Prevention Systematic review Updated review

Evidence-Based Medicine (Requires free registration)2015

104. Systematic review with meta-analysis: Low-dose aspirin reduces morbidity and mortality in pregnant women at high-risk for preeclampsia

Systematic review with meta-analysis: Low-dose aspirin reduces morbidity and mortality in pregnant women at high-risk for preeclampsia Low-dose aspirin reduces morbidity and mortality in pregnant women at high-risk for preeclampsia | Evidence-Based Nursing This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name (...) or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Low-dose aspirin reduces morbidity and mortality in pregnant women at high-risk for preeclampsia Article Text Midwifery Systematic review with meta-analysis Low-dose aspirin reduces morbidity and mortality in pregnant women at high-risk for preeclampsia Emmanuel Bujold

Evidence-Based Nursing (Requires free registration)2015

105. Low-Dose Aspirin for Primary Prevention of Cardiovascular Events in Japanese Patients 60 Years or Older With Atherosclerotic Risk Factors: A Randomized Clinical Trial.

Low-Dose Aspirin for Primary Prevention of Cardiovascular Events in Japanese Patients 60 Years or Older With Atherosclerotic Risk Factors: A Randomized Clinical Trial. IMPORTANCE: Prevention of atherosclerotic cardiovascular diseases is an important public health priority in Japan due to an aging population. OBJECTIVE: To determine whether daily, low-dose aspirin reduces the incidence of cardiovascular events in older Japanese patients with multiple atherosclerotic risk factors. DESIGN, SETTING (...) . INTERVENTIONS: Patients were randomized 1:1 to enteric-coated aspirin 100 mg/d or no aspirin in addition to ongoing medications. MAIN OUTCOMES AND MEASURES: Composite primary outcome was death from cardiovascular causes (myocardial infarction, stroke, and other cardiovascular causes), nonfatal stroke (ischemic or hemorrhagic, including undefined cerebrovascular events), and nonfatal myocardial infarction. Secondary outcomes included individual end points. RESULTS: The study was terminated early by the data

JAMA2014 Full Text: Link to full Text with Trip Pro

106. Perioperative Aspirin and Clonidine and Risk of Acute Kidney Injury: A Randomized Clinical Trial.

Perioperative Aspirin and Clonidine and Risk of Acute Kidney Injury: A Randomized Clinical Trial. IMPORTANCE: Acute kidney injury, a common complication of surgery, is associated with poor outcomes and high health care costs. Some studies suggest aspirin or clonidine administered during the perioperative period reduces the risk of acute kidney injury; however, these effects are uncertain and each intervention has the potential for harm. OBJECTIVE: To determine whether aspirin compared (...) with placebo, and clonidine compared with placebo, alters the risk of perioperative acute kidney injury. DESIGN, SETTING, AND PARTICIPANTS: A 2 × 2 factorial randomized, blinded, clinical trial of 6905 patients undergoing noncardiac surgery from 88 centers in 22 countries with consecutive patients enrolled between January 2011 and December 2013. INTERVENTIONS: Patients were assigned to take aspirin (200 mg) or placebo 2 to 4 hours before surgery and then aspirin (100 mg) or placebo daily up to 30 days

JAMA2014 Full Text: Link to full Text with Trip Pro

107. Low-Dose Aspirin Use for the Prevention of Morbidity and Mortality From Preeclampsia: U.S. Preventive Services Task Force Recommendation Statement.

Low-Dose Aspirin Use for the Prevention of Morbidity and Mortality From Preeclampsia: U.S. Preventive Services Task Force Recommendation Statement. DESCRIPTION: Update of the 1996 U.S. Preventive Services Task Force (USPSTF) recommendation on aspirin prophylaxis in pregnancy. METHODS: The USPSTF reviewed the evidence on the effectiveness of low-dose aspirin in preventing preeclampsia in women at increased risk and in decreasing adverse maternal and perinatal health outcomes, and assessed (...) the maternal and fetal harms of low-dose aspirin during pregnancy. POPULATION: This recommendation applies to asymptomatic pregnant women who are at increased risk for preeclampsia and who have no prior adverse effects with or contraindications to low-dose aspirin. RECOMMENDATION: The USPSTF recommends the use of low-dose aspirin (81 mg/d) as preventive medication after 12 weeks of gestation in women who are at high risk for preeclampsia. (B recommendation).

Annals of Internal Medicine2014 Full Text: Link to full Text with Trip Pro

108. Aspirin as adjunctive treatment for giant cell arteritis.

Aspirin as adjunctive treatment for giant cell arteritis. BACKGROUND: Giant cell arteritis (GCA) is a common inflammatory condition that affects medium and large-sized arteries and can cause sudden, permanent blindness. At present there is no alternative to early treatment with high-dose corticosteroids as the recommended standard management. Corticosteroid-induced side effects can develop and further disease-related ischaemic complications can still occur. Alternative and adjunctive therapies (...) are sought. Aspirin has been shown to have effects on the immune-mediated inflammation in GCA, hence it may reduce damage caused in the arterial wall. OBJECTIVES: To assess the safety and effectiveness of low-dose aspirin, as an adjunctive, in the treatment of giant cell arteritis (GCA). SEARCH METHODS: We searched CENTRAL (which contains the Cochrane Eyes and Vision Group Trials Register) (2013, Issue 12), Ovid MEDLINE, Ovid MEDLINE In-Process and Other Non-Indexed Citations, Ovid MEDLINE Daily, Ovid

Cochrane2014

109. Aspirin for VTE prophylaxis in hip and knee replacement surgery

Aspirin for VTE prophylaxis in hip and knee replacement surgery Aspirin for VTE prophylaxis in hip and knee replacement surgery Aspirin for VTE prophylaxis in hip and knee replacement surgery Mitchell MD, Williams K Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Mitchell MD, Williams K. Aspirin for VTE prophylaxis in hip and knee replacement surgery (...) . Philadelphia: Center for Evidence-based Practice (CEP). 2014 Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Aspirins; Venous Thromboembolism Language Published English Country of organisation United States English summary An English language summary is available. Address for correspondence Center for Evidence-based Practice, University of Pennsylvania Health System, 3535 Market St. Suite 50, Philadelphia PA 19104

Health Technology Assessment (HTA) Database.2014

110. Low-dose aspirin for the prevention of morbidity and mortality from pre-eclampsia: a systematic evidence review for the U.S. preventive services task force

Low-dose aspirin for the prevention of morbidity and mortality from pre-eclampsia: a systematic evidence review for the U.S. preventive services task force Low-dose aspirin for the prevention of morbidity and mortality from pre-eclampsia: a systematic evidence review for the U.S. preventive services task force Low-dose aspirin for the prevention of morbidity and mortality from pre-eclampsia: a systematic evidence review for the U.S. preventive services task force Henderson JT, Whitlock EP (...) , O'Connor E, Senger CA, Thompson JH, Rowland MG Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Henderson JT, Whitlock EP, O'Connor E, Senger CA, Thompson JH, Rowland MG. Low-dose aspirin for the prevention of morbidity and mortality from pre-eclampsia: a systematic evidence review for the U.S. preventive services task force. Rockville: Agency

Health Technology Assessment (HTA) Database.2014

111. Low-dose aspirin for prevention of morbidity and mortality from pre-eclampsia: a systematic evidence review for the U.S Preventive Services Task Force

Low-dose aspirin for prevention of morbidity and mortality from pre-eclampsia: a systematic evidence review for the U.S Preventive Services Task Force Low-dose aspirin for prevention of morbidity and mortality from preeclampsia: a systematic evidence review for the U.S Preventive Services Task Force Low-dose aspirin for prevention of morbidity and mortality from preeclampsia: a systematic evidence review for the U.S Preventive Services Task Force Henderson JT, Whitlock EP, O'Connor E, Senger CA (...) , Thompson JH, Rowland MG CRD summary Based on available evidence, this good-quality review concluded that daily low-dose aspirin had modest but important benefits for preventing preeclampsia and consequent illness in high-risk women during pregnancy, although rare or long-term harms could not be ruled out. The authors identified uncertainties in the evidence and their carefully considered conclusions are likely to be reliable. Authors' objectives To review the benefits and harms of low-dose aspirin for

DARE.2014

112. Low-dose aspirin for prevention of morbidity and mortality from preeclampsia: a systematic evidence review for the U.S. Preventive Services Task Force.

Low-dose aspirin for prevention of morbidity and mortality from preeclampsia: a systematic evidence review for the U.S. Preventive Services Task Force. BACKGROUND: Preeclampsia is a leading cause of maternal and perinatal morbidity and mortality. PURPOSE: To systematically review benefits and harms of low-dose aspirin for preventing morbidity and mortality from preeclampsia. DATA SOURCES: MEDLINE, Database of Abstracts of Reviews of Effects, PubMed, and Cochrane Central Register of Controlled (...) large, multisite RCTs and 13 smaller RCTs of high-risk women (8 good-quality) were included, in addition to 6 RCTs and 2 observational studies of average-risk women to assess harms (7 good-quality). Depending on baseline risk, aspirin use was associated with absolute risk reductions of 2% to 5% for preeclampsia (relative risk [RR], 0.76 [95% CI, 0.62 to 0.95]), 1% to 5% for intrauterine growth restriction (RR, 0.80 [CI, 0.65 to 0.99]), and 2% to 4% for preterm birth (RR, 0.86 [CI, 0.76 to 0.98

Annals of Internal Medicine2014

113. Aspirin versus vitamin K antagonist treatment guided by transoesophageal echocardiography in patients with atrial fibrillation: a pilot study

Aspirin versus vitamin K antagonist treatment guided by transoesophageal echocardiography in patients with atrial fibrillation: a pilot study 24488608 2014 03 06 2014 04 28 2017 02 15 1468-201X 100 7 2014 Apr Heart (British Cardiac Society) Heart Aspirin versus vitamin K antagonist treatment guided by transoesophageal echocardiography in patients with atrial fibrillation: a pilot study. 563-8 10.1136/heartjnl-2013-305017 Current stroke risk schemes need improvement of predictive value (...) in patients with atrial fibrillation. Transoesophageal echocardiography (TEE) may facilitate stroke risk assessment in such patients and guide antithrombotic treatment. We randomised 238 patients with non-valvular atrial fibrillation and a moderate stroke risk to aspirin or adjusted vitamin K antagonist therapy after TEE had ruled out thrombogenic features in the atria and aorta. The primary outcome was a composite of stroke, major bleeding, peripheral embolism and all-cause mortality. Mean CHA2DS2-VASc

EvidenceUpdates2014

114. Cohort study: Long-term aspirin use and neovascular age-related macular degeneration: association or causation?

Cohort study: Long-term aspirin use and neovascular age-related macular degeneration: association or causation? Long-term aspirin use and neovascular age-related macular degeneration: association or causation? | Evidence-Based Medicine This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search (...) for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Long-term aspirin use and neovascular age-related macular degeneration: association or causation? Article Text Aetiology Cohort study Long-term aspirin use and neovascular age-related macular degeneration: association or causation? William G Christen Statistics from Altmetric.com No Altmetric data

Evidence-Based Medicine (Requires free registration)2014

115. Cohort study: In infants born extremely preterm, aspirin or NSAID use during pregnancy are associated with increased risk of quadriparetic cerebral palsy

Cohort study: In infants born extremely preterm, aspirin or NSAID use during pregnancy are associated with increased risk of quadriparetic cerebral palsy In infants born extremely preterm, aspirin or NSAID use during pregnancy are associated with increased risk of quadriparetic cerebral palsy | Evidence-Based Nursing This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in via your Society Log in using your username and password For personal (...) accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in via your Society Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here In infants born extremely preterm, aspirin or NSAID use during pregnancy are associated with increased risk of quadriparetic cerebral palsy Article Text Child health

Evidence-Based Nursing (Requires free registration)2014

116. Preconception low-dose aspirin and pregnancy outcomes: results from the EAGeR randomised trial.

Preconception low-dose aspirin and pregnancy outcomes: results from the EAGeR randomised trial. 24702835 2014 07 07 2014 07 14 2016 12 15 1474-547X 384 9937 2014 Jul 05 Lancet (London, England) Lancet Preconception low-dose aspirin and pregnancy outcomes: results from the EAGeR randomised trial. 29-36 10.1016/S0140-6736(14)60157-4 S0140-6736(14)60157-4 Preconception-initiated low-dose aspirin might positively affect pregnancy outcomes, but this possibility has not been adequately assessed. Our (...) aim was to investigate whether low-dose aspirin improved livebirth rates in women with one to two previous pregnancy losses. In this multicentre, block-randomised, double-blind, placebo-controlled trial, women aged 18-40 years who were attempting to become pregnant were recruited from four medical centres in the USA. Participants were stratified by eligibility criteria--the original stratum was restricted to women with one loss at less than 20 weeks' gestation during the previous year, whereas

Lancet2014 Full Text: Link to full Text with Trip Pro

117. Aspirin in Patients Undergoing Noncardiac Surgery.

Aspirin in Patients Undergoing Noncardiac Surgery. 24679062 2014 04 17 2014 05 06 2015 03 16 1533-4406 370 16 2014 Apr 17 The New England journal of medicine N. Engl. J. Med. Aspirin in patients undergoing noncardiac surgery. 1494-503 10.1056/NEJMoa1401105 There is substantial variability in the perioperative administration of aspirin in patients undergoing noncardiac surgery, both among patients who are already on an aspirin regimen and among those who are not. Using a 2-by-2 factorial trial (...) design, we randomly assigned 10,010 patients who were preparing to undergo noncardiac surgery and were at risk for vascular complications to receive aspirin or placebo and clonidine or placebo. The results of the aspirin trial are reported here. The patients were stratified according to whether they had not been taking aspirin before the study (initiation stratum, with 5628 patients) or they were already on an aspirin regimen (continuation stratum, with 4382 patients). Patients started taking aspirin

NEJM2014

118. Randomised controlled trial: Questions linger over POISE-2 and perioperative aspirin management

Randomised controlled trial: Questions linger over POISE-2 and perioperative aspirin management Questions linger over POISE-2 and perioperative aspirin management | Evidence-Based Medicine This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log (...) in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Questions linger over POISE-2 and perioperative aspirin management Article Text Therapeutics Randomised controlled trial Questions linger over POISE-2 and perioperative aspirin management Neal Stuart Gerstein 1 , Gerald A Charlton 2 , 3 Statistics from Altmetric.com No Altmetric data available for this article. Commentary on : Devereaux PJ

Evidence-Based Medicine (Requires free registration)2014

119. Aspirin

Aspirin USE OF ASPIRIN IN PREGNANCY 0344 892 0909 USE OF ASPIRIN IN PREGNANCY (Date of issue: July 2014 , Version: 2 ) This is a UKTIS monograph for use by health care professionals. For case-specific advice please contact UKTIS on 0344 892 0909. To report an exposure please download and complete a . Please encourage all women to complete an . A corresponding patient information leaflet on is available at . Summary Low-dose aspirin (75-300mg/day) is used as an antiplatelet medication (...) in the prophylaxis of thromboembolic cerebrovascular disease, myocardial infarction and pre-eclampsia. Higher doses of aspirin (up to 4g/day) are used in the control of mild to moderate pain and pyrexia. There is a large body of evidence that shows no association between the use of low-dose aspirin (LDA) during pregnancy and increased risk of spontaneous abortion or stillbirth. Fewer data are available regarding aspirin use at analgesic doses, but again no association with these two outcomes has been reported

UK Teratology Information Service2014

120. Aspirin overdose

Aspirin overdose ASPIRIN OVERDOSE IN PREGNANCY 0344 892 0909 ASPIRIN OVERDOSE IN PREGNANCY (Date of issue: December 2012 , Version: 2 ) This is a UKTIS monograph for use by health care professionals. For case-specific advice please contact UKTIS on 0344 892 0909. To report an exposure please download and complete a . Please encourage all women to complete an . Summary Low-dose aspirin (75-300mg/day) is used as an antiplatelet medication to reduce the risk of thrombosis in cerebrovascular (...) disease and myocardial infarction, and in the prevention of pre-eclampsia. Higher doses of aspirin (up to 4g/day) are used in the control of mild to moderate pain and pyrexia. Various malformations have been reported following therapeutic maternal use of aspirin during pregnancy, however with the exception of a possible increased incidence of gastroschisis, no specific pattern of malformations has been observed and a causative role for aspirin has not been proven. The available data on fetal outcome

UK Teratology Information Service2014