Latest & greatest articles for aspirin

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on aspirin or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on aspirin and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Aspirin

Acetylsalicylic acid (ASA) more commonly known as aspirin is a painkiller that has a wide range of uses. It is frequently used to treat fever, mild pain, tooth aches, headaches and muscle aches. Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) and can be used in the management of conditions such as heart attack, arthritis, blood clots and stroke. Aspirin, has been used for thousands of years, initially extracted from the leaves of willow trees.

Aspirin works in much the same way as other NSAIDs but has additional properties, such as antiplatelet activity which can make it additionally useful. More recently aspirin has been linked with cancer prevention. But the potential benefits of aspirin need to be weighed against the potential side effects, which includes gastrointestinal bleeding and Reye’s syndrome. It should be noted that aspirin should not be used in people who are allergic to drugs such as ibuprofen or a more generalized intolerance to NSAIDs. It should also be used cautiously in asthmatics and/or those with bronchospasm associated with NSAID use.

Research evidence, clinical trials and guidelines on Aspirin

The Trip Database has an extensive collection of articles on aspirin ranging from clinical trials, systematic reviews, clinical guidelines and case reports. These can be found via searching the site.

Top results for aspirin

281. WITHDRAWN: Anticoagulant and aspirin prophylaxis for preventing thromboembolism after major gynaecological surgery.

WITHDRAWN: Anticoagulant and aspirin prophylaxis for preventing thromboembolism after major gynaecological surgery. BACKGROUND: The reported overall risk of deep venous thrombosis in gynaecological surgery ranges from 7 to 45%. Fatal pulmonary embolism is estimated to occur in nearly 1% of these women. Pharmaceutical interventions are one possible prophylactic measure for preventing emboli in women undergoing major gynaecological surgery. Agents include unfractionated heparin (low -dose (...) and adjusted-dose), low-molecular-weight heparins, heparinoids and warfarin. OBJECTIVES: The objective of this review was to evaluate the effectiveness of warfarin, heparin and aspirin in preventing thromboembolism after major gynaecological surgery. SEARCH STRATEGY: We searched the Cochrane Menstrual Disorders and Subfertility Group trials register (searched 15 August 2003), the Cochrane Central Register of Controlled Trials (CENTRAL) (Cochrane Library issue 2, 2003), MEDLINE (1966 to April 2003), EMBASE

Cochrane2007

282. Review: aspirin was effective for primary prevention of stroke in women and MI in men but increased major bleeding

Review: aspirin was effective for primary prevention of stroke in women and MI in men but increased major bleeding Review: aspirin was effective for primary prevention of stroke in women and MI in men but increased major bleeding | Evidence-Based Nursing This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in via your Society Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password (...) * your user name or password? Search for this keyword Search for this keyword Main menu Log in via your Society Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Review: aspirin was effective for primary prevention of stroke in women and MI in men but increased major bleeding Article Text Treatment Review: aspirin was effective for primary prevention of stroke in women and MI in men

Evidence-Based Nursing (Requires free registration)2007

283. Addition of clopidogrel to aspirin, but not early use of metoprolol, improved overall outcome in acute myocardial infarction

Addition of clopidogrel to aspirin, but not early use of metoprolol, improved overall outcome in acute myocardial infarction Addition of clopidogrel to aspirin, but not early use of metoprolol, improved overall outcome in acute myocardial infarction | Evidence-Based Medicine This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your (...) user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Addition of clopidogrel to aspirin, but not early use of metoprolol, improved overall outcome in acute myocardial infarction Article Text Therapeutics Addition of clopidogrel to aspirin, but not early use of metoprolol, improved overall outcome in acute

Evidence-Based Medicine (Requires free registration)2007

284. Aspirin and the risk of colorectal cancer in relation to the expression of COX-2.

Aspirin and the risk of colorectal cancer in relation to the expression of COX-2. BACKGROUND: Regular use of aspirin reduces the risk of a colorectal neoplasm, but the mechanism by which aspirin affects carcinogenesis in the colon is not well understood. METHODS: We estimated cyclooxygenase-2 (COX-2) expression by immunohistochemical assay of sections from paraffin-embedded colorectal-cancer specimens from two large cohorts of participants who provided data on aspirin use from a questionnaire (...) every 2 years. We applied Cox regression to a competing-risks analysis to compare the effects of aspirin use on the relative risk of colorectal cancer in relation to the expression of COX-2 in the tumor. RESULTS: During 2,446,431 person-years of follow-up of 82,911 women and 47,363 men, we found 636 incident colorectal cancers that were accessible for determination of COX-2 expression. Of the tumors, 423 (67%) had moderate or strong COX-2 expression. The effect of aspirin use differed significantly

NEJM2007

285. Review: aspirin plus warfarin decreases cardiovascular morbidity with an increase in major bleeding in acute coronary syndromes

Review: aspirin plus warfarin decreases cardiovascular morbidity with an increase in major bleeding in acute coronary syndromes Review: aspirin plus warfarin decreases cardiovascular morbidity with an increase in major bleeding in acute coronary syndromes | Evidence-Based Medicine This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password (...) * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Review: aspirin plus warfarin decreases cardiovascular morbidity with an increase in major bleeding in acute coronary syndromes Article Text Therapeutics Review: aspirin plus warfarin decreases cardiovascular morbidity with an increase in major bleeding

Evidence-Based Medicine (Requires free registration)2007

286. Routine aspirin or nonsteroidal anti-inflammatory drugs for the primary prevention of colorectal cancer: U.S. Preventive Services Task Force recommendation statement.

Routine aspirin or nonsteroidal anti-inflammatory drugs for the primary prevention of colorectal cancer: U.S. Preventive Services Task Force recommendation statement. This statement summarizes the U.S. Preventive Services Task Force (USPSTF) recommendation and supporting scientific evidence on routine use of aspirin or nonsteroidal anti-inflammatory drugs for the primary prevention of colorectal cancer. The complete information on which this statement is based, including evidence tables

Annals of Internal Medicine2007

287. Should high risk patients receive clopidogrel as well as aspirin post coronary arterial bypass grafting?

Should high risk patients receive clopidogrel as well as aspirin post coronary arterial bypass grafting? BestBets: Should high risk patients receive clopidogrel as well as aspirin post coronary arterial bypass grafting? Should high risk patients receive clopidogrel as well as aspirin post coronary arterial bypass grafting? Report By: Babu Kunadian, Andrew R. Thornley, Thotala N. Babu - Specialist Registrars in Cardiothoracic Surgery Search checked by Joel Dunning - Cardiothoracic Registrar RCS (...) Institution: Department of Cardiothoracic Surgery, James Cook University Hospital and Department of Cardiology, Lincoln Medical Health Center, New York Date Submitted: 21st December 2006 Date Completed: 13th February 2007 Last Modified: 13th March 2007 Status: Green (complete) Three Part Question In patients post [urgent coronary arterial bypass grafting] should [clopidogrel be given in addition to aspirin] to reduce the chance of [thrombotic complications]. Clinical Scenario You are reviewing a 55-year

BestBETS2007

288. Aspirin or Nonsteroidal Anti-inflammatory Drugs for the Primary Prevention of Colorectal Cancer

Aspirin or Nonsteroidal Anti-inflammatory Drugs for the Primary Prevention of Colorectal Cancer Preventive Medication: Aspirin or Nonsteroidal Anti-inflammatory Drugs for the Primary Prevention of Colorectal Cancer U.S. Preventive Services Task Force Aspirin or Nonsteroidal Anti-inflammatory Drugs for the Primary Prevention of Colorectal Cancer Release Date: March 2007 / Summary of Recommendation The USPSTF recommends against the routine use of aspirin and nonsteroidal anti-inflammatory drugs (...) (NSAIDs) to prevent colorectal cancer in individuals at average risk for colorectal cancer. Rating: Rationale Importance: Colorectal cancer represents the third most common type of cancer in both men and women and is the second leading cause of cancer-related deaths in the United States. Recognition of risk status: The vast majority of cases of colorectal cancer arise from adenomatous polyps in average-risk individuals older than 50 years of age. Benefits of aspirin and NSAID use: There is fair

Publication 3262007

289. Low dose aspirin did not prevent cancer in healthy women

Low dose aspirin did not prevent cancer in healthy women Low dose aspirin did not prevent cancer in healthy women | Evidence-Based Medicine This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal (...) accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Low dose aspirin did not prevent cancer in healthy women Article Text Therapeutics Low dose aspirin did not prevent cancer in healthy women Free Laura Rees Willett , MD Statistics from Altmetric.com No Altmetric data available for this article. Cook NR, Lee IM, Gaziano JM, et al . Low dose aspirin in the primary prevention of cancer: the Women’s Health Study: a randomized controlled trial. JAMA

Evidence-Based Medicine (Requires free registration)2007

290. Low-dose aspirin for in vitro fertilization: a systematic review and meta-analysis

Low-dose aspirin for in vitro fertilization: a systematic review and meta-analysis Low-dose aspirin for in vitro fertilization: a systematic review and meta-analysis Low-dose aspirin for in vitro fertilization: a systematic review and meta-analysis Gelbaya TA, Kyrgiou M, Li TC, Stern C, Nardo LG CRD summary The authors concluded that there were no significant differences between low-dose aspirin and control for any pregnancy-related outcomes in women undergoing assisted reproductive technology (...) treatment; treatment with low-dose aspirin cannot, therefore, be routinely recommended. The evidence appears to support the authors’ conclusions, but poor reporting of study quality along with other review limitations make it difficult to assess the strength of the evidence. Authors' objectives To evaluate the effects of low-dose aspirin on pregnancy rates in women undergoing in vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI). Searching MEDLINE, EMBASE, the Cochrane Controlled

DARE.2007

291. Does the use of preoperative aspirin increase the risk of bleeding in patients undergoing coronary artery bypass grafting surgery: systematic review and meta-analysis

Does the use of preoperative aspirin increase the risk of bleeding in patients undergoing coronary artery bypass grafting surgery: systematic review and meta-analysis Does the use of preoperative aspirin increase the risk of bleeding in patients undergoing coronary artery bypass grafting surgery: systematic review and meta-analysis Does the use of preoperative aspirin increase the risk of bleeding in patients undergoing coronary artery bypass grafting surgery: systematic review and meta (...) -analysis Alghamdi A A, Moussa F, Fremes S E CRD summary This review concluded that aspirin is associated with an increased risk of post-operative bleeding and a greater need for blood product transfusion in patients undergoing first-time elective coronary artery bypass grafting surgery. These conclusions seem reliable, although there is a possibility of language and publication bias. Authors' objectives To evaluate the effects of pre-operative aspirin on bleeding and the need for blood transfusions

DARE.2007

292. The use of aspirin for primary prevention of colorectal cancer: a systematic review prepared for the U.S. Preventive Services Task Force

The use of aspirin for primary prevention of colorectal cancer: a systematic review prepared for the U.S. Preventive Services Task Force The use of aspirin for primary prevention of colorectal cancer: a systematic review prepared for the U.S. Preventive Services Task Force The use of aspirin for primary prevention of colorectal cancer: a systematic review prepared for the U.S. Preventive Services Task Force Dube C, Rostom A, Lewin G, Tsertsvadze A, Barrowman N, Code C, Sampson M, Moher D CRD (...) summary This review concluded that aspirin reduces the incidence of colonic adenoma and colorectal cancer (CRC), particularly if used in high doses for more than 10 years. The conclusions were primarily based on lower evidence level studies: randomised controlled trials failed to support the findings regarding CRC incidence and mortality, or for adenoma in average-risk populations. Authors' objectives To evaluate the benefits and harms of aspirin chemoprevention. Harm was assessed in a review

DARE.2007

293. Combined aspirin-oral anticoagulant therapy compared with oral anticoagulant therapy alone among patients at risk for cardivascular disease: a meta-analysis of randomized trials

Combined aspirin-oral anticoagulant therapy compared with oral anticoagulant therapy alone among patients at risk for cardivascular disease: a meta-analysis of randomized trials Combined aspirin-oral anticoagulant therapy compared with oral anticoagulant therapy alone among patients at risk for cardivascular disease: a meta-analysis of randomized trials Combined aspirin-oral anticoagulant therapy compared with oral anticoagulant therapy alone among patients at risk for cardivascular disease (...) : a meta-analysis of randomized trials Dentali F, Douketis J D, Lim W, Crowther M CRD summary This well-conducted review compared the effectiveness and safety of oral anticoagulant (OAC) therapy plus aspirin with OAC alone. The authors concluded that, except for patients with a mechanical heart valve, the benefits of OAC therapy plus aspirin in reducing thromboembolic events were unclear and there were increased risks of major bleeding. This conclusion is likely to be reliable. Authors' objectives

DARE.2007

294. A health economic evaluation of aspirin in the primary prevention of cardiovascular disease in Japan

A health economic evaluation of aspirin in the primary prevention of cardiovascular disease in Japan A health economic evaluation of aspirin in the primary prevention of cardiovascular disease in Japan A health economic evaluation of aspirin in the primary prevention of cardiovascular disease in Japan Tsutani K, Igarashi A, Fujikawa K, Evers T, Kubin M, Lamotte M, Annemans L Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED (...) . Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The study examined the use of low-dose aspirin (100 mg/day) as primary prevention in patients at increased risk of cardiovascular disease (CVD). Type of intervention Primary prevention. Economic study type Cost-effectiveness analysis. Study population The study population comprised a hypothetical

NHS Economic Evaluation Database.2007

295. Aspirin for the primary prevention of cardiovascular disease in women

Aspirin for the primary prevention of cardiovascular disease in women Aspirin for the primary prevention of cardiovascular disease in women Aspirin for the primary prevention of cardiovascular disease in women Pignone M, Earnshaw S, Pletcher M J, Tice J A Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment (...) on the reliability of the study and the conclusions drawn. Health technology The study examined low-dose aspirin (100 mg every other day) for the primary prevention of cardiovascular disease in women. The comparator was no aspirin. Type of intervention Primary prevention. Economic study type Cost-utility analysis. Study population The study population comprised a hypothetical cohort of women at "moderate risk" of cardiovascular disease. Specifically, 65-year-old women with the following risk factor profile

NHS Economic Evaluation Database.2007

296. Warfarin reduced major stroke more than aspirin in elderly patients with atrial fibrillation in primary care

Warfarin reduced major stroke more than aspirin in elderly patients with atrial fibrillation in primary care Warfarin reduced major stroke more than aspirin in elderly patients with atrial fibrillation in primary care. | Evidence-Based Medicine This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search (...) for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Warfarin reduced major stroke more than aspirin in elderly patients with atrial fibrillation in primary care. Article Text Therapeutics Warfarin reduced major stroke more than aspirin in elderly patients with atrial fibrillation in primary care. Free Statistics from Altmetric.com No Altmetric data

Evidence-Based Medicine (Requires free registration)2007

297. Drugs - Aspirin

Drugs - Aspirin Aspirin ASP Drugs October 2006 Page 1 of 1 Drugs PRESENTATION 300 milligram aspirin (acetylsalicylic acid) in tablet form (dispersible). ACTIONS Has an anti-platelet action which reduces clot formation. Analgesic, anti-pyretic and anti-in?ammatory. CAUTIONS As the likely bene?ts of a single 300 milligram aspirin outweigh the potential risks, aspirin may be given to patients with: Asthma Pregnancy Kidney or liver failure Gastric or duodenal ulcer SIDE EFFECTS Gastric bleeding (...) . Wheezing in some asthmatics. DOSAGE AND ADMINISTRATION Adults Adults with apparent, suspected or possible myocardial infarction. Route: Oral – chewed or dissolved in water INDICATIONS Adults with: clinical or ECG evidence of myocardial infarction or ischaemia central chest pain, possibly of cardiac origin. Aspirin should be administered to any patient with chest pain unless the diagnosis is very clearly non- cardiac or the drug is contraindicated. CONTRA-INDICATIONS Known aspirin allergy or sensitivity

Joint Royal Colleges Ambulance Liaison Committee2007

298. Low dose aspirin and cognitive function in the women's health study cognitive cohort.

Low dose aspirin and cognitive function in the women's health study cognitive cohort. 17468120 2007 05 11 2007 05 22 2016 10 19 1756-1833 334 7601 2007 May 12 BMJ (Clinical research ed.) BMJ Low dose aspirin and cognitive function in the women's health study cognitive cohort. 987 To determine whether low dose aspirin protects women aged 65 or more against cognitive decline. Cohort study within both arms of the women's health study, a randomised, double blind, placebo controlled trial of low (...) dose aspirin for the primary prevention of cardiovascular disease and cancer, 1992-5. Women's health study, 1998-2004. 6377 women aged 65 or more. Low dose aspirin (100 mg on alternate days) or placebo for a mean of 9.6 years. Women had three cognitive assessments at two year intervals by telephone. The battery to assess cognition included five tests measuring general cognition, verbal memory, and category fluency. The primary prespecified outcome was a global score, averaging performance across

BMJ2007 Full Text: Link to full Text with Trip Pro

299. Warfarin versus aspirin for stroke prevention in an elderly community population with atrial fibrillation (the Birmingham Atrial Fibrillation Treatment of the Aged Study, BAFTA): a randomised controlled trial.

Warfarin versus aspirin for stroke prevention in an elderly community population with atrial fibrillation (the Birmingham Atrial Fibrillation Treatment of the Aged Study, BAFTA): a randomised controlled trial. 17693178 2007 08 13 2007 08 21 2016 11 22 1474-547X 370 9586 2007 Aug 11 Lancet (London, England) Lancet Warfarin versus aspirin for stroke prevention in an elderly community population with atrial fibrillation (the Birmingham Atrial Fibrillation Treatment of the Aged Study, BAFTA (...) ): a randomised controlled trial. 493-503 Anticoagulants are more effective than antiplatelet agents at reducing stroke risk in patients with atrial fibrillation, but whether this benefit outweighs the increased risk of bleeding in elderly patients is unknown. We assessed whether warfarin reduced risk of major stroke, arterial embolism, or other intracranial haemorrhage compared with aspirin in elderly patients. 973 patients aged 75 years or over (mean age 81.5 years, SD 4.2) with atrial fibrillation were

Lancet2007

300. Use of aspirin in acute stroke

Use of aspirin in acute stroke BestBets: Use of aspirin in acute stroke Use of aspirin in acute stroke Report By: Craig Ferguson - Clinical Research Fellow Search checked by Richard Body - Clinical Research Fellow Institution: MRI Date Submitted: 11th August 2006 Date Completed: 22nd September 2006 Last Modified: 29th August 2006 Status: Green (complete) Three Part Question In [patients presenting with symptoms suggestive of a CVA [cerebrovascular accident]] does [the administration of aspirin (...) ] prior to CT scan improve [outcome]? Clinical Scenario A 67 year-old man with a history of angina presents with a sudden onset of left sided weakness in the early evening. You know that the patient will not receive a CT scan until the following day and that if he is having a cerebral infarction he may receive some benefit from administration of aspirin. You wonder if the potential benefit out-weighs a possible increase in the risk of worsening any intracranial haemorrhage. Search Strategy Medline

BestBETS2006