Latest & greatest articles for appendicitis

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Appendicitis

Appendicitis is an inflammation of the appendix. Both children and adults can suffer from appendicitis. If untreated the appendix can perforate, causing the release of infectious material in the body, which can be life threatening.

Symptoms and causes of appendicitis

Common symptoms of appendicitis include sharp pain in the abdomen, loss of appetite, fever, severe cramps, diarrhoea and nausea.

It is believed that the main cause of appendicitis is an obstruction of the appendix. The blockage can eventually lead to necrosis giving bacteria and opportunity to cause infection. The blockages is typically calcified faecal deposits.

Diagnosis is typically based on a clinical examination and this can be supported by ultrasound and/or CT scan.

Typically the main cure for an appendicitis has been surgery, but more recently other interventions – namely antibiotics have been tried.

The evidence base, clinical trials, studies etc.

Experts have believed for a long time that the appendix has little purpose in the human body as it shows no negative affects to the body once removed, thus the human body can function perfectly fine without it. However, extensive appendicitis research concludes that the appendix protects good bacteria in the gut. Clinical trials and case studies are ongoing to help understand appendicitis.

Trip is an excellent source of evidence around appendicitis including clinical guidelines, systematic reviews, randomised controlled trials, case studies etc. These can easily be found via a search of the site.

Top results for appendicitis

101. Reliability of diagnostic imaging techniques in suspected acute appendicitis: proposed diagnostic protocol

Reliability of diagnostic imaging techniques in suspected acute appendicitis: proposed diagnostic protocol Reliability of diagnostic imaging techniques in suspected acute appendicitis: proposed diagnostic protocol Reliability of diagnostic imaging techniques in suspected acute appendicitis: proposed diagnostic protocol Del Cura J L, Oleaga L, Grande D, Vela A C, Ibanez A M Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each (...) abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology A diagnostic protocol for the detection of acute appendicitis, based on ultrasound and computed tomography (CT), was studied. Type of intervention Diagnosis. Economic study type Cost-effectiveness analysis. Study population The study population comprised patients admitted to the emergency department

NHS Economic Evaluation Database.2001

102. Comparison of open and laparoscopic treatment of acute appendicitis

Comparison of open and laparoscopic treatment of acute appendicitis Comparison of open and laparoscopic treatment of acute appendicitis Comparison of open and laparoscopic treatment of acute appendicitis Kurtz R J, Heimann T M Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability (...) of the study and the conclusions drawn. Health technology The study compared open and laparoscopic appendectomy for the treatment of acute appendicitis. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population The study population comprised patients undergoing surgical treatment with a preoperative diagnosis of acute appendicitis. Patients undergoing incidental appendectomy as part of another operative procedure were excluded. Setting The setting was secondary care

NHS Economic Evaluation Database.2001

103. Costs and effectiveness of ultrasonography and limited computed tomography for diagnosing appendicitis in children

Costs and effectiveness of ultrasonography and limited computed tomography for diagnosing appendicitis in children Costs and effectiveness of ultrasonography and limited computed tomography for diagnosing appendicitis in children Costs and effectiveness of ultrasonography and limited computed tomography for diagnosing appendicitis in children Garcia Pena B M, Taylor G A, Fishman S J, Mandl K D Record Status This is a critical abstract of an economic evaluation that meets the criteria (...) for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology A protocol of ultrasonography (USG) followed by computed tomography with rectal contrast (CTRC) was used in the diagnosis of acute appendicitis in children. Type of intervention Diagnosis. Economic study type Cost-effectiveness analysis. Study population The study population

NHS Economic Evaluation Database.2000

104. An economic evaluation of sonographic examination of children with suspected appendicitis

An economic evaluation of sonographic examination of children with suspected appendicitis An economic evaluation of sonographic examination of children with suspected appendicitis An economic evaluation of sonographic examination of children with suspected appendicitis Axelrod D A, Sonnad S S, Hirschl R B Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results (...) and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Sonographic examination of children with suspected appendicitis. Type of intervention Diagnosis and treatment. Economic study type Cost-effectiveness analysis. Study population Children with suspected appendicitis. Setting The study setting was the hospital. The economic study was conducted in the USA. Dates to which data relate Effectiveness and resource use data were

NHS Economic Evaluation Database.2000

105. Ultrasonography improves diagnostic accuracy of acute appendicitis and provides cost savings to hospitals in Japan

Ultrasonography improves diagnostic accuracy of acute appendicitis and provides cost savings to hospitals in Japan Ultrasonography improves diagnostic accuracy of acute appendicitis and provides cost savings to hospitals in Japan Ultrasonography improves diagnostic accuracy of acute appendicitis and provides cost savings to hospitals in Japan Fujii Y, Hata J, Futagami K, Hamada T, Mitsuoka H, Teramen K, Konemori G, Suenaga K Record Status This is a critical abstract of an economic evaluation (...) that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Ultrasonography was assessed as a diagnostic tool for acute appendicitis. The sonographic equipment used was a Toshiba SSA-260 A or SSA-380A, equipped with 3.5 to 5.0 MHz convex sectorial probes for the entire abdomen and 7.5 to 10.0 MHz linear probes

NHS Economic Evaluation Database.2000

106. Randomised controlled trial of ultrasonography in diagnosis of acute appendicitis, incorporating the Alvarado score.

Randomised controlled trial of ultrasonography in diagnosis of acute appendicitis, incorporating the Alvarado score. 11030676 2000 11 20 2000 11 20 2016 11 24 0959-8138 321 7266 2000 Oct 14 BMJ (Clinical research ed.) BMJ Randomised controlled trial of ultrasonography in diagnosis of acute appendicitis, incorporating the Alvarado score. 919-22 To determine whether diagnosis by graded compression ultrasonography improves clinical outcomes for patients with suspected appendicitis. A randomised (...) controlled trial comparing clinical diagnosis (control) with a diagnostic protocol incorporating ultrasonography and the Alvarado score (intervention group). Single tertiary referral centre. 302 patients (age 5-82 years) referred to the surgical service with suspected appendicitis. 160 patients were randomised to the intervention group, of whom 129 underwent ultrasonography. Ultrasonography was omitted for patients with extreme Alvarado scores (1-3, 9, or 10) unless requested by the admitting surgical

BMJ2000 Full Text: Link to full Text with Trip Pro

107. A meta-analysis of laparoscopic versus open appendectomy in patients suspected of having acute appendicitis

A meta-analysis of laparoscopic versus open appendectomy in patients suspected of having acute appendicitis A meta-analysis of laparoscopic versus open appendectomy in patients suspected of having acute appendicitis A meta-analysis of laparoscopic versus open appendectomy in patients suspected of having acute appendicitis Temple L K, Litwin D E, McLeod R S Authors' objectives To determine whether any significant differences exist between laparoscopic surgery (LA) and open appendectomy (OA (...) ). Searching The authors searched the MEDLINE electronic database (January 1990 and March 1997) using the search terms: 'appendicitis' or 'appendectomy' and 'laparoscopy'. The authors also searched the bibliographies of retrieved articles and handsearched abstracts from relevant meetings and consulted with a content expert for additional relevant studies. The search was limited to English language publications. Study selection Study designs of evaluations included in the review Randomised controlled trials

DARE.1999

108. Effect of computed tomography on patient management and costs in children with suspected appendicitis

Effect of computed tomography on patient management and costs in children with suspected appendicitis Effect of computed tomography on patient management and costs in children with suspected appendicitis Effect of computed tomography on patient management and costs in children with suspected appendicitis Garcia Pena B M, Taylor G A, Lund D P, Mandl K D Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains (...) a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Three different strategies for using computed tomography (CT) to diagnose and manage children with suspected appendicitis were studied. The diagnostic strategies proposed were: to obtain CT scans on all children who were to be admitted for observation, and to discharge home all those with negative CT scans (CThome

NHS Economic Evaluation Database.1999

109. A new economic benchmark for surgical treatment of appendicitis

A new economic benchmark for surgical treatment of appendicitis A new economic benchmark for surgical treatment of appendicitis A new economic benchmark for surgical treatment of appendicitis Firilas A M, Higginbotham P H, Johnson D D, Jackson R J, Wagner C W, Smith S D Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed (...) critical assessment on the reliability of the study and the conclusions drawn. Health technology Surgical treatment of appendicitis. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population Patients with acute non-perforated appendicitis and perforated appendicitis with peritonitis. Setting Hospital. This study was carried out at Arkansas Children's Hospital, Little Rock, Arkansas, USA. Dates to which data relate Effectiveness, resource use and cost data were

NHS Economic Evaluation Database.1999

110. Accuracy of leukocyte count in the diagnosis of acute appendicitis

Accuracy of leukocyte count in the diagnosis of acute appendicitis DEFINE_ME_WA This site requires Cookies to be enabled to function. Please ensure Cookies are turned on and then re-visit the desired page.

Evidence-Based Emergency Medicine1999

111. An evidenced-based clinical pathway for acute appendicitis decreases hospital duration and cost

An evidenced-based clinical pathway for acute appendicitis decreases hospital duration and cost An evidenced-based clinical pathway for acute appendicitis decreases hospital duration and cost An evidenced-based clinical pathway for acute appendicitis decreases hospital duration and cost Warner B W, Kulick R M, Stoops M M, Mehta S, Stephan M, Kotagal U R Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains (...) a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology An evidence-based clinical pathway for acute appendicitis. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population The study population consisted of paediatric patients with acute appendicitis. Exclusion criteria were: age three years or younger; previous appendectomy; history

NHS Economic Evaluation Database.1998

112. Laparoscopic appendectomy is an acceptable alternative for the treatment of perforated appendicitis

Laparoscopic appendectomy is an acceptable alternative for the treatment of perforated appendicitis Laparoscopic appendectomy is an acceptable alternative for the treatment of perforated appendicitis Laparoscopic appendectomy is an acceptable alternative for the treatment of perforated appendicitis Johnson A B, Peetz M E Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods (...) , the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Laparoscopy and open procedures for the treatment of perforated appendicitis. Type of intervention Diagnosis and treatment. Economic study type Cost-effectiveness analysis. Study population Patients undergoing surgery for suspected acute appendicitis. Setting Hospital setting. The study was carried out at the North Colorado Medical Center, USA. Dates to which

NHS Economic Evaluation Database.1998

113. The accuracy of C-reactive protein in diagnosing acute appendicitis

The accuracy of C-reactive protein in diagnosing acute appendicitis The accuracy of C-reactive protein in diagnosing acute appendicitis The accuracy of C-reactive protein in diagnosing acute appendicitis Hallan S, Asberg A Authors' objectives To determine the accuracy of C-reactive protein (CRP) in diagnosing acute appendicitis. Searching Major textbooks were consulted and MEDLINE was searched from 1983 to 1995 using the following search strategy: (explode) 'appendicitis' AND (explode (...) for inclusion. Reference standard test against which the new test was compared Studies that used histology as the reference standard for diagnosing acute appendicitis were eligible for inclusion. Participants included in the review Studies of children and adults who had suspected appendicitis and those who were already selected for appendectomy were included. Outcomes assessed in the review Studies had to report the sensitivity and specificity to be included. How were decisions on the relevance of primary

DARE.1997

114. Ultrasonography to evaluate adults for appendicitis: decision making based on meta-analysis and probabilistic reasoning

Ultrasonography to evaluate adults for appendicitis: decision making based on meta-analysis and probabilistic reasoning Ultrasonography to evaluate adults for appendicitis: decision making based on meta-analysis and probabilistic reasoning Ultrasonography to evaluate adults for appendicitis: decision making based on meta-analysis and probabilistic reasoning Orr R K, Porter D, Hartman D Authors' objectives To assess the performance of ultrasonography (US), and to develop recommendations for its (...) use in the evaluation of potential appendicitis. Searching MEDLINE was searched from 1986 to 1994 for English language reports using the following subject headings and keywords: 'ultrasound', 'ultrasonography', 'sonography', 'appendix' and 'appendicitis'. The citation lists of retrieved literature were searched for additional material, and recent journals in radiology, surgery and emergency medicine were examined. Unpublished data were not sought and the individual authors were not contacted about

DARE.1995

115. Laparoscopic versus conventional surgery for suspected appendicitis in women

Laparoscopic versus conventional surgery for suspected appendicitis in women Laparoscopic versus conventional surgery for suspected appendicitis in women Laparoscopic versus conventional surgery for suspected appendicitis in women Zaninotto G, Rossi M, Anselmino M, Costantini M, Pianalto S, Baldan N, Pizzato D, Ancona E Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods (...) , the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Laparoscopic surgery for suspected appendicitis in women. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population Female patients admitted to the surgical ward with right lower abdominal pain and a suspected diagnosis of appendicitis. Setting Hospital. The economic study was conducted in Padova, Italy. Dates to which

NHS Economic Evaluation Database.1995

116. Interval appendectomy in perforated appendicitis

Interval appendectomy in perforated appendicitis Interval appendectomy in perforated appendicitis Interval appendectomy in perforated appendicitis Weiner D J, Katz A, Hirschl R B, Drongowski R, Coran A G Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions (...) drawn. Health technology Nonoperative therapy for perforated appendicitis in children followed by interval appendectomy. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population Children undergoing admission for appendicitis. Setting Hospital. The economic study was conducted in the USA. Dates to which data relate Effectiveness data were collected between 1979-1989. The year to which the costs related was not stated. Source of effectiveness data Single study

NHS Economic Evaluation Database.1995