Latest & greatest articles for appendicitis

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Appendicitis

Appendicitis is an inflammation of the appendix. Both children and adults can suffer from appendicitis. If untreated the appendix can perforate, causing the release of infectious material in the body, which can be life threatening.

Symptoms and causes of appendicitis

Common symptoms of appendicitis include sharp pain in the abdomen, loss of appetite, fever, severe cramps, diarrhoea and nausea.

It is believed that the main cause of appendicitis is an obstruction of the appendix. The blockage can eventually lead to necrosis giving bacteria and opportunity to cause infection. The blockages is typically calcified faecal deposits.

Diagnosis is typically based on a clinical examination and this can be supported by ultrasound and/or CT scan.

Typically the main cure for an appendicitis has been surgery, but more recently other interventions – namely antibiotics have been tried.

The evidence base, clinical trials, studies etc.

Experts have believed for a long time that the appendix has little purpose in the human body as it shows no negative affects to the body once removed, thus the human body can function perfectly fine without it. However, extensive appendicitis research concludes that the appendix protects good bacteria in the gut. Clinical trials and case studies are ongoing to help understand appendicitis.

Trip is an excellent source of evidence around appendicitis including clinical guidelines, systematic reviews, randomised controlled trials, case studies etc. These can easily be found via a search of the site.

Top results for appendicitis

81. Acute appendicitis: meta-analysis of diagnostic performance of CT and graded compression US related to prevalence of disease

Acute appendicitis: meta-analysis of diagnostic performance of CT and graded compression US related to prevalence of disease Acute appendicitis: meta-analysis of diagnostic performance of CT and graded compression US related to prevalence of disease Acute appendicitis: meta-analysis of diagnostic performance of CT and graded compression US related to prevalence of disease van Randen A, Bipat S, Zwinderman AH, Ubbink DT, Stoker J, Boermeester MA CRD summary This well-conducted review directly (...) compared computed tomography (CT) and compression graded ultrasonography for the diagnosis of acute appendicitis. The authors' conclusion that CT performed better than ultrasonography, is a valid interpretation of the available data, but these data were sparse. Authors' objectives To compare the accuracy of graded compression ultrasonography and computed tomography (CT) for the diagnosis of acute appendicitis, and to examine how diagnostic performance (in terms of post-test probability) varies

DARE.2008

82. Review: symptoms, signs, and lab tests have moderate accuracy for detecting appendicitis in children

Review: symptoms, signs, and lab tests have moderate accuracy for detecting appendicitis in children Review: symptoms, signs, and lab tests have moderate accuracy for detecting appendicitis in children | Evidence-Based Medicine This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword (...) Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Review: symptoms, signs, and lab tests have moderate accuracy for detecting appendicitis in children Article Text Diagnosis Review: symptoms, signs, and lab tests have moderate accuracy for detecting appendicitis in children Statistics from Altmetric.com No Altmetric data available for this article. Request

Evidence-Based Medicine (Requires free registration)2008

83. Does this child have appendicitis?

Does this child have appendicitis? CONTEXT: Evaluation of abdominal pain in children can be difficult. Rapid, accurate diagnosis of appendicitis in children reduces the morbidity of this common cause of pediatric abdominal pain. Clinical evaluation may help identify (1) which children with abdominal pain and a likely diagnosis of appendicitis should undergo immediate surgical consultation for potential appendectomy and (2) which children with equivocal presentations of appendicitis should (...) undergo further diagnostic evaluation. OBJECTIVE: To systematically assess the precision and accuracy of symptoms, signs, and basic laboratory test results for evaluating children with possible appendicitis. DATA SOURCES: We searched English-language articles in MEDLINE (January 1966-March 2007) and the Cochrane Database, as well as physical examination textbooks and bibliographies of retrieved articles, yielding 2521 potentially relevant articles. STUDY SELECTION: Studies were included if they (1

JAMA2007 Full Text: Link to full Text with Trip Pro

84. Ultrasound scanning in the diagnosis of acute appendicitis in pregnancy

Ultrasound scanning in the diagnosis of acute appendicitis in pregnancy BestBets: Ultrasound scanning in the diagnosis of acute appendicitis in pregnancy Ultrasound scanning in the diagnosis of acute appendicitis in pregnancy Report By: Robert Williams - Specialist Registrar in Emergency Medicine Search checked by Jonathan Shaw - SpR in Emergency Medicine Institution: Royal Oldham Hospital Date Submitted: 1st March 2000 Date Completed: 4th May 2007 Last Modified: 20th March 2007 Status: Green (...) (complete) Three Part Question In [women with possible appendicitis in pregnancy] is [abdominal ultrasonography] good at [ruling in or ruling out appendicular disease] Clinical Scenario A 28 year old woman presents to the emergency department with a 4 hour history of right iliac fossa pain, and an examination suggestive of acute appendicitis. You are aware that an isolated blood count is neither specific nor sensitive in the diagnosis of appendicitis, and the on-call surgeon suggests that an ultrasound

BestBETS2007

85. Does this child have appendicitis?

Does this child have appendicitis? Does this child have appendicitis? Does this child have appendicitis? Bundy D G, Byerley J S, Liles E A, Perrin E M, Katznelson J, Rice H E CRD summary The review assessed the performance of clinical examination and basic laboratory tests in the diagnostic evaluation of children with suspected appendicitis. The authors concluded that clinical examination does not establish diagnosis, but may be useful to select children for immediate surgical assessment (...) or further testing. These conclusions are likely to be reliable. Authors' objectives To assess the precision and accuracy of symptoms, signs and laboratory test results in diagnosing children with suspected appendicitis. Searching MEDLINE was searched from 1966 to March 2007; the search terms were reported. The bibliographies of retrieved articles and reviews, medical textbooks and the Cochrane Library were searched for additional articles. Study selection Study designs of evaluations included

DARE.2007

86. Computed tomography and ultrasonography in the diagnosis of equivocal acute appendicitis. a meta-analysis

Computed tomography and ultrasonography in the diagnosis of equivocal acute appendicitis. a meta-analysis Computed tomography and ultrasonography in the diagnosis of equivocal acute appendicitis. a meta-analysis Computed tomography and ultrasonography in the diagnosis of equivocal acute appendicitis. a meta-analysis Al-Khayal KA, Al-Omran MA CRD summary This review concluded that although CT scan was more sensitive than ultrasonography, either CT scan or ultrasonography could be used (...) for the initial diagnosis of acute appendicitis in patients presenting with equivocal findings. The reliability of these conclusions may be limited by potential flaws in the review process. Authors' objectives To evaluate the diagnostic accuracy of computed tomography (CT) and ultrasonography for the early detection of acute appendicitis in patients presenting with equivocal findings. Searching MEDLINE was searched for English-language studies from 1966 to December 2005. Search terms were reported

DARE.2007

87. US or CT for diagnosis of appendicitis in children and adults: a meta-analysis

US or CT for diagnosis of appendicitis in children and adults: a meta-analysis US or CT for diagnosis of appendicitis in children and adults: a meta-analysis US or CT for diagnosis of appendicitis in children and adults: a meta-analysis Doria A S, Moineddin R, Kellenberger C J, Epelman M, Beyene J, Schuh S, Babyn P S, Dick P T CRD summary The authors concluded that computed tomography is more sensitive than ultrasound, i.e. fewer cases of appendicitis are missed, but that specificity is similar (...) , i.e. similar numbers of false positives are generated. These conclusions reflect the data presented, but should be viewed with caution given the methodological limitations of the review. Authors' objectives To evaluate the diagnostic performance of ultrasonography (US) and computed tomography (CT) for the detection of appendicitis in children and adults. Searching Studies published between 1986 and December 2004 were sought by searching MEDLINE, EMBASE, CINAHL, the Cochrane Controlled Trials

DARE.2006

88. Review: the use of computed tomographic scanning has high sensitivity, specificity, and accuracy for diagnosing acute appendicitis in adults

Review: the use of computed tomographic scanning has high sensitivity, specificity, and accuracy for diagnosing acute appendicitis in adults Review: the use of computed tomographic scanning has high sensitivity, specificity, and accuracy for diagnosing acute appendicitis in adults | Evidence-Based Medicine This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in using your username and password For personal accounts OR managers of institutional (...) accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Review: the use of computed tomographic scanning has high sensitivity, specificity, and accuracy for diagnosing acute appendicitis in adults Article Text Diagnosis Review: the use of computed tomographic scanning has high

Evidence-Based Medicine (Requires free registration)2005

89. Review: inflammatory response variables, descriptors of peritoneal irritation, and migration of pain are most discriminatory of appendicitis

Review: inflammatory response variables, descriptors of peritoneal irritation, and migration of pain are most discriminatory of appendicitis Review: inflammatory response variables, descriptors of peritoneal irritation, and migration of pain are most discriminatory of appendicitis | Evidence-Based Medicine This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in using your username and password For personal accounts OR managers of institutional (...) accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Review: inflammatory response variables, descriptors of peritoneal irritation, and migration of pain are most discriminatory of appendicitis Article Text Diagnosis Review: inflammatory response variables, descriptors

Evidence-Based Medicine (Requires free registration)2005

90. Diagnosis of appendicitis in adults by ultrasonography or computed tomography: a systematic review and meta-analysis

Diagnosis of appendicitis in adults by ultrasonography or computed tomography: a systematic review and meta-analysis Diagnosis of appendicitis in adults by ultrasonography or computed tomography: a systematic review and meta-analysis Diagnosis of appendicitis in adults by ultrasonography or computed tomography: a systematic review and meta-analysis Weston A R, Jackson T J, Blamey S CRD summary This review assessed the accuracy of ultrasonography and computed tomography (CT) in diagnosing (...) appendicitis in adults. The authors concluded that evidence suggests that CT is a sensitive and specific diagnostic test, but its routine use cannot be supported. The lack of reporting of review methods and the inclusion of generally poor-quality studies mean that the conclusions may be overstated. Authors' objectives To assess the accuracy of ultrasonography and computed tomography (CT) in diagnosing acute appendicitis in adults. Searching MEDLINE, EMBASE, the Cochrane Database of Systematic Reviews, DARE

DARE.2005

91. Cost-effectiveness analysis of weekday and weeknight or weekend shifts for assessment of appendicitis

Cost-effectiveness analysis of weekday and weeknight or weekend shifts for assessment of appendicitis Cost-effectiveness analysis of weekday and weeknight or weekend shifts for assessment of appendicitis Cost-effectiveness analysis of weekday and weeknight or weekend shifts for assessment of appendicitis Doria A S, Amernic H, Dick P, Babyn P, Chait P, Langer J, Coyte P C, Ungar W J Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS (...) EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The study examined diagnostic assessment of paediatric appendicitis during two different periods of activity in a hospital. The weeknight or weekend shift (after-hours period, AHP) was compared with the weekday shift (standard-hours period, SHP). The SHP was defined as the work shift occurring

NHS Economic Evaluation Database.2005

92. Watchful waiting versus interval appendectomy for patients who recovered from acute appendicitis with tumor formation: a cost-effectiveness analysis

Watchful waiting versus interval appendectomy for patients who recovered from acute appendicitis with tumor formation: a cost-effectiveness analysis Watchful waiting versus interval appendectomy for patients who recovered from acute appendicitis with tumor formation: a cost-effectiveness analysis Watchful waiting versus interval appendectomy for patients who recovered from acute appendicitis with tumor formation: a cost-effectiveness analysis Lai H W, Loong C C, Wu C W, Lui W Y Record Status (...) This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The use of interval appendectomy (IA) for patients with a diagnosis of appendicitis. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population The study population

NHS Economic Evaluation Database.2005

93. Systematic review: computed tomography and ultrasonography to detect acute appendicitis in adults and adolescents

Systematic review: computed tomography and ultrasonography to detect acute appendicitis in adults and adolescents Systematic review: computed tomography and ultrasonography to detect acute appendicitis in adults and adolescents Systematic review: computed tomography and ultrasonography to detect acute appendicitis in adults and adolescents Terasawa T, Blackmore C, Bent S, Kohlwes R J CRD summary This review assessed the diagnostic accuracy of computed tomography (CT) and ultrasonography (...) in adults and adolescents with suspected appendicitis. The authors concluded that CT is probably more accurate than ultrasonography in diagnosing appendicitis. The conclusions of this well-conducted review are appropriately cautious given the methodological weaknesses of the included studies. Authors' objectives To assess the diagnostic accuracy of computed tomography (CT) and ultrasonography in adults and adolescents with suspected acute appendicitis. Searching MEDLINE and EMBASE were searched from

DARE.2004

94. Laparoscopic appendectomy in children: technically feasible and safe in all stages of acute appendicitis

Laparoscopic appendectomy in children: technically feasible and safe in all stages of acute appendicitis Laparoscopic appendectomy in children: technically feasible and safe in all stages of acute appendicitis Laparoscopic appendectomy in children: technically feasible and safe in all stages of acute appendicitis Vegunta R K, Ali A, Wallace L J, Switzer D M, Pearl R H Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each (...) in the smaller children. All patients were given cefoxitin preoperatively, while those who were thought to have a ruptured appendix at the time of surgery were given ampicillin, gentamicin and metronidazole intravenously. The comparator treatment was open appendectomy (OAP). Patients in both treatment groups with a ruptured appendicitis, who presented late with a walled-off periappendiceal abscess, underwent percutaneous drain placement with intravenous antibiotics and had an interval appendectomy (IA) 6

NHS Economic Evaluation Database.2004

95. Ultrasound diagnosis of acute appendicitis: impact on cost and outcome in pediatric patients

Ultrasound diagnosis of acute appendicitis: impact on cost and outcome in pediatric patients Ultrasound diagnosis of acute appendicitis: impact on cost and outcome in pediatric patients Ultrasound diagnosis of acute appendicitis: impact on cost and outcome in pediatric patients Tiu C M, Chou Y H, Chen J D, Chiou Y Y, Wei C F, Chin T W, Chiou H J, Chiou S Y, Wang H K, Chen S P Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED (...) . Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The study examined ultrasound (US) diagnosis in children with clinical suspected acute appendicitis. Grade compression US examination was applied using 7.0- to 10-MHz linear array transducers. A detailed US examination of the right lower abdomen was followed by a general survey of the whole abdomen

NHS Economic Evaluation Database.2004

96. Laparoscopic vs conventional appendectomy for suspected acute appendicitis

Laparoscopic vs conventional appendectomy for suspected acute appendicitis Laparoscopic vs conventional appendectomy for suspected acute appendicitis Laparoscopic vs conventional appendectomy for suspected acute appendicitis Ferrante D Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Ferrante D. Laparoscopic vs conventional appendectomy (...) for suspected acute appendicitis. Institute for Clinical Effectiveness and Health Policy (IECS). Informe de Respuesta Rapida No.2. 2003 Authors' objectives The aim of this report was to summarise the available evidence on laparoscopic vs conventional appendectomy for suspected acute appendicitis. Authors' conclusions In those settings/institutions where experience and equipment are available, and there are resources, diagnostic laparoscopy and LS are recommended according to clinical guidelines, although

Health Technology Assessment (HTA) Database.2003

97. Imaging in appendicitis: a review with special emphasis on the treatment of women

Imaging in appendicitis: a review with special emphasis on the treatment of women Imaging in appendicitis: a review with special emphasis on the treatment of women Imaging in appendicitis: a review with special emphasis on the treatment of women Neumayer L, Kennedy A CRD summary This review assessed computed tomography (CT) in diagnosing appendicitis in adults. The authors concluded that the results support the routine use of CT in men and women with suspected appendicitis. The exclusion (...) of equivocal results from the included studies might have inflated the diagnostic accuracy of CT. The results presented were insufficient to support the authors' conclusions. Authors' objectives To assess the accuracy of computed tomography (CT) scanning in diagnosing appendicitis in adults. Searching PubMed was searched from January to July 2003 for studies published in English; the search terms were stated. The reference lists in identified studies were also checked. Study selection Study designs

DARE.2003

98. Monotherapy versus multi-drug therapy for the treatment of perforated appendicitis in children

Monotherapy versus multi-drug therapy for the treatment of perforated appendicitis in children Monotherapy versus multi-drug therapy for the treatment of perforated appendicitis in children Monotherapy versus multi-drug therapy for the treatment of perforated appendicitis in children Nadler E P, Reblock K K, Ford H R, Gaines B A Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary (...) of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The authors assessed monotherapy treatment for children with perforated appendicitis. Monotherapy consisted of a 100 mg/kg dose of the piperacillin-tazobactam (PT) component given every 8 hours if the patient was younger than 12 years old, and a 4 g dose given every 8 hours if the patient was older than 12 years old. Treatment lasted for 10 to 14

NHS Economic Evaluation Database.2003

99. Impact of a clinical pathway and standardization of treatment for acute appendicitis

Impact of a clinical pathway and standardization of treatment for acute appendicitis Impact of a clinical pathway and standardization of treatment for acute appendicitis Impact of a clinical pathway and standardization of treatment for acute appendicitis Takegami K, Kawaguchi Y, Nakayama H, Kubota Y, Nagawa H Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results (...) and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The health technology studied was a clinical pathway and standardisation of treatment for acute appendicitis. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population The study population comprised patients admitted to hospital with acute appendicitis between January 1998 and December 1999. From January 2000, all patients admitted

NHS Economic Evaluation Database.2003

100. Antibiotic therapy for acute appendicitis: Ampicillin, metronidazole plus gentamycin versus cephalosporin

Antibiotic therapy for acute appendicitis: Ampicillin, metronidazole plus gentamycin versus cephalosporin Antibiotic therapy for acute appendicitis: Ampicillin, metronidazole plus gentamycin versus cephalosporin Antibiotic therapy for acute appendicitis: Ampicillin, metronidazole plus gentamycin versus cephalosporin Muggli E Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database (...) . Citation Muggli E. Antibiotic therapy for acute appendicitis: Ampicillin, metronidazole plus gentamycin versus cephalosporin. Clayton, Victoria: Centre for Clinical Effectiveness (CCE) 2002: 12 Authors' objectives This aim of this report was to assess which antibiotic regimen is more appropriate for acute appendicitis: Ampicillin, metronidazole plus gentamycin or cephalosporin (+/- metronidazole). Authors' conclusions - One randomised trial was reviewed that met inclusion and exclusion criteria

Health Technology Assessment (HTA) Database.2002