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Latest & greatest articles for anticoagulation
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New generation anticoagulants may be safer than warfarin for people with chronic kidney disease NIHR DC | Signal - New generation anticoagulants may be safer than warfarin for people with chronic kidney disease Dissemination Centre Discover Portal NIHR DC Discover NIHR Signal New generation anticoagulants may be safer than warfarin for people with chronic kidney disease Published on 26 April 2016 Newer generation anticoagulants appear to reduce the risk of bleeding compared with older (...) anticoagulants like warfarin, when used to prevent clots in people who also have mild to moderate chronic kidney disease. This group of drugs, called direct oral anticoagulants, have been well researched in healthy people with atrial fibrillation or at risk of thromboembolism but this was the first review to look at their safety, in terms of bleeding and risk of bleeding within the brain, in people with kidney disease. As a group, these newer drugs appear safer than older anticoagulants such as warfarin
An anticoagulant, bivalirudin, may not be safer than the alternative, heparin, when unblocking arteries in the heart NIHR DC | Signal - An anticoagulant, bivalirudin, may not be safer than the alternative, heparin, when unblocking arteries in the heart Dissemination Centre Discover Portal NIHR DC Discover NIHR Signal An anticoagulant, bivalirudin, may not be safer than the alternative, heparin, when unblocking arteries in the heart Published on 14 June 2016 Bivalirudin is currently recommended (...) procedures were carried out in the UK. It involves inserting a small tube called a stent into the heart’s arteries, to hold them open. Anticoagulant treatment is needed at the same time to reduce the risk of clotting during and after the procedure. Heparin is the long established anticoagulant, but newer bivalirudin may now be used as an alternative. To date, different trials have produced contradictory evidence comparing the safety and effectiveness of the two anticoagulants when given to patients
The Society of Thoracic Surgeons, The Society of Cardiovascular Anesthesiologists, and The American Society of ExtraCorporeal Technology: Clinical Practice Guidelines - Anticoagulation During Cardiopulmonary Bypass CLINICAL PRACTICE GUIDELINES The Society of Thoracic Surgeons, The Society of Cardiovascular Anesthesiologists, and The American Society of ExtraCorporeal Technology: Clinical Practice Guidelines*—Anticoagulation During Cardiopulmonary Bypass Linda Shore-Lesserson, MD, Robert (...) Management, University of Texas-Southwestern Medical Center, Dallas, Texas; Division of Cardiovascular Perfusion, Medical University of South Carolina, Charleston, South Carolina; Department of Anesthesiology, Saint Anthony Hospital, Lakewood, Colorado; and Department of Cardiothoracic Surgery, Wake Forest University School of Medicine, Winston-Salem, North Carolina Despite more than a half century of “safe” cardiopulmo- nary bypass (CPB), the evidence base surrounding the conduct of anticoagulation therapy for CPB
Timing of Anticoagulation for Portal Vein Thrombosis in Liver Cirrhosis: A US Hepatologistâ€™s Perspective 29607296 2018 11 14 2450-131X 6 1 2018 Mar Journal of translational internal medicine J Transl Int Med Timing of Anticoagulation for Portal Vein Thrombosis in Liver Cirrhosis: A US Hepatologist's Perspective. 1-5 10.2478/jtim-2018-0001 Northup Patrick G PG MD Center for the Study of Coagulation in Liver Disease, Division of Gastroenterology and Hepatology, University of Virginia
Timing of Anticoagulation for Portal Vein Thrombosis in Liver Cirrhosis: An Italian Internistâ€™s Perspective 29607297 2018 11 14 2450-131X 6 1 2018 Mar Journal of translational internal medicine J Transl Int Med Timing of Anticoagulation for Portal Vein Thrombosis in Liver Cirrhosis: An Italian Internist's Perspective. 6-10 10.2478/jtim-2018-0002 Riva Nicoletta N Department of Pathology, University of Malta, Msida, Malta. Ageno Walter W Department of Medicine and Surgery, University
VKORC1 and VKORC1L1 have distinctly different oral anticoagulant dose-response characteristics and binding sites 29581108 2018 11 14 2473-9537 2 6 2018 03 27 Blood advances Blood Adv VKORC1 and VKORC1L1 have distinctly different oral anticoagulant dose-response characteristics and binding sites. 691-702 10.1182/bloodadvances.2017006775 Vitamin K reduction is catalyzed by 2 enzymes in vitro: the vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1) and its isozyme VKORC1-like1 (VKORC1L1 (...) ). In vivo, VKORC1 reduces vitamin K to sustain γ-carboxylation of vitamin K-dependent proteins, including coagulation factors. Inhibition of VKORC1 by oral anticoagulants (OACs) is clinically used in therapy and in prevention of thrombosis. However, OACs also inhibit VKORC1L1, which was previously shown to play a role in intracellular redox homeostasis in vitro. Here, we report data for the first time on specific inhibition of both VKOR enzymes for various OACs and rodenticides examined in a cell-based
The Significance of Drugâ€”Drug and Drugâ€”Food Interactions of Oral Anticoagulation 29636974 2018 11 14 2050-3369 7 1 2018 Mar Arrhythmia & electrophysiology review Arrhythm Electrophysiol Rev The Significance of Drug-Drug and Drug-Food Interactions of Oral Anticoagulation. 55-61 10.15420/aer.2017.50.1 Vitamin K antagonists (VKAs) such as warfarin are the most commonly prescribed oral anticoagulants worldwide. However, factors affecting the pharmacokinetics of VKAs, such as food and drugs, can (...) cause deviations from their narrow therapeutic window, increasing the bleeding or thrombosis risk and complicating their long-term use. The use of direct oral anticoagulants (DOACs) offers a safer and more convenient alternative to VKAs. However, it is important to be aware that plasma levels of DOACs are affected by drugs that alter the cell efflux transporter P-glycoprotein and/or cytochrome P450. In addition to these pharmacokinetic-based interactions, DOACs have the potential for pharmacodynamic
Combination of the low anticoagulant heparin CX-01 with chemotherapy for the treatment of acute myeloid leukemia 29467192 2018 11 13 2473-9537 2 4 2018 02 27 Blood advances Blood Adv Combination of the low anticoagulant heparin CX-01 with chemotherapy for the treatment of acute myeloid leukemia. 381-389 10.1182/bloodadvances.2017013391 Relapses in acute myelogenous leukemia (AML) are a result of quiescent leukemic stem cells (LSCs) in marrow stromal niches, where they resist chemotherapy. LSCs (...) employ CXCL12/CXCR4 to home toward protective marrow niches. Heparin disrupts CXCL12-mediated sequestration of cells in the marrow. CX-01 is a low-anticoagulant heparin derivative. In this pilot study, we combined CX-01 with chemotherapy for the treatment of AML. Induction consisted of cytarabine and idarubicin (7 + 3) with CX-01. Twelve patients were enrolled (median age, 56 years; 3 women). Three, 5, and 4 patients had good-, intermediate-, and poor-risk disease, respectively. Day 14 bone marrows
Ischaemic stroke, haemorrhage, and mortality in older patients with chronic kidney disease newly started on anticoagulation for atrial fibrillation: a population based study from UK primary care. OBJECTIVE: To assess the association between anticoagulation, ischaemic stroke, gastrointestinal and cerebral haemorrhage, and all cause mortality in older people with atrial fibrillation and chronic kidney disease. DESIGN: Propensity matched, population based, retrospective cohort analysis from (...) with a previous diagnosis of atrial fibrillation or receiving anticoagulation in the preceding 120 days were excluded, as were patients requiring dialysis and recipients of renal transplants. INTERVENTION: Receipt of an anticoagulant prescription within 60 days of atrial fibrillation diagnosis. MAIN OUTCOME MEASURES: Ischaemic stroke, cerebral or gastrointestinal haemorrhage, and all cause mortality. RESULTS: 6977 patients with chronic kidney disease and newly diagnosed atrial fibrillation were identified
The safety of regional citrate anticoagulation in renal replacement therapy SAGE Journals: Your gateway to world-class journal research MENU Sign In Institution Society Access Options You can be signed in via any or all of the methods shown below at the same time. My Profile Sign in here to access free tools such as favourites and alerts, or to access personal subscriptions Email (required) Password (required) Remember me I don't have a profile I am signed in as: With my free profile I can: Set
Comparative effectiveness of direct oral anticoagulants and warfarin in patients with cancer and atrial fibrillation REGULARARTICLE Comparative effectiveness of direct oral anticoagulants and warfarin in patients with cancer and atrial?brillation Surbhi Shah, 1 Faye L. Norby, 2 Yvonne H. Datta, 1 Pamela L. Lutsey, 2 Richard F. MacLehose, 2 Lin Y. Chen, 1 and Alvaro Alonso 3 1 Department of Medicine, Universityof Minnesota Medical School, Minneapolis,MN; 2 Division of Epidemiologyand Community (...) Health, School of Public Health, University of Minnesota, Minneapolis, MN; and 3 Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA Key Points ? In AF and cancer pa- tients, rate of bleeding is lower with apixaban, similar in dabigatran and rivaroxaban users, compared to warfarin users. ? Ischemic stroke rates did not differ among anticoagulant users. Incident VTE risk was lower in all DOAC compared with warfarin users
Association of Intracerebral Hemorrhage Among Patients Taking Non-Vitamin K Antagonist vs Vitamin K Antagonist Oral Anticoagulants With In-Hospital Mortality. Importance: Although non-vitamin K antagonist oral anticoagulants (NOACs) are increasingly used to prevent thromboembolic disease, there are limited data on NOAC-related intracerebral hemorrhage (ICH). Objective: To assess the association between preceding oral anticoagulant use (warfarin, NOACs, and no oral anticoagulants [OACs (...) ]) and in-hospital mortality among patients with ICH. Design, Setting, and Participants: Retrospective cohort study of 141 311 patients with ICH admitted from October 2013 to December 2016 to 1662 Get With The Guidelines-Stroke hospitals. Exposures: Anticoagulation therapy before ICH, defined as any use of OACs within 7 days prior to hospital arrival. Main Outcomes and Measures: In-hospital mortality. Results: Among 141 311 patients with ICH (mean [SD] age, 68.3 [15.3] years; 48.1% women), 15 036 (10.6%) were
Less dementia with oral anticoagulation in atrial fibrillation 29077849 2017 10 27 1522-9645 2017 Oct 24 European heart journal Eur. Heart J. Less dementia with oral anticoagulation in atrial fibrillation. 10.1093/eurheartj/ehx579 The association between atrial fibrillation (AF) and dementia is well documented, but it is not clear if oral anticoagulant treatment offers protection. The aim of the study is therefore to compare the incidence of new dementia in patients with AF with and without (...) oral anticoagulants, and to explore if there is a difference between novel anticoagulants and warfarin in this respect. Retrospective registry study of all patients with hospital diagnosis of AF and no previous diagnosis of dementia in Sweden between 2006 and 2014. Propensity score matching, falsification endpoints, and analyses according to intention to treat as well as on-treatment principles were used. The study included 444 106 patients and over 1.5 million years at risk. Patients
Meta-Analysis of the Safety and Efficacy of the Oral Anticoagulant Agents (Apixaban, Rivaroxaban, Dabigatran) in Patients With Acute Coronary Syndrome 29195825 2018 01 08 1879-1913 121 3 2018 Feb 01 The American journal of cardiology Am. J. Cardiol. Meta-Analysis of the Safety and Efficacy of the Oral Anticoagulant Agents (Apixaban, Rivaroxaban, Dabigatran) in Patients With Acute Coronary Syndrome. 301-307 S0002-9149(17)31692-2 10.1016/j.amjcard.2017.10.035 The significance of adding new oral (...) anticoagulants (NOACs) to antiplatelet therapy in patients with acute coronary syndrome (ACS) is unclear. We conducted a meta-analysis to assess the safety and efficacy of adding NOACs (apixaban, rivaroxaban, and dabigatran) to single antiplatelet agent (SAP) or dual antiplatelet therapy (DAPT) in patients with ACS. Seven randomized controlled trials were selected using PubMed or MEDLINE, Scopus, and Cochrane library (inception to August 2017). The summary measure was random effects hazard ratio (HR) with 95
Should We Maintain Anticoagulation after Successful Radiofrequency Catheter Ablation of Atrial Fibrillation? The Need for a Randomized Study December 2017 | Volume 4 | Article 85 1 Hypot Hesis and tH eory published: 21 December 2017 doi: 10.3389/fcvm.2017.00085 Frontiers in Cardiovascular Medicine | www.frontiersin.org Edited by: Shimon Rosenheck, Meir Medical Center, Israel Reviewed by: Benjamin Berte, Klinik Im Park, Zurich Javier Eduardo Banchs, Baylor Scott and White Health, United States (...) Marco Proietti, Birmingham University, United Kingdom *Correspondence: Ciro Indolfi firstname.lastname@example.org Specialty section: This article was submitted to Cardiac Rhythmology, a section of the journal Frontiers in Cardiovascular Medicine Received: 27 April 2017 Accepted: 08 December 2017 Published: 21 December 2017 Citation: Santarpia G, De Rosa S, Sabatino J, Curcio A and Indolfi C (2017) Should We Maintain Anticoagulation after Successful Radiofrequency Catheter Ablation of Atrial Fibrillation
Sociodemographic factors in patients continuing warfarin vs those transitioning to direct oral anticoagulants 29296905 2018 11 13 2473-9529 1 26 2017 Dec 12 Blood advances Blood Adv Sociodemographic factors in patients continuing warfarin vs those transitioning to direct oral anticoagulants. 2536-2540 10.1182/bloodadvances.2017012377 Clinical factors and patient preferences are important for selecting oral anticoagulants for venous thromboembolism (VTE) and atrial fibrillation (AF). The (...) relative association of sociodemographic factors with anticoagulant use is unknown. We evaluated a prospective cohort to compare sociodemographic variables in patients who continued on warfarin for AF or VTE to those who transitioned to 1 of the direct oral anticoagulants (DOACs). Adult patients, newly started on warfarin, were enrolled through 6 anticoagulation clinics across Michigan. Of 8468 patients, 53.3% had AF, 45.6% had VTE, and 1.1% had both. Of these, 696 (8.2%) switched from warfarin