Latest & greatest articles for antibiotics

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This page lists the very latest high quality evidence on antibiotics and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

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Antibiotics

Antibiotics also referred to as antibacterial are a type of medicine that prevents the growth of bacteria. As such they are used to treat infections caused by bacteria. They kill or prevents bacteria from spreading.

Antibiotics are vital in modern day medicine; they are among the most frequently prescribed drug. There are over a 100 types of antibiotics, the main types and most commonly prescribed are penicillin, cephalosporin, macrolides, fluoroquinolone and tetracycline. They tend to be classified by mechanism of action. So, those that target the bacterial cell wall (penicillins and cephalosporins) or the cell membrane (polymyxins), or interfere with essential bacterial enzymes (rifamycins, lipiarmycins, quinolones, and sulfonamides) have bactericidal activities. Antibiotics such as macrolides, lincosamides and tetracyclines inhibit protein synthesis.

Antibiotics can all be defined by their specificity. “Narrow-spectrum” antibiotics target specific types of bacteria, for instance gram-negative (-ve) or gram-positive (+ve), whereas broad-spectrum antibiotics affect a wide range of bacteria.

Antibiotics are increasingly suffering from antibiotic resistance caused by bacterial mutations meaning the bacteria evolves to not be sensitive to the specific antibiotics being used.

Clinical trials are important to the development and understanding of antibiotics and their side effects. Although they are deemed safe, over use of the drug can kill good bacteria and lead to antibiotic resistance. This halts the ability of bacteria and microorganisms to resist the effects of the antibiotic. Clinical trials and research allow scientists and medical professionals to study the effects and develop new antibiotics.

Trip has extensive coverage of the evidence base on antibiotics allowing users to easily find trusted answers. Coverage include guidelines, systematic reviews, controlled trials and evidence-based synopses.

Top results for antibiotics

141. Systematic review and meta-analysis of strategies for minimising unnecessary exposure to early life antibiotics in neonates

Systematic review and meta-analysis of strategies for minimising unnecessary exposure to early life antibiotics in neonates Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any

2019 PROSPERO

142. Prophylactic antibiotic prescriptions in oral implant surgery. Systematic review and meta-analysis

Prophylactic antibiotic prescriptions in oral implant surgery. Systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external

2019 PROSPERO

143. A systematic review comparing the efficacy and safety for different routes of antibiotic administration (partial oral therapy vs intravenous therapy) in the treatment of infective endocarditis

A systematic review comparing the efficacy and safety for different routes of antibiotic administration (partial oral therapy vs intravenous therapy) in the treatment of infective endocarditis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears

2019 PROSPERO

144. Antibiotic regimens for neonatal sepsis. A protocol for a systematic review with meta-analysis and trial sequential analysis

Antibiotic regimens for neonatal sepsis. A protocol for a systematic review with meta-analysis and trial sequential analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any

2019 PROSPERO

145. An evaluation of daptomycin alone and in combination with ß-lactam antibiotics against resistant phenotypes of gram-positive cocci

An evaluation of daptomycin alone and in combination with ß-lactam antibiotics against resistant phenotypes of gram-positive cocci Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record

2019 PROSPERO

146. To determine the safety and effectiveness of long-term inhaled antibiotics in the treatment of adult patients with non-cystic fibrosis bronchiectasis (NCFBE) and chronic Pseudomonas aeruginosa infection.

To determine the safety and effectiveness of long-term inhaled antibiotics in the treatment of adult patients with non-cystic fibrosis bronchiectasis (NCFBE) and chronic Pseudomonas aeruginosa infection. Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears

2019 PROSPERO

147. The relationship of prenatal antibiotic exposure and infant antibiotic administration with childhood allergies: a systematic review

The relationship of prenatal antibiotic exposure and infant antibiotic administration with childhood allergies: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record

2019 PROSPERO

148. Systemic antibiotics in the treatment of periodontitis: a systematic review and meta-analysis of randomized clinical trials

Systemic antibiotics in the treatment of periodontitis: a systematic review and meta-analysis of randomized clinical trials Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any

2019 PROSPERO

149. The effect of adjunctive use of antibiotics on the outcome of surgical treatment for peri-implantitis: a systematic review and meta-analysis

The effect of adjunctive use of antibiotics on the outcome of surgical treatment for peri-implantitis: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration

2019 PROSPERO

150. Surgical antibiotic prophylaxis in children undergoing surgery: a systematic review and meta-analysis

Surgical antibiotic prophylaxis in children undergoing surgery: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files

2019 PROSPERO

151. A systematic review of human antibiotic consumption, use and stewardship in Indonesia.

A systematic review of human antibiotic consumption, use and stewardship in Indonesia. Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites

2019 PROSPERO

152. The effect of prophylactic antibiotics for preterm premature rupture of membranes on perinatal outcomes: a network meta-analysis

The effect of prophylactic antibiotics for preterm premature rupture of membranes on perinatal outcomes: a network meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any

2019 PROSPERO

153. What symptoms and clinical markers are associated poor prognosis, such as prolonged symptoms, re-consultation, antibiotic prescription, hospitalisation, and death in children with a suspected RTI in the home and presenting to primary care?

What symptoms and clinical markers are associated poor prognosis, such as prolonged symptoms, re-consultation, antibiotic prescription, hospitalisation, and death in children with a suspected RTI in the home and presenting to primary care? Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission

2019 PROSPERO

154. Comparative efficacy of long-term antibiotic treatments in the primary prophylaxis of spontaneous bacterial peritonitis: a network meta-analysis

Comparative efficacy of long-term antibiotic treatments in the primary prophylaxis of spontaneous bacterial peritonitis: a network meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content

2019 PROSPERO

155. Drug exposure of antibiotics after dose reduction in patients with impaired renal function: a systematic review

Drug exposure of antibiotics after dose reduction in patients with impaired renal function: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files

2019 PROSPERO

156. Antibiotic prophylaxis for urinary catheter manipulation following arthroplasty: a systematic review

Antibiotic prophylaxis for urinary catheter manipulation following arthroplasty: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files

2019 PROSPERO

157. The impact of antibiotic-mediated alterations of the intestinal microbiome on outcomes of allogeneic hematopoietic cell transplantation: systematic review and meta-analysis

The impact of antibiotic-mediated alterations of the intestinal microbiome on outcomes of allogeneic hematopoietic cell transplantation: systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability

2019 PROSPERO

158. The use of postoperative antibiotics following endoscopic sinus surgery for chronic rhinosinusitis: a systematic review

The use of postoperative antibiotics following endoscopic sinus surgery for chronic rhinosinusitis: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any

2019 PROSPERO

159. Serum procalcitonin for the prediction of bacterial exacerbation and guidance of antibiotic administration in severe COPD exacerbations: a systematic review and meta-analysis

Serum procalcitonin for the prediction of bacterial exacerbation and guidance of antibiotic administration in severe COPD exacerbations: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability

2019 PROSPERO

160. Inhaled antibiotics for the treatment of adults patients with bronchiectasis

Inhaled antibiotics for the treatment of adults patients with bronchiectasis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email

2019 PROSPERO