Latest & greatest articles for antibiotics

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This page lists the very latest high quality evidence on antibiotics and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

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Antibiotics

Antibiotics also referred to as antibacterial are a type of medicine that prevents the growth of bacteria. As such they are used to treat infections caused by bacteria. They kill or prevents bacteria from spreading.

Antibiotics are vital in modern day medicine; they are among the most frequently prescribed drug. There are over a 100 types of antibiotics, the main types and most commonly prescribed are penicillin, cephalosporin, macrolides, fluoroquinolone and tetracycline. They tend to be classified by mechanism of action. So, those that target the bacterial cell wall (penicillins and cephalosporins) or the cell membrane (polymyxins), or interfere with essential bacterial enzymes (rifamycins, lipiarmycins, quinolones, and sulfonamides) have bactericidal activities. Antibiotics such as macrolides, lincosamides and tetracyclines inhibit protein synthesis.

Antibiotics can all be defined by their specificity. “Narrow-spectrum” antibiotics target specific types of bacteria, for instance gram-negative (-ve) or gram-positive (+ve), whereas broad-spectrum antibiotics affect a wide range of bacteria.

Antibiotics are increasingly suffering from antibiotic resistance caused by bacterial mutations meaning the bacteria evolves to not be sensitive to the specific antibiotics being used.

Clinical trials are important to the development and understanding of antibiotics and their side effects. Although they are deemed safe, over use of the drug can kill good bacteria and lead to antibiotic resistance. This halts the ability of bacteria and microorganisms to resist the effects of the antibiotic. Clinical trials and research allow scientists and medical professionals to study the effects and develop new antibiotics.

Trip has extensive coverage of the evidence base on antibiotics allowing users to easily find trusted answers. Coverage include guidelines, systematic reviews, controlled trials and evidence-based synopses.

Top results for antibiotics

81. Early discontinuation of antibiotics for febrile neutropenia versus continuation until neutropenia resolution in people with cancer. Full Text available with Trip Pro

Early discontinuation of antibiotics for febrile neutropenia versus continuation until neutropenia resolution in people with cancer. People with cancer with febrile neutropenia are at risk of severe infections and mortality and are thus treated empirically with broad-spectrum antibiotic therapy. However, the recommended duration of antibiotic therapy differs across guidelines.To assess the safety of protocol-guided discontinuation of antibiotics regardless of neutrophil count, compared (...) to continuation of antibiotics until neutropenia resolution in people with cancer with fever and neutropenia, in terms of mortality and morbidity. To assess the emergence of resistant bacteria in people with cancer treated with short courses of antibiotic therapy compared with people with cancer treated until resolution of neutropenia.We searched the Cochrane Central Register of Controlled Trials (CENTRAL; 2018, Issue 10) in the Cochrane Library, MEDLINE, Embase, and LILACS up to 1 October 2018. We searched

2019 Cochrane

82. Adult and Pediatric Antibiotic Prophylaxis during Vascular and IR Procedures: A Society of Interventional Radiology Practice Parameter Update Endorsed by the Cardiovascular and Interventional Radological Society of Europe and the Canadian Association for

Adult and Pediatric Antibiotic Prophylaxis during Vascular and IR Procedures: A Society of Interventional Radiology Practice Parameter Update Endorsed by the Cardiovascular and Interventional Radological Society of Europe and the Canadian Association for STANDARDS OF PRACTICE Adult and Pediatric Antibiotic Prophylaxis during Vascular and IR Procedures: A Society of Interventional Radiology Practice Parameter Update Endorsed by the Cardiovascular and Interventional Radiological Society of Europe (...) , MD, MBA, and Aradhana M. Venkatesan, MD ABBREVIATIONS CI¼ con?dence interval, IV¼ intravenous, IVC¼ inferior vena cava, TIPS¼ transjugular intrahepatic portosystemic shunt, UAE¼ uterine artery embolization PREAMBLE In 2010, the Society of Interventional Radiology (SIR) published its ?rst practice guidelines regarding the use of antibiotic prophylaxis in vascular and interventional radiology (IR) (1). The present update to the original guidelines aims to address the expanding breadth of IR

2019 Society of Interventional Radiology

83. Tailored Helicobacter pylori eradication based on prior intake of macrolide antibiotics allows the use of triple therapy with optimal results in an area with high clarithromycin resistance. Full Text available with Trip Pro

Tailored Helicobacter pylori eradication based on prior intake of macrolide antibiotics allows the use of triple therapy with optimal results in an area with high clarithromycin resistance. the previous intake of macrolide antibiotics is associated with a failure to eradicate Helicobacter pylori (H. pylori) with clarithromycin-containing regimens. However, the standard triple therapy achieves eradication rates of over 90% in patients without a previous use of macrolides in our health area

2019 Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva Controlled trial quality: uncertain

84. Prophylactic antibiotics for mastectomy with immediate breast reconstruction: a meta-analysis

Prophylactic antibiotics for mastectomy with immediate breast reconstruction: a meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external

2019 PROSPERO

85. Short- versus standard-course antibiotic therapy in acute exacerbations of chronic obstructive pulmonary disease: a systematic review and meta-analysis of RCTs

Short- versus standard-course antibiotic therapy in acute exacerbations of chronic obstructive pulmonary disease: a systematic review and meta-analysis of RCTs Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content

2019 PROSPERO

86. Prevention of early-onset Group B streptococcal sepsis in infants, using universal screening versus risk-based protocols for antibiotic prophylaxis: a systematic review and meta-analysis

Prevention of early-onset Group B streptococcal sepsis in infants, using universal screening versus risk-based protocols for antibiotic prophylaxis: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility

2019 PROSPERO

87. The efficacy of Carbapenems versus new antibiotics for treatments of adult patients with complicated urinary tract infections: a systematic review and meta-analysis

The efficacy of Carbapenems versus new antibiotics for treatments of adult patients with complicated urinary tract infections: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability

2019 PROSPERO

88. Effects of timing of adjunctive systemic antibiotics on the clinical outcome of periodontal therapy: a systematic review

Effects of timing of adjunctive systemic antibiotics on the clinical outcome of periodontal therapy: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any

2019 PROSPERO

89. Examination of antibiotic administration period guided by procalcitonin in sepsis or septic shock: systematic review and meta-analysis

Examination of antibiotic administration period guided by procalcitonin in sepsis or septic shock: systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration

2019 PROSPERO

90. Healthcare-associated infections (HAI) and prescribing of antibiotics in hospital inpatients in the Caribbean Community (CARICOM) states: a mixed methods systematic review

Healthcare-associated infections (HAI) and prescribing of antibiotics in hospital inpatients in the Caribbean Community (CARICOM) states: a mixed methods systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability

2019 PROSPERO

91. Harmful outcomes due to reported patient antibiotic allergy labels

Harmful outcomes due to reported patient antibiotic allergy labels Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g

2019 PROSPERO

92. Fuke Qianjin combined with antibiotics in treatment of acute pelvic inflammatory disease (PID): a systematic review

Fuke Qianjin combined with antibiotics in treatment of acute pelvic inflammatory disease (PID): a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated

2019 PROSPERO

93. Oral antibiotic therapy for infective endocarditis: a systematic review

Oral antibiotic therapy for infective endocarditis: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation

2019 PROSPERO

94. Systematic review and meta-analysis of the impact of antibiotics on the survival outcomes for non-small cell lung cancer patients treated with immune checkpoint inhibitors

Systematic review and meta-analysis of the impact of antibiotics on the survival outcomes for non-small cell lung cancer patients treated with immune checkpoint inhibitors Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability

2019 PROSPERO

95. Antibiotics exposure during childhood and risk of inflammatory bowel disease: a meta-analysis

Antibiotics exposure during childhood and risk of inflammatory bowel disease: a meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external

2019 PROSPERO

96. The association between socioeconomic deprivation and antibiotics misuse: a systematic review

The association between socioeconomic deprivation and antibiotics misuse: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external

2019 PROSPERO

97. Efficacy of adjunctive systemic antibiotics in surgical therapy of peri-implantitis: a systematic review and network meta-analyses

Efficacy of adjunctive systemic antibiotics in surgical therapy of peri-implantitis: a systematic review and network meta-analyses Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record

2019 PROSPERO

98. The status of antibiotic resistance among the WHO-GLASS priority bacteria in Indonesia: a systematic review

The status of antibiotic resistance among the WHO-GLASS priority bacteria in Indonesia: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files

2019 PROSPERO

99. Influences on antibiotic prescribing by non-medical prescribers for respiratory tract infections: a systematic review using the theoretical domains framework

Influences on antibiotic prescribing by non-medical prescribers for respiratory tract infections: a systematic review using the theoretical domains framework Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content

2019 PROSPERO

100. A systematic review of antibiotic resistance of Listeria monocytogenes isolated from human meningitis in the last 15 years in the world

A systematic review of antibiotic resistance of Listeria monocytogenes isolated from human meningitis in the last 15 years in the world Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration

2019 PROSPERO