Latest & greatest articles for anesthesia

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on anesthesia or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on anesthesia and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Anesthesia

Clinical anesthesia is used to induce a temporary medical state of controlled unconsciousness, inducing a loss of sensation or awareness. There are three main types of anesthesia:

  • Local and Regional
  • General
  • Sedation

Anesthesia is primarily used during surgical procedures to block pain. While unconscious, blood flow and heart rate is monitored.

Research and development in the use of anesthesia has helped anesthesiologists in the progression of patient safety before and after surgery and medical procedures. The developments and research of anesthesia through the years has massively influences medicine and surgery today.

Case studies and clinical trials help aid researchers in the development of aftercare during postoperative recovery. Research is a vital part in the field of anesthesia, it allows anesthesiologists to improve the delivery of patient safety while unconscious.

Learn more on the emerging technology in anesthesia and the advancements in anesthesia practise by searching Trip.

Top results for anesthesia

141. A comparison of dexmedetomidine-midazolam with propofol for maintenance of anesthesia in children undergoing magnetic resonance imaging

A comparison of dexmedetomidine-midazolam with propofol for maintenance of anesthesia in children undergoing magnetic resonance imaging 19020127 2008 11 21 2008 12 30 2013 11 21 1526-7598 107 6 2008 Dec Anesthesia and analgesia Anesth. Analg. A comparison of dexmedetomidine-midazolam with propofol for maintenance of anesthesia in children undergoing magnetic resonance imaging. 1832-9 10.1213/ane.0b013e31818874ee Dexmedetomidine is an alpha(2) agonist that is currently being investigated for its (...) suitability to provide anesthesia for children. We compared the pharmacodynamic responses to dexmedetomidine-midazolam and propofol in children anesthetized with sevoflurane undergoing magnetic resonance imaging (MRI). Forty ASA 1 or 2 children, 1-10 yr of age, were randomized to receive either dexmedetomidine-midazolam or propofol for maintenance of anesthesia for MRI after a sevoflurane induction. Dexmedetomidine was administered as an initial loading dose (1 microg/kg) followed by a continuous infusion

EvidenceUpdates2009

142. Does regional anesthesia improve outcome after total knee arthroplasty?

Does regional anesthesia improve outcome after total knee arthroplasty? Does regional anesthesia improve outcome after total knee arthroplasty? Does regional anesthesia improve outcome after total knee arthroplasty? Macfarlane AJ, Prasad GA, Chan VW, Brull R CRD summary This review compared regional anaesthesia with general anaesthesia for total knee arthroplasty. The authors concluded that insufficient evidence existed to support superiority of either technique for clinical outcomes, although (...) regional anaesthesia may benefit postoperative hypotension and pain, morphine consumption, opioid-related adverse effects, length of hospital stay and rehabilitation. The authors' conclusions are likely to be reliable. Authors' objectives To compare regional anaesthesia with general anaesthesia in patients who underwent total knee arthroplasty in terms of clinical outcomes, length of hospital stay and rehabilitation. Searching MEDLINE, EMBASE and Cochrane Central Register of Controlled Trials (CENTRAL

DARE.2009

143. Ultrasound-guided regional anesthesia and analgesia: a qualitative systematic review

Ultrasound-guided regional anesthesia and analgesia: a qualitative systematic review Ultrasound-guided regional anesthesia and analgesia: a qualitative systematic review Ultrasound-guided regional anesthesia and analgesia: a qualitative systematic review Liu SS, Ngeow JE, YaDeau JT CRD summary The authors concluded that, compared with most other techniques, use of ultrasound for peripheral nerve blocks hastened block performance and onset of block, but it did not show significant benefits (...) for the onset of surgical anaesthesia and conversion to general anaesthesia. Without further details on study quality and given the other methodological concerns, it is difficult to judge their reliability. Authors' objectives To compare the efficacy and safety of ultrasound guidance with other techniques for regional anaesthesia and analgesia. Searching MEDLINE was searched from inception to November 2007. Search terms were reported. Reference lists of retrieved publications were screened. The authors

DARE.2009

144. Postoperative disposable ambulatory regional anesthesia

Postoperative disposable ambulatory regional anesthesia Postoperative disposable ambulatory regional anesthesia Postoperative disposable ambulatory regional anesthesia Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Report may be purchased from Citation Postoperative disposable ambulatory regional anesthesia . Lansdale: HAYES, Inc.. 2009 Authors' objectives Postoperative (...) disposable ambulatory regional anesthesia (PDARA) uses a disposable pump to deliver anesthesia to a specific region of the body. The goal of this procedure is to relieve postoperative pain and reduce reliance on analgesics that can have systemic effects. Project page URL Indexing Status Subject indexing assigned by CRD MeSH Anesthesia, Conductions; Pain, Postoperative Language Published English Country of organisation United States Address for correspondence 157 S. Broad Street, Suite 200, Lansdale, PA

Health Technology Assessment (HTA) Database.2009

145. A randomized double-blinded comparison of phenylephrine and ephedrine infusion combinations to maintain blood pressure during spinal anesthesia for cesarean delivery: the effects on fetal acid-base status and hemodynamic control

A randomized double-blinded comparison of phenylephrine and ephedrine infusion combinations to maintain blood pressure during spinal anesthesia for cesarean delivery: the effects on fetal acid-base status and hemodynamic control 18806043 2008 09 22 2008 10 09 2013 11 21 1526-7598 107 4 2008 Oct Anesthesia and analgesia Anesth. Analg. A randomized double-blinded comparison of phenylephrine and ephedrine infusion combinations to maintain blood pressure during spinal anesthesia for cesarean (...) delivery: the effects on fetal acid-base status and hemodynamic control. 1295-302 10.1213/ane.0b013e31818065bc Phenylephrine and ephedrine are both used to maintain arterial blood pressure during spinal anesthesia for cesarean delivery. Usually, either drug is given alone but several previous studies have described combining the drugs. However, the effect of varying the proportion of vasopressors in such combinations has not been reported. One-hundred-twenty-five parturients having spinal anesthesia

EvidenceUpdates2008

146. P6 stimulation for the prevention of nausea and vomiting associated with cesarean delivery under neuraxial anesthesia: a systematic review of randomized controlled trials

P6 stimulation for the prevention of nausea and vomiting associated with cesarean delivery under neuraxial anesthesia: a systematic review of randomized controlled trials 18806045 2008 09 22 2008 10 09 2008 09 22 1526-7598 107 4 2008 Oct Anesthesia and analgesia Anesth. Analg. P6 stimulation for the prevention of nausea and vomiting associated with cesarean delivery under neuraxial anesthesia: a systematic review of randomized controlled trials. 1308-12 10.1213/ane.0b013e31816d1864 A number (...) of studies investigated the use of P6 stimulation for the prevention of intraoperative and postoperative nausea and vomiting (IONV and PONV) in women having cesarean delivery under neuraxial anesthesia. We performed a systematic review to determine the overall efficacy of these techniques in preventing IONV and PONV in this patient population. We performed a literature search of all randomized controlled trials (1966-2007) that compared different methods of P6 stimulation with placebo in women having

EvidenceUpdates2008

147. Extra-1 acupressure for children undergoing anesthesia

Extra-1 acupressure for children undergoing anesthesia 18713889 2008 08 20 2008 09 11 2015 06 15 1526-7598 107 3 2008 Sep Anesthesia and analgesia Anesth. Analg. Extra-1 acupressure for children undergoing anesthesia. 811-6 10.1213/ane.0b013e3181804441 Acupuncture and related techniques have been used as adjuncts for perioperative anesthesia management. We examined whether acupressure in the Extra-1 (Yin-Tang) point would result in decreased preprocedural anxiety and reduced intraprocedural (...) propofol requirements in a group of children undergoing endoscopic procedures. Fifty-two children were randomized to receive acupressure bead intervention either at the Extra-1 acupuncture point or at a sham point. A Bispectral Index (BIS) monitor was applied to all children before the onset of the intervention. Anxiety was assessed at baseline and before entrance to the operating room. Anesthetic techniques were standardized and maintained with IV propofol infusion titrated to keep BIS values of 40-60

EvidenceUpdates2008

148. Comparing the Effectiveness of Modified Forearm and Conventional Minidose Intravenous Regional Anesthesia for Reduction of Distal Forearm Fractures in Children

Comparing the Effectiveness of Modified Forearm and Conventional Minidose Intravenous Regional Anesthesia for Reduction of Distal Forearm Fractures in Children 18520275 2008 06 03 2008 10 21 2013 11 21 0271-6798 28 4 2008 Jun Journal of pediatric orthopedics J Pediatr Orthop Comparing the effectiveness of modified forearm and conventional minidose intravenous regional anesthesia for reduction of distal forearm fractures in children. 410-6 10.1097/BPO.0b013e31816d7235 Minidose intravenous (...) regional anesthesia (IVRA) and modified forearm IVRA have been used for closed reduction of forearm fractures and for hand surgery in children. Children (5-17 years old) with forearm fractures presenting to a pediatric emergency department were enrolled in a randomized controlled trial to test if modified forearm and minidose IVRA together would provide improved analgesia with reduced risk of anesthetic toxicity compared with conventional minidose IVRA. Pain was assessed using a visual analog scale

EvidenceUpdates2008

149. A comparison of intranasal dexmedetomidine and oral midazolam for premedication in pediatric anesthesia: a double-blinded randomized controlled trial

A comparison of intranasal dexmedetomidine and oral midazolam for premedication in pediatric anesthesia: a double-blinded randomized controlled trial 18499600 2008 05 23 2008 06 05 2013 11 21 1526-7598 106 6 2008 Jun Anesthesia and analgesia Anesth. Analg. A comparison of intranasal dexmedetomidine and oral midazolam for premedication in pediatric anesthesia: a double-blinded randomized controlled trial. 1715-21 10.1213/ane.0b013e31816c8929 Midazolam is the most commonly used premedication (...) in children. It has been shown to be more effective than parental presence or placebo in reducing anxiety and improving compliance at induction of anesthesia. Clonidine, an alpha(2) agonist, has been suggested as an alternative. Dexmedetomidine is a more alpha(2) selective drug with more favorable pharmacokinetic properties than clonidine. We designed this prospective, randomized, double-blind, controlled trial to evaluate whether intranasal dexmedetomidine is as effective as oral midazolam

EvidenceUpdates2008

150. Combined general/epidural anesthesia (ropivacaine 0.375%) versus general anesthesia for upper abdominal surgery

Combined general/epidural anesthesia (ropivacaine 0.375%) versus general anesthesia for upper abdominal surgery 18420877 2008 04 18 2008 05 01 2013 11 21 1526-7598 106 5 2008 May Anesthesia and analgesia Anesth. Analg. Combined general/epidural anesthesia (ropivacaine 0.375%) versus general anesthesia for upper abdominal surgery. 1562-5, table of contents 10.1213/ane.0b013e31816d1976 We designed this study to investigate the effect of 0.375% ropivacaine on stress hormone responses (...) and anesthetic requirements in combined epidural/general anesthesia for nephrectomy. Thirty-two adults, ASA physical status I-II, undergoing nephrectomy lasting about 2 h for renal carcinoma were randomly assigned to one of two groups: epidural (saline)/general anesthesia (group C) and epidural (0.375% ropivacaine)/general (group R) anesthesia. Induction of anesthesia was performed with target-controlled infusion sufentanil and propofol titrated to achieve bispectral index score (define) between 40 and 50

EvidenceUpdates2008

152. P6 stimulation for the prevention of nausea and vomiting associated with cesarean delivery under neuraxial anesthesia: a systematic review of randomized controlled trials

P6 stimulation for the prevention of nausea and vomiting associated with cesarean delivery under neuraxial anesthesia: a systematic review of randomized controlled trials P6 stimulation for the prevention of nausea and vomiting associated with cesarean delivery under neuraxial anesthesia: a systematic review of randomized controlled trials P6 stimulation for the prevention of nausea and vomiting associated with cesarean delivery under neuraxial anesthesia: a systematic review of randomized (...) associated with caesarean delivery. Searching MEDLINE, the Cochrane Central Register of Controlled Trials, Scopus and CINAHL were searched up to September 2007 without language restrictions. Search terms were reported. Reference lists of retrieved articles were also searched. Study selection Randomised controlled trials (RCTs) investigating the use of P6 stimulation for the prevention of intra- and post-operative nausea and vomiting in women undergoing caesarean delivery under neuraxial anaesthesia were

DARE.2008

153. Greater incidence of emergence agitation in children after sevoflurane anesthesia as compared with halothane: a meta-analysis of randomized controlled trials

Greater incidence of emergence agitation in children after sevoflurane anesthesia as compared with halothane: a meta-analysis of randomized controlled trials Greater incidence of emergence agitation in children after sevoflurane anesthesia as compared with halothane: a meta-analysis of randomized controlled trials Greater incidence of emergence agitation in children after sevoflurane anesthesia as compared with halothane: a meta-analysis of randomized controlled trials Kuratani N, Oi Y CRD (...) . Any disagreements were resolved by consensus. Assessment of study quality Two independent reviewers assessed the studies for quality based on: randomisation; standardised anesthesia protocol; blinding for outcomes measurement; comparability; withdrawals; and definition of emergence agitation. The maximum quality score was 6. Disagreements were resolved through consensus. Data extraction Data were extracted in order to calculate odds ratios (ORs), with 95% confidence intervals (CIs) calculated

DARE.2008

154. Anesthesia awareness and the bispectral index.

Anesthesia awareness and the bispectral index. 18337600 2008 03 13 2008 03 20 2015 11 19 1533-4406 358 11 2008 Mar 13 The New England journal of medicine N. Engl. J. Med. Anesthesia awareness and the bispectral index. 1097-108 10.1056/NEJMoa0707361 Awareness during anesthesia is a serious complication with potential long-term psychological consequences. Use of the bispectral index (BIS), developed from a processed electroencephalogram, has been reported to decrease the incidence of anesthesia (...) awareness when the BIS value is maintained below 60. In this trial, we sought to determine whether a BIS-based protocol is better than a protocol based on a measurement of end-tidal anesthetic gas (ETAG) for decreasing anesthesia awareness in patients at high risk for this complication. We randomly assigned 2000 patients to BIS-guided anesthesia (target BIS range, 40 to 60) or ETAG-guided anesthesia (target ETAG range, 0.7 to 1.3 minimum alveolar concentration [MAC]). Postoperatively, patients were

NEJM2008

155. In patients undergoing cardiac surgery, thoracic epidural analgesia combined with general anesthesia results in faster recovery and fewer complications but does not affect length of hospital stay

In patients undergoing cardiac surgery, thoracic epidural analgesia combined with general anesthesia results in faster recovery and fewer complications but does not affect length of hospital stay BestBets: In patients undergoing cardiac surgery, thoracic epidural analgesia combined with general anesthesia results in faster recovery and fewer complications but does not affect length of hospital stay In patients undergoing cardiac surgery, thoracic epidural analgesia combined with general (...) anesthesia results in faster recovery and fewer complications but does not affect length of hospital stay Report By: Andrew Roland, K. Anuar Abdul Azizb, Thomas George Day and Martin Scott - Consultant in Anaesthestics Search checked by Joel Dunning - Specialist Registrar in Cardiothoracic Surgery Institution: Department of Cardiac Anaesthesia, Aberdeen Royal Infirmary, Aberdeen, Manchester Royal Infirmary and Wythenshawe Hospital, Manchester Respectively Date Submitted: 8th June 2006 Date Completed

BestBETS2006

156. Evidence-based clinical update: general anesthesia and the risk of delirium and postoperative cognitive dysfunction

Evidence-based clinical update: general anesthesia and the risk of delirium and postoperative cognitive dysfunction Evidence-based clinical update: general anesthesia and the risk of delirium and postoperative cognitive dysfunction Evidence-based clinical update: general anesthesia and the risk of delirium and postoperative cognitive dysfunction Bryson G L, Wyand A CRD summary This review found no significant difference in the incidence of delirium or post-operative cognitive dysfunction (...) between patients receiving general anaesthesia and those receiving regional anaesthesia. Given the small size and poor quality of the included studies, the authors conclusions would appear valid. Authors' objectives To assess the risk of delirium and post-operative cognitive dysfunction (POCD) associated with general versus regional anaesthesia. Searching MEDLINE was searched from 1966 to June 2005; the search terms were reported. The reference lists of eligible studies were screened for additional

DARE.2006

157. Comparison of the time to extubation after use of remifentanil or sufentanil in combination with propofol as anesthesia in adults undergoing nonemergency intracranial surgery: a prospective, randomized, double-blind trial

Comparison of the time to extubation after use of remifentanil or sufentanil in combination with propofol as anesthesia in adults undergoing nonemergency intracranial surgery: a prospective, randomized, double-blind trial Comparison of the time to extubation after use of remifentanil or sufentanil in combination with propofol as anesthesia in adults undergoing nonemergency intracranial surgery: a prospective, randomized, double-blind trial Comparison of the time to extubation after use (...) of remifentanil or sufentanil in combination with propofol as anesthesia in adults undergoing nonemergency intracranial surgery: a prospective, randomized, double-blind trial Djian M C, Blanchet B, Pesce F, Sermet A, Disdet M, Vazquez V, Gury C, Roux F X, Raggueneau J L, Coste J, Joly L M Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed

NHS Economic Evaluation Database.2006

158. Meta-analysis of trials comparing postoperative recovery after anesthesia with sevoflurane or desflurane

Meta-analysis of trials comparing postoperative recovery after anesthesia with sevoflurane or desflurane Meta-analysis of trials comparing postoperative recovery after anesthesia with sevoflurane or desflurane Meta-analysis of trials comparing postoperative recovery after anesthesia with sevoflurane or desflurane Macario A, Dexter F, Lubarsky D CRD summary This review compared differences in recovery between patients receiving sevoflurane and desflurane. The authors concluded that desflurane (...) reduced the time to recovery by 1.0 to 1.2 minutes, but there were no significant differences between the anaesthetics for time to discharge and post-operative nausea and vomiting. It is difficult to assess the robustness of the conclusions given the limited search and that differences between the studies were not assessed. Authors' objectives To compare the differences in post-operative recovery between sevoflurane and desflurane. Searching MEDLINE was searched to December 2003; the search terms were

DARE.2005

159. Bispectral index monitoring for anesthesia awareness

Bispectral index monitoring for anesthesia awareness Bispectral index monitoring for anesthesia awareness Bispectral index monitoring for anesthesia awareness Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Bispectral index monitoring for anesthesia awareness. Lansdale: HAYES, Inc.. Directory Publication. 2005 Authors' objectives Anesthesia awareness (AA (...) ) is a condition that occurs when a patient under general anesthesia becomes aware of some or all events during surgery or a procedure and has direct recall of those events. Bispectral index (BIS) monitoring technology utilizes electroencephalography to assess the depth of anesthesia. The goal of BIS monitoring is to decrease the incidence of AA and promote proper anesthetic dosing by monitoring depth of anesthesia and identifying conscious state. Indexing Status Subject indexing assigned by CRD MeSH

Health Technology Assessment (HTA) Database.2005

160. The efficiency of different adjunct techniques for regional anesthesia

The efficiency of different adjunct techniques for regional anesthesia The efficiency of different adjunct techniques for regional anesthesia The efficiency of different adjunct techniques for regional anesthesia Pongraweewan O, Lertakyamanee J, Luangnateethep U, Pooviboonsuk P, Nanthaniran M, Sathanasaowapak P, Chainchop P Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods (...) , the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The following five different adjunct techniques for regional anaesthesia were examined. Explanation and music: the patients listened to music and an explanation about the benefits and care during regional anaesthesia, via an earphone during the perioperative period. The explanation took 2 minutes and was repeated twice after which there was music. The patients

NHS Economic Evaluation Database.2005