Latest & greatest articles for anesthesia

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This page lists the very latest high quality evidence on anesthesia and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

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Anesthesia

Clinical anesthesia is used to induce a temporary medical state of controlled unconsciousness, inducing a loss of sensation or awareness. There are three main types of anesthesia:

  • Local and Regional
  • General
  • Sedation

Anesthesia is primarily used during surgical procedures to block pain. While unconscious, blood flow and heart rate is monitored.

Research and development in the use of anesthesia has helped anesthesiologists in the progression of patient safety before and after surgery and medical procedures. The developments and research of anesthesia through the years has massively influences medicine and surgery today.

Case studies and clinical trials help aid researchers in the development of aftercare during postoperative recovery. Research is a vital part in the field of anesthesia, it allows anesthesiologists to improve the delivery of patient safety while unconscious.

Learn more on the emerging technology in anesthesia and the advancements in anesthesia practise by searching Trip.

Top results for anesthesia

121. Intravenous dexmedetomidine, but not midazolam, prolongs bupivacaine spinal anesthesia

Intravenous dexmedetomidine, but not midazolam, prolongs bupivacaine spinal anesthesia 20039221 2010 01 21 2010 03 30 2013 11 21 1496-8975 57 1 2010 Jan Canadian journal of anaesthesia = Journal canadien d'anesthesie Can J Anaesth Intravenous dexmedetomidine, but not midazolam, prolongs bupivacaine spinal anesthesia. 39-45 10.1007/s12630-009-9231-6 Midazolam has only sedative properties. However, dexmedetomidine has both analgesic and sedative properties that may prolong the duration of sensory (...) and motor block obtained with spinal anesthesia. This study was designed to compare intravenous dexmedetomidine with midazolam and placebo on spinal block duration, analgesia, and sedation in patients undergoing transurethral resection of the prostate. In this double-blind randomized placebo-controlled trial, 75 American Society of Anesthesiologists' I and II patients received dexmedetomidine 0.5 microg . kg(-1), midazolam 0.05 mg . kg(-1), or saline intravenously before spinal anesthesia

EvidenceUpdates2010

122. A randomized, dose-response study of sugammadex given for the reversal of deep rocuronium- or vecuronium-induced neuromuscular blockade under sevoflurane anesthesia

A randomized, dose-response study of sugammadex given for the reversal of deep rocuronium- or vecuronium-induced neuromuscular blockade under sevoflurane anesthesia 19933538 2009 12 21 2010 01 12 2017 03 09 1526-7598 110 1 2010 01 01 Anesthesia and analgesia Anesth. Analg. A randomized, dose-response study of sugammadex given for the reversal of deep rocuronium- or vecuronium-induced neuromuscular blockade under sevoflurane anesthesia. 74-82 10.1213/ANE.0b013e3181c3be3c Sugammadex is the first (...) of a new class of selective muscle relaxant binding drugs developed for the rapid and complete reversal of neuromuscular blockade induced by rocuronium and vecuronium. Many studies have demonstrated a dose-response relationship with sugammadex for reversal of neuromuscular blockade in patients induced and maintained under propofol anesthesia. However, sevoflurane anesthesia, unlike propofol, can prolong the effect of neuromuscular blocking drugs (NMBDs) such as rocuronium and vecuronium. We designed

EvidenceUpdates2010

123. Monitored anesthesia care with dexmedetomidine: a prospective, randomized, double-blind, multicenter trial

Monitored anesthesia care with dexmedetomidine: a prospective, randomized, double-blind, multicenter trial 19713256 2009 12 21 2010 01 12 2013 11 21 1526-7598 110 1 2010 Jan 01 Anesthesia and analgesia Anesth. Analg. Monitored anesthesia care with dexmedetomidine: a prospective, randomized, double-blind, multicenter trial. 47-56 10.1213/ane.0b013e3181ae0856 Dexmedetomidine (DEX) is increasingly being used as a sedative for monitored anesthesia care (MAC) because of its analgesic properties (...) h(-1) of DEX (or equivalent volume of saline) titrated to a targeted level of sedation (< or = 4 on the Observer's Assessment of Alertness/Sedation Scale [OAA/S]). Study drug was started at least 15 min before placement of regional or local anesthetic block. Midazolam was given for OAA/S > 4 and fentanyl for pain. The primary end-point was the percentage of patients not requiring rescue midazolam. Significantly fewer patients in the 0.5- and 1-microg/kg DEX groups required supplemental midazolam

EvidenceUpdates2010

124. The effects of crystalloid and colloid preload on cardiac output in the parturient undergoing planned cesarean delivery under spinal anesthesia: a randomized trial

The effects of crystalloid and colloid preload on cardiac output in the parturient undergoing planned cesarean delivery under spinal anesthesia: a randomized trial 19923521 2009 11 20 2009 12 03 2016 11 25 1526-7598 109 6 2009 Dec Anesthesia and analgesia Anesth. Analg. The effects of crystalloid and colloid preload on cardiac output in the parturient undergoing planned cesarean delivery under spinal anesthesia: a randomized trial. 1916-21 10.1213/ANE.0b013e3181bbfdf6 Hypotension after spinal (...) anesthesia for cesarean delivery remains a major clinical problem. Fluid preloading regimens together with vasopressors have been used to reduce its incidence. Previous studies have used noninvasive arterial blood pressure measurement and vasopressor requirements to evaluate the effect of preload. We used a suprasternal Doppler flow technique to measure maternal cardiac output (CO) and corrected flow time (FTc, a measure of intravascular volume) before and after spinal anesthesia after 3 fluid preload

EvidenceUpdates2010

125. The effect of stimulating versus nonstimulating catheter techniques for continuous regional anesthesia: a semiquantitative systematic review

The effect of stimulating versus nonstimulating catheter techniques for continuous regional anesthesia: a semiquantitative systematic review The effect of stimulating versus nonstimulating catheter techniques for continuous regional anesthesia: a semiquantitative systematic review The effect of stimulating versus nonstimulating catheter techniques for continuous regional anesthesia: a semiquantitative systematic review Morin AM, Kranke P, Wulf H, Stienstra R, Eberhart LHJ CRD summary (...) This review found that stimulating catheters were associated with superior regional anaesthesia compared with non-stimulating catheters. Potential methodological flaws in the review and the unknown quality of the included trials mean that the authors' conclusions should be interpreted with caution. Authors' objectives To compare clinical outcomes of stimulating and non-stimulating catheter techniques for post-operative analgesia. Searching MEDLINE and EMBASE were searched from 1999 to 2009 for relevant

DARE.2010

126. Preload or coload for spinal anesthesia for elective cesarean delivery: a meta-analysis

Preload or coload for spinal anesthesia for elective cesarean delivery: a meta-analysis Preload or coload for spinal anesthesia for elective cesarean delivery: a meta-analysis Preload or coload for spinal anesthesia for elective cesarean delivery: a meta-analysis Banerjee A, Stocche RM, Angle P, Halpern SH CRD summary The review found that in women who underwent elective caesarean delivery under spinal anaesthesia, the timing of fluid loading did not affect the incidence of hypotension (...) regardless of whether colloid or crystalloid fluids were used. Although only a few small studies were available, their findings were consistent. The review was well-conducted and the authors’ conclusions appear reliable. Authors' objectives To determine whether the timing of fluid infusion (before or after induction of spinal anaesthesia) influenced the outcomes of elective Caesarean delivery. Searching MEDLINE, EMBASE and LILACS were searched from 1980 to May 2009 without language restrictions. A search

DARE.2010

127. The impact of general and regional anesthesia on the incidence of post-operative cognitive dysfunction and post-operative delirium: a systematic review with meta-analysis

The impact of general and regional anesthesia on the incidence of post-operative cognitive dysfunction and post-operative delirium: a systematic review with meta-analysis The impact of general and regional anesthesia on the incidence of post-operative cognitive dysfunction and post-operative delirium: a systematic review with meta-analysis The impact of general and regional anesthesia on the incidence of post-operative cognitive dysfunction and post-operative delirium: a systematic review (...) with meta-analysis Mason SE, Noel-Storr A, Ritchie CW CRD summary The authors concluded that general anaesthesia could increase the risk of postoperative cognitive dysfunction, compared with regional or combined anaesthesia, but this was not shown for delirium after surgery. This conclusion should be interpreted with caution as the outcomes varied between trials, and the differences between general, regional, and combined anaesthesia were not statistically significant. Authors' objectives To compare

DARE.2010

128. A greater incidence of post local anesthesia soft tissue trauma occurs in children less than 4 years of age compared to other children.

A greater incidence of post local anesthesia soft tissue trauma occurs in children less than 4 years of age compared to other children. UTCAT622, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title A Greater Incidence Of Post Local Anesthesia Soft Tissue Trauma Occurs In Children Less Than 4 Years Of Age Compared To Other Children Clinical Question What is the incidence of post local anesthesia and post operative soft (...) tissue trauma in young children following administration of local anesthetic in comparison to adolescents? Clinical Bottom Line 18% of children under 4 years of age experienced soft tissue trauma as opposed to only 7% of children over 12. (See Comments on the CAT below) Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) College/2000 Children Prospective Case Series Key results Soft tissue trauma occurred

UTHSCSA Dental School CAT Library2010

129. Role of Phentolamine Mesylate in Reversal of Local Anesthesia for Adult Patients

Role of Phentolamine Mesylate in Reversal of Local Anesthesia for Adult Patients UTCAT487, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Role of Phentolamine Mesylate in Reversal of Local Anesthesia for Adult Patients Clinical Question Does phentolamine induce reversal of soft-tissue local anesthesia faster than no treatment? Clinical Bottom Line Phentolamine injection decreases the duration of soft-tissue local (...) anesthesia. (See Comments on the CAT below) Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Hersh/2008 484 subjects received local anesthesia for restorative or scaling procedures. After completion of the procedures, randomized subjects received either an injection of phentolamine or a sham injection (an injection where the needle does not penetrate the soft tissue) at the same site as the local anesthetic

UTHSCSA Dental School CAT Library2010

130. A randomized comparison of low doses of hyperbaric bupivacaine in combined spinal-epidural anesthesia for cesarean delivery

A randomized comparison of low doses of hyperbaric bupivacaine in combined spinal-epidural anesthesia for cesarean delivery 19843797 2009 10 21 2009 11 05 2014 11 20 1526-7598 109 5 2009 Nov Anesthesia and analgesia Anesth. Analg. A randomized comparison of low doses of hyperbaric bupivacaine in combined spinal-epidural anesthesia for cesarean delivery. 1600-5 10.1213/ANE.0b013e3181b72d35 The aim of our study was to investigate the block characteristics of intrathecal hyperbaric bupivacaine 7 (...) , 8, or 9 mg administered during combined spinal-epidural anesthesia for cesarean delivery and to elucidate the dose that produces adequate sensory blockade for surgery while minimizing the incidence of hypotension, high neuroblockade, and the need for intraoperative epidural supplementation. Sixty women presenting for elective cesarean delivery were randomly assigned to one of the 3 groups. Group 7 received intrathecal hyperbaric bupivacaine 7 mg, Group 8 received 8 mg, and Group 9 received 9 mg

EvidenceUpdates2010

131. The Cardiopulmonary Consequences of the Trendelenburg Position in Patients Under General Anesthesia

The Cardiopulmonary Consequences of the Trendelenburg Position in Patients Under General Anesthesia "The Cardiopulmonary Consequences of the Trendelenburg Position in Pati" by Aaron T. Carter < > > > > > Title Author Date of Award 8-14-2010 Degree Type Capstone Project Degree Name Master of Science in Physician Assistant Studies First Advisor Rob Rosenow, PharmD, OD Second Advisor Annjanette Sommers MS, PAC Rights . Abstract Background: Acute hypotension has been treated with the Trendelenburg (...) was conducted to identify pertinent articles. The inclusionary criteria were, the use of HDT of greater than, or equal 10̊, and patients under general anesthesia. Results: Six articles were identified and critically appraised. The data compiled in this systematic review suggest there is an increase in cardiac preload with no consequent increase in cardiac output or performance. The data suggest there are multiple negative consequences of HDT on pulmonary function including a decrease of functional residual

Pacific University EBM Capstone Project2010

132. Morphine-based cardiac anesthesia provides superior early recovery compared with fentanyl in elective cardiac surgery patients

Morphine-based cardiac anesthesia provides superior early recovery compared with fentanyl in elective cardiac surgery patients 19608797 2009 07 17 2009 07 30 2014 11 20 1526-7598 109 2 2009 Aug Anesthesia and analgesia Anesth. Analg. Morphine-based cardiac anesthesia provides superior early recovery compared with fentanyl in elective cardiac surgery patients. 311-9 10.1213/ane.0b013e3181a90adc Experimental and clinical data suggest that morphine possesses unique cardioprotective (...) and antiinflammatory properties. In this clinical investigation, we sought to determine whether the choice of intraoperative opioid (morphine or fentanyl) influences early recovery after cardiac surgery. Ninety patients undergoing cardiac surgery with cardiopulmonary bypass were randomized to receive either morphine (40 mg) or fentanyl (600 mug) as part of a standardized opioid-isoflurane anesthetic. Quality of recovery was assessed using the QoR-40 questionnaire administered preoperatively and daily

EvidenceUpdates2009

133. Does regional anesthesia improve outcome after total knee arthroplasty?

Does regional anesthesia improve outcome after total knee arthroplasty? 19130163 2009 07 29 2009 08 27 2017 02 20 1528-1132 467 9 2009 Sep Clinical orthopaedics and related research Clin. Orthop. Relat. Res. Does regional anesthesia improve outcome after total knee arthroplasty? 2379-402 10.1007/s11999-008-0666-9 Total knee arthroplasty (TKA) is amenable to various regional anesthesia techniques that may improve patient outcome. We sought to answer whether regional anesthesia decreased (...) mortality, cardiovascular morbidity, deep venous thrombosis and pulmonary embolism, blood loss, duration of surgery, pain, opioid-related adverse effects, cognitive defects, and length of stay. We also questioned whether regional anesthesia improved rehabilitation. To do so, we performed a systematic review of the contemporary literature comparing general anesthesia and/or systemic analgesia with regional anesthesia and/or regional analgesia for TKA. To reflect contemporary surgical and anesthetic

EvidenceUpdates2009 Full Text: Link to full Text with Trip Pro

134. Reversal of neuromuscular blockade by sugammadex after continuous infusion of rocuronium in patients randomized to sevoflurane or propofol maintenance anesthesia

Reversal of neuromuscular blockade by sugammadex after continuous infusion of rocuronium in patients randomized to sevoflurane or propofol maintenance anesthesia 19512873 2009 06 24 2009 07 21 2014 11 20 1528-1175 111 1 2009 Jul Anesthesiology Anesthesiology Reversal of neuromuscular blockade by sugammadex after continuous infusion of rocuronium in patients randomized to sevoflurane or propofol maintenance anesthesia. 30-5 10.1097/ALN.0b013e3181a51cb0 Sugammadex rapidly reverses neuromuscular (...) blockade induced by bolus rocuronium doses, but it has not been investigated after continuous rocuronium infusion in surgical patients. We therefore examined the clinical effect of sugammadex for neuromuscular blockade induced by continuous rocuronium infusion in adults undergoing surgery under maintenance anesthesia with sevoflurane or propofol. This four-center, comparative, parallel-group study, randomly assigned 52 adult patients (American Society of Anesthesiologists Class I-III) to maintenance

EvidenceUpdates2009

135. Preoperative melatonin and its effects on induction and emergence in children undergoing anesthesia and surgery

Preoperative melatonin and its effects on induction and emergence in children undergoing anesthesia and surgery 19546692 2009 06 23 2009 07 21 2013 11 21 1528-1175 111 1 2009 Jul Anesthesiology Anesthesiology Preoperative melatonin and its effects on induction and emergence in children undergoing anesthesia and surgery. 44-9 10.1097/ALN.0b013e3181a91870 Studies conducted in adults undergoing surgery reported a beneficial effect of oral melatonin administered before surgery. There is a paucity (...) of such data in children undergoing anesthesia and surgery. Children undergoing surgery were randomly assigned to receive preoperatively oral midazolam 0.5 mg/kg or oral melatonin 0.05 mg/kg, 0.2 mg/kg, or 0.4 mg/kg. The primary outcome of the study was preoperative anxiety (Yale Preoperative Anxiety Scale). The secondary outcomes were the children's compliance with induction (Induction Compliance Checklist), emergence behavior (Keegan scale), and parental anxiety (State-Trait Anxiety Inventory). Repeated

EvidenceUpdates2009

136. Postoperative neurocognitive dysfunction in elderly patients after xenon versus propofol anesthesia for major noncardiac surgery: a double-blinded randomized controlled pilot study

Postoperative neurocognitive dysfunction in elderly patients after xenon versus propofol anesthesia for major noncardiac surgery: a double-blinded randomized controlled pilot study 19352169 2009 04 23 2009 05 14 2014 11 20 1528-1175 110 5 2009 May Anesthesiology Anesthesiology Postoperative neurocognitive dysfunction in elderly patients after xenon versus propofol anesthesia for major noncardiac surgery: a double-blinded randomized controlled pilot study. 1068-76 10.1097/ALN.0b013e31819dad92 (...) Postoperative cognitive dysfunction (POCD) in elderly patients after noncardiac surgery is a common problem. The noble gas xenon has been demonstrated to exert substantial neuroprotective properties in animal studies. Therefore, this study was designed to assess POCD after xenon anesthesia in comparison to propofol in elderly patients undergoing major noncardiac surgery. After approval of the local ethical committee was obtained, 101 patients (American Society of Anesthesiologists physical status I-III; age

EvidenceUpdates2009

137. The effect of forced-air warming during arthroscopic shoulder surgery with general anesthesia

The effect of forced-air warming during arthroscopic shoulder surgery with general anesthesia 19409309 2009 05 04 2009 07 24 2009 05 04 1526-3231 25 5 2009 May Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association Arthroscopy The effect of forced-air warming during arthroscopic shoulder surgery with general anesthesia. 510-4 10.1016/j.arthro.2008.10.022 The aim (...) is significantly more efficient than a cotton blanket alone at maintaining perioperative normothermia during arthroscopic shoulder surgery. Level I, randomized controlled trial. Yoo Hyung Seok HS Department of Anesthesiology and Pain Medicine, College of Medicine, Kyung Hee University, Seoul, South Korea. Park Sung Wook SW Yi Jae Woo JW Kwon Moo Il MI Rhee Yong Girl YG eng Comparative Study Journal Article Randomized Controlled Trial United States Arthroscopy 8506498 0749-8063 IM Adult Anesthesia, General

EvidenceUpdates2009

138. Early exposure to anesthesia and learning disabilities in a population-based birth cohort

Early exposure to anesthesia and learning disabilities in a population-based birth cohort 19293700 2009 03 24 2009 04 28 2016 12 03 1528-1175 110 4 2009 Apr Anesthesiology Anesthesiology Early exposure to anesthesia and learning disabilities in a population-based birth cohort. 796-804 10.1097/01.anes.0000344728.34332.5d Anesthetic drugs administered to immature animals may cause neurohistopathologic changes and alterations in behavior. The authors studied association between anesthetic exposure (...) before age 4 yr and the development of reading, written language, and math learning disabilities (LD). This was a population-based, retrospective birth cohort study. The educational and medical records of all children born to mothers residing in five townships of Olmsted County, Minnesota, from 1976 to 1982 and who remained in the community at 5 yr of age were reviewed to identify children with LD. Cox proportional hazards regression was used to calculate hazard ratios for anesthetic exposure

EvidenceUpdates2009 Full Text: Link to full Text with Trip Pro

139. A randomized, double-blind comparison of the total dose of 1.0% lidocaine with 1:100,000 epinephrine versus 0.5% lidocaine with 1:200,000 epinephrine required for effective local anesthesia during Mohs micrographic surgery for skin cancers

A randomized, double-blind comparison of the total dose of 1.0% lidocaine with 1:100,000 epinephrine versus 0.5% lidocaine with 1:200,000 epinephrine required for effective local anesthesia during Mohs micrographic surgery for skin cancers 19231641 2009 02 23 2009 03 23 2013 11 21 1097-6787 60 3 2009 Mar Journal of the American Academy of Dermatology J. Am. Acad. Dermatol. A randomized, double-blind comparison of the total dose of 1.0% lidocaine with 1:100,000 epinephrine versus 0.5% lidocaine (...) with 1:200,000 epinephrine required for effective local anesthesia during Mohs micrographic surgery for skin cancers. 444-52 10.1016/j.jaad.2008.08.001 We sought to compare total lidocaine dose and patient comfort when using 1.0% lidocaine with 1:100,000 epinephrine versus 0.5% lidocaine with 1:200,000 epinephrine during Mohs micrographic surgery. In all, 149 patients were randomized to receive 1.0% lidocaine with 1:100,000 epinephrine or 0.5% lidocaine with 1:200,000 epinephrine during Mohs

EvidenceUpdates2009

140. Spray-as-you-go airway topical anesthesia in patients with a difficult airway: a randomized, double-blind comparison of 2% and 4% lidocaine

Spray-as-you-go airway topical anesthesia in patients with a difficult airway: a randomized, double-blind comparison of 2% and 4% lidocaine 19151284 2009 01 19 2009 02 09 2013 11 21 1526-7598 108 2 2009 Feb Anesthesia and analgesia Anesth. Analg. Spray-as-you-go airway topical anesthesia in patients with a difficult airway: a randomized, double-blind comparison of 2% and 4% lidocaine. 536-43 10.1213/ane.0b013e31818f1665 We designed this randomized, double-blind clinical study to compare (...) the safety and efficacy of 2% and 4% lidocaine during airway topical anesthesia with a spray-as-you-go technique via the fiberoptic bronchoscope. Fifty-two adult patients with a difficult airway were randomly assigned to 1 of 2 study groups to receive 2% (Group 1) or 4% lidocaine (Group 2) by a spray-as-you-go technique with the fiberoptic bronchoscope, in a double-blind manner. After airway topical anesthesia, awake fiberoptic orotracheal intubation (FOI) was performed. Level of sedation, time for each

EvidenceUpdates2009