Latest & greatest articles for analgesia

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Analgesia

Analgesic drugs are used to provide analgesia, the inability to feel pain. There are numerous groups of analgesics including simple analgesics, non-steroidal anti-inflammatory drugs (NSAIDs) and opioids. Analgesics types are prescribed differently depending on the severity of pain relief needed.

The most common type of analgesic generally known and used is non-steroidal anti-inflammatory drugs such as paracetamol, aspirin and ibuprofen. Opioid drugs include morphine, codeine, oxycodone, dihydromorphine and pethidine.

Research shows that analgesic drugs have an effect on the peripheral and central nervous system, relieving pain without the loss of consciousness. Opioids are highly effect pain relievers however case studies prove they can be highly addictive. Therefore use should be guided by the World Health Organization (WHO) pain ladder which specifies mild analgesics as its first step.

Clinical trials and studies carried out across all groups of analgesia have proven the drugs are highly effective painkillers, opioids in particular. However, years of research and clinical trials conclude that some groups have significant side effects such as addiction or cardiovascular side effects. Research evidence is broad including clinical guidelines, systematic reviews, randomised controlled trials, case studies etc. These can easily be found via a search of the Trip Database.

Top results for analgesia

141. Comparing effects of intravenous patient-controlled analgesia and intravenous injection in patients who have undergone total hysterectomy

Comparing effects of intravenous patient-controlled analgesia and intravenous injection in patients who have undergone total hysterectomy 23656176 2014 03 10 2015 04 06 2015 06 08 1365-2702 23 7-8 2014 Apr Journal of clinical nursing J Clin Nurs Comparing effects of intravenous patient-controlled analgesia and intravenous injection in patients who have undergone total hysterectomy. 967-75 10.1111/jocn.12221 To compare the effects of two pain management methods, intravenous patient-controlled (...) analgesia and conventional intravenous injection, in terms of pain level, adverse reactions experienced, nursing care time spent for pain management, satisfaction with pain management and total cost of pain management for patients who underwent total abdominal hysterectomy. Patient-controlled intravenous analgesia has been used most commonly for management of postoperative pain. Although it can be very effective in management of postoperative pain, patients still complained of many adverse reactions

EvidenceUpdates2013

142. Efficacy of Multimodal Perioperative Analgesia Protocol With Periarticular Medication Injection in Total Knee Arthroplasty: A Randomized, Double-Blinded Study

Efficacy of Multimodal Perioperative Analgesia Protocol With Periarticular Medication Injection in Total Knee Arthroplasty: A Randomized, Double-Blinded Study 23608085 2013 09 03 2014 05 12 2015 01 15 1532-8406 28 8 2013 Sep The Journal of arthroplasty J Arthroplasty Efficacy of multimodal perioperative analgesia protocol with periarticular medication injection in total knee arthroplasty: a randomized, double-blinded study. 1274-7 10.1016/j.arth.2013.03.008 S0883-5403(13)00250-7 Pain control (...) . Copyright © 2013 Elsevier Inc. All rights reserved. Kelley Todd C TC Department of Orthopaedics, University of Cincinnati, Cincinnati, Ohio, USA. Adams Mary Jo MJ Mulliken Brian D BD Dalury David F DF eng Journal Article Randomized Controlled Trial 2013 04 20 United States J Arthroplasty 8703515 0883-5403 0 Amides 0 Analgesics 7IO5LYA57N ropivacaine MN3L5RMN02 Clonidine YKH834O4BH Epinephrine YZI5105V0L Ketorolac IM J Arthroplasty. 2014 Oct;29(10):2057 Adult Aged Aged, 80 and over Amides administration

EvidenceUpdates2013

143. A randomized controlled comparison of epidural analgesia and combined spinal-epidural analgesia in a private practice setting: pain scores during first and second stages of labor and at delivery

A randomized controlled comparison of epidural analgesia and combined spinal-epidural analgesia in a private practice setting: pain scores during first and second stages of labor and at delivery 23400985 2013 02 26 2013 06 12 2013 02 26 1526-7598 116 3 2013 Mar Anesthesia and analgesia Anesth. Analg. A randomized controlled comparison of epidural analgesia and combined spinal-epidural analgesia in a private practice setting: pain scores during first and second stages of labor and at delivery (...) . 636-43 10.1213/ANE.0b013e31827e4e29 There has been no prospective evaluation of combined spinal-epidural (CSE) analgesia in a private practice setting and few studies have focused on pain relief during the second stage of labor and at delivery. In this randomized controlled trial, we compared verbal pain scores during the first and second stages of labor and at delivery in women receiving CSE or traditional epidural analgesia at a busy private maternity hospital. Healthy, term parturients received

EvidenceUpdates2013

144. Epidural versus continuous preperitoneal analgesia during fast-track open colorectal surgery: a randomized controlled trial

Epidural versus continuous preperitoneal analgesia during fast-track open colorectal surgery: a randomized controlled trial 23426208 2013 02 21 2013 04 19 2013 10 07 1528-1175 118 3 2013 Mar Anesthesiology Anesthesiology Epidural versus continuous preperitoneal analgesia during fast-track open colorectal surgery: a randomized controlled trial. 622-30 10.1097/ALN.0b013e3182800d94 Effective postoperative analgesia is essential for early rehabilitation after surgery. Continuous wound infiltration (...) (CWI) of local anesthetics has been proposed as an alternative to epidural analgesia (EA) during colorectal surgery. This prospective, double-blind trial compared CWI and EA in patients undergoing elective open colorectal surgery. Fifty consecutive patients were randomized to receive EA or CWI for 48 h. In both groups, patients were managed according to Enhanced Recovery After Surgery recommendations. The primary outcome was the dynamic pain score measured during mobilization 24 h after surgery

EvidenceUpdates2013

145. Effect of Postoperative Analgesia on Energy Metabolism and Role of Cyclooxygenase-2 Inhibitors for Postoperative Pain Management After Abdominal Surgery in Adults

Effect of Postoperative Analgesia on Energy Metabolism and Role of Cyclooxygenase-2 Inhibitors for Postoperative Pain Management After Abdominal Surgery in Adults 23328338 2013 06 05 2014 01 06 2013 06 05 1536-5409 29 7 2013 Jul The Clinical journal of pain Clin J Pain Effect of postoperative analgesia on energy metabolism and role of cyclooxygenase-2 inhibitors for postoperative pain management after abdominal surgery in adults. 570-6 10.1097/AJP.0b013e318270f97b It is questionable whether (...) the stress response to surgery is necessary. The objective of this study was to evaluate the effectiveness of postoperative analgesia on energy metabolism and compare cyclooxygenase-2 selective inhibitor with tramadol in postoperative pain management after major abdominal surgery. A total of 112 patients undergoing major abdominal surgery were randomly assigned to one of the 4 treatment groups before surgery. Then, patients were scheduled to receive different analgesic drugs after surgery: group

EvidenceUpdates2013

146. For Patients With Dental Pain, Combination Therapy With Ibuprofen And Acetaminophen Is More Effective In Producing Analgesia Than Monotherapy With Ibuprofen Alone

For Patients With Dental Pain, Combination Therapy With Ibuprofen And Acetaminophen Is More Effective In Producing Analgesia Than Monotherapy With Ibuprofen Alone UTCAT2379, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title For Patients With Dental Pain, Combination Therapy With Ibuprofen And Acetaminophen Is More Effective In Producing Analgesia Than Monotherapy With Ibuprofen Alone Clinical Question In patients (...) with inflammatory pain, does the combination of ibuprofen and acetaminophen compared to ibuprofen alone produce greater analgesia? Clinical Bottom Line Combination therapy with ibuprofen and acetaminophen produces greater analgesia than ibuprofen alone in patients with inflammatory pain. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Daniels/2011 678 patients at least 16 years old with at least 3 impacted 3rd

UTHSCSA Dental School CAT Library2013

147. Comparing the Analgesia Effects of Single-injection and Continuous Femoral Nerve Blocks with Patient Controlled Analgesia after Total Knee Arthroplasty

Comparing the Analgesia Effects of Single-injection and Continuous Femoral Nerve Blocks with Patient Controlled Analgesia after Total Knee Arthroplasty 23142441 2013 03 18 2013 09 30 2013 03 18 1532-8406 28 4 2013 Apr The Journal of arthroplasty J Arthroplasty Comparing the analgesia effects of single-injection and continuous femoral nerve blocks with patient controlled analgesia after total knee arthroplasty. 608-13 10.1016/j.arth.2012.06.039 S0883-5403(12)00531-1 We compared the analgesic (...) effects of single-injection or continuous femoral nerve block (FNB) with intravenous patient controlled analgesia (PCA) opioids. Two hundred patients undergoing knee arthroplasty were randomized to one of the three regimens. Significant knee pain on movement at postoperative 24h was reduced with single-injection (OR 0.30; 95% CI 0.12 to 0.74; P=0.009) or continuous (OR 0.21; 95% CI 0.08 to 0.51; P=0.001) FNB, compared with PCA. Allocation to FNBs also resulted in significantly less opioid consumption

EvidenceUpdates2013

148. Codeine for analgesia: restricted use in children because of reports of morphine toxicity

Codeine for analgesia: restricted use in children because of reports of morphine toxicity Codeine for analgesia: restricted use in children because of reports of morphine toxicity Drug Safety Update - GOV.UK GOV.UK uses cookies to make the site simpler. Search Codeine for analgesia: restricted use in children because of reports of morphine toxicity From: Published: 10 July 2013 Therapeutic area: , , , , and Codeine should only be used to relieve acute moderate pain in children older than 12 (...) years and only if it cannot be relieved by other painkillers such as paracetamol or ibuprofen alone. Furthermore, a significant risk of serious and life-threatening adverse reactions has been identified in children with obstructive sleep apnoea who received codeine after tonsillectomy or adenoidectomy (or both). Codeine is now contraindicated in all children younger than 18 years who undergo these procedures for obstructive sleep apnoea Article date: July 2013 Codeine is used for pain relief

MHRA Drug Safety Update2013

149. Randomised controlled trial: Intravenous analgesia for out-of-hospital traumatic pain in adults: ketamine gives a greater reduction in pain than morphine but causes more adverse effects

Randomised controlled trial: Intravenous analgesia for out-of-hospital traumatic pain in adults: ketamine gives a greater reduction in pain than morphine but causes more adverse effects Intravenous analgesia for out-of-hospital traumatic pain in adults: ketamine gives a greater reduction in pain than morphine but causes more adverse effects | Evidence-Based Nursing This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in via your Society Log (...) in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in via your Society Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Intravenous analgesia for out-of-hospital traumatic pain in adults: ketamine gives a greater reduction in pain than

Evidence-Based Nursing (Requires free registration)2013

150. Systematic review: Women who receive continuous support during labour have reduced risk of caesarean, instrumental delivery or need for analgesia compared to usual care

Systematic review: Women who receive continuous support during labour have reduced risk of caesarean, instrumental delivery or need for analgesia compared to usual care Women who receive continuous support during labour have reduced risk of caesarean, instrumental delivery or need for analgesia compared to usual care | Evidence-Based Nursing This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Log in via your Society Log in using your username (...) and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in via your Society Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Women who receive continuous support during labour have reduced risk of caesarean, instrumental delivery or need for analgesia compared

Evidence-Based Nursing (Requires free registration)2013

151. Local Infiltration Analgesia in Hip and Knee Arthroplasty: A Rapid Review

Local Infiltration Analgesia in Hip and Knee Arthroplasty: A Rapid Review Local infiltration analgesia in hip and knee arthroplasty: a rapid review Local infiltration analgesia in hip and knee arthroplasty: a rapid review Brener S Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Brener S. Local infiltration analgesia in hip and knee (...) arthroplasty: a rapid review. Toronto: Health Quality Ontario (HQO). Rapid Review. 2013 Authors' objectives The objective of this rapid review was to examine the effectiveness of local infiltration analgesia in patients who have undergone primary hip arthroplasty or primary knee arthroplasty. Authors' conclusions Based on very low quality of evidence: The results for the impact of local infiltration analgesia on pain in patients undergoing either total hip or knee arthroplasty were inconsistent

Health Technology Assessment (HTA) Database.2013

152. Antihistamine agents added to opioid analgesia

Antihistamine agents added to opioid analgesia Antihistamine agents added to opioid analgesia Antihistamine agents added to opioid analgesia Leas B, Williams K Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Leas B, Williams K. Antihistamine agents added to opioid analgesia. Philadelphia: Center for Evidence-based Practice (CEP). 2013 Final publication URL (...) Indexing Status Subject indexing assigned by CRD MeSH Analgesics, Opioid; Histamine Antagonists; Humans Language Published English Country of organisation United States English summary An English language summary is available. Address for correspondence Center for Evidence-based Practice, University of Pennsylvania Health System, 3535 Market St. Suite 50, Philadelphia PA 19104 Email: Cep2@uphs.upenn.edu AccessionNumber 32014000613 Date abstract record published 17/06/2014 Health Technology Assessment

Health Technology Assessment (HTA) Database.2013

153. Local Infiltration Analgesia in Hip and Knee Arthroplasty

Local Infiltration Analgesia in Hip and Knee Arthroplasty Local Infiltration Analgesia in Hip and Knee Arthroplasty: A Rapid Review. November 2013; pp. 1–22 Local Infiltration Analgesia in Hip and Knee Arthroplasty: A Rapid Review S Brener November 2013 Evidence Development and Standards Branch at Health Quality Ontario Local Infiltration Analgesia in Hip and Knee Arthroplasty: A Rapid Review. November 2013; pp. 1–22 2 Suggested Citation This report should be cited as follows: Brener, S. Local (...) infiltration analgesia in hip and knee arthroplasty: a rapid review. Toronto: Health Quality Ontario; 2013 November. 22 p. Available from: http://www.hqontario.ca/evidence/publications-and-ohtac- recommendations/rapid-reviews. Permission Requests All inquiries regarding permission to reproduce any content in Health Quality Ontario reports should be directed to EvidenceInfo@hqontario.ca. How to Obtain Rapid Reviews From Health Quality Ontario All rapid reviews are freely available in PDF format

Health Quality Ontario2013

154. Beyond opioid patient-controlled analgesia: a systematic review of analgesia after major spine surgery

Beyond opioid patient-controlled analgesia: a systematic review of analgesia after major spine surgery Beyond opioid patient-controlled analgesia: a systematic review of analgesia after major spine surgery Beyond opioid patient-controlled analgesia: a systematic review of analgesia after major spine surgery Sharma S, Balireddy RK, Vorenkamp KE, Durieux ME CRD summary The authors concluded that there was a lack of evidence of overall benefit on postoperative pain after spine surgery of most (...) regional analgesic techniques, of gabapentinoids and of most non-steroidal anti-inflammatory drugs. The authors' cautious conclusions reflect the limitations of the evidence and seem appropriate. Authors' objectives To evaluate postoperative pain management in patients undergoing major spine surgery. Searching PubMed and MD Consult databases were searched up to 2011 for articles published in English. Broad search terms were reported. Reference lists of related studies were searched. Study selection

DARE.2012

155. The sequence of administration of 1.5% mepivacaine and 0.5% bupivacaine does not affect latency of block onset or duration of analgesia in ultrasound-guided interscalene block

The sequence of administration of 1.5% mepivacaine and 0.5% bupivacaine does not affect latency of block onset or duration of analgesia in ultrasound-guided interscalene block 22798531 2012 09 24 2012 12 03 2013 11 21 1526-7598 115 4 2012 Oct Anesthesia and analgesia Anesth. Analg. The sequence of administration of 1.5% mepivacaine and 0.5% bupivacaine does not affect latency of block onset or duration of analgesia in ultrasound-guided interscalene block. 963-7 During peripheral nerve blockade (...) the primary outcomes. Block onset was also assessed. Duration of motor block was similar between group A and group B (10.1 ± 4.7 hours vs 10.3 ± 5.1 hours, mean difference 0.2 hours, 95% confidence interval [CI] -3.3 to 2.9, P = 0.9). Duration of analgesia was also similar between group A and group B (9.5 ± 5.6 hours vs 10.2 ± 4.5 hours, mean difference 0.7 hours, 95% CI -3.2 to 1.9, P = 0.42). Onset of sensory block was similar between the 2 groups (15.9 ± 7.1 minutes for group A, 13.9 ± 7.0 minutes

EvidenceUpdates2012

156. Combination of low-dose bupivacaine and opioids provides satisfactory analgesia with less intraoperative hypotension for spinal anesthesia in cesarean section

Combination of low-dose bupivacaine and opioids provides satisfactory analgesia with less intraoperative hypotension for spinal anesthesia in cesarean section Combination of low-dose bupivacaine and opioids provides satisfactory analgesia with less intraoperative hypotension for spinal anesthesia in cesarean section Combination of low-dose bupivacaine and opioids provides satisfactory analgesia with less intraoperative hypotension for spinal anesthesia in cesarean section Qiu MT, Lin FQ, Fu SK (...) anaesthesia in caesarean section. Searching MEDLINE (from 1966), EMBASE (from 1985) and The Cochrane Library were searched up to October 2011 for relevant published studies; search terms were reported. Study selection Randomised controlled trials (RCTs) of elective caesarean section were eligible for the review. Eligible reviews were required to compare the incidence of hypotension and analgesia effects of low dose bupivacaine or low dose bupivacaine combined with opioids with high dose bupivacaine used

DARE.2012

157. The 2012 Chitranjan Ranawat Award: Intraarticular Analgesia After TKA Reduces Pain: A Randomized, Double-blinded, Placebo-controlled, Prospective Study

The 2012 Chitranjan Ranawat Award: Intraarticular Analgesia After TKA Reduces Pain: A Randomized, Double-blinded, Placebo-controlled, Prospective Study 23011843 2012 12 24 2013 05 28 2017 02 20 1528-1132 471 1 2013 Jan Clinical orthopaedics and related research Clin. Orthop. Relat. Res. The 2012 Chitranjan Ranawat award: intraarticular analgesia after TKA reduces pain: a randomized, double-blinded, placebo-controlled, prospective study. 64-75 10.1007/s11999-012-2596-9 Postoperative pain after (...) total knee arthroplasty remains one of the most important challenges facing patients undergoing this surgery. Providing a balance of adequate analgesia while limiting the functional impact of regional anesthesia and minimizing opioid side effects is critical to minimize adverse events and improve patient satisfaction. We asked whether bupivacaine delivered through an elastomeric device decreases the (1) patients' perception of pain after TKA; (2) narcotic consumption; and (3) narcotic-related side

EvidenceUpdates2012 Full Text: Link to full Text with Trip Pro

158. Minimally invasive surgery did not improve outcome compared to conventional surgery following unicompartmental knee arthroplasty using local infiltration analgesia

Minimally invasive surgery did not improve outcome compared to conventional surgery following unicompartmental knee arthroplasty using local infiltration analgesia 23043272 2012 11 26 2013 01 24 2016 12 15 1745-3682 83 6 2012 Dec Acta orthopaedica Acta Orthop Minimally invasive surgery did not improve outcome compared to conventional surgery following unicompartmental knee arthroplasty using local infiltration analgesia: a randomized controlled trial with 40 patients. 634-41 10.3109 (...) /17453674.2012.736169 There has recently been interest in the advantages of minimally invasive surgery (MIS) over conventional surgery, and on local infiltration analgesia (LIA) during knee arthroplasty. In this randomized controlled trial, we investigated whether MIS would result in earlier home-readiness and reduced postoperative pain compared to conventional unicompartmental knee arthroplasty (UKA) where both groups received LIA. 40 patients scheduled for UKA were randomized to a MIS group or a conventional

EvidenceUpdates2012 Full Text: Link to full Text with Trip Pro

159. Patient-controlled versus scheduled, nurse-administered analgesia following vaginal reconstructive surgery: a randomized trial

Patient-controlled versus scheduled, nurse-administered analgesia following vaginal reconstructive surgery: a randomized trial 22863282 2012 10 30 2013 01 22 2013 11 21 1097-6868 207 5 2012 Nov American journal of obstetrics and gynecology Am. J. Obstet. Gynecol. Patient-controlled versus scheduled, nurse-administered analgesia following vaginal reconstructive surgery: a randomized trial. 433.e1-6 10.1016/j.ajog.2012.06.040 S0002-9378(12)00654-0 To determine whether patient-controlled analgesia (...) or scheduled intravenous analgesia provides superior pain relief and satisfaction with pain control after vaginal reconstructive surgery. Fifty-nine women scheduled for vaginal reconstructive surgery were enrolled in this randomized trial. Operative procedures and postoperative orders were standardized. Visual analog scales for pain and satisfaction with pain control were recorded during the hospital stay and 2 weeks after surgery. Patients receiving patient-controlled analgesia had less pain

EvidenceUpdates2012

160. Randomized trial of transversus abdominis plane block at total laparoscopic hysterectomy: effect of regional analgesia on quality of recovery

Randomized trial of transversus abdominis plane block at total laparoscopic hysterectomy: effect of regional analgesia on quality of recovery 22840413 2012 10 30 2013 01 22 2016 11 25 1097-6868 207 5 2012 Nov American journal of obstetrics and gynecology Am. J. Obstet. Gynecol. Randomized trial of transversus abdominis plane block at total laparoscopic hysterectomy: effect of regional analgesia on quality of recovery. 419.e1-5 10.1016/j.ajog.2012.06.052 S0002-9378(12)00666-7 The objective (...) Amides 0 Anesthetics, Local 7IO5LYA57N ropivacaine AIM IM Abdominal Muscles diagnostic imaging drug effects Adult Amides therapeutic use Analgesia methods Anesthetics, Local therapeutic use Female Humans Hysterectomy methods Laparoscopy methods Length of Stay Middle Aged Nerve Block methods Pain Measurement Recovery of Function drug effects Treatment Outcome Ultrasonography 2012 01 09 2012 05 03 2012 06 27 2012 7 31 6 0 2012 7 31 6 0 2013 1 23 6 0 ppublish 22840413 S0002-9378(12)00666-7 10.1016

EvidenceUpdates2012