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Latest & greatest articles for anaesthesia
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Clinical Anaesthesia is used to induce a temporary medical state of controlled unconsciousness, inducing a loss of sensation or awareness. There are three main types of Anaesthesia:
Local and Regional
Anaesthesia is primarily used during surgical procedures to block pain. While unconscious, blood flow and heart rate is monitored.
Research and development in the use of Anaesthesia has helped anesthesiologists in the progression of patient safety before and after surgery and medical procedures. The developments and research of Anaesthesia through the years has massively influences medicine and surgery today.
Case studies and clinical trials help aid researchers in the development of aftercare during postoperative recovery. Research is a vital part in the field of Anaesthesia, it allows anesthesiologists to improve the delivery of patient safety while unconscious.
Learn more on the emerging technology in Anaesthesia and the advancements in Anaesthesia practise by searching Trip.
Intravenous Lidocaine Alleviates the Pain of Propofol Injection by Local Anesthetic and Central Analgesic Effects Lidocaine alleviates propofol injection pain. However, whether lidocaine works through a local anesthetic effect at the site of intravenous injection or through a systemic effect on the central nervous system remains unknown. This study aimed to determine the pain-alleviating mechanism of lidocaine.A randomized controlled study.A gastroscopy facility.The study was divided into two (...) vein. Lidocaine reduces propofol injection pain through both a local anesthetic effect and a central analgesic effect when the dosage reaches 1.5 mg/kg.
General Anesthesia Versus Conscious Sedation for Endovascular Treatment of Acute Ischemic Stroke: The AnStroke Trial (Anesthesia During Stroke) Retrospective studies have found that patients receiving general anesthesia for endovascular treatment in acute ischemic stroke have worse neurological outcome compared with patients receiving conscious sedation. In this prospective randomized single-center study, we investigated the impact of anesthesia technique on neurological outcome in acute (...) ischemic stroke patients.Ninety patients receiving endovascular treatment for acute ischemic stroke in 2013 to 2016 were included and randomized to general anesthesia or conscious sedation. Difference in neurological outcome at 3 months, measured as modified Rankin Scale score, was analyzed (primary outcome) and early neurological improvement of National Institutes of Health Stroke Scale and cerebral infarction volume. Age, sex, comorbidities, admission National Institutes of Health Stroke Scale score
Safety Aspects of Postanesthesia Care Unit Discharge without Motor Function Assessment after Spinal Anesthesia: A Randomized, Multicenter, Semiblinded, Noninferiority, Controlled Trial Postanesthesia care unit (PACU) discharge without observation of lower limb motor function after spinal anesthesia has been suggested to significantly reduce PACU stay and enhance resource optimization and early rehabilitation but without enough data to allow clinical recommendations.A multicenter, semiblinded (...) , noninferiority randomized controlled trial of discharge from the PACU with or without assessment of lower limb motor function after elective total hip or knee arthroplasty under spinal anesthesia was undertaken. The primary outcome was frequency of a successful fast-track course (length of stay 4 days or less and no 30-day readmission). Noninferiority would be declared if the odds ratio (OR) for a successful fast-track course was no worse for those patients receiving no motor function assessment versus those
Sequential compression pump effect on hypotension due to spinal anesthesia for cesarean section: A double blind clinical trial Spinal anesthesia (SA) is a standard technique for cesarean section. Hypotension presents an incident of 80-85% after SA in pregnant women.To determine the effect of intermittent pneumatic compression of lower limbs on declining spinal anesthesia induced hypotension during cesarean section.This double-blind clinical prospective study was conducted on 76 non-laboring (...) parturient patients, aged 18-45 years, with the American Society of Anesthesiologist physical status I or II who were scheduled for elective cesarean section at Razi Hospital, Ahvaz, Iran from December 21, 2015 to January 20, 2016. Patients were divided into treatment mechanical pump (Group M) or control group (Group C) with simple random sampling. Fetal presentation, birth weight, Apgar at 1 and 5 min, time taken for pre-hydration (min), pre-hydration to the administration of spinal anesthesia (min
New global surgical and anaesthesia indicators in the World Development Indicators dataset 29225929 2018 11 13 2059-7908 2 2 2017 BMJ global health BMJ Glob Health New global surgical and anaesthesia indicators in the World Development Indicators dataset. e000265 10.1136/bmjgh-2016-000265 Raykar Nakul P NP Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA. Program in Global Surgery and Social Change, Harvard Medical School, Boston (...) . Leather Andrew J M AJM King's Centre for Global Health, King's Health Partners and King's College London, London, UK. McQueen K A Kelly KAK Vanderbilt Anesthesia Global Health & Development, Nashville, Tennessee, USA. Department of Anesthesia, Vanderbilt University Medical Center, Nashville, Tennessee, USA. Mukhopadhyay Swagoto S Program in Global Surgery and Social Change, Harvard Medical School, Boston, Massachusetts, USA. Department of Surgery, University of Connecticut School of Medicine, Hartford
Comparative experimental study on two designed intravenous anaesthetic combinations in dogs The goal of the present study is to design a good anaesthetic program for dogs which can lead to optimal anaesthesia with no or minimal post-operative adverse effects. For this purpose, we designed two anaesthetic combinations and compared their effects in Mongrel dogs: combination 'A' consisting of atropine, xylazine, ketamine plus propofol, and combination 'B' consisting of atropine, diazepam, ketamine (...) plus propofol. The onset and duration of anaesthesia induction, the duration of maintenance as well as the period of recovery were recorded and compared for both combinations. Furthermore, heart rate, respiratory rate, body temperature as well as blood picture were analyzed before and after administration of the proposed anaesthetic regimens. Administration of combination 'A' lead to rapid onset, within seconds, and induction of anaesthesia. The anaesthetic effect was maintained for approximately
__________________________________________________________________________________ For further information: Prof Andrew R Wolf, President APAGBI firstname.lastname@example.org References:  Andropoulos DB, Greene MF. Anesthesia and Developing Brains - Implications of the FDA Warning. N Engl J Med 2017.  Creeley CE. From Drug-Induced Developmental Neuroapoptosis to Pediatric Anesthetic Neurotoxicity-Where Are We Now? Brain Sci 2016;6(3).  Davidson A. The effect of anaesthesia on the infant brain. Early Hum Dev 2016;102:37-40.  Davidson AJ, Disma N, de Graaff JC, Withington DE (...) the Association between Surgery in Early Life and Child Development at Primary School Entry. Anesthesiology 2016;125(2):272-279.  Sun LS, Li G, Miller TL, Salorio C, Byrne MW, Bellinger DC, Ing C, Park R, Radcliffe J, Hays SR, DiMaggio CJ, Cooper TJ, Rauh V, Maxwell LG, Youn A, McGowan FX. Association Between a Single General Anesthesia Exposure Before Age 36 Months and Neurocognitive Outcomes in Later Childhood. JAMA 2016;315(21):2312-2320.  Vutskits L, Xie Z. Lasting impact of general anaesthesia
Intraoperative Completion Studies, Local Anesthesia, and Antiplatelet Medication Are Associated With Lower Risk in Carotid Endarterectomy In Germany, all surgical and endovascular procedures on the carotid bifurcation must be documented in a statutory nationwide quality assurance database. We aimed to analyze the association between procedural and perioperative variables and in-hospital stroke or death rates after carotid endarterectomy.Between 2009 and 2014, overall 142 074 elective carotid (...) . In the multivariable analysis, lower risks of stroke or death were independently associated with local anesthesia (versus general anesthesia: RR, 0.85; 95% confidence interval [CI], 0.75-0.95), carotid endarterectomy with patch plasty compared with primary closure (RR, 0.71; 95% CI, 0.52-0.97), intraoperative completion studies by duplex ultrasound (RR, 0.74; 95% CI, 0.63-0.88) or angiography (RR, 0.80; 95% CI, 0.71-0.90), and perioperative antiplatelet medication (RR, 0.83; 95% CI, 0.71-0.97). No shunting
performance in adolescence. There may be vulnerable groups that are at higher risk. Conflicts of interest: the authors had no conflicts of interest. Funding source: various grants from Swedish institutions. Critical Commentary Justification: data from animal model studies suggest that exposure to anaesthetic agents at early ages causes neuronal apoptosis and long-term learning and memory impairment. 1 Since millions of children require anaesthesia for surgical interventions every year, these findings have (...) anestésicos versus retrasos en los procedimientos indicados que podrían ser perjudiciales para los pacientes. Referencias 1 Andropoulos DB, Greene MF. Anesthesia and developing brains – Implications of the FDA warning. NEJM. 2017. DOI: 10.1056/NEJMp1700196 2 Davidson AJ, Disma N, de Graaff JC, Withington DE, Dorris L, Bell G, et al . Neurodevelopmental outcome at 2 years of age after general anaesthesia and awake-regional anaesthesia in infancy (GAS): an international multicentre, randomised controlled
patients requiring bilateral local anesthetic injections. Randomized Controlled Trial Key results The split-mouth study evaluated anticipated and actual pain for inferior-alveolar, palatal, long buccal, and infraorbital injections given via an intraoral vibration device. Actual pain upon injection was significantly less than anticipated pain for inferior alveolar (P Evidence Search ("pain"[MeSH Terms] OR "pain"[All Fields]) AND ("local anaesthesia"[All Fields] OR "anesthesia, local"[MeSH Terms (...) Research indicates Reduction of Pain upon Inferior Alveolar and Infraorbatial injection Using Vibrating Intraoral Local Anesthetic Devices UTCAT3207, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Research indicates Reduction of Pain upon Inferior Alveolar and Infraorbatial injection Using Vibrating Intraoral Local Anesthetic Devices Clinical Question In patients with fear of dental injections, do vibrating intraoral
Liposomal Bupivacaine May Prove to Provide Adequate Long-Term Local Anesthesia UTCAT3208, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Liposomal Bupivacaine May Prove to Provide Adequate Long-Term Local Anesthesia Clinical Question Is liposomal bupivacaine (Exparel) effective in providing extended local anesthesia and reducing post-operative opioid use in a variety of dental procedures? Clinical Bottom Line (...) For patients receiving endodontic care or third molar extractions, there is not enough evidence to support the conclusion that liposomal bupivacaine is any more effective than other anesthesia medications. This is supported by a randomized double-blinded study in which buccal infiltration of liposomal bupivacaine was shown to not achieve clinically relevant levels of anesthesia for prolonged periods of time. A systematic review of liposomal bupivacaine showed inconclusive evidence to support that liposomal
local anesthesia infiltration, does the warming of the cartridge pre-injection reduce the anticipated injection pain compared to using cartridges at room temperature? Clinical Bottom Line Warming of local anesthetic cartridges does not reduce pain and discomfort during intraoral infiltration injections. This is supported by a randomized controlled clinical trial that showed that children's objective and subjective reactions to warmed and room temperature injections were not statistically different (...) between the children’s reactions to the warm (W) and room temperature (RT) injections on any of the three parameters. Evidence Search ("review"[All Fields] OR "review literature as topic"[MeSH Terms] OR "systematic review"[All Fields]) AND warming[All Fields] AND ("local anaesthesia"[All Fields] OR "anesthesia, local"[MeSH Terms] OR ("anesthesia"[All Fields] AND "local"[All Fields]) OR "local anesthesia"[All Fields] OR ("local"[All Fields] AND "anesthesia"[All Fields])) Comments on The Evidence
Local anesthetic toxicity: acute and chronic management Local anesthetics are commonly used medicines in clinical settings. They are used for pain management during minor interventional treatments, and for postoperative care after major surgeries. Cocaine is the well-known origin of local anesthetics, and the drug and related derivatives have long history of clinical usage for more than several centuries. Although illegal use of cocaine and its abuse are social problem in some countries, other (...) local anesthetics are safely and effectively used in clinics and hospitals all over the world. However, still this drug category has several side-effects and possibilities of rare but serious complications. Acute neurotoxicity and cardiac toxicity are derived from unexpected high serum concentration. Allergic reactions are observed in some cases, especially following the use of ester structure drugs. Chronic toxicity is provoked when nerve fibers are exposed to local anesthetics at a high
The Influence of Oral Ginger before Operation on Nausea and Vomiting after Cataract Surgery under General Anesthesia: A double-blind placebo-controlled randomized clinical trial. According to Iranian traditional medicine, using safe ginger may contribute to taking less chemical medicines and result in fewer side effects.To determine the influence of using ginger before operation on nausea and vomiting, after cataract surgery under general anesthesia.This study was a double-blind placebo
Topical anaesthesia for needle-related pain in newborn infants. Hospitalised newborn neonates frequently undergo painful invasive procedures that involve penetration of the skin and other tissues by a needle. One intervention that can be used prior to a needle insertion procedure is application of a topical local anaesthetic.To evaluate the efficacy and safety of topical anaesthetics such as amethocaine and EMLA in newborn term or preterm infants requiring an invasive procedure involving (...) anaesthetics amethocaine and eutectic mixture of local anaesthetics (EMLA) in terms of anaesthetic efficacy and safety in newborn term or preterm infants requiring an invasive procedure involving puncture of skin and other tissues with a needle DATA COLLECTION AND ANALYSIS: From the reports of the clinical trials we extracted data regarding clinical outcomes including pain, number of infants with methaemoglobin level 5% and above, number of needle prick attempts prior to successful needle-related procedure
Comparison of Regional vs. General Anesthesia for Surgical Repair of Open-Globe Injuries at a University Referral Center This study compares the clinical features and physician selection of either Regional Anesthesia (peribulbar or retrobulbar block) with Monitored Anesthesia Care (RA-MAC) or General Anesthesia (GA) for open globe injury repair.A non-randomized, comparative, retrospective case series at a University Referral Center.All adult repairable open globe injuries receiving primary (...) repair between January 1st, 2004 and December 31st, 2014 (11 years). Exclusion criteria were patients less than 18 years of age and those treated with primary enucleation.Data was gathered via retrospective chart review.Data collected from each patient was age, gender, injury type, location, length of wound, presenting visual acuity, classification of anesthesia used, duration of the procedure performed, months of clinical follow-up, and final visual acuity.During the 11 years study period, 448
Palliative radiation therapy for superior vena cava syndrome in metastatic Wilms tumor using 10XFFF and 3D surface imaging to avoid anesthesia in a pediatric patientâ€”a teaching case 28740919 2018 11 13 2452-1094 2 1 2017 Jan-Mar Advances in radiation oncology Adv Radiat Oncol Palliative radiation therapy for superior vena cava syndrome in metastatic Wilms tumor using 10XFFF and 3D surface imaging to avoid anesthesia in a pediatric patient-a teaching case. 101-104 10.1016/j.adro.2016.12.007
AND DEPOLARIZING MUSCLE RELAXANTS Background Potent volatile anesthetic agents are widely used and generally safe agents for inducing general anesthesia. The mechanism of action of these agents is unknown in spite of many hypotheses and inves- tigations. The agents include sevoflurane, halothane, enflurane, isoflurane, methoxyflurane, and desflurane; all of the currently available potent inhalation anesthetics are presumed to be equiva- lent triggers of malignant hyperthermia (MH). Depolarizing muscle (...) . If succinylcholine was administered, masseter muscle rigidity is often the first sign of MH. 5 If left untreated, an MH reaction can re- sult in cardiac arrest and death. 4 Any of the potent volatile anes- thetics, and the depolarizing muscle relaxant succinylcholine, can trigger an MH reaction in susceptible individuals. 5 Potent volatile anesthetics and succinylcholine are contraindicated in individu- als with MHS. MH episodes have an estimated incidence of be- tween 1/10,000 and 1/250,000 anesthesias
serve only as guidelines for the care of breastfeeding mothers and infants and do not delineate an exclusive course of treatment or serve as standards of medical care. Variations in treatment may be appropriate according to the needs of an individual patient. Background T hereislittlerigorousinformationinthescienti?c literature about anesthesia or procedural sedation in breastfeeding mothers. Recommendations in this area typi- cally focus on pharmacologic properties of anesthetic agents, limited (...) , single doses of meperidine/pethidine or diazepam are unlikely to affect the breastfeeding infant. 15 (III) Local anesthetics given by injection or topical application are considered safe for breastfeeding mothers. 2,3 (IV) Regional anesthesia. Regional anesthesia, including spinal, epidural, or peripheral nerve block, should be con- sidered whenever possible, whether for intraoperative anes- thesia or postoperative analgesia. 3 (IV) Regional anesthesia reduces the need for intraoperative medications
Pre-procedural fasting for inpatients undergoing interventional radiology or cardiac procedures not requiring general anesthesia Pre-procedural fasting for inpatients undergoing interventional radiology or cardiac procedures not requiring general anesthesia Pre-procedural fasting for inpatients undergoing interventional radiology or cardiac procedures not requiring general anesthesia Lavenberg JG, Holland S, Solano L, Stoudt G, Mitchell MD, Mull, N. Record Status This is a bibliographic record (...) of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Lavenberg JG, Holland S, Solano L, Stoudt G, Mitchell MD, Mull, N.. Pre-procedural fasting for inpatients undergoing interventional radiology or cardiac procedures not requiring general anesthesia. Philadelphia: Center for Evidence-based Practice (CEP). 2017 Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Anesthesia