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Latest & greatest articles for amlodipine
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A comparison of nisoldipine ER and amlodipine for the treatment of mild to moderate hypertension A comparison of nisoldipine ER and amlodipine for the treatment of mild to moderate hypertension A comparison of nisoldipine ER and amlodipine for the treatment of mild to moderate hypertension Whitcomb C, Enzmann G, Pershadsingh H A, Johnson R, Ciuryla V, Reisin E Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract (...) contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The use of two long-acting dihydropyridine calcium antagonists, amlodipine and nisoldipine extended-release, for the treatment of mild to moderate hypertension. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population The study population comprised adult patients with Stage I
Effect of amlodipine on morbidity and mortality in severe chronic heart failure. Prospective Randomized Amlodipine Survival Evaluation Study Group. Previous studies have shown that calcium-channel blockers increase morbidity and mortality in patients with chronic heart failure. We studied the effect of a new calcium-channel blocker, amlodipine, in patients with severe chronic heart failure.We randomly assigned 1153 patients with severe chronic heart failure and ejection fractions of less than (...) 30 percent to double-blind treatment with either placebo (582 patients) or amlodipine (571 patients) for 6 to 33 months, while their usual therapy was continued. The randomization was stratified on the basis of whether patients had ischemic or nonischemic causes of heart failure. The primary end point of the study was death from any cause and hospitalization for major cardiovascular events.Primary end points were reached in 42 percent of the placebo group and 39 percent of the amlodipine group